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Δ-9-Thc Effect On The Dopamine Transporter, Brooke E. Nielsen 2018 CUNY John Jay College

Δ-9-Thc Effect On The Dopamine Transporter, Brooke E. Nielsen

Student Theses

Understanding the mechanism behind drugs of abuse is one of the key elements to understanding why addiction is so prevalent in society. The goal of this research was to determine the effect that a popular cannabinoid, Δ -9-tetrahydrocannabinol has on the regulation of dopamine neurotransmitter in the synapses. It was hypothesized that the addictive high users experience from using Δ-9-THC had a direct effect on lowering the dopamine transporter protein on cell surface causing a buildup of dopamine in the synapse. The results of the study show that the higher concentration of Δ-9-THC that the cells were exposed to caused ...


Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young, Kathleen King Siwicki, P. E. Hardin, J. L. Price 2018 Swarthmore College

Reflections On Contributing To “Big Discoveries” About The Fly Clock: Our Fortunate Paths As Post-Docs With 2017 Nobel Laureates Jeff Hall, Michael Rosbash, And Mike Young, Kathleen King Siwicki, P. E. Hardin, J. L. Price

Biology Faculty Works

In the early 1980s Jeff Hall and Michael Rosbash at Brandeis University and Mike Young at Rockefeller University set out to isolate the period (per) gene, which was recovered in a revolutionary genetic screen by Ron Konopka and Seymour Benzer for mutants that altered circadian behavioral rhythms. Over the next 15 years the Hall, Rosbash and Young labs made a series of groundbreaking discoveries that defined the molecular timekeeping mechanism and formed the basis for them being awarded the 2017 Nobel Prize in Physiology or Medicine. Here the authors recount their experiences as post-docs in the Hall, Rosbash and Young ...


Women In Science: Why So Few? [Liberal Arts: Math And Science], Reem Jaafar, Benjamin J. Taylor 2018 CUNY LaGuardia Community College

Women In Science: Why So Few? [Liberal Arts: Math And Science], Reem Jaafar, Benjamin J. Taylor

Open Educational Resources

This assigment was developed in the context of LaGuardia’s Center for Teaching and Learning sponsored Learning Matters mini grant “Connection Between First Year Seminar and Capstone Learning Experiences.” It provides Liberal Arts experience to students across the academic spectrum and is designed for students in LMF 101 (First-Year Seminar for Liberal Arts: Math & Science) and is conducted in conjunction with students from a capstone course, LIB 200 (Science, Technology, and Humanism). The assignment aligns with the Inquiry and Problem-Solving Core Competency and the Written Ability. In this assignment, LMF 101 students research and read several articles centered on the topic of Women in STEM. They then write an essay that integrates the information from these sources to address the history, biases, and potential causes of the underrepresentation of Women in STEM. LIB 200 students peer review these essays, and LMF 101 students, in turn, respond to these peer reviews. The assignment concludes with a combined class discussion on the topic and the process. The overall goals for this assignment which also reflect the dimensions of the Inquiry and Problem Solving Core Competency and the Written Communication Ability rubrics are the following:

  1. Students will utilize the appropriate library search engines to find a resource relevant to a particular topic.
  2. Students will analyze and integrate evidence from multiple sources on a complicated topic, and they will use the evidence they gathered to answer questions and arrive at logical conclusions.
  3. Students will assess the reliability of data and/or claims made in the literature.
  4. Students will cite sources appropriately.
  5. Students will understand the importance of peer review, understand how constructive criticism can help improve scholarly work, and learn how to respond to feedback in ways to improve the outcome of their work.

LaGuardia’s Core Competencies and Communication Abilities

Main Course Learning Objectives:

LMF 101 Course Goals Associated with Assignment:

  • Demonstrate understanding of habits of mind essential to college success (e.g., persistence, flexibility, and metacognition) and foundational knowledge in mathematics and science.
  • Interpret the values and ethics of mathematics and science and discuss how these values and ethics directly influence personal, academic, and professional success in their careers.
  • Demonstrate an understanding of the structure and logic of technical writing; show a basic level of proficiency in the fundamental writing, reading and speaking skills necessary to deliver information in a contextual and coherent manner.
  • Demonstrate the use of skills and knowledge gained from diverse experiences to enhance learning and success.
  • Describe the diversity of LaGuardia Community ...

Forage News [2018-06], University of Kentucky Department of Plant and Soil Sciences 2018 University of Kentucky

Forage News [2018-06], University Of Kentucky Department Of Plant And Soil Sciences

Forage News

  • New Publication – Crabgrass as Forage (AGR-232)
  • New Publication – Foxtail Millet (AGR-233)
  • Sivanto Prime (insecticide) Available on Sweet Sorghum for 2018


Arabidopsis Thaliana Ei-5: Minor Vein Architecture Adjustment Compensates For Low Vein Density In Support Of Photosynthesis, Jared J. Stewart, Stephanie K. Polutchko, Barbara Demmig-Adams, William W. Adams III 2018 University of Colorado Boulder

Arabidopsis Thaliana Ei-5: Minor Vein Architecture Adjustment Compensates For Low Vein Density In Support Of Photosynthesis, Jared J. Stewart, Stephanie K. Polutchko, Barbara Demmig-Adams, William W. Adams Iii

University Libraries Open Access Fund Supported Publications

An Arabidopsis thaliana accession with naturally low vein density, Eifel-5 (Ei-5), was compared to Columbia-0 (Col-0) with respect to rosette growth, foliar vein architecture, photosynthesis, and transpiration. In addition to having to a lower vein density, Ei-5 grew more slowly, with significantly lower rates of rosette expansion, but had similar capacities for photosynthetic oxygen evolution on a leaf area basis compared to Col-0. The individual foliar minor veins were larger in Ei-5, with a greater number of vascular cells per vein, compared to Col-0. This compensation for low vein density resulted in similar values for the product of vein density ...


Trophic Shifts Introduced To The Saco River Estuary By A Central Secondary Consumer, The Invasive European Green Crab (Carcinus Maenas), Andrew Paul Davidsohn 2018 University of New England

Trophic Shifts Introduced To The Saco River Estuary By A Central Secondary Consumer, The Invasive European Green Crab (Carcinus Maenas), Andrew Paul Davidsohn

All Theses And Dissertations

The European green crab (Carcinus maenus) is one of the most notorious invasive species found along the East coast of the United States. Green crabs were introduced to the US in the 1800s when they supposedly rode in ballast water across the Atlantic Ocean. Green crabs are native to the Atlantic coasts of Europe and Northern Africa. Once established on the Atlantic coast of North America, they started to migrate mostly north, and will continue to do so with warming waters due to climate change. (Glude 1955). Warmer winters will lead to greater crab egg survival, increasing the green crabs ...


Integrating Species Traits Into Species Pools, Marko J. Spasojevic, Christopher P. Catano, Joseph A. LaManna 2018 Washington University in St. Louis

Integrating Species Traits Into Species Pools, Marko J. Spasojevic, Christopher P. Catano, Joseph A. Lamanna

Biology Faculty Publications & Presentations

Despite decades of research on the species‐pool concept and the recent explosion of interest in trait‐based frameworks in ecology and biogeography, surprisingly little is known about how spatial and temporal changes in species‐pool functional diversity (SPFD) influence biodiversity and the processes underlying community assembly. Current trait‐based frameworks focus primarily on community assembly from a static regional species pool, without considering how spatial or temporal variation in SPFD alters the relative importance of deterministic and stochastic assembly processes. Likewise, species‐pool concepts primarily focus on how the number of species in the species pool influences local biodiversity ...


Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding., Helen Fogarty, Mary Byrne, Niamh M. O'Connell, Kevin Ryan, Barry White, James S. O'Donnell, Michelle Lavin 2018 St. James’s Hospital, Dublin

Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding., Helen Fogarty, Mary Byrne, Niamh M. O'Connell, Kevin Ryan, Barry White, James S. O'Donnell, Michelle Lavin

Molecular and Cellular Therapeutics Articles

Factor XIII (FXIII) is a plasma clotting protein involved in clot stabilization. Severe FXIII deficiency may present with severe, even fatal bleeding. Critically however, routine coagulation assays may be normal and only specific FXIII assays will detect the abnormality. Herein we discuss a case report of a patient with acquired FXIII deficiency in order to highlight the clinical challenges associated with establishing the diagnosis and discuss the treatment approach. A 70-year-old man presented with a gluteal haematoma despite no preceding personal history of bleeding. Extensive initial haemostatic investigations were normal until a specific FXIII assay showed a marked reduction in ...


Gene Therapy With Rala/Inos Composite Nanoparticles Significantly Enhances Survival In A Model Of Metastatic Prostate Cancer, Cian M. mcCrudden, John W. McBride, Joanne McCaffrey, Emma M. McErlean, Nicholas J. Dunne, Vickly L. Katt, Jonathan A. Coulter, Tracy Robson, Helen O. McCarthy 2018 Queen's University Belfast

Gene Therapy With Rala/Inos Composite Nanoparticles Significantly Enhances Survival In A Model Of Metastatic Prostate Cancer, Cian M. Mccrudden, John W. Mcbride, Joanne Mccaffrey, Emma M. Mcerlean, Nicholas J. Dunne, Vickly L. Katt, Jonathan A. Coulter, Tracy Robson, Helen O. Mccarthy

Molecular and Cellular Therapeutics Articles

Background: Recent approvals of gene therapies by the FDA and the EMA for treatment of inherited disorders have further opened the door for assessment of nucleic acid pharmaceuticals for clinical usage. Arising from the presence of damaged or inappropriate DNA, cancer is a condition particularly suitable for genetic intervention. The RALA peptide has been shown to be a potent non-viral delivery platform for nucleic acids. This study examines the use of RALA to deliver a plasmid encoding inducible nitric oxide synthase (iNOS) as an anti-cancer treatment. Methods: The physiochemical properties of the RALA/DNA nanoparticles were characterized via dynamic light ...


Ephrinb3 Modulates Hippocampal Neurogenesis And The Reelin Signaling Pathway In A Pilocarpineinduced Model Of Epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng 2018 Central South University

Ephrinb3 Modulates Hippocampal Neurogenesis And The Reelin Signaling Pathway In A Pilocarpineinduced Model Of Epilepsy, Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng

Open Access Articles

EphrinB3 is important in the regulation of cell proliferation, differentiation and migration via cellcell contact, and can activate the reelin pathway during brain development. However, the effect of ephrinB3 on hippocampal neurogenesis and the reelin pathway in epilepsy remains to be fully elucidated. In the present study, the expression of ephrinB3 in pilocarpineinduced status epilepticus (SE) rats was investigated. SYBR Greenbased reverse transcriptionquantitative polymerase chain reaction analysis, immunohistochemical labeling and western blot analysis were used to detect the gene and protein expression levels of ephrinB3 and reelin pathway proteins. Immunofluorescence staining of doublecortin (DCX) was utilized to analyze hippocampal neurogenesis ...


Avoiding Death Like The Plague: Wound Care In The Roman Army, Gwendolyn E. Dougherty 2018 Nazareth College of Rochester

Avoiding Death Like The Plague: Wound Care In The Roman Army, Gwendolyn E. Dougherty

#History: A Journal of Student Research

At its peak, Roman Empire controlled over two million square miles of territory. To conquer and control that much land, Rome produced a highly skilled army. Casualties and deaths were to be expected, but ancient medical sources about caring for the wounded in the Roman army point to treatments considered advanced for the time period. Galen of Pergamum was an important contributor to this field. The use of food products and natural resources helped combat infections, healing the wounded soldiers and returning them to their military units. This paper identifies and analyzes what those specific products for wound care were ...


Defining The Radioresponse Of Mossy Cells, Devon Ivy 2018 California State University, San Bernardino

Defining The Radioresponse Of Mossy Cells, Devon Ivy

Electronic Theses, Projects, and Dissertations

Clinical radiotherapy is used to treat a variety of brain tumors within the central nervous system. While effective, it can result in progressive and debilitating cognitive impairment that can diminish quality of life. These impairments have been linked to hippocampal dysfunction and corresponding deficits in spatial learning and memory. Mossy cells are a major population of excitatory neurons located within the dentate hilus and highly involved in hippocampal circuitry. They play critical roles in spatial navigation, neurogenesis, memory, and are particularly vulnerable to a variety of neurotoxic insults. However, their sensitivity to ionizing radiation has yet to be investigated in ...


Characterizing The Role Of N Terminus Of Influenza A Nucleoprotein For Location And Viral Rnp Activity, Jared Lin 2018 California State University - San Bernardino

Characterizing The Role Of N Terminus Of Influenza A Nucleoprotein For Location And Viral Rnp Activity, Jared Lin

Electronic Theses, Projects, and Dissertations

The influenza viral ribonucleoprotein complexes (vRNPs) are responsible for viral RNA synthesis. Each vRNP is comprised of one vRNA segment, the viral RNA dependent RNA polymerase complex (RdRP), and multiple copies of nucleoprotein (NP). NP serves as scaffold in formation of vRNPs, but also regulates vRNP activity. The N-terminus of NP contains a nonconventional nuclear localization signal (NLS1) essential for initial vRNP nuclear import, but also interacts with host RNA helicases to enhance viral RNA replication in the nucleus. NP contains at least one additional NLS sequence, with bioinformatics revealing a third NLS in some NP proteins.

Published yeast-two hybrid ...


An Evaluation Of Host Factors As Novel Therapeutic Targets During Influenza Infection Using Rna Technologies, Michael Ryan Haden Thompson 2018 California State University - San Bernardino

An Evaluation Of Host Factors As Novel Therapeutic Targets During Influenza Infection Using Rna Technologies, Michael Ryan Haden Thompson

Electronic Theses, Projects, and Dissertations

Influenza A is a single-stranded, multi-segmented, negative sense RNA virus of the family Orthomyxoviridae and is the causative agent of seasonal Influenza. Influenza viruses cause significant impacts on a global scale regarding public health and economics. Annual influenza virus infections in the United States account for over 200,000 hospitalizations, up to 49,000 deaths, and an $87.1 billion economic burden. Influenza A virus has caused several pandemics since the turn of the 20th century. The effects of Influenza on public health and economics, compounded with low efficacy of the annual vaccine and emerging antiviral resistance, brings to light ...


Correctional Officers’ Perceptions And Attitudes Toward Mental Health Within The Prison System, Alexandra Rose Serafini 2018 California State University - San Bernardino

Correctional Officers’ Perceptions And Attitudes Toward Mental Health Within The Prison System, Alexandra Rose Serafini

Electronic Theses, Projects, and Dissertations

This research explored correction officers’ perceptions and attitudes in relation to inmates with mental health issues. In a qualitative fashion, semi-structured interviews were conducted with five correction officers in Southern California (N = 5) during the Winter 2018 Quarter. Using thematic analysis, this study identified six major themes from the interview data: mental health has remained a prominent issue within the prison population; correction officers were fairly knowledgeable about mental health; correction officers perceived themselves as having to play a limited role in the rehabilitation of inmates with mental health problems; constant prompts in daily activities and medication management were two ...


The Effect Of Team Sports In Classical, Christian Education, Hannah Grey 2018 Liberty University

The Effect Of Team Sports In Classical, Christian Education, Hannah Grey

Masters Theses

Antoine de Saint-Exupery once noted if you want to build a ship, don’t drum up the men to gather wood, divide the work, and give orders. Instead, teach them to yearn for the vast and endless sea (“A quote by Antoine de Saint-Exupery,” n.d.). This quote embodies the goal of classical education, but it also parallels the values taught in sport. There has been a resurgence of classical education in recent years, and these new schools are focusing on instilling in students a love for learning, a passion for truth and beauty, and a simultaneous prudent understanding of ...


Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth 2018 CUNY John Jay College

Zolpidem Facilitated Sexual Assaults: A Hair Method Validation, Danielle N. Chasworth

Student Theses

A liquid chromatography tandem mass spectrometry (LC-MSMS) method was developed and validated to detect for the presence of zolpidem in human hair samples. Zolpidem is a sedative hypnotic whose adverse effects make it a common drug found in drug facilitated crimes (DFC). It is important to be able to detect and quantitate the drug after a long period of time due to the victim’s delayed reporting of the crime. Hair’s long window of detection makes it a useful matrix for DFC investigations. The linear range of the assay was targeted at 2 pg/mg to 1,000 pg ...


Controllability Analysis Of Discrete-Map Models Of Cardiac Alternans, Mark O. Ampofo, Laura M. Munoz, Elizabeth Cherry 2018 Rochester Institute of Technology

Controllability Analysis Of Discrete-Map Models Of Cardiac Alternans, Mark O. Ampofo, Laura M. Munoz, Elizabeth Cherry

Biology and Medicine Through Mathematics Conference

No abstract provided.


Optimal Flow Patterns In Branching Lymphatic Vessels, Anne Talkington 2018 Virginia Commonwealth University

Optimal Flow Patterns In Branching Lymphatic Vessels, Anne Talkington

Biology and Medicine Through Mathematics Conference

No abstract provided.


Generation Of Nonlinear-Differential-Equations System From A Model Of Boolean Relationships In Arabidopsis Salt Stress Network, Renee Dale 2018 Louisiana State University and Agricultural and Mechanical College

Generation Of Nonlinear-Differential-Equations System From A Model Of Boolean Relationships In Arabidopsis Salt Stress Network, Renee Dale

Biology and Medicine Through Mathematics Conference

No abstract provided.


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