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H-Ns Binding And Repression Of The Ctx Promoter In Vibrio Cholerae, Emily A. Stonehouse, Robin R. Hulbert, Melinda B. Nye, Karen Skorupski, Ronald K. Taylor 2010 Dartmouth College

H-Ns Binding And Repression Of The Ctx Promoter In Vibrio Cholerae, Emily A. Stonehouse, Robin R. Hulbert, Melinda B. Nye, Karen Skorupski, Ronald K. Taylor

Open Dartmouth: Faculty Open Access Articles

Expression of the ctx and tcp genes, which encode cholera toxin and the toxin coregulated pilus, the Vibrio cholerae O1 virulence determinants having the largest contribution to cholera disease, is repressed by the nucleoid-associated protein H-NS and activated by the AraC-like transcriptional regulator ToxT. To elucidate the molecular mechanism by which H-NS controls transcription of the ctxAB operon, H-NS repression and binding were characterized by using a promoter truncation series, gel mobility shift assays, and DNase I footprinting. Promoter regions found to be important for H-NS repression correlated with in vitro binding. Four main H-NS binding regions are present at ...


Ua66/5 Agriculture, WKU University Archives 2010 Western Kentucky University

Ua66/5 Agriculture, Wku University Archives

WKU Archives Collection Inventories

Unprocessed records created by the Department of Agriculture.

Series 1. Student Organizations

Records created by and about Department of Agriculture student organizations such as Block & Bridle.

Series 2. Publications

Publications created by and about the Department of Agriculture.

Series 3. Correspondence

Unprocessed correspondence to and from the Department of Agriculture.


Gender And Color Specific Differences In Event Related Potentials, Abhishek Trikha 2010 Brigham Young University - Provo

Gender And Color Specific Differences In Event Related Potentials, Abhishek Trikha

All Theses and Dissertations

This project analyzed gender and color-specific differences in event-related potentials (ERPs). Previous studies have shown that males process color differently than females. In a recent study, sex differences were found in ERPs during a visual object recognition task. There were higher EEG amplitudes in females (especially P300) than males. Significant sex and color-specific differences have been found in diseases involving altered dopamine (DA) machinery. Thus, we analyzed differences between ERPs in males vs females during a color task. We also compared the color-specific differences in ERPs between males and females. Males and females participated in EEG recording sessions for 2 ...


Host Cell Attachment By Lyme Disease And Relapsing Fever Spirochetes: A Dissertation, Vivian M. Benoit 2010 University of Massachusetts Medical School Worcester

Host Cell Attachment By Lyme Disease And Relapsing Fever Spirochetes: A Dissertation, Vivian M. Benoit

GSBS Dissertations and Theses

Host cell attachment by pathogenic bacteria can play very different roles in the course of infection. The pathogenic spirochetes Borrelia hermsii and Borrelia burgdorferi sensu lato which cause relapsing fever and Lyme disease, respectively, are transmitted by the bite of infected ticks. After transmission, these spirochetes can cause systemic infection. Relapsing fever spirochetes remain largely in the bloodstream causing febrile episodes, while Lyme disease will often colonize a variety of tissues, such as the heart, joint and nervous system, resulting in a chronic multisystemic disorder. Borrelia species have the ability to bind to various cell types, a process which plays ...


Distinct Functions For The Drosophila Pirna Pathway In Genome Maintenance And Telomere Protection, Jaspreet S. Khurana, Jia Xu, Zhiping Weng, William E. Theurkauf 2010 University of Massachusetts Medical School

Distinct Functions For The Drosophila Pirna Pathway In Genome Maintenance And Telomere Protection, Jaspreet S. Khurana, Jia Xu, Zhiping Weng, William E. Theurkauf

Open Access Articles

Transposons and other selfish DNA elements can be found in all phyla, and mobilization of these elements can compromise genome integrity. The piRNA (PIWI-interacting RNA) pathway silences transposons in the germline, but it is unclear if this pathway has additional functions during development. Here we show that mutations in the Drosophila piRNA pathway genes, armi, aub, ago3, and rhi, lead to extensive fragmentation of the zygotic genome during the cleavage stage of embryonic divisions. Additionally, aub and armi show defects in telomere resolution during meiosis and the cleavage divisions; and mutations in lig-IV, which disrupt non-homologous end joining, suppress these ...


Huntingtin Cleavage Product A Forms In Neurons And Is Reduced By Gamma-Secretase Inhibitors, Kimberly B. Kegel, Ellen Sapp, Jonathan Alexander, Patrick Reeves, Dorothee Bleckmann, Linsday Sobin, Nicholas Masso, Antonio Valencia, Hyunkyung Jeong, Dimitri Krainc, James Palacino, Daniel Curtis, Rainer Kuhn, Claudia Betschart, Miguel Sena-Esteves, Neil Aronin, Paolo Paganetti, Marian DiFiglia 2010 Massachusetts General Hospital

Huntingtin Cleavage Product A Forms In Neurons And Is Reduced By Gamma-Secretase Inhibitors, Kimberly B. Kegel, Ellen Sapp, Jonathan Alexander, Patrick Reeves, Dorothee Bleckmann, Linsday Sobin, Nicholas Masso, Antonio Valencia, Hyunkyung Jeong, Dimitri Krainc, James Palacino, Daniel Curtis, Rainer Kuhn, Claudia Betschart, Miguel Sena-Esteves, Neil Aronin, Paolo Paganetti, Marian Difiglia

Open Access Articles

BACKGROUND: The mutation in Huntington's disease is a polyglutamine expansion near the N-terminus of huntingtin. Huntingtin expressed in immortalized neurons is cleaved near the N-terminus to form N-terminal polypeptides known as cleavage products A and B (cpA and cpB). CpA and cpB with polyglutamine expansion form inclusions in the nucleus and cytoplasm, respectively. The formation of cpA and cpB in primary neurons has not been established and the proteases involved in the formation of these fragments are unknown.

RESULTS: Delivery of htt cDNA into the mouse striatum using adeno-associated virus or into primary cortical neurons using lentivirus generated cpA ...


Phylogenetics, Morpohology, And Genomic Evolution In Physarieae (Brassicaceae), Sara Fuentes-Soriano 2010 University of Missouri-St. Louis

Phylogenetics, Morpohology, And Genomic Evolution In Physarieae (Brassicaceae), Sara Fuentes-Soriano

Dissertations

The mustard family (Brassicaceae) is economically important but the evolution of its morphology is not well understood. I investigate the evolution of morphological and genomic characters and calculate ancestral trait values in the Brassicaceae within a phylogenetic context using the tribe Physarieae as a model system. Physarieae are a unique and diverse group of American mustards characterized by multi-aperturate pollen. Phylogenetic analyses of DNA sequences (chloroplast ndhF and nuclear ITS and LUMINIDEPENDENS) were used to test the monophyly and explore evolutionary relationships of Physarieae. The phylogenetic inferences were used to identify morphological traits to delimit the tribe, to interpret the ...


Crop Advantage Series Provides Latest Crop Production Information, Brent A. Pringnitz 2010 Iowa State University

Crop Advantage Series Provides Latest Crop Production Information, Brent A. Pringnitz

Integrated Crop Management News

Anyone involved in Iowa crop production should plan to attend a 2011 Crop Advantage Series meeting. The meetings provide information to help producers make profitable decisions for the upcoming growing season. Sponsored by Iowa State University Extension, the meetings will be held at 14 locations across Iowa in January.


Isu Extension Offers Soil Fertility Short Course, Brent A. Pringnitz 2010 Iowa State University

Isu Extension Offers Soil Fertility Short Course, Brent A. Pringnitz

Integrated Crop Management News

With high input costs and volatile nutrient prices it is more important than ever to make sound management soil fertility decisions. ISU Extension will be offering a two-day short course focusing on principles of soils, soil fertility and nutrient management to help crop production professionals make informed decisions. In addition to classroom work, attendees will visit the ISU Soil and Plant Analysis Laboratory.


Development Of A Methodology To Attain High Levels Of Storage Proteins In Cassava Tuberized Roots And Its Implications, Mohammad Abhary 2010 University of Missouri-St. Louis

Development Of A Methodology To Attain High Levels Of Storage Proteins In Cassava Tuberized Roots And Its Implications, Mohammad Abhary

Dissertations

Cassava (Manihot esculenta Crantz.) is a member of the Euphorbiaceae family, cultivated in the tropics and subtropical areas as a staple food crop for more than 700 million people around the world. The starchy storage roots of cassava are rich in calories and deficient in all other nutrients, cassava meals has the lowest of all sources of dietary protein. Severe protein deficiencies and malnutrition problems are common among those who rely on cassava as their daily meal. Although cassava is ranked the fifth most important crop in the world, the research on this crop is very limited. Among the limited ...


The Effectiveness Of A Short Food Frequency Questionnaire In Determining The Adequacy Of Vitamin D Intake In Children, Caitlin Russell 2010 Georgia State University

The Effectiveness Of A Short Food Frequency Questionnaire In Determining The Adequacy Of Vitamin D Intake In Children, Caitlin Russell

Nutrition Theses

Background: Studies have consistently found a high prevalence of vitamin D deficiency in adolescents. Few validated dietary intake assessment tools for vitamin D exist for adolescents.

Objective: The aim of this study was to determine if a short food frequency questionnaire (SFFQ) can be used to effectively assess vitamin D intake in adolescents compared to a previously validated long food frequency questionnaire (LFFQ).

Participants/setting: 140 healthy 6-12 year old (male n=81) Caucasian and African American (n=94) children from Pittsburgh, Pennsylvania completed a SFFQ and LFFQ at two time points 6 months apart.

Main outcome measures: Reliability and ...


Serum Vitamin Concentrations Are Associated With Metabolic Syndrome And Insulin Resistance In Us Children, Nida I. Shaikh 2010 Georgia State University

Serum Vitamin Concentrations Are Associated With Metabolic Syndrome And Insulin Resistance In Us Children, Nida I. Shaikh

Nutrition Theses

Background: Vitamin D deficiency is a concern in the US. Association between vitamin D status and metabolic syndrome (MetS), insulin resistance (IR), and inflammation is unclear in children. Objective: The relationship between serum vitamin D and MetS, C-reactive protein (CRP), and Homeostatic Model Assessment-IR (HOMA-IR) was investigated. Design: Data from 3 cycles of National Health and Nutrition Examination Survey, 2001-2006 for 3700 (1820, boys; 1880, girls) children and adolescents, aged 12-17 y were used to assess prevalence of vitamin D deficiency (<20 ng>/mL) and association between serum vitamin D and prevalence of MetS, various components of MetS, CRP, and HOMA-IR using ...


The Effect Of Passive Stretching And Isometric Contractions On Delayed Onset Muscle Soreness After A Typical Bout Of Exercise, John W. Gibson 2010 Brigham Young University - Provo

The Effect Of Passive Stretching And Isometric Contractions On Delayed Onset Muscle Soreness After A Typical Bout Of Exercise, John W. Gibson

All Theses and Dissertations

Delayed Onset Muscle Soreness (DOMS) is a common response to activities involving lengthening contractions. Muscle inflammation is associated with DOMS and may play an integral role in protecting a muscle from damage and soreness in response to subsequent bouts of lengthening contractions. Research in animals has shown that prior exposure to passive stretching and isometric contractions of a muscle resulting in muscle inflammation attenuates the muscle inflammatory response following subsequent bouts of lengthening contractions. The purpose of this study was to determine whether passive stretching and isometric contractions in humans would reduce DOMS following a typical bout of resistance exercise ...


Food Store Audits: Examining Food Price, Availability, And Quailty, Before And After Relocation Of Public Housing Residents, Anjenique Anderson 2010 Georgia State University

Food Store Audits: Examining Food Price, Availability, And Quailty, Before And After Relocation Of Public Housing Residents, Anjenique Anderson

Nutrition Theses

In an effort to deconcentrate poverty, Atlanta is attempting to become the first city in the U.S. to completely eliminate public housing by relocating ≈ 10,000 residents. Research has shown that the health status of public housing residents is worse than any other population. Evidence also suggests that there is an inverse relationship between neighborhood availability of healthy, affordable foods and diet intake. The aim of this study was to compare the price, availability, and quality of food items in the public housing residents’ communities, before and after relocation. Using Nutrition Environment Measures Survey (NEMS), a total of 42 ...


Immunity, Pathogenesis, And Prevention Of Poxvirus Infections: A Dissertation, Mina O. Seedhom 2010 University of Massachusetts Medical School

Immunity, Pathogenesis, And Prevention Of Poxvirus Infections: A Dissertation, Mina O. Seedhom

GSBS Dissertations and Theses

Vaccinia virus (VAC) is the prototypical member of the orthopoxvirus genus of the poxvirus family and the virus used for smallpox vaccinations. The following describes the testing of VAC variants designed to have similar immuno-protective profiles with decreased pathogenicity, examines the immune response to VAC after lethal infection in wild type and lupus-prone mice, and describes a method that allows for the enumeration of VAC-specific CD8+ T in naïve and VAC-immune mice.

The first part describes work examining VAC Wyeth (VAC-Wy) variants engineered to be less pathogenic in vivo. VAC-Wy variants included genes that code for three immunomodulatory proteins, an ...


Changes In Soil Respiration Across A Chronosequence Of Tallgrass Prairie Reconstructions, Ryan M. Maher, Heidi Asbjornsen, Randall K. Kolka, Cynthia A. Cambardella, James W. Raich 2010 Iowa State University

Changes In Soil Respiration Across A Chronosequence Of Tallgrass Prairie Reconstructions, Ryan M. Maher, Heidi Asbjornsen, Randall K. Kolka, Cynthia A. Cambardella, James W. Raich

Ecology, Evolution and Organismal Biology Publications

Close relationships among climatic factors and soil respiration (Rs) are commonly reported. However, variation in Rs across the landscape is compounded by site-specific differences that impede the development of spatially explicit models. Among factors that influence Rs, the effect of ecosystem age is poorly documented. We hypothesized that Rs increases with grassland age and tested this hypothesis in a chronosequence of tallgrass prairie reconstructions in central Iowa, U.S.A. We also assessed changes in root biomass, root ingrowth, aboveground net primary productivity (ANPP), and the strength of soil temperature and moisture in predicting Rs ...


Chemical Vapor Deposition Of Silanes And Patterning On Silicon, Feng Zhang 2010 Brigham Young University - Provo

Chemical Vapor Deposition Of Silanes And Patterning On Silicon, Feng Zhang

All Theses and Dissertations

Self assembled monolayers (SAMs) are widely used for surface modification. Alkylsilane monolayers are one of the most widely deposited and studied SAMs. My work focuses on the preparation, patterning, and application of alkysilane monolayers. 3-aminopropyltriethoxysilane (APTES) is one of the most popular silanes used to make active surfaces for surface modification. To possibly improve the surface physical properties and increase options for processing this material, I prepared and studied a series of amino silane surfaces on silicon/silicon dioxide from APTES and two other related silanes by chemical vapor deposition (CVD). I also explored CVD of 3-mercaptopropyltrimethoxysilane on silicon and ...


The Effects Of Chronic Ampk Activation On Hepatic Triglyceride Accumulation And Glycerol-3-Phosphate Acyltransferaseactivity With High Fat Feeding, Mary E. Curtis 2010 Brigham Young University - Provo

The Effects Of Chronic Ampk Activation On Hepatic Triglyceride Accumulation And Glycerol-3-Phosphate Acyltransferaseactivity With High Fat Feeding, Mary E. Curtis

All Theses and Dissertations

High fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated Protein Kinase (AMPK) is thought to inhibit lipid synthesis by the acute inhibition of glycerol-3-phosphate acyltransferase (GPAT) activity and transcriptional regulation via SREBP-1c. The purpose of this study was to determine if chronic activation of AMPK prevented an increase in GPAT1 activity in rats fed a high fat diet. Rats were fed a control (C), or a high fat (HF) diet (60% fat) for 6 weeks and injected with saline or a daily AICAR dose of 0.5 mg/g body weight. Chronic AMPK ...


Differential Gene Expression In Bugula Neritina During Symbiotic Association With "Candidatus Endobugula Sertula", Meril Mathew 2010 Georgia State University

Differential Gene Expression In Bugula Neritina During Symbiotic Association With "Candidatus Endobugula Sertula", Meril Mathew

Biology Theses

The colonial marine bryozoan, Bugula neritina, harbors an uncultured endosymbiont, “Candidatus Endobugula sertula” throughout its life stages. The bacterial symbiont has been proposed to be a source of complex polyketide metabolites, the bryostatins, that chemically defend B. neritina larvae from predation. Within a bryozoan colony, significantly higher amounts of bryostatins are found in ovicell-bearing zooids where the developing larvae are brooded, as compared to ovicell-free zooids. It is hypothesized that signaling between B. neritina and “Ca. Endobugula sertula” may be involved in the regulation of bryostatin production in different zooids, as well as in maintenance of the symbiosis. In this ...


The Effects Of Selective Estrogenic Drugs In The Medial Amygdala On Male Rat Sexual Behavior, Ejiroghene V. Ogaga-Mgbonyebi 2010 Georgia State University

The Effects Of Selective Estrogenic Drugs In The Medial Amygdala On Male Rat Sexual Behavior, Ejiroghene V. Ogaga-Mgbonyebi

Biology Theses

Male rat copulatory behavior is dependent on Testosterone (T) and its metabolites, estradiol (E2) and dihydrotestosterone (DHT). The estrogen receptor (ER) isoforms, ERα and ERβ, exist in the medial Amygdala (MEA) and either receptor might mediate mating behavior. Therefore, the effects of selective estrogenic MEA implants: propyl pyrazole triol (PPT, ERα agonist), diarylpropionitrile (DPN, ERβ agonist), and 1-methyl-4-phenyl pyridinium (MPP, ERα antagonist) were compared to E2 in maintaining sexual behavior. Four groups of male rats were castrated and administered DHT s.c. and bilateral MEA implants containing either cholesterol, E2, PPT or DPN. An additional group of gonadally intact male ...


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