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Emergence, Change And Precarious Systems: A New Lens On People And Organisation, Helen M. Hasan, Mary Barrett 2010 University of Wollongong

Emergence, Change And Precarious Systems: A New Lens On People And Organisation, Helen M. Hasan, Mary Barrett

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.


Biochemical Characterization Of Human Mismatch Recognition Proteins Mutsα And Mutsβ, Lei Tian 2010 University of Kentucky

Biochemical Characterization Of Human Mismatch Recognition Proteins Mutsα And Mutsβ, Lei Tian

University of Kentucky Doctoral Dissertations

The integrity of an organism's genome depends on the fidelity of DNA replication and the efficiency of DNA repair. The DNA mismatch repair (MMR) system, which is highly conserved from prokaryotes to eukaryotes, plays an important role in maintaining genome stability by correcting base-base mismatches and insertion/deletion (ID) mispairs generated during DNA replication and other DNA transactions. Mismatch recognition is a critical step in MMR. Two mismatch recognition proteins, MutSα (MSH2-MSH6 heterodimer) and MutSβ (MSH2-MSH3 heterodimer), have been identified in eukaryotic cells. MutSα and MutSβ have partially overlapping functions, with MutSα recognizing primarily base-base mismatches and 1-2 nt ...


Role Of Group X Secretory Phospholipase A2 In Murine Adipocytes, Xia Li 2010 University of Kentucky

Role Of Group X Secretory Phospholipase A2 In Murine Adipocytes, Xia Li

University of Kentucky Doctoral Dissertations

The secretory phospholipase A2 (sPLA2) family is a group of enzymes that catalyze the hydrolysis of glycerophospholipids at the sn-2 position, generating free fatty acids and lysophospholipids. The sPLA2 family has been implicated in various physiological and pathological activities. Eleven sPLA2’s have been identified in mammals, and the function of each isoform likely reflects its tissue distribution and substrate specificity. Studies in vitro indicate that Group X (GX) sPLA2 potently releases arachidonic acid (AA) and lysophosphatidylcholine from mammalian cell membranes. Interestingly, some of the biological effects mediated by GX sPLA2 in vitro are ...


Glycemic Index And Pregnancy: A Systematic Literature Review, Jimmy Chun Yu Louie, Jennie C. Brand-Miller, Tania P. Markovic, Glynis P. Ross, Robert G. Moses 2010 University of Wollongong

Glycemic Index And Pregnancy: A Systematic Literature Review, Jimmy Chun Yu Louie, Jennie C. Brand-Miller, Tania P. Markovic, Glynis P. Ross, Robert G. Moses

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background/Aim. Dietary glycemic index (GI) has received considerable research interest over the past 25 years although its application to pregnancy outcomes is more recent. This paper critically evaluates the current evidence regarding the effect of dietary GI on maternal and fetal nutrition. Methods. A systematic literature search using MEDLINE, EMBASE, CINAHL, Cochrane Library, SCOPUS, and ISI Web of Science, from 1980 through September 2010, was conducted. Results. Eight studies were included in the systematic review. Two interventional studies suggest that a low-GI diet can reduce the risk of large-for-gestational-age (LGA) infants in healthy pregnancies, but one epidemiological study reported ...


Nursing Care - Moving Beyond Being A Commodity And Measuring The Actual Contribution That Nurses Make To Patient Outcomes, Jenny Sim, Patrick A. Crookes, Kenneth Walsh 2010 University of Wollongong

Nursing Care - Moving Beyond Being A Commodity And Measuring The Actual Contribution That Nurses Make To Patient Outcomes, Jenny Sim, Patrick A. Crookes, Kenneth Walsh

Faculty of Health and Behavioural Sciences - Papers (Archive)

There is a new imperative on nursing as a profession to identify and measure the contribution that nurses make to patient outcomes. This is not an easy task. All nurses know that nursing is complex. Largely because of the complexity of the nursing task there has been no collective agreement in the literature or in practice of what constitutes good nursing care and no consensus or universal measure of quality nursing practice. This lack of consensus and inability to define a set of nursing indicators that quantify the impact that nursing care has on patient outcomes has left the nursing ...


Nursing Sensitive Outcomes: Identifying A Definition, Exploration Of Conceptual Challenges And An Overview Of The Literature, Jenny Sim, Patrick A. Crookes, Kenneth D. Walsh 2010 University of Wollongong

Nursing Sensitive Outcomes: Identifying A Definition, Exploration Of Conceptual Challenges And An Overview Of The Literature, Jenny Sim, Patrick A. Crookes, Kenneth D. Walsh

Faculty of Health and Behavioural Sciences - Papers (Archive)

Introduction/background: A literature review on nursing sensitive outcomes has been conducted as part of a larger research project. The literature was reviewed to: - identify a definition of nursing sensitive outcomes - determine the conceptual models used to describe nursing sensitive outcomes - identify significant contributions made by researchers on the development and use of nursing sensitive outcomes in clinical practice.The overall aim of the research project is to develop a set of indicators that provides a balanced view of nursing care and its contribution to patient outcomes. It is anticipated that this research will broaden the debate on nursing sensitive ...


Harms To Body And Soul: An Ideological Balancing Act For Preventing And Reducing Cannabis Use, Nadia Solowij 2010 University of Wollongong

Harms To Body And Soul: An Ideological Balancing Act For Preventing And Reducing Cannabis Use, Nadia Solowij

Faculty of Health and Behavioural Sciences - Papers (Archive)

In their piece for debate, Macleod & Hickman [1] present some credible arguments around the ways in which ideology may shape evidence and policy and describe the inevitable use of select aspects of scientific evidence to advance an agenda and drive funding directions. While the strength of evidence regarding causality in the association between cannabis and schizophrenia may not be incontrovertible, some of their arguments are indeed driven by their own ideology and advancement of their proposition that the main harmassociated with cannabis use pertains to its intimate relation to tobacco use, and that this, and the development of dependence, are ...


Orientation Tuning Of Contrast Masking Caused By Motion Streaks, Deborah Apthorp, John Cass, David Alais 2010 University of Sydney

Orientation Tuning Of Contrast Masking Caused By Motion Streaks, Deborah Apthorp, John Cass, David Alais

Faculty of Health and Behavioural Sciences - Papers (Archive)

We investigated whether the oriented trails of blur left by fast-moving dots (i.e., “motion streaks”) effectively mask grating targets. Using a classic overlay masking paradigm, we varied mask contrast and target orientation to reveal underlying tuning. Fast-moving Gaussian blob arrays elevated thresholds for detection of static gratings, both monoptically and dichoptically. Monoptic masking at high mask (i.e., streak) contrasts is tuned for orientation and exhibits a similar bandwidth to masking functions obtained with grating stimuli (È30 degrees). Dichoptic masking fails to show reliable orientation-tuned masking, but dichoptic masks at very low contrast produce a narrowly tuned facilitation (È17 ...


Anisotropies In Judging The Direction Of Moving Natural Scenes, Steven C. Dakin, Deborah Apthorp, David Alais 2010 University College London

Anisotropies In Judging The Direction Of Moving Natural Scenes, Steven C. Dakin, Deborah Apthorp, David Alais

Faculty of Health and Behavioural Sciences - Papers (Archive)

Although visual systems are optimized to deal with the natural visual environment, our understanding of human motion perception is in large part based on the use of artificial stimuli. Here, we assessed observers’ ability to estimate the direction of translating natural images and fractals by having them adjust the orientation of a subsequently viewed line. A system of interleaved staircases, driven by observers’ direction estimates, ensured that stimuli were presented near one of 16 reference directions. The resulting error distributions (i.e., the differences between reported and true directions) reveal several anisotropies in global motion processing. First, observers’ estimates are ...


A Psychometric Analysis Of The Mental Health Consumer Participation Questionnaire, Brenda Happell, Lorna Moxham, Chris Platania-Phung 2010 Central Queensland University

A Psychometric Analysis Of The Mental Health Consumer Participation Questionnaire, Brenda Happell, Lorna Moxham, Chris Platania-Phung

Faculty of Health and Behavioural Sciences - Papers (Archive)

If consumer participation is to be translated from rhetoric into reality, the attitudes of health professionals need to be addressed. Educational strategies can play an important role, but measures of attitudes are needed to determine the effectiveness of these strategies. This paper seeks to establish the Mental Health Consumer Participation Questionnaire (MHCPQ) on psychometric grounds, and explore attitude levels. Overall, the 150 nursing students who participated saw consumer participation in a favourable light, although this varied with the nature and extent of involvement. Psychometric properties, attitude structure, and attitude differences are reported. The MHCPQ displays good face validity and can ...


Postural Responses To Multidirectional Perturbations To The Hand During Stance, Ali Forghani, Sheida Rabipour, Theodore E. Milner, Paul J. Stapley 2010 McGill University

Postural Responses To Multidirectional Perturbations To The Hand During Stance, Ali Forghani, Sheida Rabipour, Theodore E. Milner, Paul J. Stapley

Faculty of Health and Behavioural Sciences - Papers (Archive)

Humans are easily able to maintain their balance while applying force with their hands to move or stabilize objects. Based on Newton's laws, the applied force must be counteracted by ground reaction force (GRF) to maintain balance. However, because the GRF is partitioned between the two legs there is no unique solution. Furthermore, central nervous system (CNS) can employ an infinite number of muscle activation patterns to achieve ground reaction force (GRF) vectors needed to satisfy both the task-level goal and balance. This study examines the postural response when hand position must remain stable as an external force is ...


Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara J. Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang 2010 University of Wollongong

Alterations In 5-Ht2a Receptor Binding In Various Brain Regions Among 6-Hydroxydopamine-Induced Parkinsonian Rats, Yun Li, Xu-Feng Huang, Chao Deng, Barbara J. Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori Yenari, Qing Wang

Faculty of Health and Behavioural Sciences - Papers (Archive)

The serotonergic system has close interactions with the dopaminergic system and is strongly implicated in the pathophysiological mechanisms and therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate regional changes in 5-hydroxytryptamine (5-HT) 2A receptors in the rat brain 3 weeks after unilateral medial forebrain bundle lesion by 6-hydroxydopamine (6-OHDA). 5-HT 2A receptor distributions and alterations in the postmortem rat brain were detected by [3H]ketanserin-binding autoradiography. In the 6-OHDA-induced Parkinson’s rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [3H]ketanserin binding, predominantly in the agranular insular cortex (17.3%, P 5 0.03 ...


Is Bra Discomfort A Barrier To Exercise For Breast Cancer Patients?, Sheridan A. Gho, Julie R. Steele, Bridget J. Munro 2010 University of Wollongong

Is Bra Discomfort A Barrier To Exercise For Breast Cancer Patients?, Sheridan A. Gho, Julie R. Steele, Bridget J. Munro

Faculty of Health and Behavioural Sciences - Papers (Archive)

Goals of work Although exercise can provide a range of benefits for women living with a breast cancer diagnosis, many impediments to exercise exist. Several psychosocial and physical capacity impediments to exercise have been investigated, but no study has systematically investigated whether bras impede breast cancer patients from exercising. This study aimed to assess the extent to which exerciseinduced breast pain and bra discomfort were reported by women living with breast cancer and whether this breast pain and bra discomfort impeded these women from participating in physical activity. Patients and methods Seventy-four women living with a breast cancer diagnosis completed ...


Energy Expenditure Does Not Differ, But Protein Oxidation Rates Appear Lower In Meals Containing Predominantly Meat Versus Soy Sources Of Protein, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell 2010 University of Wollongong

Energy Expenditure Does Not Differ, But Protein Oxidation Rates Appear Lower In Meals Containing Predominantly Meat Versus Soy Sources Of Protein, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: High protein meals produce 3 relevant effects in weight management: i) higher thermogenic cost, ii) enhanced fat oxidation, and iii) greater satiation. Pork has been reported to be more thermogenic than soy, suggesting meat protein may be superior to plant protein in a high-protein weight loss diet context. In this study, we aimed to compare the effects of high-protein meals using meat, dairy, and soy sources respectively.

Methods: This crossover feeding trial measured energy expenditure, substrate oxidation, and satiety levels of 12 adults during 8-hour stays in a whole-room calorimeter. The 3 isoenergetic high-protein test meals (30% protein, 40 ...


Developing Pandemic Communication Strategies: Preparation Without Panic, Sandra C. Jones, Louise Waters, Omnia Holland, John Bevins, Donald C. Iverson 2010 University of Wollongong

Developing Pandemic Communication Strategies: Preparation Without Panic, Sandra C. Jones, Louise Waters, Omnia Holland, John Bevins, Donald C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Communication in the media regarding a potential avian influenza epidemic can serve to accurately and effectively inform the public OR misinform and contribute to unnecessary public panic and subsequent undesirable responses. Governments have time to develop communication strategies and specific messages that can effectively convey desired information at different stages of the anticipated pandemic. Effective social marketing incorporates the concepts of formative research, audience segmentation, and consumer focus. Based on the findings from earlier research on public awareness and understanding of bird flu, the collaborators of the project developed evidence-based advertising messages for two primary time-points in pandemic preparation and ...


Membrane Fatty Acid Composition Of Rat Skeletal Muscle Is Most Responsive To The Balance Of Dietary N-3 And N-6 Pufa, Sarah K. Abbott, P. L. Else, A. Hulbert 2010 University of Wollongong

Membrane Fatty Acid Composition Of Rat Skeletal Muscle Is Most Responsive To The Balance Of Dietary N-3 And N-6 Pufa, Sarah K. Abbott, P. L. Else, A. Hulbert

Faculty of Health and Behavioural Sciences - Papers (Archive)

The present study quantifies the relationships between diet fatty acid profile and fatty acid composition of rat skeletal muscle phospholipids. Young adult male Sprague–Dawley rats were fed, for 8 weeks, on one of twelve moderate-fat diets (25 % of total energy) differing only in fatty acid profile. SFA content ranged from 8–88 % of total fatty acids, MUFA 6–65 %, total PUFA 4–81 %, n-6 PUFA 3–70 % and n-3 PUFA 1–70 %. Diet PUFA included only essential fatty acids 18 : 2n-6 and 18 : 3n-3. The balance between n-3 and n-6 PUFA ...


The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang 2010 University of Wollongong

The Role Of Histaminergic H1 And H3 Receptors In Food Intake: A Mechanism For Atypical Antipsychotic-Induced Weight Gain?, Chao Deng, Katrina Western-Green, Xu-Feng Huang

Faculty of Health and Behavioural Sciences - Papers (Archive)

Atypical antipsychotics such as olanzapine and clozapine are effective at treating the multiple domains of schizophrenia, with a lowrisk of extra-pyramidal side-effects. However amajor downfall to their use is metabolicside-effects particularly weight gain/obesity,which occurs by unknownmechanisms. The present paper explores the potential candidature of histaminergic neurotransmission in the mechanisms of atypical antipsychoticinduced weight gain, with a focus on the histaminergic H1 and H3 receptors. Olanzapine and clozapine have a high affinity for the H1 receptor, andmeta-analyses showa strong correlation between risk ofweight gain andH1 receptor affinity. In addition, olanzapine treatment decreases H1 receptor binding and mRNA expression in ...


Stereoscopic Perception Of Real Depths At Large Distances, Stephen Palmisano, Barbara Gillam, Donovan Govan, Robert Allison, Julie Harris 2010 University of Wollongong

Stereoscopic Perception Of Real Depths At Large Distances, Stephen Palmisano, Barbara Gillam, Donovan Govan, Robert Allison, Julie Harris

Faculty of Health and Behavioural Sciences - Papers (Archive)

There has been no direct examination of stereoscopic depth perception at very large observation distances and depths. We measured perceptions of depth magnitude at distances where it is frequently reported without evidence that stereopsis is non-functional. We adapted methods pioneered at distances up to 9 m by R. S. Allison, B. J. Gillam, and E. Vecellio (2009) for use in a 381-m-long railway tunnel. Pairs of Light Emitting Diode (LED) targets were presented either in complete darkness or with the environment lit as far as the nearest LED (the observation distance). We found that binocular, but not monocular, estimates of ...


Health Warning Labels On Alcohol Products - The Views Of Australian University Students, Sandra C. Jones, Parri Gregory 2010 University of Wollongong

Health Warning Labels On Alcohol Products - The Views Of Australian University Students, Sandra C. Jones, Parri Gregory

Faculty of Health and Behavioural Sciences - Papers (Archive)

While Australian legislation does not currently require health warning labels on alcohol products, several medical and advocacy organisations have been campaigning for their mandatory inclusion. The current study examines the attitudes and opinions of university students (a particularly high risk group) relating to these messages, and the likelihood of such labeling influencing personal behaviours, in order to establish whether the introduction of these labels is likely to be effective. Alcohol warning labels have the potential to influence behaviours of adolescents and young adults, especially if modifications are made to the content and format of these – suggestions are given in this ...


The Time Course Of Configural Change Detection For Novel 3-D Objects, Simone Favelle, Stephen Palmisano 2010 University of Wollongong

The Time Course Of Configural Change Detection For Novel 3-D Objects, Simone Favelle, Stephen Palmisano

Faculty of Health and Behavioural Sciences - Papers (Archive)

The present study investigated the time course of visual information processing that is responsible for successful object change detection involving the configuration and shape of 3-D novel object parts. Using a one-shot change detection task, we manipulated stimulus and interstimulus mask durations (40–500 msec). Experiments 1A and 1B showed no change detection advantage for configuration at very short (40-msec) stimulus durations, but the configural advantage did emerge with durations between 80 and 160 msec. In Experiment 2, we showed that, at shorter stimulus durations, the number of parts changing was the best predictor of change detection performance. Finally, in ...


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