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Calcium And Calmodulin Dependent Protein Kinase Ii Hyperactivity In Cardiac Remodeling, Beixin Julie He 2012 University of Iowa

Calcium And Calmodulin Dependent Protein Kinase Ii Hyperactivity In Cardiac Remodeling, Beixin Julie He

Theses and Dissertations

The multifunctional calcium and calmodulin dependent protein kinase II (CaMKII) is implicated in both animal models and human forms of cardiovascular disease. CaMKII is activated by elevated neurohormonal signals including enhanced â-adrenergic stimulation and angiotensin II signaling, whereas CaMKII inhibition is cardioprotective from these pathologic triggers. In addition to â-blockers and angiotensin II inhibitors, aldosterone antagonist drugs are the third and most recent class of pharmacologic agents comprising the frontline therapy for heart disease patients. Here, I show that CaMKII activation is important for cardiac aldosterone signaling in the post-myocardial infarction (MI) mouse model. Aldosterone infusion to MI mice increases ...


Function Of Replication Protein A In Dna Repair And Cell Checkpoints, Cathy Staloch Hass 2012 University of Iowa

Function Of Replication Protein A In Dna Repair And Cell Checkpoints, Cathy Staloch Hass

Theses and Dissertations

Replication Protein A (RPA), the major eukaryotic single-strand DNA (ssDNA) binding protein, is essential for replication, repair, recombination, and checkpoint activation. Defects in RPA-associated cellular activities lead to genomic instability, a major factor in the pathogenesis of cancer. The ssDNA-binding activity of RPA is primarily mediated by two domains in the RPA1 subunit. I characterized mutant forms of RPA to elucidate the contribution of specific residues in the high affinity DNA binding domains to the cellular function of RPA. These studies enhance the understanding of the properties of RPA that contribute to DNA repair and cellular checkpoints.

Mutation of a ...


Toxoplasma On The Brain: Understanding Host-Pathogen Interactions In Chronic Cns Infection, Sushrut kamerkar, Paul H. Davis 2012 University of Nebraska at Omaha

Toxoplasma On The Brain: Understanding Host-Pathogen Interactions In Chronic Cns Infection, Sushrut Kamerkar, Paul H. Davis

Biology Faculty Publications

Toxoplasma gondii is a prevalent obligate intracellular parasite which chronically infects more than a third of the world’s population. Key to parasite prevalence is its ability to form chronic and nonimmunogenic bradyzoite cysts, which typically form in the brain and muscle cells of infected mammals, including humans. While acute clinical infection typically involves neurological and/or ocular damage, chronic infection has been more recently linked to behavioral changes. Establishment and maintenance of chronic infection involves a balance between the host immunity and parasite evasion of the immune response. Here, we outline the known cellular interplay between Toxoplasma gondii and ...


Levels Of CaV1.2 L-Type Ca2+ Channels Peak In The First Two Weeks In Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase Through Development, Audra A. Kramer, Nicholas E. Ingraham, Emily J. Sharpe, Michelle Mynlieff 2012 Marquette University

Levels Of CaV1.2 L-Type Ca2+ Channels Peak In The First Two Weeks In Rat Hippocampus Whereas CaV1.3 Channels Steadily Increase Through Development, Audra A. Kramer, Nicholas E. Ingraham, Emily J. Sharpe, Michelle Mynlieff

Biological Sciences Faculty Research and Publications

Influx of calcium through voltage-dependent channels regulates processes throughout the nervous system. Specifically, influx through L-type channels plays a variety of roles in early neuronal development and is commonly modulated by G-protein-coupled receptors such as GABAB receptors. Of the four isoforms of L-type channels, only Cav1.2 and Cav1.3 are predominately expressed in the nervous system. Both isoforms are inhibited by the same pharmacological agents, so it has been difficult to determine the role of specific isoforms in physiological processes. In the present study, Western blot analysis and confocal microscopy were utilized to study ...


Rna Unwinding By The Trf4/Air2/Mtr4 Polyadenylation (Tramp) Complex, Huijue Jia, Xuying Wang, James T. Anderson, Eckhard Jankowsky 2012 Case Western Reserve University

Rna Unwinding By The Trf4/Air2/Mtr4 Polyadenylation (Tramp) Complex, Huijue Jia, Xuying Wang, James T. Anderson, Eckhard Jankowsky

Biological Sciences Faculty Research and Publications

Many RNA-processing events in the cell nucleus involve the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex, which contains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p. TRAMP polyadenylates RNAs designated for processing by the nuclear exosome. In addition, TRAMP functions as an exosome cofactor during RNA degradation, and it has been speculated that this role involves disruption of RNA secondary structure. However, it is unknown whether TRAMP displays RNA unwinding activity. It is also not clear how unwinding would be coordinated with polyadenylation and the function of the RNA helicase Mtr4p in modulating poly(A ...


A Modified Method To Screen For Partial Resistance To Phytophthora Sojae In Soybean, Silvina Stewart, Alison E. Robertson 2012 Iowa State University

A Modified Method To Screen For Partial Resistance To Phytophthora Sojae In Soybean, Silvina Stewart, Alison E. Robertson

Plant Pathology and Microbiology Publications

Phytophthora root and stem rot, caused by Phytophthora sojae Kauf and Gerd, is one of the most damaging diseases of soybean [Glycine max (L.) Merr.] in the United States. Partial resistance (PR), which is defined as the relative ability of a soybean plant to survive root infection without showing severe symptoms, is an effective way to manage this disease. A modification of the layer test method used to screen for PR to P. sojae in soybean was evaluated. Instead of the P. sojae-colonized agar layer, which is used in the current greenhouse cup assay, P. sojaeinfested rice (Oryza sativa L ...


Where Is The Rain-On-Snow Zone In The West-Central Washington Cascades?: Monte Carlo Simulation Of Large Storms In The Northwest, Matthew John Brunengo 2012 Portland State University

Where Is The Rain-On-Snow Zone In The West-Central Washington Cascades?: Monte Carlo Simulation Of Large Storms In The Northwest, Matthew John Brunengo

Dissertations and Theses

Rain-on-snow (ROS) occurs when warm, wet air moves into latitudes and/or elevations having vulnerable snowpacks, where it can alter water inputs to infiltration, runoff and erosion. The Pacific Northwest is particularly susceptible: winter storms off the Pacific cause locally heavy rain plus snowmelt almost annually, and disastrous flooding and landsliding intermittently. In maritime mountainous terrain, the effects seem more likely and hydrologically important where warm rains and seasonal snowpacks are liable to coincide, in middle elevations. Several questions arise: (1) In the PNW, does ROS affect the long-term frequency and magnitude of water delivery to the ground, versus total ...


Odour Attributes And Volatile Chemical Composition Of Milk Produced In Subtropical Eastern Australia, Victoria CF Westbrooke 2012 Southern Cross University

Odour Attributes And Volatile Chemical Composition Of Milk Produced In Subtropical Eastern Australia, Victoria Cf Westbrooke

Theses

Sensory attributes, in particular grassy odour, are important determinants of milk product acceptability in Japan. The effect of commercial farming system (n=8) and season (n=3) on the volatile chemical composition and sensory attributes, specifically grassy, mothball, cowy, sweet, creamy, sour and heated, of milk was investigated.

Selected individual milk samples (n=5) could be distinguished by their volatile chemical composition, while the intensity of grassy odour was significantly higher in milk produced in spring compared to summer. Potential sensitive and specific chemical predictors (n=9) of grassy odour intensity were identified, using multivariate statistical methods.


Trophic Ecology Of The Nearshore Zone In East Antarctica : A Stable Isotope Approach, Christopher L. Gillies 2012 Southern Cross University

Trophic Ecology Of The Nearshore Zone In East Antarctica : A Stable Isotope Approach, Christopher L. Gillies

Theses

This thesis describes the food webs of two, shallow-water benthic communities from the Windmill Island and Vestfold Hills, East Antarctica. Isotopes of carbon and nitrogen were analysed to establish baseline descriptions of community structure and function. Both food webs shared similar features, and there were clear energy pathways to first order-consumers, yet higher-order consumers displayed considerable trophic diversity, resulting in complex food webs characterised by many trophic links. A review of the global literature for isotope marine food webs was conducted and revealed that: food chain length was similar across all habitats, food webs were negatively correlated with oceanographic primary ...


Physical Impacts Of Recreational Terminal Fishing Rigs In Nsw, Australia, Shane Patrick McGrath 2012 Southern Cross University

Physical Impacts Of Recreational Terminal Fishing Rigs In Nsw, Australia, Shane Patrick Mcgrath

Theses

Globally, recreational fishing is one of the most popular leisure activities with participation rates estimated at > 40% in some developed countries. Such high participation put more strain on an already depleted fisheries resource; however, while fishing pressure has increased so has the number of released individuals. This is due to anglers releasing at least part of their catch, either voluntarily or in response to regulations that include legal sizes and personal quotas. Australia is no different with a combined release rates of > 30% for all species. More specifically, three of the most important coastal species targeted by recreational anglers are ...


Evaluating Grain Food Potential Of Wild Relatives Of Rice, Shabana Kasem 2012 Southern Cross University

Evaluating Grain Food Potential Of Wild Relatives Of Rice, Shabana Kasem

Theses

Cultivated rice, Oryza sativa, is the major calorie provider for two thirds of the world population and in developing countries is a major source of proteins and some micro nutrients. Rice is mainly favoured for its starch content which has a myriad of applications in food and non-food industries. Rice comes from just two species of the Oryza genus which consists of 23 species. A number of these have contributed to the production of a commercial species with increased pest and disease resistance and male sterility. Despite this the starch properties and the cropping potential of many these varieties are ...


Exercise Adherence In Sedentary University Employees After An 8-Week Web-Based Intervention, Summer Huntington 2012 Western Washington University

Exercise Adherence In Sedentary University Employees After An 8-Week Web-Based Intervention, Summer Huntington

WWU Graduate School Collection

Worksite health promotion has received attention from many researchers in an effort to find cost effective ways to improve employee health. If a simple web-based intervention is found to increase exercise adherence among sedentary adults, it may be a useful tool in improving the health of the workforce. PURPOSE: The purpose of the study was to investigate the effect of a web-based intervention on biometric measures related to exercise adherence, as well as the Stage of Change in sedentary university employees over an eight week period. METHODS: Thirty three sedentary adults were recruited from WWU university staff and faculty to ...


Physiochemical Characteristics Contributing To The Cytotoxicity Of Transition Metal Oxides, Chi-heng Wu 2012 Missouri University of Science and Technology

Physiochemical Characteristics Contributing To The Cytotoxicity Of Transition Metal Oxides, Chi-Heng Wu

Masters Theses

"In the past ten years nanotechnology has not only evolved to play a prominent role in our economy but also increased the concern over potential adverse effects caused by nanomaterials to human health and the environment. Nanotoxicity is to understand the nature and origin of the toxicity imposed by nanomaterials. Studies from our laboratory have shown that nanoparticle induces oxidative stress, perturbs calcium homeostasis, alter gene expression, and produces pro-inflammatory responses. We also identified a trend of toxicity: TiO₂ < Cr₂O₃ < Fe₂O₃ < Mn₂O₃ < NiO < ZnO < CuO. We then asked a question: what are physiochemical factors of transition metal nanoparticles that contributed to this increasing cytotoxicity. In this thesis I investigated the correlation between physicochemical properties and toxicity of the transition metal oxides in the 4th Period of the Periodic Table of Elements. Particle size, BET surface area, point of zero charge, metal dissolution, and degree of surface adsorption of transition metal oxide nanoparticles were measured. There were no increasing trends in both particle size and specific surface area. The point of zero charge showed an increasing trend as TiO₂ < Cr₂O₃ < Fe₂O₃ < NiO < CuO = ZnO < Mn₂O₃. The number of available binding sites of nanoparticle showed an increasing trend as Cr₂O₃ > ZnO > CuO > NiO > Fe₂O₃ > Mn₂O₃ > TiO₂. The degree of adsorption on the surface of nanoparticles showed an increasing trend with atomic ...


Important Information Literacy Standards For Life And Health Sciences, Betsy S. Hopkins 2012 Brigham Young University

Important Information Literacy Standards For Life And Health Sciences, Betsy S. Hopkins

All Faculty Publications

Information literacy in the life and health sciences is a dynamic field, with challenges, opportunities, and rewards for the successful practitioner. This chapter will describe the big picture of information literacy in these disciplines, list relevant performance indicators from the ALA/ACRL/STS Task Force on Information Literacy for Science and Technology [STS-TFILST] (2006) Information Literacy Standards for Science and Technology (hereafter Standards), and give some practical advice for life and health sciences librarians and librarians with instructional responsibilities in those disciplines. The focus is on undergraduates at research universities, although many principles and strategies will apply to other circumstances.


Corrigendum To “Avian Use Of Solid Waste Transfer Stations” [Landscape Urban Plan. 104 (2012) 388–394], Brian E. Washburn 2012 United States Department of Agriculture

Corrigendum To “Avian Use Of Solid Waste Transfer Stations” [Landscape Urban Plan. 104 (2012) 388–394], Brian E. Washburn

USDA National Wildlife Research Center - Staff Publications

No abstract provided.


The Effects Of Seat Post Angle In Cycling Performance, Saori Hanaki-Martin 2012 University of Kentucky

The Effects Of Seat Post Angle In Cycling Performance, Saori Hanaki-Martin

Theses and Dissertations--Kinesiology and Health Promotion

Triathlon involves three different modes of endurance events, swim, bike and run, consecutively. Transitions between events are critical to be successful in the sport; however, many triathletes report impaired running performance due to adverse residual effects from cycling. One of the strategies that triathletes use to manage the adverse effects is to use a bicycle with a more vertical seat post angle. There is limited evidence that support the effectiveness of such bicycle geometry, but many of these studies lacks ecological validity.

Twelve triathletes and cyclists completed a 20-km simulated course with instrumentations for 3D motion, kinetic, and electromyographic analyses ...


Kale, Carolyn Washburn 2012 Utah State University Extension

Kale, Carolyn Washburn

All Current Publications

This publication is part of the Food Sense Guide to Eating Fresh Fruits and Vegetables and includes information on selecting, preparing, cooking, and storing kale.


Lipids Of The Sea Anemone Anthopleura Elegantissima: Season And Symbiont Affect Content And Fractionation, Monica R. Ponce-McDermott 2012 Western Washington University

Lipids Of The Sea Anemone Anthopleura Elegantissima: Season And Symbiont Affect Content And Fractionation, Monica R. Ponce-Mcdermott

WWU Graduate School Collection

Anthopleura elegantissima, the common Pacific sea anemone, can host two very different algal endosymbionts: zooxanthellae (Symbiodinium muscatinei) and zoochlorellae (Elliptochloris marina). The photosynthetic carbon provided by the symbionts supplements the host's heterotrophic feeding, with zooxanthellae potentially translocating five times more carbon to the host than do zoochlorellae. We developed a method to measure lipid levels of zooxanthellate and zoochlorellate A. elegantissima in different seasons, focusing on non-polar lipids that are important components of gonad and gametes. In July 2009 and January 2010, zooxanthellate and zoochlorellate A. elegantissima were collected from the same habitat at the same tidal height. Non-polar ...


Non-Lethal Determination Of Heavy Metals In Spiny Dogfish (Squalus Suckleyi) Spines Using La-Icp-Ms, Clayton L. (Clayton Louis) Bailes 2012 Western Washington University

Non-Lethal Determination Of Heavy Metals In Spiny Dogfish (Squalus Suckleyi) Spines Using La-Icp-Ms, Clayton L. (Clayton Louis) Bailes

WWU Graduate School Collection

Biological structures that develop incremental growth patterns over time present a unique opportunity to study chronological aspects of the organism's chemical environment. Spiny Dogfish (Squalus suckleyi), an abundant shark species, develop two dorsal spines that exhibit this type of growth pattern. The growth patterns on these spines have been used extensively as indicators of age. However, the chronological patterns of trace metal deposits in these spines have yet to be assessed. The main goals of this study were to develop the methods for analyzing this chronology and to explore techniques to analyze these data. Laser ablation inductively coupled plasma ...


Making The Most Of Marriage Therapy, Jana Darrington, Naomi Brower, Eric Walker 2012 Utah State University

Making The Most Of Marriage Therapy, Jana Darrington, Naomi Brower, Eric Walker

All Current Publications

While meeting with a skilled marriage therapist can be helpful in strengthening a marriage, the couple greatly influences the effectiveness of the marriage therapy experience. This fact sheet concludes that aAn effective therapist can provide a framework to help couples work on their relationship, but the couple is ultimately in charge and has great influence in the goals, changes and outcomes based on their level of commitment and effort. By recognizing their own influence and importance, couples can take the lead in creating a satisfying and rewarding relationship that can last a lifetime.


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