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Interaction Between The Saga Complex And Chromatin Regulates Nucleosome Acetylation And Inducible Gene Transcription, Shanshan Li 2010 Iowa State University

Interaction Between The Saga Complex And Chromatin Regulates Nucleosome Acetylation And Inducible Gene Transcription, Shanshan Li

Graduate Theses and Dissertations

The SAGA family of coactivators is a group of highly conserved histone acetyltransferases that is essential for transcription of genes participating in stress adaptation and developemental processes. Misregulation of SAGA function can lead to developmental diseases and cancer. One important function of SAGA in regulating gene expression is to acetylate nucleosomes at both gene promoters and coding regions. To understand the molecular mechanism of nucleosome acetylation, much work has been done using recombinant Gcn5, the catalytic subunit of SAGA, and histone proteins or peptides. However, little is known about how histones are acetylated by full SAGA complex in the context ...


Characterization And Optimization Of Animal And Culture Models Of Leishmania Chagasi, Soi Meng Lei 2010 Iowa State University

Characterization And Optimization Of Animal And Culture Models Of Leishmania Chagasi, Soi Meng Lei

Graduate Theses and Dissertations

Leishmania spp. are an important pathogen of humans and other vertebrate animals, with significant global prevalence and impact on human and animal health. Leishmania chagasi is one species that causes visceral leishmaniasis, a potentially fatal disease of humans: annual incidence is about 0.5 mil. These insect-vector borne protozoan pathogens undergo complex development within the sand fly as they progress from morphological forms having low infectivity (to vertebrates) to a form that has high infectivity. Repeated serial passage of promastigote cultures results in cell populations that exhibit perturbations in developmental progression, in expression levels of surface macromolecules (Major Surface Protease ...


Extensive And Evolutionary Persistent Mitochondrial Trna Editing In Velvet Worms (Phylum Onychophora), Romulo Segovia 2010 Iowa State University

Extensive And Evolutionary Persistent Mitochondrial Trna Editing In Velvet Worms (Phylum Onychophora), Romulo Segovia

Graduate Theses and Dissertations

It was determined the complete mitochondrial DNA sequences of the velvet worms (Phylum Onychophora) Oroperipatus sp. (Peripatidae) and Peripatoides sympatrica (Peripatopsidae), and showed that they encode highly reduced tRNA genes. Because a well-paired acceptor stem is essential for tRNA recognition by its cognate aminoacyl-tRNA synthetase, it was suspected that their products are restored by RNA editing. Here it is showed that many reduced mt-tRNA molecules in the onychophorans Oroperipatus sp. and Peripatoides sympatrica are post-transcriptionally edited by what appears to be a novel RNA editing mechanism. During this process, up to 34 nucleotides are added to the primary truncated transcripts ...


Deciphering The Transcriptional Regulation And Response Of Barley To Obligate Fungal Biotroph Invasion, Matthew James Moscou 2010 Iowa State University

Deciphering The Transcriptional Regulation And Response Of Barley To Obligate Fungal Biotroph Invasion, Matthew James Moscou

Graduate Theses and Dissertations

Obligate fungal biotrophs have co-evolved with their plant hosts, a direct result of an intimate interaction that protects the integrity of the plant during pathogenesis, allowing it to obtain essential nutrients. To restrict the establishment of pathogen colonization, plants have evolved complex regulatory mechanisms to control the defense response, the most extreme of which involves Resistance (R) gene-mediated programmed cell death. While it is known that de novo gene expression and subsequent protein synthesis are required for several cell death programs, the primary transcriptional targets of R gene-mediated responses are unknown. Two alternative approaches were used to identify these transcriptional ...


The Regulation Of Host Translation Initiation In Plant-Pathogen Interactions, Jackson Russell Moeller 2010 Iowa State University

The Regulation Of Host Translation Initiation In Plant-Pathogen Interactions, Jackson Russell Moeller

Graduate Theses and Dissertations

Pathogens dramatically alter plant mRNA transcript levels by activating and repressing a variety of signaling pathways. However, the effects of plant pathogens on host mRNA translation have not been explored on a genome-wide scale. To assess pathogen-induced changes in host mRNA transcription and translation, we conducted DNA microarray analysis of total and polyribosomal RNA fractions in the Arabidopsis thalianaTurnip mosaic virus (TuMV) and barley-powdery mildew (Hordeum vulgareBlumeria graminis f.sp. hordei (Bgh)) interactions. The ratios of mRNA transcript abundance in total versus polyribosomal RNA fractions were compared between inoculated and non-inoculated sample types to identify mRNAs that were ...


Vitamin D Signaling In The Bovine Immune System, Corwin Drew Nelson 2010 Iowa State University

Vitamin D Signaling In The Bovine Immune System, Corwin Drew Nelson

Graduate Theses and Dissertations

Vitamin D has predominantly been associated with calcium homeostasis, but recently been associated with several infectious diseases. The active vitamin D metabolite, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is known to regulate the expression of numerous genes throughout the body. 1,25(OH)2D3 is synthesized from 25-hydroxyvitamin D3 by the enzyme 1α-hydroxylase (1α-OHase; CYP27B1). In the endocrine system, 1α-OHase expression, and subsequently 1,25(OH)2D3 synthesis, is tightly regulated in the kidney in response to calcium homeostasis. 1,25(OH)2D3 produced in the kidney acts systemically to regulate the expression of genes related to calcium homeostasis ...


Effect Of Agronomic Practices On Sudden Death Syndrome Of Soybean In Iowa, Catherine Margaret Swoboda 2010 Iowa State University

Effect Of Agronomic Practices On Sudden Death Syndrome Of Soybean In Iowa, Catherine Margaret Swoboda

Graduate Theses and Dissertations

Sudden death syndrome, SDS, of soybean [Glycine max (L.) Merr.] is caused by the soilborne pathogen Fusarium virguliforme (formerly called, F. solani f. sp. glycines; SDS; Aoki et al., 2003) and results in chlorosis, necrosis and eventual defoliation of plants if symptoms are severe enough. Sudden death syndrome was first observed in the United States in 1971 in Arkansas. Research concerning agronomic practices and management of SDS has been conducted in the south but to our knowledge this research does not exist for Iowa. Soybean cyst nematode (Heterodera glycines Ichinohe; SCN) and SDS are consistently the most yield damaging soybean ...


Phocine Distemper Virus Induced Demyelination In The Spinal Cord Of Infected Harbor Seals (Phoca Vitulina), Thomas Siemens 2010 University of New England

Phocine Distemper Virus Induced Demyelination In The Spinal Cord Of Infected Harbor Seals (Phoca Vitulina), Thomas Siemens

All Theses And Dissertations

Phocine Distemper Virus (PDV) is a Morbillivirus that has been responsible for the death of approximately 40,000 phocid seals in the last three decades. The most commonly reported pathology is virally induced demyelination of the cerebrum and brainstem which leaves axons bare and limits their conductivity of action potentials. While these conditions have been studied at length, there is little mention of spinal cord involvement. This study aims to determine whether demyelination found in the brainstem continues into the cervical spinal cord. The results indicate that demyelination in the cervical spinal cord does not occur alongside the brainstem. It ...


Long Term Impact Of Neonatal Injury In Male And Female Rats: Sex Differences, Mechanisms And Clinical Implications, Jamie L. LaPrairie, Anne Z. Murphy PhD 2010 Georgia State University

Long Term Impact Of Neonatal Injury In Male And Female Rats: Sex Differences, Mechanisms And Clinical Implications, Jamie L. Laprairie, Anne Z. Murphy Phd

Neuroscience Institute Faculty Publications

Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high‐technology intensive care over the last twenty years, ex‐preterm neonates may be exceedingly vulnerable to the long‐term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings ...


A Qualitative Optimization Technique For Biophysical Neuron Models With Many Parameters, Robert Clewley, Mirza Dobric 2010 Georgia State University

A Qualitative Optimization Technique For Biophysical Neuron Models With Many Parameters, Robert Clewley, Mirza Dobric

Neuroscience Institute Faculty Publications

We present a novel computational technique that enables more efficient optimization of qualitative features in biophysical neural models.


La Producción De Las Fresas Utilizando El Túnel Alto, Daniel Rowley, Brent Black, Dan Drost 2010 Utah State University

La Producción De Las Fresas Utilizando El Túnel Alto, Daniel Rowley, Brent Black, Dan Drost

All Current Publications

Las fresas locales y frescas son siempre un favorito en los mercados de productores y en los puestos ambulantes. Las fresas crecen mejor en las temperaturas alrededor de 70 a 75˚ F (21 a 24˚ C). Los inviernos fríos y los veranos calientes solo dejan una temporada de fresas muy corta. Se diseñan los invernaderos para mantener temperaturas óptimas para el crecimiento y se las puede usar para cultivar las fresas durante todo el año. Sin embargo, los invernaderos son muy costosos para construir y operar. Los túneles altos son relativamente baratos para construir, con algunos diseños costando menos de ...


Strawberry Plug Plant Production, Dan Drost, Brent Black, Daniel Rowley 2010 Utah State University

Strawberry Plug Plant Production, Dan Drost, Brent Black, Daniel Rowley

All Current Publications

This publication provides information on growing strawberries including planting dates and harvesting methods.


Lost In Translation?: An Essay On Law And Neuroscience, Stephen J. Morse 2010 University of Pennsylvania Carey Law School

Lost In Translation?: An Essay On Law And Neuroscience, Stephen J. Morse

Faculty Scholarship at Penn Law

The rapid expansion in neuroscientific research fuelled by the advent of functional magnetic resonance imaging [fMRI] has been accompanied by popular and scholarly commentary suggesting that neuroscience may substantially alter, and perhaps will even revolutionize, both law and morality. This essay, a contribution to, Law and Neuroscience (M. Freeman, Ed. 2011), will attempt to put such claims in perspective and to consider how properly to think about the relation between law and neuroscience. The overarching thesis is that neuroscience may indeed make some contributions to legal doctrine, practice and theory, but such contributions will be few and modest for the ...


Antidepressant Stimulation Of Cdp-Diacylglycerol Synthesis Does Not Require Monoamine Reuptake Inhibition, Ashiwel S. Undieh, Marwa A. Aboukhatwa 2010 CUNY City College

Antidepressant Stimulation Of Cdp-Diacylglycerol Synthesis Does Not Require Monoamine Reuptake Inhibition, Ashiwel S. Undieh, Marwa A. Aboukhatwa

Publications and Research

Background: Recent studies demonstrate that diverse antidepressant agents increase the cellular production of the nucleolipid CDP-diacylglycerol and its synthetic derivative, phosphatidylinositol, in depression-relevant brain regions. Pharmacological blockade of downstream phosphatidylinositide signaling disrupted the behavioral antidepressant effects in rats. However, the nucleolipid responses were resistant to inhibition by serotonin receptor antagonists, even though antidepressant-facilitated inositol phosphate accumulation was blocked. Could the neurochemical effects be additional to the known effects of the drugs on monoamine transmitter transporters? To examine this question, we tested selected agents in serotonin-depleted brain tissues, in PC12 cells devoid of serotonin transporters, and on the enzymatic activity of ...


Tumor-Stromal Interactions Influence Radiation Sensitivity In Epithelial- Versus Mesenchymal-Like Prostate Cancer Cells, Sajni Josson, Starlette Sharp, Shian-Ying Sung, Peter A. S. Johnstone, Ritu Aneja, Ruoxiang Wang, Murali Gururajan, Timothy Turner, Leland W. K. Chung, Clayton Yates 2010 Georgia State University

Tumor-Stromal Interactions Influence Radiation Sensitivity In Epithelial- Versus Mesenchymal-Like Prostate Cancer Cells, Sajni Josson, Starlette Sharp, Shian-Ying Sung, Peter A. S. Johnstone, Ritu Aneja, Ruoxiang Wang, Murali Gururajan, Timothy Turner, Leland W. K. Chung, Clayton Yates

Biology Faculty Publications

HS-27a human bone stromal cells, in 2D or 3D coultures, induced cellular plasticity in human prostate cancer ARCaPE and ARCaPM cells in an EMT model. Cocultured ARCaPE or ARCaPM cells with HS-27a developed increased colony forming capacity and growth advantage, with ARCaPE exhibiting the most significant increases in presence of bone or prostate stroma cells. Prostate (Pt-N or Pt-C) or bone (HS-27a) stromal cells induced significant resistance to radiation treatment in ARCaPE cells compared to ARCaPM cells. However pretreatment with anti-E-cadherin antibody (SHEP8-7) or anti-alpha v integrin blocking antibody (CNT095) significantly decreased stromal ...


Roles For Common Mll/Compass Subunits And The 19s Proteasome In Regulating Ciita Piv And Mhc Class Ii Gene Expression And Promoter Methylation, Olivia I. Koues, Ninad T. Mehta, Agnieszka D. Truax, R. Kyle Dudley, Jeanne K. Brooks, Susanna F. Greer 2010 Georgia State University

Roles For Common Mll/Compass Subunits And The 19s Proteasome In Regulating Ciita Piv And Mhc Class Ii Gene Expression And Promoter Methylation, Olivia I. Koues, Ninad T. Mehta, Agnieszka D. Truax, R. Kyle Dudley, Jeanne K. Brooks, Susanna F. Greer

Biology Faculty Publications

Background: Studies indicate that the 19S proteasome contributes to chromatin reorganization, independent of the role the proteasome plays in protein degradation. We have previously shown that components of the 19S proteasome are crucial for regulating inducible histone activation events in mammalian cells. The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC)-II and class II transactivator (CIITA) promoters, implicating Sug1 in events required to initiate mammalian transcription.

Results ...


Physiological Status Of Male And Female Popillia Japonica (Coleoptera: Scarabaeidae) Affects Mating And Grouping Behavior, Natasha Tigreros, Rashmi Jadhav, Katelyn Kowles, Britto Nathan, Paul Switzer 2010 Eastern Illinois University

Physiological Status Of Male And Female Popillia Japonica (Coleoptera: Scarabaeidae) Affects Mating And Grouping Behavior, Natasha Tigreros, Rashmi Jadhav, Katelyn Kowles, Britto Nathan, Paul Switzer

Faculty Research & Creative Activity

Because mating may be costly, sexually active males or females are predicted to be in relatively good physiological condition and may preferentially direct their mating behavior toward relatively high-quality mates. We tested this hypothesis in Japanese beetles (Popillia japonica Newman), a pest species in which males and females may be either isolated or in aggregations while feeding on host plants. We examined male size and lipid content and female size and egg load with respect to both their pairing status and whether they were isolated or in aggregations. Males that were paired had the highest lipid levels, and single, isolated ...


Seed Treatments Enhance Photosynthesis In Maize Seedlings By Reducing Infection With Fusarium Spp. And Consequent Disease Development In Maize, Carlos Rodriguez-Brljevich, Charles Kanobe, J. F. Shanahan, Alison E. Robertson 2010 Iowa State University

Seed Treatments Enhance Photosynthesis In Maize Seedlings By Reducing Infection With Fusarium Spp. And Consequent Disease Development In Maize, Carlos Rodriguez-Brljevich, Charles Kanobe, J. F. Shanahan, Alison E. Robertson

Plant Pathology and Microbiology Publications

Maize seed that was either treated with the fungicide Cruiser Extreme 250 ® (fludioxonil + azoxystrobin + mefenoxam + thiamethoxam) or not treated was planted at two Iowa locations in 2007. Root, mesocotyl and crown rot severity, incidence of Fusarium spp. colonisation and chlorophyll florescence (CF) were assessed at growth stages V2, V4 and V6, and stalk rot severity at R6. At both locations, seed treatment reduced disease severity and incidence of Fusarium spp. infection at all growth stages assessed. Measurements of CF decreased significantly with increased disease severity and incidence of Fusarium spp. at V2 and V4 at both locations, indicating that seedling ...


Investigation Of The Protein-Protein Interaction Between Pcbp1 And Y -Synuclein, Amanda Hunkele 2010 Seton Hall University

Investigation Of The Protein-Protein Interaction Between Pcbp1 And Y -Synuclein, Amanda Hunkele

Seton Hall University Dissertations and Theses (ETDs)

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The Fungal Connection: Characterizing The Ectomycorrhizal Community And Belowground Response To Restoration Treatments In Northern Mississippi., Ashley Jane Craig 2010 University of Mississippi

The Fungal Connection: Characterizing The Ectomycorrhizal Community And Belowground Response To Restoration Treatments In Northern Mississippi., Ashley Jane Craig

Electronic Theses and Dissertations

Ectomycorrhizal (ECM) fungi are symbionts on the roots of woody plant species throughout the world. These fungi provide plants with nutrients and are important drivers of ecosystem processes. ECM fungi vary in their effect on host plants and host-specificity, making them important considerations in restoration projects seeking to restore target tree species. Restoration strategies such as burning and thinning may have strong impacts on ECM fungi, and given the that ECM are important in structuring aboveground communities and maintaining certain dominant plant taxa, knowledge of ECM fungal response is needed to ensure restoration efforts succeed. Using molecular methods, this research ...


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