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Technical Desiderata For The Integration Of Genomic Data Into Electronic Health Records., Daniel R Masys, Gail P Jarvik, Neil F Abernethy, Nicholas R Anderson, George J Papanicolaou, Dina N Paltoo, Mark A Hoffman, Isaac S Kohane, Howard P Levy 2012 Children's Mercy Kansas City

Technical Desiderata For The Integration Of Genomic Data Into Electronic Health Records., Daniel R Masys, Gail P Jarvik, Neil F Abernethy, Nicholas R Anderson, George J Papanicolaou, Dina N Paltoo, Mark A Hoffman, Isaac S Kohane, Howard P Levy

Manuscripts, Articles, Book Chapters and Other Papers

The era of "Personalized Medicine," guided by individual molecular variation in DNA, RNA, expressed proteins and other forms of high volume molecular data brings new requirements and challenges to the design and implementation of Electronic Health Records (EHRs). In this article we describe the characteristics of biomolecular data that differentiate it from other classes of data commonly found in EHRs, enumerate a set of technical desiderata for its management in healthcare settings, and offer a candidate technical approach to its compact and efficient representation in operational systems.


Genes For The Major Structural Components Of Thermotogales Species’ Togas Revealed By Proteomic And Evolutionary Analyses Of Ompa And Ompb Homologs, Amanda K. Petrus, Kristen S. Swithers, J. Peter Gogarten, Chaman Ranjit, Kenneth M. Noll 2012 University of Connecticut - Storrs

Genes For The Major Structural Components Of Thermotogales Species’ Togas Revealed By Proteomic And Evolutionary Analyses Of Ompa And Ompb Homologs, Amanda K. Petrus, Kristen S. Swithers, J. Peter Gogarten, Chaman Ranjit, Kenneth M. Noll

Open Access Author Fund Awardees' Articles

The unifying structural characteristic of members of the bacterial order Thermotogales is their toga, an unusual cell envelope that includes a loose-fitting sheath around each cell. Only two toga-associated structural proteins have been purified and characterized in Thermotoga maritima: the anchor protein OmpA1 (or Ompα) and the porin OmpB (or Ompβ). The gene encoding OmpA1 (ompA1) was cloned and sequenced and later assigned to TM0477 in the genome sequence, but because no peptide sequence was available for OmpB, its gene (ompB) was not annotated. We identified six porin candidates in the genome sequence of T. maritima. Of these candidates, only ...


Antagonistic Pleiotropy: The Role Of Smurf2 In Cancer And Aging: A Dissertation, Charusheila Ramkumar 2012 University of Massachusetts Medical School

Antagonistic Pleiotropy: The Role Of Smurf2 In Cancer And Aging: A Dissertation, Charusheila Ramkumar

GSBS Dissertations and Theses

In response to telomere shortening, oxidative stress, DNA damage or aberrant activation of oncogenes, normal somatic cells exit the cell cycle and enter an irreversible growth arrest termed senescence. The limited proliferative capacity imposed by senescence on cells impedes the accumulation of mutations necessary for tumorigenesis and prevents proliferation of cells at risk of neoplastic transformation. Opposite to the tumor suppressor function, accumulation of senescent cells in adult organisms is thought to contribute to aging by depleting the renewal capacity of tissues and stem/progenitor cells, and by interfering with tissue homeostasis and functions. The Antagonistic Pleiotropy Theory of senescence ...


Comparing Thigh Muscle Cross-Sectional Area And Squat Strength Among National Class Olympic Weightlifters, Power Lifters, And Bodybuilders, James J. Di Naso, Brian L. Pritschet, John D. Emmett, Jill W. Owen, Jeffrey Willardson, Travis W. Beck, Jason M. DeFreitas, Fabio E. Fontana 2012 Eastern Illinois University

Comparing Thigh Muscle Cross-Sectional Area And Squat Strength Among National Class Olympic Weightlifters, Power Lifters, And Bodybuilders, James J. Di Naso, Brian L. Pritschet, John D. Emmett, Jill W. Owen, Jeffrey Willardson, Travis W. Beck, Jason M. Defreitas, Fabio E. Fontana

Faculty Research and Creative Activity

Few studies have compared anthropometric characteristics among national class athletes from different resistance training disciplines, such as Olympic Weightlifting (OL), Power Lifting (PL), and Bodybuilding (BB). Objective: The purpose of the current study was to determine if significant differences exist in the relationship between thigh muscle cross-sectional area and back squat strength among national class athletes from the sports of OL, PL, and BB. Methods: Fifteen national class athletes were assessed for back squat strength, mid-thigh circumference, and mid-thigh skinfold from which total thigh cross-sectional was estimated. A series of One-Way ANOVAs and Pearson Product Moment Correlations were used to ...


The Effect Of Various Chemical Factors On Angiogenesis In The Chick Chorio-Allantoic Membrane, Heather Hammond 2012 Virginia Commonwealth University

The Effect Of Various Chemical Factors On Angiogenesis In The Chick Chorio-Allantoic Membrane, Heather Hammond

Theses and Dissertations

The chick chorio-allantoic membrane (CAM) contains a complex vascular network commonly used to study angiogenesis. The application of chemical factors and oxygen barrier films onto this tissue can easily influence the process of angiogenesis. In this study, oxygen barrier film patches (Krehalon, polyvinylidene chloride, 12 μm thick, O2 transmission rate = 2.19 cm3•ml/100 in2•day•atm) were applied to areas of the CAM. Holes were made in the film and alginate beads incubated in various chemical factors were placed in the holes. After 24 and 48 hours of exposure to the alginate beads, images were taken of the ...


Topical Anomaly Detection From Twitter Streams, Pramod Anantharam, Krishnaprasad Thirunarayan, Amit P. Sheth 2012 Wright State University - Main Campus

Topical Anomaly Detection From Twitter Streams, Pramod Anantharam, Krishnaprasad Thirunarayan, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.


A Web-Based Study Of Self-Treatment Of Opioid Withdrawal Symptoms With Loperamide, Raminta Daniulaityte, Robert G. Carlson, Russel S. Falck, Delroy H. Cameron, Sujan Udayanaga, Lu Chen, Amit P. Sheth 2012 Wright State University - Main Campus

A Web-Based Study Of Self-Treatment Of Opioid Withdrawal Symptoms With Loperamide, Raminta Daniulaityte, Robert G. Carlson, Russel S. Falck, Delroy H. Cameron, Sujan Udayanaga, Lu Chen, Amit P. Sheth

Kno.e.sis Publications

Aims: Many websites provide a medium for individuals to freely share their experiences and knowledge about different drugs. Such user-generated content can be used as a rich data source to study emerging drug use practices and trends. The study aims to examine web-based reports of loperamide use practices among non-medical opioid users. Loperamide, a piperidine derivative, is an opioid agonist approved for the control of diarrhea symptoms. Because of its general inability to cross the blood-brain barrier, it is considered to have no abuse potential and is available without a prescription. Methods: A website that allows free discussion of illicit ...


The Spatial Games: Investigating The Spatial Distribution Of Anax And Select Prey As A Function Of Predator-Prey Interactions, Shane Elizabeth Johnson, Nene Kumashe Ugbah 2012 California Polytechnic State University - San Luis Obispo

The Spatial Games: Investigating The Spatial Distribution Of Anax And Select Prey As A Function Of Predator-Prey Interactions, Shane Elizabeth Johnson, Nene Kumashe Ugbah

Biological Sciences

Our study investigated the spatial distribution and movement behavior of predatory dragonfly larvae (Anax) and of two prey types: mosquito larvae and amphipods. Predator-prey interactions have important consequences for the population dynamics of both predator and prey groups and these interactions can shape community structure. We measured behavior of each prey type in the presence of the Anax predator and the behavior of the predator in the presence of these alternative prey types. Observations were made in five-gallon aquaria where a grid pattern allowed us to track the number of moves made by individuals. We compiled data from ten, one ...


The Regulatory Role Of Ros On Cxcr4 Expression And Function In Prostate Cancer Cells, Mahandranauth A. Chetram 2012 Clark Atlanta University

The Regulatory Role Of Ros On Cxcr4 Expression And Function In Prostate Cancer Cells, Mahandranauth A. Chetram

ETD Collection for AUC Robert W. Woodruff Library

Inactivation of the tumor suppressor phosphatase and tensin liomolog deleted on chromosome 10 (PTEN) is heavily implicated in the tumorigenesis of prostate cancer. Conversely, the upregulation of the chemokine (CXC) receptor 4 (CXCR4) is associated with prostate cancer progression and metastasis. The inactivation of functional PTEN is typically due to genetic and epigenetic modulations, as well as active site oxidation by reactive oxygen species (ROS); likewise ROS upregulates CXCR4 expression. Furthermore, the pathways of CXCR4 and PTEN converge, leading to the promotion and regulation of turnorigenesis, respectively. Based on these observation we hypothesized that, PTEN inhibits CXCR4-mediated functions in prostate ...


Pyrosequencing Of Bacterial Symbionts Within Axinella Corrugata Sponges: Diversity And Seasonal Variability, James R. White, Jignasa Patel, Andrea Ottesen, Gabriela Arce, Patricia Blackwelder, Jose V. Lopez 2012 Nova Southeastern University

Pyrosequencing Of Bacterial Symbionts Within Axinella Corrugata Sponges: Diversity And Seasonal Variability, James R. White, Jignasa Patel, Andrea Ottesen, Gabriela Arce, Patricia Blackwelder, Jose V. Lopez

Oceanography Faculty Articles

Background: Marine sponge species are of significant interest to many scientific fields including marine ecology, conservation biology, genetics, host-microbe symbiosis and pharmacology. One of the most intriguing aspects of the sponge ‘‘holobiont’’ system is the unique physiology, interaction with microbes from the marine environment and the development of a complex commensal microbial community. However, intraspecific variability and temporal stability of sponge-associated bacterial symbionts remain relatively unknown.

Methodology/Principal Findings: We have characterized the bacterial symbiont community biodiversity of seven different individuals of the Caribbean reef sponge Axinella corrugata, from two different Florida reef locations during variable seasons using multiplex 454 ...


Open And Closed Seascapes: Where Does Habitat Patchiness Create Populations With High Fractions Of Self-Recruitment?, Malin L. Pinsky, Stephen R. Palumbi, Serge Andrefouet, Samuel J. Purkis 2012 Princeton University

Open And Closed Seascapes: Where Does Habitat Patchiness Create Populations With High Fractions Of Self-Recruitment?, Malin L. Pinsky, Stephen R. Palumbi, Serge Andrefouet, Samuel J. Purkis

Oceanography Faculty Articles

Which populations are replenished primarily by immigrants (open) and which by local production (closed) remains an important question for management with implications for response to exploitation, protection, and disturbance. However, we lack methods for predicting population openness. Here, we develop a model for openness and show that considering habitat isolation explains the existence of surprisingly closed populations in high-dispersal species, including many marine organisms. Relatively closed populations are expected when patch spacing is more than twice the standard deviation of a species' dispersal kernel. In addition, natural scales of habitat patchiness on coral reefs are sufficient to create both largely ...


Comparing Thigh Muscle Cross-Sectional Area And Squat Strength Among National Class Olympic Weightlifters, Power Lifters, And Bodybuilders, James J. Di Naso, Brian L. Pritschet, John D. Emmett, Jill W. Owen, Jeffrey Willardson, Travis W. Beck, Jason M. DeFreitas, Fabio E. Fontana 2012 Eastern Illinois University

Comparing Thigh Muscle Cross-Sectional Area And Squat Strength Among National Class Olympic Weightlifters, Power Lifters, And Bodybuilders, James J. Di Naso, Brian L. Pritschet, John D. Emmett, Jill W. Owen, Jeffrey Willardson, Travis W. Beck, Jason M. Defreitas, Fabio E. Fontana

Jeffrey Willardson

Few studies have compared anthropometric characteristics among national class athletes from different resistance training disciplines, such as Olympic Weightlifting (OL), Power Lifting (PL), and Bodybuilding (BB). Objective: The purpose of the current study was to determine if significant differences exist in the relationship between thigh muscle cross-sectional area and back squat strength among national class athletes from the sports of OL, PL, and BB. Methods: Fifteen national class athletes were assessed for back squat strength, mid-thigh circumference, and mid-thigh skinfold from which total thigh cross-sectional was estimated. A series of One-Way ANOVAs and Pearson Product Moment Correlations were used to ...


Communication Sources Used By Fish Farmers And Field Extension Functionaries In Floodplain Wetland Fisheries Of Assam : A Comparative Study, Ganesh Chandra 2012 ICAR-Central Inland Fisheries Research Institute, (ICAR) Barrackpore, India

Communication Sources Used By Fish Farmers And Field Extension Functionaries In Floodplain Wetland Fisheries Of Assam : A Comparative Study, Ganesh Chandra

Ganesh Chandra

A study was carried out in 106 floodplain wetlands of Assam with the objective of ascertaining the preference of communication media use by the fishers of floodplain wetlands and extent of their use by field extension functionaries. Two categories of respondents namely 106 lessee fishermen and 30 officials lower level field extension functionaries constituted the sample of the study. The findings revealed that the interpersonal communication sources like consultation with FEO/ Beel manager was the most important sources for obtaining information by fishers. Demonstration and consultation with progressive farmers were assigned second and third rank. Field extension functionaries preferred group ...


The Suitability Of Ground Date (Phoenix Dactylifera L.) Pits And Ghaf (Prosopis Cineraria L.) Pods As Horticultural Growth Media Or Soil Amendments, Saeed Khalifa Alshaali 2012 United Arab Emirates University

The Suitability Of Ground Date (Phoenix Dactylifera L.) Pits And Ghaf (Prosopis Cineraria L.) Pods As Horticultural Growth Media Or Soil Amendments, Saeed Khalifa Alshaali

Theses

The UAE and its neighboring countries are encountering scarcity of water resources and soil degradation due to salinization. The current over-exploitation of aquifers by the agricultural sector is a major concern for the government. Open field production of forage as a feed for camels, cows and small ruminants requires particularly high amounts of irrigation water. Greenhouse production of fodder might save water, but would require a suitable growth substrate that is readily available in the UAE, and ideally constitutes a palatable fodder itself. The objective of this study was to evaluate the suitability of ground D.pits and G.pods ...


Seasonality Of Infant Feeding Practices In Three Brazilian Birth Cohorts, David A. González-Chica, Helen Gonçalves, Aydin Nazmi, Iná S. Santos, Aluísio J. D. Barros, Alicia Matijasevich, Cesar G. Victora 2012 Federal University of Santa Catarina

Seasonality Of Infant Feeding Practices In Three Brazilian Birth Cohorts, David A. González-Chica, Helen Gonçalves, Aydin Nazmi, Iná S. Santos, Aluísio J. D. Barros, Alicia Matijasevich, Cesar G. Victora

Food Science and Nutrition

Background We assessed the influence of season of birth on duration of breastfeeding and other feeding patterns in three population-based birth cohort studies in the city of Pelotas, Southern Brazil.

Methods In 1982, 1993 and 2004, all hospital-born children in the city were enrolled in three cohort studies (n =  5914, 5249 and 4287, respectively). Children and their mothers were periodically visited in the first 2 years of life, to collect information on the duration of breastfeeding and the ages at which different types of foods were introduced on a regular basis. Two independent variables were studied: month of birth and ...


Transposition Driven Genomic Heterogeneity In The Drosophila Brain: A Dissertation, Paola N. Perrat 2012 University of Massachusetts Medical School

Transposition Driven Genomic Heterogeneity In The Drosophila Brain: A Dissertation, Paola N. Perrat

GSBS Dissertations and Theses

In the Drosophila brain, memories are processed and stored in two mirrorsymmetrical structures composed of approximately 5,000 neurons called Mushroom Bodies (MB). Depending on their axonal extensions, neurons in the MB can be further classified into three different subgroups: αβ, α’β’ and γ. In addition to the morphological differences between these groups of neurons, there is evidence of functional differences too. For example, it has been previously shown that while neurotransmission from α’β’ neurons is required for consolidation of olfactory memory, output from αβ neurons is required for its later retrieval. To gain insight into the functional ...


3d Sonar Measurements In Wakes Of Ships Of Opportunity, Alexander Soloviev, Christopher Maingot, Mike Agor, Lou Nash, Keith Dixon 2012 Nova Southeastern University

3d Sonar Measurements In Wakes Of Ships Of Opportunity, Alexander Soloviev, Christopher Maingot, Mike Agor, Lou Nash, Keith Dixon

Oceanography Faculty Articles

The aim of this work is to test the potential capabilities of 3D sonar technology for studying small-scale processes in the near-surface layer of the ocean, using the centerline wake of ships of opportunity as the object of study. The first tests conducted in Tampa Bay, Florida, with the 3D sonar have demonstrated the ability of this technology to observe the shape of the centerlinewake in great detail starting from centimeter scale, using air bubbles as a proxy. An advantage of the 3Dsonar technology is that it allows quantitative estimates of the ship wake geometry, which presents new opportunities for ...


Muscle Contraction Duration And Fibre Recruitment Influence Blood Flow And Vo2 Independent Of Contractile Work During Steady-State Exercise In Humans, Jennifer C. Richards, Anne R. Crecelius, Brett S. Kirby, Dennis G. Larson, Frank A. Dinenno 2012 Colorado State University - Fort Collins

Muscle Contraction Duration And Fibre Recruitment Influence Blood Flow And Vo2 Independent Of Contractile Work During Steady-State Exercise In Humans, Jennifer C. Richards, Anne R. Crecelius, Brett S. Kirby, Dennis G. Larson, Frank A. Dinenno

Health and Sport Science Faculty Publications

We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption (O2) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultrasound) during 4 minutes of rhythmic handgrip exercise in 24 healthy young adults and calculated forearm O2 via blood samples obtained from a catheter placed in retrograde fashion into a deep vein draining the forearm muscle. In Protocol 1 (n = 11), subjects performed rhythmic isometric handgrip exercise at mild and moderate intensities under conditions in ...


Agents Of Change: Three Women Who Made A Difference, Linda J. Lear '62 2012 Connecticut College

Agents Of Change: Three Women Who Made A Difference, Linda J. Lear '62

Reunion Addresses

No abstract provided.


Protocol For Trichomonas Diagnosis In Cattle For Utah, Bruce King, Kerry Rood 2012 Utah State University Extension

Protocol For Trichomonas Diagnosis In Cattle For Utah, Bruce King, Kerry Rood

All Current Publications

Trichomoniasis, caused by the protozoan Tritrichomonas foetus, is a serious reproductive (venereal) disease found in some Utah cattle herds. Diagnosis of trichomoniasis is made when trichomonad organisms are detected in the smegma or preputial flush samples of bulls, or the uterine/vaginal fluids of cows


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