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Microtubule Stabilization By Bone Morphogenetic Protein Receptor-Mediated Scaffolding Of C-Jun N-Terminal Kinase Promotes Dendrite Formation, Monika Podkowa, Xin Zhao, Chi-Wing Chow, Eleanor T. Coffey, Roger J. Davis, Liliana Attisano 2010 University of Toronto

Microtubule Stabilization By Bone Morphogenetic Protein Receptor-Mediated Scaffolding Of C-Jun N-Terminal Kinase Promotes Dendrite Formation, Monika Podkowa, Xin Zhao, Chi-Wing Chow, Eleanor T. Coffey, Roger J. Davis, Liliana Attisano

Davis Lab Publications

Neuronal outgrowth occurs via coordinated remodeling of the cytoskeleton involving both actin and microtubules. Microtubule stabilization drives the extending neurite, yet little is known of the molecular mechanisms whereby extracellular cues regulate microtubule dynamics. Bone morphogenetic proteins (BMPs) play an important role in neuronal differentiation and morphogenesis, and BMP7 in particular induces the formation of dendrites. Here, we show that BMP7 induces stabilization of microtubules in both a MAP2-dependent neuronal cell culture model and in dendrites of primary cortical neurons. BMP7 rapidly activates c-Jun N-terminal kinases (JNKs), known regulators of microtubule dynamics, and we show that JNKs associate with the ...


Analysis Of Apoptosis Of Memory T Cells And Dendritic Cells During The Early Stages Of Viral Infection Or Exposure To Toll-Like Receptor Agonists, Kapil Bahl, Anette Hubner, Roger J. Davis, Raymond M. Welsh 2010 Yale University

Analysis Of Apoptosis Of Memory T Cells And Dendritic Cells During The Early Stages Of Viral Infection Or Exposure To Toll-Like Receptor Agonists, Kapil Bahl, Anette Hubner, Roger J. Davis, Raymond M. Welsh

Davis Lab Publications

Profound type I interferon (IFN-I)-dependent attrition of memory CD8 and CD4 T cells occurs early during many infections. It is dramatic at 2 to 4 days following lymphocytic choriomeningitis virus (LCMV) infection of mice and can be elicited by the IFN-inducing Toll receptor agonist poly(I:C). We show that this attrition occurs in many organs, indicating that it is due to T cell loss rather than redistribution. This loss correlated with elevated intracellular staining of T cells ex vivo for activated caspases but with only low levels of ex vivo staining with annexin V, probably due to the ...


Diurnal Temperature Range Variability Due To Land Cover And Airmass Types In The Southeast, Kelsey N. Scheitlin, P. Grady Dixon 2010 Longwood University

Diurnal Temperature Range Variability Due To Land Cover And Airmass Types In The Southeast, Kelsey N. Scheitlin, P. Grady Dixon

Biology and Environmental Sciences Faculty Publications

This study examines the relationship between diurnal temperature range (DTR) and land use/land cover (LULC) in a portion of the Southeast. Temperature data for all synoptically weak days within a 10-yr period are gathered from the National Climatic Data Center for 144 weather stations. Each station is classified as one of the following LULC types: urban, agriculture, evergreen forest, deciduous forest, or mixed forest.Athreeway analysis of variance and paired-sample t tests are used to test for significant DTR differences due to LULC, month, and airmass type. The LULC types display two clear groups according to their DTR, with ...


The Development Of A Comprehensive Mechanism For Intracellular Calcium Oscillations: A Theoretical Approach And An Experimental Validation, Amanda A. Borges, Deanna Salter, Sandor Kadar, Steven B. Symington 2010 Salve Regina University

The Development Of A Comprehensive Mechanism For Intracellular Calcium Oscillations: A Theoretical Approach And An Experimental Validation, Amanda A. Borges, Deanna Salter, Sandor Kadar, Steven B. Symington

Pell Scholars and Senior Theses

Calcium is an important second messenger for cellular communication. Theoretical models help scientists understand its signalling mechanism. A comprehensive model was developed in order to minimize any limitations in the models currently presented in the literature. Experimental results support the model and therefore the theoretical model provides a plausible explanation of the dynamics of the calcium-signaling mechanism. In the future, additional verification will be performed using various experimental configurations on PC12 cells. Further, the model will be used to predict the response of cells to environmental factors such as pesticides and heavy metals.


Idaho Bird Observatory: Research, Education, Conservation - 24/7, Elise Faike 2010 Boise State University

Idaho Bird Observatory: Research, Education, Conservation - 24/7, Elise Faike

Jay D. Carlisle

The Idaho Bird Observatory’s Lucky Peak bird monitoring station atop the foothills overlooking Boise is unique. During fall migration, it’s the only place in western North America that hosts some form of songbird or raptor research all day and all night—for downright fun 24/7!


Turning Packaging Into Profit, Rihaz Z. Chughatta 2010 SelectedWorks

Turning Packaging Into Profit, Rihaz Z. Chughatta

Rihaz Z Chughatta

Packaging can be an expensive function to maintain, but it doesn’t have to be. In fact, Packaging can be a source of income for a company. More accurately, what if you took a look at your company’s Profit and Loss and saw Packaging as a negative expense? That’s right, you can turn packaging into profit for your company. How do you accomplish this feat? Glad you asked … read on to find three simple ways to start this process (and satisfy your curiosity) …


Opportunities And Obstacles To The Elimination Of Malaria From Peninsular Malaysia: Knowledge, Attitudes And Practices On Malaria Among Aboriginal And Rural Communities, Rohela Mahmud 2010 Department Of Parasitology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA

Opportunities And Obstacles To The Elimination Of Malaria From Peninsular Malaysia: Knowledge, Attitudes And Practices On Malaria Among Aboriginal And Rural Communities, Rohela Mahmud

Rohela Mahmud

Background: Despite continuous efforts by the government and private sectors, malaria is still a public health problem in rural Peninsular Malaysia. This study investigated household knowledge, attitude and practices (KAP) regarding malaria in two malaria endemic communities, forest-aboriginal and rural communities, in the Lipis district of Pahang state, Malaysia. Methods: A descriptive cross-sectional study with a semi-structured questionnaire was carried out among 100 and 123 households from forest-aboriginal and rural areas, respectively. Results: Knowledge about malaria and its transmission is significantly higher among the rural participants than the aborigines (86.2% vs 76%, p < 0.01). However, use of medicinal plants and beliefs in witchcraft and sorcery in treating febrile diseases were significantly higher among the aboriginal population (p < 0.01). There were no significant differences between the two communities in terms of the knowledge about malaria symptoms, attitudes towards its severity and practices in preventive measures against malaria by using mosquito bed nets. However, the knowledge and practice of different preventive measures to combat malaria, such as insecticide and the elimination of breeding areas, was significantly higher among the rural population than the aborigines (p < 0.001). Conclusions: Both communities were aware of malaria as a disease, but knowledge, attitudes and practices were inadequate. Providing efficient health education to people residing in malaria endemic areas would improve their understanding about malaria prevention in order to bring about the elimination of malaria from the country.


Non-Senescence In Neoclassical Growth Theory, Harry D. Saunders 2010 Decision Processes Incorporated

Non-Senescence In Neoclassical Growth Theory, Harry D. Saunders

Harry D. Saunders

This presentation describes research showing that non-senescent genotypes can dominate senescent ones under certain evolutionary conditions.


Improved Plasma Stability And Sustained Release Profile Of Gemcitabine Via Polypeptide Conjugation, Kiew Lik Voon, Cheong Soon Keng, Khalifah Sidik 2010 Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA

Improved Plasma Stability And Sustained Release Profile Of Gemcitabine Via Polypeptide Conjugation, Kiew Lik Voon, Cheong Soon Keng, Khalifah Sidik

Kiew Lik Voon

To enhance the stability of the anticancer drug gemcitabine (2'-deoxy-2',2'-difluorocytidine), it was conjugated to poly-L-glutamic acid (PG-H) via a carbodiimide reaction. The synthesised poly-L-glutamic acid-gemcitabine (PG-G) was purified and characterised by using SDS-PAGE to estimate its molecular weight, HPLC to determine its purity and degree of drug loading, and NMR to elucidate the structure. In vitro aqueous hydrolytic studies showed that the gemcitabine release from the polymeric drug conjugate was pH dependent, and that the conjugation to PG-H improved its stability in human plasma. The release of the bound gemcitabine from PG-G in plasma was mediated by ...


Toward A Synthesis Of Conservation And Animal Welfare Science, David Fraser 2010 University of British Columbia

Toward A Synthesis Of Conservation And Animal Welfare Science, David Fraser

Conservation Biology and Animal Welfare

Conservation biology and animal welfare science are multidisciplinary fields of research that address social concerns about animals. Conservation biology focuses on wild animals, works at the level of populations, ecological systems and genetic types, and deals with threats to biodiversity and ecological integrity. Animal welfare science typically focuses on captive (often domestic) animals, works at the level of individuals and groups, and deals with threats to the animals’ health and quality of life. However, there are many areas of existing or potential overlap: (i) many real-life problems, such as environmental contamination, urban development and transportation, create problems for animals that ...


Aboveground Biomass Estimation For Three Common Woody Species In The Post Oak Savannah Of Texas, Brian P. Oswald, R R. Botting, Dean W. Coble, Ken W. Farrish 2010 Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, Texas 75962

Aboveground Biomass Estimation For Three Common Woody Species In The Post Oak Savannah Of Texas, Brian P. Oswald, R R. Botting, Dean W. Coble, Ken W. Farrish

Faculty Publications

The Post Oak Savannah occupies about 3.4 million hectares of gently rolling to hilly lands in east central Texas. Large post oak (Quercus stellata Wangenh.) blackjack oak (Quercus marilandica Munchh.), Eastern redcedar (Juniperus virginiana L.) and honey mesquite (Juniperus virginiana L.) usually form the overstory, often above thickets of yaupon (Ilex vomitoria), winged elm (Ulmus alata), gum bumelia (Sideroxylon lanuginosum Michx. Subsp. Oblongifolium (Nutt) T.D. Penn.), and live oak (Quercus virginiana Mill.). Historically limited to rocky hillsides and draws (Owens and Ansley 1997), these species have migrated over the last several hundred years into bottomlands where grasses once ...


Testing Hypotheses For Exotic Plant Success: Parallel Experiments In The Native And Introduced Ranges, Jennifer L. Williams, Harald Auge, John L. Maron 2010 University of Montana - Missoula

Testing Hypotheses For Exotic Plant Success: Parallel Experiments In The Native And Introduced Ranges, Jennifer L. Williams, Harald Auge, John L. Maron

Biological Sciences Faculty Publications

A central question in ecology concerns how some exotic plants that occur at low densities in their native range are able to attain much higher densities where they are introduced. This question has remained unresolved in part due to a lack of experiments that assess factors that affect the population growth or abundance of plants in both ranges. We tested two hypotheses for exotic plant success: escape from specialist insect herbivores and a greater response to disturbance in the introduced range. Within three introduced populations in Montana, USA, and three native populations in Germany, we experimentally manipulated insect herbivore pressure ...


An Antibody Directed Against The Fusion Peptide Of Junin Virus Envelope Glycoprotein Gpc Inhibits Ph-Induced Membrane Fusion, Joanne York, Jody D. Berry, Ute Stroeher, Qunnu Li, Heinz Feldmann, Min Lu, Meg Trahey, Jack H. Nunberg 2010 University of Montana - Missoula

An Antibody Directed Against The Fusion Peptide Of Junin Virus Envelope Glycoprotein Gpc Inhibits Ph-Induced Membrane Fusion, Joanne York, Jody D. Berry, Ute Stroeher, Qunnu Li, Heinz Feldmann, Min Lu, Meg Trahey, Jack H. Nunberg

Biological Sciences Faculty Publications

The arenavirus envelope glycoprotein (GPC) initiates infection in the host cell through pH-induced fusion of the viral and endosomal membranes. As in other class I viral fusion proteins, this process proceeds through a structural reorganization in GPC in which the ectodomain of the transmembrane fusion subunit (G2) engages the host cell membrane and subsequently refolds to form a highly stable six-helix bundle structure that brings the two membranes into apposition for fusion. Here, we describe a G2-directed monoclonal antibody, F100G5, that prevents membrane fusion by binding to an intermediate form of the protein on the fusion pathway. Inhibition of syncytium ...


How Anthocyanin Mutants Respond To Stress: The Need To Distinguish Between Stress Tolerance And Maximal Vigour, Eric J. von Wettberg, Maureen L. Stanton, Justen B. Whittall 2010 Santa Clara University

How Anthocyanin Mutants Respond To Stress: The Need To Distinguish Between Stress Tolerance And Maximal Vigour, Eric J. Von Wettberg, Maureen L. Stanton, Justen B. Whittall

Biology

Background: Anthocyanins are produced by plants in response to diverse stresses Mutants that block the anthocyanin biosynthetic pathway (A BP) at various steps can easily be compared across numerous abiotic stresses Hypothesis: Anthocyanins or their precursors are required for stress tolerance. Thus, ABP loss-of-function mutants should have proportionately lower fitness than wildtype plants under stress, compared with benign conditions In contrast, a decrease in maximal vigour the general capacity for growth and fecundity should be most pronounced under benign conditions that allow luxuriant growth by the most vigorous genotypes Tests: Determine whether, under stressful conditions. ABP loss-of-function mutants have relatively ...


Avoidance Of Skeletal Muscle Atrophy In Spontaneous And Facultative Hibernators, Clark Cotton, Henry J. Harlow 2010 College of Saint Benedict/Saint John's University

Avoidance Of Skeletal Muscle Atrophy In Spontaneous And Facultative Hibernators, Clark Cotton, Henry J. Harlow

Biology Faculty Publications

Smooth and skeletal muscle changes were compared from overwintering white-tailed prairie dogs, spontaneous hibernators that undergo regular, low-temperature torpor bouts, and black-tailed prairie dogs, facultative hibernators that use sporadic, moderate-temperature torpor bouts. The objectives were to assess the abilities of these two species with dramatically different torpor patterns (1) to conserve skeletal muscle morphology, protein, and strength and (2) to use labile protein in the small intestine and liver during the winter season of reduced activity and food intake. Mass and protein concentration of the extensor digitorum longus (EDL), soleus, liver, and small intestine, as well as skeletal muscle strength ...


Reproductive Failure And The Stress Response In American Kestrels Nesting Along A Human Disturbance Gradient, Erin Hennegan Strasser 2010 Boise State University

Reproductive Failure And The Stress Response In American Kestrels Nesting Along A Human Disturbance Gradient, Erin Hennegan Strasser

Boise State University Theses and Dissertations

Human disturbance may be an influential environmental stressor that affects birds across life stages. I examined whether external and endogenous factors including habitat type, habitat quality and individual quality (hereafter quality), or human disturbance affect American Kestrel reproductive success in southwestern Idaho. Specifically, I was interested in how these factors lead to nest failure or abandonment. I also investigated whether elevated corticosterone (CORT) concentrations mediate the relationships among explanatory variables and nest failure. As nestling kestrels may respond to stressors differently from adults, I examined whether conditions experienced during the nestling stage affected nestling American Kestrel (Falco sparverius) hypothalamic pituitary ...


Assessing The Efficacy Of Modis Satellite-Derived Start Of Growing Season For Jurisdictional Determination Of East Texas Bottomland Hardwood Wetlands, Karen Malone, Hans Michael Williams, I-Kuai Hung, Daniel Unger 2010 Arthur Temple College of Forestry and Agriculture Division of Stephen F. Austin State University

Assessing The Efficacy Of Modis Satellite-Derived Start Of Growing Season For Jurisdictional Determination Of East Texas Bottomland Hardwood Wetlands, Karen Malone, Hans Michael Williams, I-Kuai Hung, Daniel Unger

Faculty Publications

Introduction: Crucial to the determination of a jurisdictional wetland is the definition of “growing season”. Satellite imagery is being utilized in other ecological applications, but is lagging in wetland growing season determination. Both cost and temporal limitations historically have restrained use of satellite imagery in assessing the start up of the growing season. Multiple commercial satellites are available that provide high resolution imagery, but the cost are prohibitive for most studies. The National Aeronautics and Space Administration (NASA) and the U.S. Geological Survey (USGS) jointly manage the Landsat and the Moderate-resolution Imaging Spectroradiometer (MODIS) satellite programs. Landsat Enhanced Thematic ...


Mapping Quantitative Trait Loci Associated With Chilling Requirement And Bloom Date In Peach, Shenghua Fan 2010 Clemson University

Mapping Quantitative Trait Loci Associated With Chilling Requirement And Bloom Date In Peach, Shenghua Fan

All Dissertations

Chilling requirement (CR), together with heat requirement (HR), determines bloom date (BD), which impacts climatic distribution of genotypes of temperate tree species. The molecular basis of floral bud CR is poorly understood despite its importance to fruit tree adaptation and production. A peach F2 populations developed from two genotypes with contrasting CR values was used for QTL mapping for CR, HR and BD. Using the Contender × Fla.92-2c population, 20 QTLs with additive effects were identified for three traits including one major QTL for CR and two major QTLs for BD. Particularly, one genomic region of 2cM pleiotropic for the ...


Plantar Fasciitis: Biomechanics, Atrophy And Muscle Energetics, Ryan Chang 2010 University of Massachusetts Amherst

Plantar Fasciitis: Biomechanics, Atrophy And Muscle Energetics, Ryan Chang

Open Access Dissertations

Purpose: The purpose of this dissertation was to determine the effects of chronic plantar fasciitis on intrinsic foot structures with respect to biomechanics, muscle atrophy and muscle energetics. This was accomplished in three parts. Methods: In Part I, a three-dimensional motion capture system with a synchronized force platform quantified multi-segment foot model kinematics and ground reaction forces associated with walking. Healthy individuals were compared to individuals with chronic plantar fasciitis feet. Typical kinematic variables, measures of coupling, phase and variability were examined in rearfoot, forefoot and hallux segments. In Part II, foot and leg magnetic resonance images were taken in ...


Identifying Critical Fish Habitat And Long-Term Trends In Fish Abundances In The Hudson River Estuary, Megan Patricia O'Connor 2010 University of Massachusetts Amherst

Identifying Critical Fish Habitat And Long-Term Trends In Fish Abundances In The Hudson River Estuary, Megan Patricia O'Connor

Open Access Dissertations

The Hudson River estuary (HRE) is a well monitored aquatic resource and much secondary data exist for this system. We developed two objectives based on accessible HRE aquatic data. The first objective was to determine if changes in HRE fish community over the time period (1974 to 2005) years are correlated to local and regional climate. We addressed this objective by employing a multivariate statistical approach. We confirmed that the HRE fish community structure has changed over the time period (1974 to 2005). These changes are correlated with local hydrology (freshwater flow and water temperature) and regional climate (Atlantic Multidecadal ...


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