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Β3-Adrenergic Agonists Mimic Eustress Response And Reduce Leptin-Mediated Proliferation In A Gbm Cell Line, Johnathan E. Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn 2010 Northern Michigan University

Β3-Adrenergic Agonists Mimic Eustress Response And Reduce Leptin-Mediated Proliferation In A Gbm Cell Line, Johnathan E. Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn

Johnathan Lawrence

A great deal of mental stress, depression, and anxiety often overwhelm cancer patients; those diagnosed with glioblastoma multiforme (GBM) are no exception. Different types of stress invariably impact what has been termed “the brain-adipocyte BDNF/leptin axis” (Dr. Cao and colleagues of the Comprehensive Cancer Center at The Ohio State University). For example, eustress (good stress) and distress (bad stress) both lead to increased sympathetic activity and adrenal gland stimulation, yet eustress reduces leptin levels and attenuates tumor growth while distress increases leptin levels and augments tumor growth. Complicating matters in GBM is that leptin and its receptor are expressed ...


Analysis Of The Htlv-1 Gag Assembly Pathway By Biophysical Fluorescence, Keir H. Fogarty, Yan Chen, Iwen F. Grigsby, Patrick J. Macdonald, Elizabeth M. Smith, Jolene L. Johnson, Jonathan M. Rawson, Joachim D. Mueller, Louis M. Mansky 2010 University of Minnesota

Analysis Of The Htlv-1 Gag Assembly Pathway By Biophysical Fluorescence, Keir H. Fogarty, Yan Chen, Iwen F. Grigsby, Patrick J. Macdonald, Elizabeth M. Smith, Jolene L. Johnson, Jonathan M. Rawson, Joachim D. Mueller, Louis M. Mansky

Jolene Johnson

No abstract provided.


A Preliminary Study Of Heteromeles Arbutifolia Fruit Morphology At Ballona Wetlands And Temescal Canyon, Los Angeles, California, Victor D. Carmona 2010 Loyola Marymount University

A Preliminary Study Of Heteromeles Arbutifolia Fruit Morphology At Ballona Wetlands And Temescal Canyon, Los Angeles, California, Victor D. Carmona

Victor D. Carmona-Galindo

Heteromeles arbutifolia, or the California holly, is an evergreen shrub native to chaparral habitats of Southern California that fruits from November to January. Fruit species morphology has been shown to be a good indicator of habitat quality among other plants. The variation in fruit morphologies was examined for the native plant at two diverse Southern California sites, a wetland and a canyon. California Holly fruits had a significantly greater volume in Ballona Wetlands than at Temescal Canyon (Z=4.367, P<0.001), as well as a significantly greater variance in Ballona Wetlands than at Temescal Canyon (F=2.357, P=0.02). The production of fruits with larger and more variable volumes in Ballona Wetlands may be a response to the presence of urban influences and environmental contaminants. As the reproductive structure, fruit morphology may be a good indicator of how habitat stress influences reproductive success.


Autonomy Of Lower-Level Perception From Global Processing In Autism: Evidence From Brain Activation And Functional Connectivity, Yanni Liu, Vladimir L. Cherkassky, Nancy J. Minshew, Marcel Adam Just 2010 Carnegie Mellon University

Autonomy Of Lower-Level Perception From Global Processing In Autism: Evidence From Brain Activation And Functional Connectivity, Yanni Liu, Vladimir L. Cherkassky, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.


A New Species Of Marsupial Frog (Anura: Hemiphractidae: Gastrotheca) From The Río Abiseo National Park In Peru, Edgar Lehr, Alessandro Catenazzi 2010 Illinois Wesleyan University

A New Species Of Marsupial Frog (Anura: Hemiphractidae: Gastrotheca) From The Río Abiseo National Park In Peru, Edgar Lehr, Alessandro Catenazzi

Edgar Lehr

We describe a new species of Gastrotheca from the Río Abiseo National Park of the San Martín Region in the Andes of northern Peru. The description is based on a series of 29 specimens that were collected between 1989 and 1999 at two localities (Pampa del Cuy, Alpamachay) in the wet puna of the national park between 3380 and 3470 m elevation. The new species has a snout–vent length of 46.9–57.7 mm (53.5 ± 3.0) in females (n = 21), and 35.3–43.8 mm (41.6 ± 3.2) in males (n  =  6). In life ...


Structured Biopolymer-Based Delivery Systems For Encapsulation, Protection, And Release Of Lipophilic Compounds, Alison Matalanis, Owen Griffith Jones, D. Julian McClements 2010 University of Massachusetts - Amherst

Structured Biopolymer-Based Delivery Systems For Encapsulation, Protection, And Release Of Lipophilic Compounds, Alison Matalanis, Owen Griffith Jones, D. Julian Mcclements

D. Julian McClements

Food-grade biopolymers, such as proteins and polysaccharides, can be used to create a diverse range of delivery systems suitable for encapsulating, protecting, and delivering lipophilic functional components, such as ω-3 rich oils, conjugated linoleic acid (CLA), oil-soluble vitamins, flavors, colors, and nutraceuticals. This article provides an overview of a number of different approaches that can be used to create structured delivery systems based on biopolymers, including molecular complexation, coacervation, thermodynamic incompatibility, moulding, and extrusion methods. These delivery systems can be produced from food-grade ingredients using simple processing operations (e.g., mixing, homogenizing, and thermal processing). The structure, production, performance, and ...


Reducing Background Fluorescence Reveals Adhesions In 3d Matrices, Kristopher E. Kubow, A. R. Horwitz 2010 James Madison University

Reducing Background Fluorescence Reveals Adhesions In 3d Matrices, Kristopher E. Kubow, A. R. Horwitz

Kristopher E Kubow

No abstract provided.


Community Engagement Approach To Address Contributors To Cancer Health Disparities In Worcester, Ma. Community Health & Research: Making The Connections, Umass Medical School, Worcester, Ma, Wilfredo E. De Jesus-Monge, V. M. De Jesus-Monge 2010 University of Massachusetts Medical School Worcester

Community Engagement Approach To Address Contributors To Cancer Health Disparities In Worcester, Ma. Community Health & Research: Making The Connections, Umass Medical School, Worcester, Ma, Wilfredo E. De Jesus-Monge, V. M. De Jesus-Monge

Wilfredo E De Jesus-Monge, MD, MSc

No abstract provided.


The Structure And Composition Of A Tropical Dry Forest Landscape After Land Clearance; Azuero Peninsula, Panama, Heather P. Griscom, A. B. Connelly, M. S. Ashton, M. H. Wishnie, J. Deago 2010 James Madison University

The Structure And Composition Of A Tropical Dry Forest Landscape After Land Clearance; Azuero Peninsula, Panama, Heather P. Griscom, A. B. Connelly, M. S. Ashton, M. H. Wishnie, J. Deago

Heather P. Griscom

No abstract provided.


Influence Of Molecular Resolution On Sequence-Based Discovery Of Ecological Diversity Among Synechococcus Populations In An Alkaline Siliceous Hot Spring Microbial Mat, Melanie C. Melendrez, R. K. Lange, Frederick M. Cohan, David M. Ward 2010 Wesleyan University

Influence Of Molecular Resolution On Sequence-Based Discovery Of Ecological Diversity Among Synechococcus Populations In An Alkaline Siliceous Hot Spring Microbial Mat, Melanie C. Melendrez, R. K. Lange, Frederick M. Cohan, David M. Ward

Frederick M. Cohan

No abstract provided.


Inter-Regional Brain Communication And Its Disturbance In Autism, Sarah E. Schipul, Timothy A. Keller, Marcel Adam Just 2010 Carnegie Mellon University

Inter-Regional Brain Communication And Its Disturbance In Autism, Sarah E. Schipul, Timothy A. Keller, Marcel Adam Just

Marcel Adam Just

No abstract provided.


Coexpressed D1- And D2-Like Dopamine Receptors Antagonistically Modulate Acetylcholine Release In Caenorhabditis Elegans., Andrew T. Allen, Kathryn N. Maher, Khursheed A. Wani, Katherine E. Betts, Daniel Chase 2010 University of Massachusetts - Amherst

Coexpressed D1- And D2-Like Dopamine Receptors Antagonistically Modulate Acetylcholine Release In Caenorhabditis Elegans., Andrew T. Allen, Kathryn N. Maher, Khursheed A. Wani, Katherine E. Betts, Daniel Chase

Daniel Chase

Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activity of the neuron in which they are expressed. D1- and D2-like dopamine receptors are also coexpressed in the cholinergic ventral-cord motor neurons of Caenorhabditis elegans. To begin to understand how coexpressed dopamine receptors interact to modulate neuron activity, we performed a genetic screen in C. elegans and isolated mutants defective in ...


Systematics And Biogeography Of The Clusioid Clade (Malpighiales), Brad R. Ruhfel 2010 Eastern Kentucky University

Systematics And Biogeography Of The Clusioid Clade (Malpighiales), Brad R. Ruhfel

Brad R. Ruhfel

The clusioids are a clade of flowering plants in the diverse rosid order Malpighiales. It includes five families (i.e., Bonnetiaceae, Calophyllaceae, Clusiaceae sensu stricto, Hypericaceae, and Podostemaceae) that form a conspicuous element of tropical forests worldwide and are economically important. Their phylogenetic and biogeographical history has remained uncertain, however, which has hindered our understanding of their evolution. I conducted the first taxon-rich multigene analysis of this important clade to clarify their phylogenetic relationships (Chapter 1). Plastid (cp:matK, ndhF, and rbcL) and mitochondrial (mt: matR) nucleotide sequence data from nearly 200 taxa produced a well-resolved clusioid phylogeny and indicate ...


The Transition From Closed To Open Conformation Of Treponema Pallidum Outer Membrane-Associated Lipoprotein Tp0453 Involves Membrane Sensing And Integration By Two Amphipathic Helices, Amit Luthra, Guangyu Zhu, Daniel C. Desrosiers, Christian H. Eggers, Vishwaroop Mulay, Arvind Anand, Fiona A. McArthur, Fabian B. Romano, Melissa J. Caimano, Alejandro P. Heuck, Michael G. Malkowski, Justin D. Radolf 2010 University of Massachusetts - Amherst

The Transition From Closed To Open Conformation Of Treponema Pallidum Outer Membrane-Associated Lipoprotein Tp0453 Involves Membrane Sensing And Integration By Two Amphipathic Helices, Amit Luthra, Guangyu Zhu, Daniel C. Desrosiers, Christian H. Eggers, Vishwaroop Mulay, Arvind Anand, Fiona A. Mcarthur, Fabian B. Romano, Melissa J. Caimano, Alejandro P. Heuck, Michael G. Malkowski, Justin D. Radolf

Alejandro P. Heuck

The molecular architecture and composition of the outer membrane (OM) of Treponema pallidum (Tp), the noncultivable agent of venereal syphilis, differ considerably from those of typical Gram-negative bacteria. Several years ago we described TP0453, the only lipoprotein associated with the inner leaflet of the Tp OM. Whereas polypeptides of other treponemal lipoproteins are hydrophilic, non-lipidated TP0453 can integrate into membranes, a property attributed to its multiple amphipathic helices (AHs). Furthermore, membrane integration of the TP0453 polypeptide was found to increase membrane permeability, suggesting the molecule functions in a porin-like manner. To better understand the mechanism of membrane integration of TP0453 ...


Anaerobic Oxidation Of Benzene By The Hyperthermophilic Archaeon Ferroglobus Placidus, Derek Lovley, Dawn E. Holmes, Carla Risso, Jessica A. Smith 2010 University of Massachusetts - Amherst

Anaerobic Oxidation Of Benzene By The Hyperthermophilic Archaeon Ferroglobus Placidus, Derek Lovley, Dawn E. Holmes, Carla Risso, Jessica A. Smith

Carla Risso

Anaerobic benzene oxidation coupled to the reduction of Fe(III) was studied in Ferroglobus placidus in order to learn more about how such a stable molecule could be metabolized under strict anaerobic conditions. F. placidus conserved energy to support growth at 85°C in a medium with benzene provided as the sole electron donor and Fe(III) as the sole electron acceptor. The stoichiometry of benzene loss and Fe(III) reduction, as well as the conversion of [14C]benzene to [14C]carbon dioxide, was consistent with complete oxidation of benzene to carbon dioxide with electron transfer to Fe(III). Benzoate ...


Freshman Orientation Sessions Can Teach Incoming Students About Healthful Lifestyles, Marjorie R. Freedman, Jennifer Waldrop 2010 San Jose State University

Freshman Orientation Sessions Can Teach Incoming Students About Healthful Lifestyles, Marjorie R. Freedman, Jennifer Waldrop

Marjorie R. Freedman

Currently, 32% of college students are overweight or obese (body mass index ≥ 25),which is likely because many adolescents enter college with an elevated body mass index. Further, the transition from high school to college is associated with weight gain.On their own for the first time, freshmen have greater independence in all aspects of their lives. Increased independence, in turn, often results in changes in types of food and beverages consumed, and in overall eating and exercise patterns—changes that often affect weight gain. Although the popular media continues to perpetuate the “Freshman 15” myth, a recent meta-analysis reported ...


Are Species Cohesive?—A View From Bacteriology, Frederick M. Cohan 2010 Wesleyan University

Are Species Cohesive?—A View From Bacteriology, Frederick M. Cohan

Frederick M. Cohan

No abstract provided.


Asymmetry In Chemical Structures And In Life: My Last Two Articles, Otto Vogl 2010 University of Massachusetts - Amherst

Asymmetry In Chemical Structures And In Life: My Last Two Articles, Otto Vogl

Otto Vogl

No abstract provided.


Environmental Evidence For Net Methane Production And Oxidation In Putative Anaerobic Methanotrophic (Anme) Archaeaemi_, Karen Lloyd, Marc J. Alperin, Andreas Teske 2010 Selected Works

Environmental Evidence For Net Methane Production And Oxidation In Putative Anaerobic Methanotrophic (Anme) Archaeaemi_, Karen Lloyd, Marc J. Alperin, Andreas Teske

Karen Lloyd

Uncultured ANaerobic MEthanotrophic (ANME) archaea are often assumed to be obligate methanotrophs that are incapable of net methanogenesis, and are therefore used as proxies for anaerobic methane oxidation in many environments in spite of uncertainty regarding their metabolic capabilities. Anaerobic methane oxidation regulates methane emissions in marine sediments and appears to occur through a reversal of a methane-producing metabolism. We tested the assumption that ANME are obligate methanotrophs by detecting and quantifying gene transcription of ANME-1 across zones of methane oxidation versus methane production in sediments from the White Oak River estuary, North Carolina. ANME-1 consistently transcribe 16S rRNA and ...


Biological Activity And Mass Spectrometric Analysis Of Vernonia Amygdalina Fractions, Winston A. Anderson 2010 Howard University

Biological Activity And Mass Spectrometric Analysis Of Vernonia Amygdalina Fractions, Winston A. Anderson

Winston Anderson

Vernonia amygdalina (VA) is a tropical African plant of the Asteraceae family used as dietary supplement and as a medicinal herb. In this study, fatty acid esters, fatty acid amide, triterpene, diterpene alcohols and phytostanols were identified as the major chemical groups in the aqueous and organic fractions of VA leaf extracts. Their structures were elucidated, on the basis of GC-MS data, as hexanedioic acid, bis (2-ethylhexyl) ester (2a), erucamide (2b) and squalene (2c) in the water fraction; hexadecanoic acid methyl ester (3a), 9(Z)12(Z)15(Z)-octadecatrienoic acid, methyl ester (3b) and phytol (3c) in methanol fraction ...


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