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Comparative Study Of Factor Xa Fluorogenic Substrates And Their Influence On The Quantification Of Lmwhs, Vanessa Castro-Lopez, Leanne F. Harris, James S. O'Donnell, Anthony J. Killard 2010 CIC microGUNE

Comparative Study Of Factor Xa Fluorogenic Substrates And Their Influence On The Quantification Of Lmwhs, Vanessa Castro-Lopez, Leanne F. Harris, James S. O'Donnell, Anthony J. Killard

Articles

Low molecular weight heparins (LMWHs) are recognised as the preferred anticoagulants in the prevention and treatment of venous thromboembolism. Anti-Factor Xa (anti-FXa) levels are used to monitor the anticoagulant effect of LMWHs and such assays are routinely employed in hospital diagnostic laboratories. In this study, a fluorogenic anti-FXa assay was developed using a commercially available fluorogenic substrate with an attached 6-amino-1- naphthalene-sulfonamide (ANSN) fluorophore and was used for the determination of two LMWHs, enoxaparin and tinzaparin and the heparinoid, danaparoid. The assay was based on the complexation of heparinised plasma with 100 nM exogenous FXa and 25 μM of the ...


Synthesis And Evaluation Of Azetidinone Analogues Of Combretastatin A-4 As Tubulin Targeting Agents, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Orla Bergin, Seema M. Nathwani, Thomas McCabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan 2010 Technological University Dublin

Synthesis And Evaluation Of Azetidinone Analogues Of Combretastatin A-4 As Tubulin Targeting Agents, Niamh O'Boyle, Miriam Carr, Lisa M. Greene, Orla Bergin, Seema M. Nathwani, Thomas Mccabe, David G. Lloyd, Daniela M. Zisterer, Mary J. Meegan

Articles

The synthesis and antiproliferative activity of a new series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds are also substituted at position 3 of the β-lactam ring with an aryl ring. A number of analogues showed potent nanomolar activity in human MCF-7 and MDA-MB-231 breast cancer cell lines, displayed in vitro inhibition of tubulin polymerization and did not cause significant cytotoxicity in normal murine breast epithelial cells. 4-(4-Methoxyaryl)-substituted compound 32, 4-(3-hydroxy-4-methoxyaryl)-substituted ...


Development Of A Fluorescent Anti-Factor Xa Assay To Monitor Unfractionated And Low Molecular Weight Heparins, Leanne Harris, Vanessa Castro-Lopez, Nissrin Hammadi, James S. O'Donnell, Tony Killard 2010 Technological University Dublin

Development Of A Fluorescent Anti-Factor Xa Assay To Monitor Unfractionated And Low Molecular Weight Heparins, Leanne Harris, Vanessa Castro-Lopez, Nissrin Hammadi, James S. O'Donnell, Tony Killard

Articles

Fluorogenic assays have many potential advantages over traditional clot-based and chromogenic assays such as the absence of interference from a range of factor deficiencies as well as offering the possibility of assays in platelet rich plasma or whole blood. A fluorogenic anti-factor Xa (anti-FXa) assay has been developed for the determination of heparin-like anticoagulants including unfractionated heparin (UFH), low-molecular weight heparins (LMWHs), namely enoxaparin and tinzaparin, and the synthetic heparinoid danaparoid, in commercial human pooled plasma. The assay was based on the complexation of heparin-spiked plasmas with exogenous FXa at a concentration of 4 nM in the presence of 0 ...


The Role Of Traditional Knowledge In Fisheries Management : A Study Case Of Panglima Laot (Sea Commander) In The Aceh Province Of Indonesia., Prayudi Budi Utomo 2010 World Maritime University

The Role Of Traditional Knowledge In Fisheries Management : A Study Case Of Panglima Laot (Sea Commander) In The Aceh Province Of Indonesia., Prayudi Budi Utomo

World Maritime University Dissertations

No abstract provided.


Tetrapod Fauna Of The Lowermost Usili Formation (Songea Group, Ruhuhu Basin) Of Southern Tanzania, With A New Burnetiid Record, Christian A. Sidor, Kenneth D. Angielczyk, D. Marie Weide, Roger M. H. Smith, Sterling J. Nesbitt, Linda A. Tsuji 2010 University of Washington - Seattle Campus

Tetrapod Fauna Of The Lowermost Usili Formation (Songea Group, Ruhuhu Basin) Of Southern Tanzania, With A New Burnetiid Record, Christian A. Sidor, Kenneth D. Angielczyk, D. Marie Weide, Roger M. H. Smith, Sterling J. Nesbitt, Linda A. Tsuji

Papers in the Earth and Atmospheric Sciences

Vertebrate fossils from the Ruhuhu Basin of southern Tanzania have been known for over 75 years, but the details of their stratigraphic distribution remain imperfectly understood. Recent fieldwork in the Upper Permian Usili Formation (Songea Group) has led to the discovery of a tetrapod assemblage in a conglomeratic unit at its base. The fossils are concentrated in matrix-supported intraformational clay pebble conglomerates interpreted as mass flow deposits in wide, shallow channels in the distal reaches of an alluvial fan. Included in this new collection are fossils representing the first record of a burnetiid therapsid from Tanzania. The anatomy of the ...


Genetic Diversity, Micro Propagation, And Cold Hardiness Of Ilex Glabra (L.) A. Gray, Youping Sun 2010 The University of Maine

Genetic Diversity, Micro Propagation, And Cold Hardiness Of Ilex Glabra (L.) A. Gray, Youping Sun

Electronic Theses and Dissertations

Ilex glabra (L.) A.Gray (inkberry) is a native evergreen shrub with dark green foliage and compact habit. This shrub has gained popularity in the northern landscapes of the United States and more nursery growers would like to produce it. To better understand genetic relationships among inkberry cultivars and breed cold-hardy cultivars for northern nursery growers and landscape specialists, the following projects were conducted. A group of 48 inkberry accessions and two other Ilex species (Ilex crenata Thunb. and I. mutchagara Makino) were studied using amplified fragment length polymorphism (AFLP) markers. A total of 229 markers between 50 and 500 ...


Genome3d: A Viewer-Model Framework For Integrating And Visualizing Multi-Scale Epigenomic Information Within A Three-Dimensional Genome, Thomas M. Asbury, Matt Mitman, Jijun Tang, W. Jim Zheng 2010 University of South Carolina - Columbia

Genome3d: A Viewer-Model Framework For Integrating And Visualizing Multi-Scale Epigenomic Information Within A Three-Dimensional Genome, Thomas M. Asbury, Matt Mitman, Jijun Tang, W. Jim Zheng

Faculty Publications

Background
New technologies are enabling the measurement of many types of genomic and epigenomic information at scales ranging from the atomic to nuclear. Much of this new data is increasingly structural in nature, and is often difficult to coordinate with other data sets. There is a legitimate need for integrating and visualizing these disparate data sets to reveal structural relationships not apparent when looking at these data in isolation.

Results
We have applied object-oriented technology to develop a downloadable visualization tool, Genome3D, for integrating and displaying epigenomic data within a prescribed three-dimensional physical model of the human genome. In order ...


Xenopus Development From Late Gastrulation To Feeding Tadpole In Simulated Microgravity, Wendy M. Olson, Darrell Wiens, Theresa L. Gaul, Manuela Rodriguez, Cherie L. Hauptmeier 2010 University of Northern Iowa

Xenopus Development From Late Gastrulation To Feeding Tadpole In Simulated Microgravity, Wendy M. Olson, Darrell Wiens, Theresa L. Gaul, Manuela Rodriguez, Cherie L. Hauptmeier

Faculty Publications

Microgravity (microG) is known to influence cytoskeletal structure, but its effects on cell migration are not well understood. To examine the effects of altered gravity on neural crest cell (NCC) migration, we inserted Xenopus laevis embryos into two separate microG-simulating slow turning lateral vessels (STLVs) just before neurulation (stage 11-12), and exposed them until feeding stage (stage 45), when the jaws and branchial apparatus are fully functional. To evaluate apparatus-related artifacts, we used two different STLVs and a vibration control as well as a stationary control vessel. Larval growth, pattern of NCC-derived cartilage formation, and incidence of malformations were analyzed ...


Biology News, Winter 2010, University of Northern Iowa. Department of Biology. 2010 University of Northern Iowa

Biology News, Winter 2010, University Of Northern Iowa. Department Of Biology.

Biology News

Inside this issue:

-- Greetings from the Department of Biology
-- Focus on UNI Biology Alumni
-- Let us hear from you...
-- Faculty and Staff News
-- Trip to Chicago for Darwin Bicentennial
-- Botanical Center Wins Second Place
-- Focus on UNI Biology Students
-- Student Nature Society
-- Retirements
-- You Make a Difference! Messages from our donors....
-- New Advisor for Biology
-- Biology Video
-- You Can Make a Difference!
-- Scholarships and Funding
-- Support for students or department


Phocine Distemper Virus Induced Demyelination In The Spinal Cord Of Infected Harbor Seals (Phoca Vitulina), Thomas Siemens 2010 University of New England

Phocine Distemper Virus Induced Demyelination In The Spinal Cord Of Infected Harbor Seals (Phoca Vitulina), Thomas Siemens

All Theses And Dissertations

Phocine Distemper Virus (PDV) is a Morbillivirus that has been responsible for the death of approximately 40,000 phocid seals in the last three decades. The most commonly reported pathology is virally induced demyelination of the cerebrum and brainstem which leaves axons bare and limits their conductivity of action potentials. While these conditions have been studied at length, there is little mention of spinal cord involvement. This study aims to determine whether demyelination found in the brainstem continues into the cervical spinal cord. The results indicate that demyelination in the cervical spinal cord does not occur alongside the brainstem. It ...


Homocysteine Metabolism And Its Relation To Health And Disease., Kelly T. Williams, Kevin Schalinske 2010 Iowa State University

Homocysteine Metabolism And Its Relation To Health And Disease., Kelly T. Williams, Kevin Schalinske

Food Science and Human Nutrition Publications

Homocysteine is a metabolic intermediate in methyl group metabolism that is dependent on a number of nutritional B-vitamin cofactors. An emerging aspect of homocysteine metabolism is its relation to health and disease. Perturbations of homocysteine metabolism, particularly intracellular and subsequently circulating accumulation of homocysteine (i.e., hyperhomocysteinemia), are associated with vascular disease risk, as well as other pathologies. However, intervention with B-vitamin supplementation has been shown to successfully restore normal homocysteine concentrations, but without concomitant reductions in disease risk. Thus, the mechanistic relation between homocysteine balance and disease states, as well as the value of homocysteine management, remains an area ...


The Natural History, Conservation Status And Ecology Of The Eastern Pygmy-Possum (Cercartetus Nanus), Jamie Mark Harris 2010 Southern Cross University

The Natural History, Conservation Status And Ecology Of The Eastern Pygmy-Possum (Cercartetus Nanus), Jamie Mark Harris

Theses

Many populations of Australian wildlife appear to be diminishing as human activities rapidly encroach on natural areas. Modern conservation efforts seek to provide management solutions, focussing particularly on those species that are officially classed as threatened. However, knowledge of the true status of most species is glaringly incomplete, with fundamental information about distribution and abundance yet to be properly assembled. Hence, there is an increasing need for applied research, particularly on the under-studied species, to assist efforts to conserve wildlife. The eastern pygmy-possum (Cercartetus nanus) provides a good example of a species that requires further study, particularly because it is ...


Conservation Status Of Australian Snubfin Dolphin, Orcaella Heinsohni, And Indo-Pacific Humpback Dolphin, Sousa Chinensis, In The Capricorn Coast, Central Queensland, Australia, Daniele Cagnazzi 2010 Southern Cross University

Conservation Status Of Australian Snubfin Dolphin, Orcaella Heinsohni, And Indo-Pacific Humpback Dolphin, Sousa Chinensis, In The Capricorn Coast, Central Queensland, Australia, Daniele Cagnazzi

Theses

This study examined populations of Australian snubfin dolphins (Orcaella heinsohni) and Indo-Pacific humpback dolphins (Sousa chinensis) inhabiting the coastal waters of the Capricorn Section of the Great Barrier Reef Marine Park, Queensland, Australia. A total of 189 humpback dolphins and 54 snubfin dolphins were identified during 1,760 hours and 20,248 kms of transect surveys completed between 2006 and 2008 in the Capricorn Coast region. Humpback dolphins were found in three different sites: Port Curtis, Keppel Bay and the Northern Region of the study area. In contrast, snubfin dolphins were found only in the Keppel Bay study area. Both ...


La Producción De Las Fresas Utilizando El Túnel Alto, Daniel Rowley, Brent Black, Dan Drost 2010 Utah State University

La Producción De Las Fresas Utilizando El Túnel Alto, Daniel Rowley, Brent Black, Dan Drost

All Current Publications

Las fresas locales y frescas son siempre un favorito en los mercados de productores y en los puestos ambulantes. Las fresas crecen mejor en las temperaturas alrededor de 70 a 75˚ F (21 a 24˚ C). Los inviernos fríos y los veranos calientes solo dejan una temporada de fresas muy corta. Se diseñan los invernaderos para mantener temperaturas óptimas para el crecimiento y se las puede usar para cultivar las fresas durante todo el año. Sin embargo, los invernaderos son muy costosos para construir y operar. Los túneles altos son relativamente baratos para construir, con algunos diseños costando menos de ...


Dynamic Acromiohumeral Interval Changes During Scapular Plane Arm Motions, Melissa Deen Thompson 2010 Louisiana State University and Agricultural and Mechanical College

Dynamic Acromiohumeral Interval Changes During Scapular Plane Arm Motions, Melissa Deen Thompson

LSU Doctoral Dissertations

This purpose of this dissertation is to explore changes in the acromiohumeral interval during dynamic motion in the scapular plane. All of the experiments were completed in the Football Operations Athletic Training Room at Louisiana State University. The first experiment which investigated dynamic acromiohumeral interval changes in baseball players during a loaded and unloaded scaption exercise from 0°-75°, has been accepted for publication by the Journal of Shoulder and Elbow Surgery (in press, 2010). The mean acromiohumeral interval (AHI) for unloaded and loaded scaption decreased significantly (p<.001) from the arm at the side until 45° and loaded scaption narrowed AHI at 60° (p=.005) and 75° (p=.003). The second experiment investigates AHI and scapular upward rotation (SUR) changes in baseball and softball players during scaption exercises from 0°-75°. Significant load related narrowing of the AHI at 45°(p=.005), 60°(p=.001), and 75°(p<.001) and a significant load-position interaction (p=.001) at 0° and 75°was observed for all subjects. No gender differences in SUR or AHI were found. AHI and SUR displayed moderate positive correlations at 30° for both the unloaded scaption (r=.648, p=.001) and the loaded scaption (r=.445, p=.038) however, no significant relationships were present at 0°, 45°, 60° or 75°. The third experiment compared dynamic acromiohumeral interval and scapulohumeral rhythm changes in trained and untrained females during scaption exercises from 0°-90°. In general, AHI was maximal with the arm at the side and declined significantly (p<.001) during arm elevation until 60°, but increased significantly (p<.001) between 60° and 90°. Significant load related narrowing of the AHI at all positions (p<.05), a more negative SUR at 0° (p<.001) and a more positive SUR at 90° (p=.009) was observed for all subjects. Female athletes had significantly stronger external rotators (p<.001), larger overall AHI (p=.003) and more SUR (p=.008) than untrained females. Significant positive correlations (p<.05) between AHI and SUR were observed at 0°, 30°, and 60° during both loaded and unloaded scaption.


Off-Farm Labor Supply By Farm Operators And Spouses: A Comparison Of Estimation Methods, Mahesh Pandit 2010 Louisiana State University and Agricultural and Mechanical College

Off-Farm Labor Supply By Farm Operators And Spouses: A Comparison Of Estimation Methods, Mahesh Pandit

LSU Master's Theses

This thesis studies the off-farm labor supply decision of farm operators and their spouses in the United States. The data used in this study is from the Agricultural Resource Management survey, 2006. The objective of this study is twofold. First, to identify those factors that affect off-farm labor supply of farm operators and their spouses. In particular, this study investigates the impact of human capital of farm operators and spouses, personal, family, farm and location characteristics on labor allocation for on- and off-farm work. Empirical results indicate that farm operators’ and their spouses’ human capital are positively correlated with off-farm ...


Evaluation Of Green Tea Extract As A Glazing Material For Shrimp Frozen By Cryogenic And Air-Blast Freezing, Srijanani Sundararajan 2010 Louisiana State University and Agricultural and Mechanical College

Evaluation Of Green Tea Extract As A Glazing Material For Shrimp Frozen By Cryogenic And Air-Blast Freezing, Srijanani Sundararajan

LSU Master's Theses

Green tea (Camellia sinensis) extract (GTE) is rich in polyphenolic compounds, especially catechins that are potent antioxidants. The antioxidant property of GTE may make it ideal for use as a glazing solution for suppressing lipid oxidation in shrimp (Litopenaeus setiferus) during frozen storage. In this study, GTE was evaluated as a glazing material for shrimp frozen by air-blast (BF) and cryogenic freezing (CF). Two percent, three percent and/or five percent green tea extract solutions (2GTE, 3GTE, 5TGE) were used for glazing. Distilled water glazed (GDW) and non-glazed (NG) shrimp were used as controls. The GTE was characterized by measuring ...


Swine Producer Appraisal Of The Community Assessment Model For Odor Dispersion (Cam), John Tyndall, Jay D. Harmon, Steven J. Hoff 2010 Iowa State University

Swine Producer Appraisal Of The Community Assessment Model For Odor Dispersion (Cam), John Tyndall, Jay D. Harmon, Steven J. Hoff

Natural Resource Ecology and Management Publications

The community assessment model (CAM) for odor dispersion is a tool to assist in the siting of swine production facilities. CAM considers the size and type of a swine production system, local historical weather conditions, and odor control implementation. It predicts the number of hours of exposure to various levels of odor, by month, for each receptor in a given community. A follow‐up survey of all CAM users since 2005 was conducted. The survey was designed to provide: 1) formative feedback for programming adjustments to improve Extension efficiency, usability, and reduce costs; and 2) summative feedback used to provide ...


Echinacea-Induced Cytosolic Ca2+ Elevation In Hek293, Lankun Wu, Eric W. Rowe, Ksenija Jeftinija, Srdija Jeftinija, Ludmila Rizhsky, Basil Nikolau, Jodi McKay, Marian L. Kohut, Eve Wurtele 2010 Iowa State University

Echinacea-Induced Cytosolic Ca2+ Elevation In Hek293, Lankun Wu, Eric W. Rowe, Ksenija Jeftinija, Srdija Jeftinija, Ludmila Rizhsky, Basil Nikolau, Jodi Mckay, Marian L. Kohut, Eve Wurtele

Biochemistry, Biophysics and Molecular Biology Publications

Background: With a traditional medical use for treatment of various ailments, herbal preparations of Echinacea are now popularly used to improve immune responses. One likely mode of action is that alkamides from Echinacea bind to cannabinoid type 2 (CB2) receptors and induce a transient increase in intracellular Ca2+. Here, we show that unidentified compounds from Echinacea purpurea induce cytosolic Ca2+ elevation in non-immune-related cells, which lack CB2 receptors and that the Ca2+ elevation is not influenced by alkamides. Methods: A non-immune human cell line, HEK293, was chosen to evaluate E. purpurea root extracts and constituents as potential regulators of intracellular ...


Toxins Reduce Palatability, USU Extension 2010 Utah State University

Toxins Reduce Palatability, Usu Extension

All Current Publications

Several years ago we had two research projects we assumed were unrelated. One focused on why goats avoid the current season’s growth of blackbrush and the other on how livestock learn to avoid foods high in toxins.


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