Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

182,330 Full-Text Articles 221,440 Authors 28,865,135 Downloads 392 Institutions

All Articles in Life Sciences

Faceted Search

182,330 full-text articles. Page 3852 of 4434.

Kinetic Characterization Of Salmonella Flik-Flhb Interactions Demonstrates Complexity Of The Type Iii Secretion Substrate-Specificity Switch, Daniel P. Morris, Eric D. Roush, J. Will Thompson, M. Arthur Moseley, James W. Murphy, Jonathan L. McMurry 2011 Duke University

Kinetic Characterization Of Salmonella Flik-Flhb Interactions Demonstrates Complexity Of The Type Iii Secretion Substrate-Specificity Switch, Daniel P. Morris, Eric D. Roush, J. Will Thompson, M. Arthur Moseley, James W. Murphy, Jonathan L. Mcmurry

Jonathan McMurry

The bacterial flagellum is a complex macromolecular machine consisting of more than 20000 proteins, most of which must be exported from the cell via a dedicated Type III secretion apparatus. At a defined point in flagellar morphogenesis, hook completion is sensed and the apparatus switches substrate specificity type from rod and hook proteins to filament ones. How the switch works is a subject of intense interest. FIiK and F1hBs play central roles. In the present study, two optical biosensing methods were used to characterize FIiK-F1hB interactions using wild-type and two variant FlhBs from mutants with severe flagellar structural defects. Binding ...


The Helicobacter Pylori Anti-Sigma Factor Flgm Is Predominantly Cytoplasmic And Cooperates With The Flagellar Basal Body Protein Flha, Melanie Rust, Sophie Borchert, Eike Niehus, Sarah A. Gripp, Afrodita Bajceta, Jonathan L. McMurry, Sebastian Suerbaum, Kelly T. Hughes, Christine Josenhans 2011 Hannover Medical School

The Helicobacter Pylori Anti-Sigma Factor Flgm Is Predominantly Cytoplasmic And Cooperates With The Flagellar Basal Body Protein Flha, Melanie Rust, Sophie Borchert, Eike Niehus, Sarah A. Gripp, Afrodita Bajceta, Jonathan L. Mcmurry, Sebastian Suerbaum, Kelly T. Hughes, Christine Josenhans

Jonathan McMurry

Helicobacter pylori requires flagellar motility and orientation to persist actively in its habitat. A particular feature of flagella in most Helicobacter species including H. pylori is a membraneous flagellar sheath. The anti-sigma factor FlgM of H. pylori is unusual, since it lacks an N-terminal domain present in other FlgM homologs, e.g., FlgM of Salmonella spp., whose regulatory function is intimately coupled to its secretion through the flagellar type III secretion system. The aim of the present study was to characterize the localization and secretion of the short H. pylori FlgM in the presence of a flagellar sheath and to ...


Win-Win For Wind And Wildlife: A Vision To Facilitate Sustainable Development, Joseph M. Kiesecker, Jeffrey S. Evans, Joe Fargione, Kevin Doherty, Kerry R. Foresman, Thomas H. Kunz, David E. Naugle, Nathan P. Nibbelink, Neal D. Niemuth 2011 University of Montana - Missoula

Win-Win For Wind And Wildlife: A Vision To Facilitate Sustainable Development, Joseph M. Kiesecker, Jeffrey S. Evans, Joe Fargione, Kevin Doherty, Kerry R. Foresman, Thomas H. Kunz, David E. Naugle, Nathan P. Nibbelink, Neal D. Niemuth

Biological Sciences Faculty Publications

Wind energy offers the potential to reduce carbon emissions while increasing energy independence and bolstering economic development. However, wind energy has a larger land footprint per Gigawatt (GW) than most other forms of energy production, making appropriate siting and mitigation particularly important. Species that require large unfragmented habitats and those known to avoid vertical structures are particularly at risk from wind development. Developing energy on disturbed lands rather than placing new developments within large and intact habitats would reduce cumulative impacts to wildlife. The U.S. Department of Energy estimates that it will take 241 GW of terrestrial based wind ...


Cholinergic Modulation Of Narcoleptic Attacks In Double Orexin Receptor Knockout Mice, Mike Kalogiannis, Emily Hsu, Jon Willie, Richard Chemelli, Yaz Kisanuki, Masashi Yanagisawa, Christopher S. Leonard 2011 New York Medical College

Cholinergic Modulation Of Narcoleptic Attacks In Double Orexin Receptor Knockout Mice, Mike Kalogiannis, Emily Hsu, Jon Willie, Richard Chemelli, Yaz Kisanuki, Masashi Yanagisawa, Christopher S. Leonard

NYMC Faculty Publications

To investigate how cholinergic systems regulate aspects of the sleep disorder narcolepsy, we video-monitored mice lacking both orexin (hypocretin) receptors (double knockout; DKO mice) while pharmacologically altering cholinergic transmission. Spontaneous behavioral arrests in DKO mice were highly similar to those reported in orexin-deficient mice and were never observed in wild-type (WT) mice. A survival analysis revealed that arrest lifetimes were exponentially distributed indicating that random, Markovian processes determine arrest lifetime. Low doses (0.01, 0.03 mg/kg, i.p.), but not a high dose (0.08 mg/kg, i.p.) of the cholinesterase inhibitor physostigmine increased the number of ...


Impact Of Maternal Education About Complementary Feeding And Provision Of Complementary Foods On Child Growth In Developing Countries, Aamer Imdad, Mohammad Yawar Yakoob, Zulfiqar Ahmed Bhutta 2011 Aga Khan University

Impact Of Maternal Education About Complementary Feeding And Provision Of Complementary Foods On Child Growth In Developing Countries, Aamer Imdad, Mohammad Yawar Yakoob, Zulfiqar Ahmed Bhutta

Woman and Child Health

Background:Childhood undernutrition is prevalent in low and middle income countries. It is an important indirect cause of child mortality in these countries. According to an estimate, stunting (height for age Z score < -2) and wasting (weight for height Z score < -2) along with intrauterine growth restriction are responsible for about 2.1 million deaths worldwide in children < 5 years of age. This comprises 21 % of all deaths in this age group worldwide. The incidence of stunting is the highest in the first two years of life especially after six months of life when exclusive breastfeeding alone cannot fulfill the energy needs of a rapidly growing child. Complementary feeding for an infant refers to timely introduction of safe and nutritional foods in addition to breast-feeding (BF) i.e. clean and nutritionally rich additional foods introduced at about six months of infant age. Complementary feeding strategies encompass a wide variety of interventions designed to improve not only the quality and quantity of these foods but also improve the feeding behaviors. In this review, we evaluated the effectiveness of two most commonly applied strategies of complementary feeding i.e. timely provision of appropriate complementary foods (+/- nutritional counseling) and education to mothers about practices of complementary feeding on growth. Recommendations have been made for input to the Lives Saved Tool (LiST) model by following standardized guidelines developed by Child Health Epidemiology Reference Group (CHERG).

Methods:

We conducted a systematic review of published randomized and quasi-randomized trials on PubMed, Cochrane Library and WHO regional databases. The included studies were abstracted and graded according to Study Design, limitations, intervention details and outcome effects. The primary outcomes were change in weight and height during the study period among children 6-24 months of age. We hypothesized that provision of complementary food and education of mother ...


Morphological Variation Between Juvenile White Bass And Juvenile Hybrid Striped Bass, Ryan W. Lueckenhoff 2011 University of Nebraska-Lincoln

Morphological Variation Between Juvenile White Bass And Juvenile Hybrid Striped Bass, Ryan W. Lueckenhoff

Dissertations & Theses in Natural Resources

While identifying recruitment bottlenecks for white bass Morone chrysops, we encountered difficulty distinguishing between age-0 white bass and age-0 hybrid striped bass M. saxatilis x chrysops. Accurate identification of juvenile white bass and hybrid striped bass will improve the quality of data gathered for research and monitoring efforts. The first objective of this study was to estimate biologists’ accuracy identifying juvenile white bass and juvenile hybrid striped bass, and to determine which characteristics biologists were using during identification. Overall, identification accuracy was 71%. Biologists who placed less emphasis using the characteristic "broken horizontal lines" or who examined >99 age-0 Morone ...


Activation Of Multiple Apoptotic Pathways In Human Nasopharyngeal Carcinoma Cells By The Prenylated Isoflavone, Osajin, Tsung-Teng Huang, Fu-Guo Liu, Chia-Fong Wei, Chia-Chen Lu, Chang-Chieh Chen, Hung-Chi Lin, David M. Ojcius, Hsin-Chih Lai 2011 National Central University

Activation Of Multiple Apoptotic Pathways In Human Nasopharyngeal Carcinoma Cells By The Prenylated Isoflavone, Osajin, Tsung-Teng Huang, Fu-Guo Liu, Chia-Fong Wei, Chia-Chen Lu, Chang-Chieh Chen, Hung-Chi Lin, David M. Ojcius, Hsin-Chih Lai

Dugoni School of Dentistry Faculty Articles

Osajin is a prenylated isoflavone showing antitumor activity in different tumor cell lines. The underlying mechanism of osajin-induced cancer cell death is not clearly understood. In the present study, the mechanisms of osajin-induced cell death of human nasopharyngeal carcinoma (NPC) cells were explored. Osajin was found to significantly induce apoptosis of NPC cells in a dose- and time-dependent manner. Multiple molecular effects were observed during osajin treatment including a significant loss of mitochondrial transmembrane potential, release of cytochrome c into the cytosol, enhanced expression of Fas ligand (FasL), suppression of glucose-regulated protein 78 kDa (GRP78), and activation of caspases-9, -8 ...


What Does Biologically Meaningful Mean? A Perspective On Gene Regulatory Network Validation, Albertha J. M. Walhout 2011 University of Massachusetts Medical School

What Does Biologically Meaningful Mean? A Perspective On Gene Regulatory Network Validation, Albertha J. M. Walhout

Program in Gene Function and Expression Publications and Presentations

Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.


Scholar Week, Gregg Chenoweth 2011 Olivet Nazarene University

Scholar Week, Gregg Chenoweth

Scholar Week Archives (2011-2015)

During Scholar Week we take inspiration from 18th century preacher-scholar |ohn Wesley. As “a denominational university in the Wesleyan tradition,” scholarship and piety are thoroughly compatible here. So, in Scholar Week we tune our ear to the gong and echo of Wesley. It is not just history, but his story, even to this day. In our own scholarship projects we join a great cloud of Christians not educated out of their faith, but fashioning an educated faith, where the love of the Lord by heart, soul, strength, and mind is our great and worthy cause.


Investigate Gene Expression Responses Of A Regenerative Rat Liver Model Using A Partial Hepatectomy Method, Tracee L. Popielarczyk 2011 Thomas Jefferson University of Graduate Studies

Investigate Gene Expression Responses Of A Regenerative Rat Liver Model Using A Partial Hepatectomy Method, Tracee L. Popielarczyk

Theses & Dissertations

Characterization of transcriptional changes after partial hepatectomy (PH) may provide an understanding of the underlying biological processes involved in compensatory growth and regeneration of liver mass after drug induced liver injury (DILI). Development of this type of model would prove useful as a model for assessment of potential drug induced liver injury that induces a compensatory proliferative response. In this project, we developed a surgical regeneration model (70% partial hepatectomy) in liver of male Sprague Dawley rats. Individual gene markers associated with a regenerative response in liver were evaluated in the partial hepatectomy model and compared to five previous studies ...


Screening Synteny Blocks In Pairwise Genome Comparisons Through Integer Programming, Haibao Tang, Eric Lyons, Brent S. Pedersen, James C. Schnable, Andrew H. Paterson, Michael Freeling 2011 University of California - Berkeley

Screening Synteny Blocks In Pairwise Genome Comparisons Through Integer Programming, Haibao Tang, Eric Lyons, Brent S. Pedersen, James C. Schnable, Andrew H. Paterson, Michael Freeling

Agronomy & Horticulture -- Faculty Publications

Background:

It is difficult to accurately interpret chromosomal correspondences such as true orthology and paralogy due to significant divergence of genomes from a common ancestor. Analyses are particularly problematic among lineages that have repeatedly experienced whole genome duplication (WGD) events. To compare multiple “subgenomes” derived from genome duplications, we need to relax the traditional requirements of “one-to-one” syntenic matchings of genomic regions in order to reflect “one-to-many” or more generally “many-to-many” matchings. However this relaxation may result in the identification of synteny blocks that are derived from ancient shared WGDs that are not of interest. For many downstream analyses, we ...


An Enzyme Assay Of The Bchc-Encoded Enzyme 2-Desacetyl-2-Hydroxyethyl Bacteriochlorophyllide A Dehydrogenase, Ronald Grider, David Bollivar, Faculty Advisor 2011 Illinois Wesleyan University

An Enzyme Assay Of The Bchc-Encoded Enzyme 2-Desacetyl-2-Hydroxyethyl Bacteriochlorophyllide A Dehydrogenase, Ronald Grider, David Bollivar, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Uptake Of Dissolved Macromolecules By Larvae Of Lytechinus Variagatus, Andrew McDonald, William Jaeckle, Faculty Advisor 2011 Illinois Wesleyan University

Uptake Of Dissolved Macromolecules By Larvae Of Lytechinus Variagatus, Andrew Mcdonald, William Jaeckle, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Evaluating The Effectiveness Of Conservation Education Incorporated In An Animal Exhibit At The Indianapolis Zoo, Vanessa Snyder, Given Harper, Faculty Advisor 2011 Illinois Wesleyan University

Evaluating The Effectiveness Of Conservation Education Incorporated In An Animal Exhibit At The Indianapolis Zoo, Vanessa Snyder, Given Harper, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Ph-Dependent 15-Lipoxygenase Catalyzed Peroxidation Of Linoleic Acid: Hplc/Esr/Ms Study, Shuting Zhong, Yan Gu, Preeti Purwaha, Benidict Law, Faculty Advisor, Steven Y. Qian, Faculty Advisor 2011 Illinois Wesleyan University

Ph-Dependent 15-Lipoxygenase Catalyzed Peroxidation Of Linoleic Acid: Hplc/Esr/Ms Study, Shuting Zhong, Yan Gu, Preeti Purwaha, Benidict Law, Faculty Advisor, Steven Y. Qian, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Evaluation Of Dom Uptake By Spionid Polychaete Larvae From Antarctica, Travis Rosenkranz, William Jaeckle, Faculty Advisor 2011 Illinois Wesleyan University

Evaluation Of Dom Uptake By Spionid Polychaete Larvae From Antarctica, Travis Rosenkranz, William Jaeckle, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Experimental Manipulation Of Maternal Investment And Effects On Juvenile Viability And Size In Physa Acuta, Lauren Awdziejcyk, William Jaeckle, Faculty Advisor 2011 Illinois Wesleyan University

Experimental Manipulation Of Maternal Investment And Effects On Juvenile Viability And Size In Physa Acuta, Lauren Awdziejcyk, William Jaeckle, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Comparison Of Eggshell Porosity And Estimated Gas Flux Between The Brown-Headed Cowbird (Molothrus Ater) And Its Hosts: The Dickcissel (Spiza Americana) And The Red-Winged Blackbird (Agelaius Phoeniceus), Brittany Childs, Miranda Kiefer, Given Harper, Faculty Advisor, William Jaeckle, Faculty Advisor 2011 Illinois Wesleyan University

Comparison Of Eggshell Porosity And Estimated Gas Flux Between The Brown-Headed Cowbird (Molothrus Ater) And Its Hosts: The Dickcissel (Spiza Americana) And The Red-Winged Blackbird (Agelaius Phoeniceus), Brittany Childs, Miranda Kiefer, Given Harper, Faculty Advisor, William Jaeckle, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Incidence Of Larval Cloning In The Sea Urchins Arbacia Punctulata And Lytechinus Variegatus, Lauren Knaack, William Jaeckle, Faculty Advisor 2011 Illinois Wesleyan University

Incidence Of Larval Cloning In The Sea Urchins Arbacia Punctulata And Lytechinus Variegatus, Lauren Knaack, William Jaeckle, Faculty Advisor

John Wesley Powell Student Research Conference

No abstract provided.


Determining The Composition Of The Colony Tubes Of Pterobranchs, Andrew McDonald, Tyler Saunders, Elizabeth Balser, Faculty Advisor, Lukasz Sewera 2011 Illinois Wesleyan University

Determining The Composition Of The Colony Tubes Of Pterobranchs, Andrew Mcdonald, Tyler Saunders, Elizabeth Balser, Faculty Advisor, Lukasz Sewera

John Wesley Powell Student Research Conference

No abstract provided.


Digital Commons powered by bepress