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Spontaneous Voltage Oscillations And Response Dynamics Of A Hodgkin-Huxley Type Model Of Sensory Hair Cells, Alexander B. Neiman, Kai Dierkes, Benjamin Lindner, Lijuan Han, Andrey Shilnikov 2011 Ohio University - Main Campus

Spontaneous Voltage Oscillations And Response Dynamics Of A Hodgkin-Huxley Type Model Of Sensory Hair Cells, Alexander B. Neiman, Kai Dierkes, Benjamin Lindner, Lijuan Han, Andrey Shilnikov

Neuroscience Institute Faculty Publications

We employ a Hodgkin-Huxley-type model of basolateral ionic currents in bullfrog saccular hair cells for studying the genesis of spontaneous voltage oscillations and their role in shaping the response of the hair cell to external mechanical stimuli. Consistent with recent experimental reports, we find that the spontaneous dynamics of the model can be categorized using conductance parameters of calciumactivated potassium, inward rectifier potassium, and mechano-electrical transduction (MET) ionic currents. The model is demonstrated for exhibiting a broad spectrumof autonomous rhythmic activity, including periodic and quasi-periodic oscillations with two independent frequencies as well as various regular and chaotic bursting patterns. Complex ...


Regulation Of Escrt-Iii Assembly And Membrane Scission Activity In The Budding Yeast Saccharomyces Cerevisiae, Megan Anne Wemmer 2011 University of Colorado at Boulder

Regulation Of Escrt-Iii Assembly And Membrane Scission Activity In The Budding Yeast Saccharomyces Cerevisiae, Megan Anne Wemmer

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

The sequential recruitment and assembly of endosomal sorting complexes required for transport (ESCRTs) at the endosomal membrane mediate the selection and clustering of cargoes into vesicles that bud into the lumen of the endosome. In addition to regulating this sorting process at endosomes, in mammalian cells ESCRTs are additionally required for the budding of many types of enveloped viruses, as well as the separation of cells during cytokinesis. These processes share a topologically similar membrane scission event facilitated by regulated ESCRT-III assembly at the cytoplasmic surface of the membrane to promote the formation and scission of internal vesicles. The Snf7 ...


An Analysis Of Latent Membrane Protein-1 Signaling Complexes And Their Contribution To Epstein-Barr Virus Infection, Ryan Akira Takeshita 2011 University of Colorado Boulder

An Analysis Of Latent Membrane Protein-1 Signaling Complexes And Their Contribution To Epstein-Barr Virus Infection, Ryan Akira Takeshita

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

In immunocompromised individuals, B cells infected with Epstein-Barr virus often display tumorigenic growth. One of the viral oncoproteins that contributes to this transformation is the latent membrane protein-1 (LMP-1), which constitutively mimics the signaling of ligand-dependent CD40, a tumor necrosis factor receptor. The experiments described in this dissertation were designed to elucidate the molecular mechanisms that underlie LMP-1's signaling potential. We investigated the relationships between LMP-1's subcellular localization, homo-oligomerization, comigration with detergent-resistant membranes, and its signaling outputs in order to bridge some of the gaps standing in the way of a unified theory of LMP-1 function. The data ...


Economic Opportunity In Local Food Systems: Baselines And Targets, David Conner, Ellen Kahler, Linda Berlin, Doug Hoffer 2011 University of Vermont

Economic Opportunity In Local Food Systems: Baselines And Targets, David Conner, Ellen Kahler, Linda Berlin, Doug Hoffer

Opportunities for Agriculture Working Paper Series

Numerous studies have measured the economic impact of increased consumption of locally grown foods. As many advocates have set goals for increasing consumption of locally grown foods to a specific percentage, the missing piece of information is, what is the current percentage of locally grown food being consumed in a given city, state or region. To date, no credible set of methods has been used to measure the percentage of food consumption that is locally grown. In this paper, we apply previously developed methods to measure how much food is currently eaten and would be eaten if USDA Dietary Guidelines ...


Creating A Community Food System: The Intervale Center (Http://Www.Intervale.Org), Elizabeth A. Berman 2011 University of Vermont

Creating A Community Food System: The Intervale Center (Http://Www.Intervale.Org), Elizabeth A. Berman

University Libraries Faculty and Staff Publications

No abstract provided.


Differential Requirement For The Cd45 Splicing Regulator Hnrnpll For Accumulation Of Nkt And Conventional T Cells, Mehmet Yabas, Dale I. Godfrey, Christopher C. Goodnow, Gerard F. Hoyne 2011 University of Notre Dame Australia

Differential Requirement For The Cd45 Splicing Regulator Hnrnpll For Accumulation Of Nkt And Conventional T Cells, Mehmet Yabas, Dale I. Godfrey, Christopher C. Goodnow, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Natural killer T (NKT) cells represent an important regulatory T cell subset that develops in the thymus and contains immature (NK1.1lo) and mature (NK1.1hi) cell subsets. Here we show in mice that an inherited mutation in heterogeneous ribonucleoprotein L-like protein (hnRNPLLthunder), that shortens the survival of conventional T cells, has no discernible effect on NKT cell development, homeostasis or effector function. Thus, Hnrpll deficiency effectively increases the NKTT cell ratio in the periphery. However, Hnrpll mutation disrupts CD45RA, RB and RC exon silencing of the Ptprc mRNA in both NKT and conventional T cells, and ...


Custom-Molded Foot-Orthosis Intervention And Multi-Segment Medial Foot Kinematics During Walking, Stephen C. Cobb, Laurie L. Tis, Jeffrey T. Johnson, Yang "Tai" Wong, Mark D. Geil 2011 University of Wisconsin - Milwaukee

Custom-Molded Foot-Orthosis Intervention And Multi-Segment Medial Foot Kinematics During Walking, Stephen C. Cobb, Laurie L. Tis, Jeffrey T. Johnson, Yang "Tai" Wong, Mark D. Geil

Kinesiology Faculty Publications

Context: Foot-orthosis (FO) intervention to prevent and treat numerous lower extremity injuries is widely accepted clinically. However, the results of quantitative gait analyses have been equivocal. The foot models used, participants receiving intervention, and orthoses used might contribute to the variability.

Objective: To investigate the effect of a custom-molded FO intervention on multisegment medial foot kinematics during walking in participants with low-mobile foot posture.

Design: Crossover study.

Setting: University biomechanics and ergonomics laboratory. Patients or Other

Participants: Sixteen participants with low-mobile foot posture (7 men, 9 women) were assigned randomly to 1 of 2 FO groups. Intervention(s): After a ...


Red-Cockaded Woodpecker Cavity Tree Damage By Hurricane Rita: An Evaluation Of Contributing Factors, Ben Bainbridge, Kristen A. Baum, Daniel Saenz, Cory K. Adams 2011 Wildlife Habitat and Silviculture Laboratory, Southern Research Station, U.S.D.A. Forest Service, Nacogdoches, TX 75962

Red-Cockaded Woodpecker Cavity Tree Damage By Hurricane Rita: An Evaluation Of Contributing Factors, Ben Bainbridge, Kristen A. Baum, Daniel Saenz, Cory K. Adams

Faculty Publications

Picoides borealis (Red-cockaded Woodpecker) is an endangered species inhabiting pine savannas of the southeastern United States. Because the intensity of hurricanes striking the southeastern United States is likely to increase as global temperatures rise, it is important to identify factors contributing to hurricane damage to Red-cockaded Woodpecker cavity-trees. Our objectives were to examine the effects of landscape-level factors on wind damage to cavity-trees and assess the relative risk of wind damage for different tree species and trees with different types of cavities. We evaluated wind damage to cavity-trees from Hurricane Rita on the Angelina, Sabine, and Davy Crockett national forests ...


National Center For Pharmaceutical Crops, Wei Yuan, Shiyou Li, Zushang Su, Ping Wang 2011 Stephen F. Austin State University

National Center For Pharmaceutical Crops, Wei Yuan, Shiyou Li, Zushang Su, Ping Wang

NCPC Presentations

The mission of the National Center for Pharmaceutical Crops is to develop crops for the production of pharmaceutical and other bioactive compounds. The NCPC, located in the Arthur Temple College of Forestry and Agriculture, is the only one of its kind in the U.S. and it seeks to improve human health, revitalize rural economies and enhance U.S. security in strategic pharmaceuticals. This poster provides a background to the department, its functions and activities and notable achievements.


From Atheoretical To Motivation Theory-Based Youth Discretionary-Time Physical Activity Promotion: Current And Future Directions, Megan Babkes Stellino, Christina Sinclair 2011 Stephen F Austin State University

From Atheoretical To Motivation Theory-Based Youth Discretionary-Time Physical Activity Promotion: Current And Future Directions, Megan Babkes Stellino, Christina Sinclair

Faculty Publications

This article describes the importance of promoting children’s discretionary-time physical activity (DTPA) in connection with the rising international obesity epidemic. School based recess is highlighted as exemplar of an opportunity for children to obtain more DTPA. Brief review of the extant research focused on efforts to increase children’s recess physical activity (RPA) is provided. Literature from the field of sports psychology that has established a strong foundation of evidence regarding factors that increase youth motivation in various physical domain contexts will guide the proposed expansion to theoretical examination of predictors of youth DTPA. Three relevant motivation theory frameworks ...


Serotonergic Lesions Of The Periaqueductal Gray, A Primary Source Of Serotonin To The Nucleus Paragigantocellularis, Facilitate Sexual Behavior In Male Rats, Joseph J. Normandin, Anne Z. Murphy PhD 2011 Georgia State University

Serotonergic Lesions Of The Periaqueductal Gray, A Primary Source Of Serotonin To The Nucleus Paragigantocellularis, Facilitate Sexual Behavior In Male Rats, Joseph J. Normandin, Anne Z. Murphy Phd

Neuroscience Institute Faculty Publications

While selective serotonin reuptake inhibitors (SSRIs) are widely used to treat anxiety and depression, they also produce profound disruptions of sexual function including delayed orgasm/ejaculation. The nucleus paragigantocellularis (nPGi), a primary source of inhibition of ejaculation in male rats, contains receptors for serotonin (5-HT). The ventrolateral periaqueductal gray (vlPAG) provides serotonin to this region, thus providing an anatomical and neurochemical basis for serotonergic regulation of the nPGi. We hypothesize that 5-HT acting at the nPGi could underlie the SSRI-induced inhibition of ejaculation in rodents. To this end, we produced 5-HT lesions of the source of 5-HT to the nPGi ...


Parameter-Sweeping Techniques For Temporal Dynamics Of Neuronal Systems: Case Study Of Hindmarsh-Rose Model, Roberto Barrio, Andrey Shilnikov 2011 Georgia State University

Parameter-Sweeping Techniques For Temporal Dynamics Of Neuronal Systems: Case Study Of Hindmarsh-Rose Model, Roberto Barrio, Andrey Shilnikov

Neuroscience Institute Faculty Publications

Background: Development of effective and plausible numerical tools is an imperative task for thorough studies of nonlinear dynamics in life science applications.

Results: We have developed a complementary suite of computational tools for twoparameter screening of dynamics in neuronal models. We test a ‘brute-force’ effectiveness of neuroscience plausible techniques specifically tailored for the examination of temporal characteristics, such duty cycle of bursting, interspike interval, spike number deviation in the phenomenological Hindmarsh-Rose model of a bursting neuron and compare the results obtained by calculus-based tools for evaluations of an entire spectrum of Lyapunov exponents broadly employed in studies of nonlinear systems ...


Use Of Granger Causality Analysis And Artificial Spike Trains To Examine Pause Coding In Purkinje Cell Spike Activity Related To Rhythmic Licking, Selva K. Maran, Ying Cao, Mukesh Dhamala 2011 Georgia State University

Use Of Granger Causality Analysis And Artificial Spike Trains To Examine Pause Coding In Purkinje Cell Spike Activity Related To Rhythmic Licking, Selva K. Maran, Ying Cao, Mukesh Dhamala

Neuroscience Institute Faculty Publications

Cerebellar Purkinje cells in mice show strong activity modulation related to rhythmic licking behavior. Here we examine whether this modulation may preferentially be related to long inter-spike intervals (ISIs), i.e. pauses in spike activity.


Trace Gas And Particle Emissions From Open Biomass Burning In Mexico, Robert J. Yokelson, I. R. Burling, S. P. Urbanski, E. Atlas, K. Adachi, P. R. Buseck, C. Wiedinmyer, S. K. Akagi, D. W. Toohey, C. E. Wold 2011 University of Montana - Missoula

Trace Gas And Particle Emissions From Open Biomass Burning In Mexico, Robert J. Yokelson, I. R. Burling, S. P. Urbanski, E. Atlas, K. Adachi, P. R. Buseck, C. Wiedinmyer, S. K. Akagi, D. W. Toohey, C. E. Wold

Chemistry and Biochemistry Faculty Publications

We report airborne measurements of emission factors (EF) for trace gases and PM(2.5) made in southern Mexico in March of 2006 on 6 crop residue fires, 3 tropical dry forest fires, 8 savanna fires, 1 garbage fire, and 7 mountain pine-oak forest fires. The savanna fire EF were measured early in the local dry season and when compared to EF measured late in the African dry season they were at least 1.7 times larger for NO(x), NH(3), H(2), and most non-methane organic compounds. Our measurements suggest that urban deposition and high windspeed may also ...


The Fire Inventory From Ncar (Finn): A High Resolution Global Model To Estimate The Emissions From Open Burning, C. Wiedinmyer, S. K. Akagi, Robert J. Yokelson, L. K. Emmons, J. A. Al-Saadi, J. J. Orlando, A. J. Soja 2011 University of Montana - Missoula

The Fire Inventory From Ncar (Finn): A High Resolution Global Model To Estimate The Emissions From Open Burning, C. Wiedinmyer, S. K. Akagi, Robert J. Yokelson, L. K. Emmons, J. A. Al-Saadi, J. J. Orlando, A. J. Soja

Chemistry and Biochemistry Faculty Publications

The Fire INventory from NCAR version 1.0 (FINNv1) provides daily, 1 km resolution, global estimates of the trace gas and particle emissions from open burning of biomass, which includes wildfire, agricultural fires, and prescribed burning and does not include biofuel use and trash burning. Emission factors used in the calculations have been updated with recent data, particularly for the non-methane organic compounds (NMOC). The resulting global annual NMOC emission estimates are as much as a factor of 5 greater than some prior estimates. Chemical speciation profiles, necessary to allocate the total NMOC emission estimates to lumped species for use ...


Use Of Microcalorimetry To Determine The Costs And Benefits To Pseudomonas Putida Strain Kt2440 Of Harboring Cadmium Efflux Genes, Sean M. Gibbons, Kevin Feris, Michele A. McGuirl, Sergio E. Morales, Anu Hynninen, Philip W. Ramsey, James E. Gannon 2011 University of Montana - Missoula

Use Of Microcalorimetry To Determine The Costs And Benefits To Pseudomonas Putida Strain Kt2440 Of Harboring Cadmium Efflux Genes, Sean M. Gibbons, Kevin Feris, Michele A. Mcguirl, Sergio E. Morales, Anu Hynninen, Philip W. Ramsey, James E. Gannon

Biological Sciences Faculty Publications

A novel microcalorimetric approach was used to analyze the responses of a metal-tolerant soil bacterium (Pseudomonas putida strain KT2440) to metal resistance gene deletions in cadmium-amended media. As hypothesized, under cadmium stress, the wild-type strain benefited from the resistance genes by entering the exponential growth phase earlier than two knockout strains. In the absence of cadmium, strain KT1, carrying a deletion in the main component (czcA1) of a Cd/Zn chemiosmotic efflux transporter (CzcCBA1), grew more efficiently than the wild type and released similar to 700 kJ (per mole of biomass carbon) less heat than the wild-type strain, showing the ...


Parallel Progressive Multiple Sequence Alignment On Reconfigurable Meshes, Ken Nguyen, Yi Pan, Ge Nong 2011 Georgia State University

Parallel Progressive Multiple Sequence Alignment On Reconfigurable Meshes, Ken Nguyen, Yi Pan, Ge Nong

Computer Science Faculty Publications

Background: One of the most fundamental and challenging tasks in bio-informatics is to identify related sequences and their hidden biological significance. The most popular and proven best practice method to accomplish this task is aligning multiple sequences together. However, multiple sequence alignment is a computing extensive task. In addition, the advancement in DNA/RNA and Protein sequencing techniques has created a vast amount of sequences to be analyzed that exceeding the capability of traditional computing models. Therefore, an effective parallel multiple sequence alignment model capable of resolving these issues is in a great demand.

Results: We design O(1) run-time ...


Dynamics Of Gene Duplication In The Genomes Of Chlorophyll D-Producing Cyanobacteria: Implications For The Ecological Niche, Scott R. Miller, A. Michelle Wood, Robert E. Blankenship, Maria Kim, Steven Ferriera 2011 University of Montana - Missoula

Dynamics Of Gene Duplication In The Genomes Of Chlorophyll D-Producing Cyanobacteria: Implications For The Ecological Niche, Scott R. Miller, A. Michelle Wood, Robert E. Blankenship, Maria Kim, Steven Ferriera

Biological Sciences Faculty Publications

Gene duplication may be an important mechanism for the evolution of new functions and for the adaptive modulation of gene expression via dosage effects. Here, we analyzed the fate of gene duplicates for two strains of a novel group of cyanobacteria (genus Acaryochloris) that produces the far-red light absorbing chlorophyll d as its main photosynthetic pigment. The genomes of both strains contain an unusually high number of gene duplicates for bacteria. As has been observed for eukaryotic genomes, we find that the demography of gene duplicates can be well modeled by a birth-death process. Most duplicated Acaryochloris genes are of ...


Quantifying Agonist Activity At G Protein-Coupled Receptors, Frederick J. Ehlert, Hinako Suga, Michael T. Griffin 2011 University of California - Irvine

Quantifying Agonist Activity At G Protein-Coupled Receptors, Frederick J. Ehlert, Hinako Suga, Michael T. Griffin

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When an agonist activates a population of G protein-coupled receptors (GPCRs), it elicits a signaling pathway that culminates in the response of the cell or tissue. This process can be analyzed at the level of a single receptor, a population of receptors, or a downstream response. Here we describe how to analyze the downstream response to obtain an estimate of the agonist affinity constant for the active state of single receptors.

Receptors behave as quantal switches that alternate between active and inactive states (Figure 1). The active state interacts with specific G proteins or other signaling partners. In the absence ...


The Green Legacy Project: Evaluating Campus Tree Benefits, Joy Fritschle, Gary Coutu, Joan Welch, Gerard Hertel 2011 West Chester University of Pennsylvania

The Green Legacy Project: Evaluating Campus Tree Benefits, Joy Fritschle, Gary Coutu, Joan Welch, Gerard Hertel

Geography & Planning Faculty Publications

No abstract provided.


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