Structural And Functional Evaluation Of C. Elegans Filamins Fln-1 And Fln-2, 2011 Northeastern University
Structural And Functional Evaluation Of C. Elegans Filamins Fln-1 And Fln-2, Christina Demaso, Ismar Kovacevic, Alper Uzun, Erin Cram
Filamins are long, flexible, multi-domain proteins composed of an N-terminal actin-binding domain (ABD) followed by multiple immunoglobulin-like repeats (IgFLN). They function to organize and maintain the actin cytoskeleton, to provide scaffolds for signaling components, and to act as mechanical force sensors. In this study, we used transcript sequencing and homology modeling to characterize the gene and protein structures of the C. elegans filamin orthologs fln-1 and fln-2. Our results reveal that C. elegans FLN-1 is well conserved at the sequence level to vertebrate filamins, particularly in the ABD and several key IgFLN repeats. Both FLN-1 and the more divergent FLN-2 ...
Non-Viral Enos Gene Delivery And Transfection With Stents For The Treatment Of Restenosis, 2011 Northeastern University
Non-Viral Enos Gene Delivery And Transfection With Stents For The Treatment Of Restenosis, Luis Brito, Saradha Chandrasekhar, Steven Little, Mansoor Amiji
Mansoor M. Amiji
Background In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy of endothelial nitric oxide synthase (eNOS) encoding plasmid DNA administered using coated stents in a rabbit iliac artery restenosis model. Methods Lipopolyplexes (LPPs) with eNOS expressing plasmid DNA were immobilized on stainless steel stents using poly(D,L-lactide-co-glycolide) (PLGA) and type B gelatin coatings. The gene-eluting stents were implanted bilaterally in the denuded iliac arteries and eNOS transfection and therapeutic efficacy were examined 14 days after implantation. Results The results show that non-viral lipopolyplex-coated stents can efficiently tranfect eNOS locally in the arterial lumen assessed ...
Role Of Hypoxia And Glycolysis In The Development Of Multi-Drug Resistance In Human Tumor Cells And The Establishment Of An Orthotopic Multi-Drug Resistant Tumor Model In Nude Mice Using Hypoxic Pre-Conditioning, 2011 Northeastern University
Role Of Hypoxia And Glycolysis In The Development Of Multi-Drug Resistance In Human Tumor Cells And The Establishment Of An Orthotopic Multi-Drug Resistant Tumor Model In Nude Mice Using Hypoxic Pre-Conditioning, Lara Milane, Zhenfeng Duan, Mansoor Amiji
Mansoor M. Amiji
Background The development of multi-drug resistant (MDR) cancer is a significant challenge in the clinical treatment of recurrent disease. Hypoxia is an environmental selection pressure that contributes to the development of MDR. Many cancer cells, including MDR cells, resort to glycolysis for energy acquisition. This study aimed to explore the relationship between hypoxia, glycolysis, and MDR in a panel of human breast and ovarian cancer cells. A second aim of this study was to develop an orthotopic animal model of MDR breast cancer. Methods Nucleic and basal protein was extracted from a panel of human breast and ovarian cancer cells ...
Fraxinus Nigra Pott, 2011 Illinois Natural History Survey
Fraxinus Nigra Pott, Loy R. Phillippe, Jason J. Zylka
Specimens by Name
No abstract provided.
A Strawberry Knox Gene Regulates Leaf, Flower And Meristem Architecture, 2011 University of Florida
A Strawberry Knox Gene Regulates Leaf, Flower And Meristem Architecture, Mithu Chatterjee, Claudia L. Bermudez-Lozano, Maureen A. Clancy, Thomas M. Davis, Kevin M. Folta
Biological Sciences Scholarship
The KNOTTED-LIKE HOMEODOMAIN (KNOX) genes play a central role in maintenance of the shoot apical meristem. They also contribute to the morphology of simple and compound leaves. In this report we characterize the FaKNOX1 gene from strawberry (Fragaria spp.) and demonstrate its function in trasgenic plants. The FaKNOX1 cDNA was isolated from a cultivated strawberry (F.×ananassa) flower EST library. The sequence is most similar to Class I KNOX genes, and was mapped to linkage group VI of the diploid strawberry genome. Unlike most KNOX genes studied, steady-state transcript levels were highest in flowers and fruits. Transcripts were also detected ...
Semantic Computing In Real-World: Vertical And Horizontal Application Within Enterprise And On The Web, 2011 Wright State University - Main Campus
Semantic Computing In Real-World: Vertical And Horizontal Application Within Enterprise And On The Web, Amit P. Sheth
No abstract provided.
Critical Stages In Viral Replication - Entry, Gene Regulation And Egress, 2011 The University of Western Ontario
Critical Stages In Viral Replication - Entry, Gene Regulation And Egress, Matthew S. Miller
Electronic Thesis and Dissertation Repository
Despite the amazing biological diversity exhibited by viruses, their very existence relies upon their ability to overcome a set of common barriers. The nature of these barriers reflects the nature of viruses themselves. During their extracellular phase, viruses are metabolically inert obligate parasites. Upon encountering a host cell, productive infection necessitates that the virus successfully enter the cell, regulate the expression of its genes, and after assembling new progeny particles, egress such that the cycle of infection can continue. These three basic processes are not only attractive candidates for therapeutic intervention, but also reveal much about virus biology in the ...
Rna Oxidation Adducts 8-Ohg And 8-Oha Change With Aβ42 Levels In Late-Stage Alzheimer's Disease, 2011 University of Kentucky
Rna Oxidation Adducts 8-Ohg And 8-Oha Change With Aβ42 Levels In Late-Stage Alzheimer's Disease, Adam M. Weidner, Melissa A. Bradley, Tina L. Beckett, Dana M. Niedowicz, Amy L.S. Dowling, Sergey V. Matveev, Harry Levine, Mark A. Lovell, M. Paul Murphy
Sanders-Brown Center on Aging Faculty Publications
While research supports amyloid-β (Aβ) as the etiologic agent of Alzheimer's disease (AD), the mechanism of action remains unclear. Evidence indicates that adducts of RNA caused by oxidation also represent an early phenomenon in AD. It is currently unknown what type of influence these two observations have on each other, if any. We quantified five RNA adducts by gas chromatography/mass spectroscopy across five brain regions from AD cases and age-matched controls. We then used a reductive directed analysis to compare the RNA adducts to common indices of AD neuropathology and various pools of Aβ. Using data from four ...
Seed Production In Weedy Setaria Spp.-Gp, 2011 Iowa State University
Seed Production In Weedy Setaria Spp.-Gp, M. J. Haar, Jack H. Dekker
Seeds from Setaria faberi, S. viridis and S. pumila panicles in three Iowa crop fields were collected for the entire reproductive period. Seed number, panicle length, and seed number per panicle length varied among species, panicle types and sites. Greater numbers of seed per plant and per panicle were observed than previously reported. Setaria seed rain exhibited some stable, and many more plastic, responses. S. faberi panicles were consistently longer than those of S. viridis. S. viridis parameters were greater than S. pumila. Earlier panicles were greater than, or similar to, later ones for all parameters. More typically, tillers and ...
Aviation Wildlife Hazard - Uk Flight Safety Committee, 2011 Embry Riddle Aeronautical University - Daytona Beach
Aviation Wildlife Hazard - Uk Flight Safety Committee, Paul F. Eschenfelder
Paul F. Eschenfelder
No abstract provided.
Sp612-A Tools For Money Management: Net Worth Statement Instructions, 2011 University of Tennessee, Knoxville
Sp612-A Tools For Money Management: Net Worth Statement Instructions, Dena Wise
No abstract provided.
Sp725 Making A Difference The Tncep Way, 2011 University of Tennessee, Knoxville
Sp725 Making A Difference The Tncep Way, Martha Jo Tolley, Michelle Vineyard
Corn, 2011 Utah State University
Corn, Brianne Sherwood, Amanda Hawks
USU Student Organic Farm Newsletter
We have so much corn right now it's coming out of our ears (great pun, right?). And it's SO incredibly cheap! This is probably because the US produces 42% of the world's corn! Most of it is used for animal feed, but other uses include exporting to other countries, human food, seed, and industrial uses such as ethanol production. Because there is so much corn available here in the U.S. You can find it in a lot more foods than you think. It's in peanut butter, snack foods, soft drinks, multivitamins, ketchup, mustard, ground beef ...
Effect Of Sodium Nitrite, Sodium Erythorbate And Organic Acid Salts On Germination And Outgrowth Of Clostridium Perfringens Spores In Ham During Abusive Cooling, Mauricio A. Redondo
Dissertations, Theses, & Student Research in Food Science and Technology
The effect of sodium nitrite (NaNO2), sodium erythorbate, sodium chloride (NaCl) and organic acid salts (potassium lactate and sodium diacetate) on C. perfringens spore germination and outgrowth in ham was evaluated. The research was divided in two parts. The first experiment consisted of potential C. perfringens spore germination and outgrowth in ham containing combinations of NaNO2 (0, 50, 100, 150 or 200 ppm) and sodium erythorbate (0 or 557 ppm) during cooling. This experiment included the evaluation of residual nitrite levels as affected by temperature (heat shock at 75°C for 20 min and subsequent cooling from 54 ...
Does Corn Lose Drymatter After Physiological Maturity? No, 2011 Iowa State University
Does Corn Lose Drymatter After Physiological Maturity? No, Roger W. Elmore
Integrated Crop Management News
Iowa’s corn this year reached dent (R5) development stage on pace with that of 2010, but well ahead of normal. Some combines are rolling across Iowa’s 14 million plus acres of corn; others will roll soon. Harvest begins. Fall approaches.
The Efficacy Of Antibiotic Residue Screening Tests For The Detection Of Natural Antimicrobials In Milk, 2011 University of Connecticut - Storrs
The Efficacy Of Antibiotic Residue Screening Tests For The Detection Of Natural Antimicrobials In Milk, Stacey L. O'Donnell
No abstract provided.
Characterization Of Hpk2-Rrp2, Two-Component Regulatory System In Treponema Denticola, 2011 Virginia Commonwealth University
Characterization Of Hpk2-Rrp2, Two-Component Regulatory System In Treponema Denticola, Sarkar Juni
Theses and Dissertations
Treponema denticola levels in the gingival crevice become elevated as periodontal disease develops. Oral treponemes may account for as much as 40% of the total bacterial population in the periodontal pocket. The stimuli that trigger enhanced growth of T. denticola and the mechanisms associated with the transmission of these signals remain to be defined. A hypothesis was set that the T. denticola ORFs tde1970 (histidine kinase) and tde1969 (response regulator) constitute a functional two component regulatory system that regulates, at least in part, responses to the changing environmental conditions associated with the development of periodontal disease. The results presented demonstrate ...
Coaching Power Tool: Success Vs. Failure, 2011 University of Nebraska-Lincoln
Coaching Power Tool: Success Vs. Failure, Connie I. Reimers-Hild
Kimmel Education and Research Center - Faculty & Staff Publications
Part of personal leadership and innovation is self-discovery, which requires introspection and the ability to see the unseen. Sometimes it is necessary to consider a different perspective. We have to shift our thinking to see possibilities in a new light. Sometimes, it is the unobvious that may be the most important. It is important for us to challenge our thinking and traditional thought to redefine success, failure and our ability to take risks.
Distribution Of The American Milliped Genus Boraria Chamberlin, 1943: Introductions Of B. Stricta (Brölemann, 1896) In New York And B. Infesta (Chamberlin, 1918) In Connecticut; Indigenous Occurrence Of B. Profuga (Causey, 1955) In Louisiana (Diplopoda: Polydesmida: Xystodesmidae)., 2011 North Carolina State Museum of Natural Sciences
Distribution Of The American Milliped Genus Boraria Chamberlin, 1943: Introductions Of B. Stricta (Brölemann, 1896) In New York And B. Infesta (Chamberlin, 1918) In Connecticut; Indigenous Occurrence Of B. Profuga (Causey, 1955) In Louisiana (Diplopoda: Polydesmida: Xystodesmidae)., Rowland M. Shelley, Chris T. Mcallister, Christopher M. Nagy, Mark E. Weckel, Roderick G. Christie, Paul Wilson, Allan Wilson
The southern Appalachian millipeds Boraria stricta (Brölemann, 1896) and B. infesta (Chamberlin, 1918) (Diplopoda: Polydesmida: Xystodesmidae) have become established in Westchester Co., New York, and Hartford Co., Connecticut, respectively. Only three individuals are available for the latter, but B. stricta has established a reproducing population in southern New York state. This species is also recorded from Bland Co., Virginia, in the Ridge and Valley Physiographic Province. Boraria profuga (Causey, 1955) comprises two allopatric populations, one in Montgomery Co., Arkansas, and the other in Ouachita Parish, Louisiana. Distributional records and gonopod drawings are presented for these species plus B. deturkiana (Causey ...
New Taxa And Combinations In Onciderini Thomson, 1860 (Coleoptera: Cerambycidae: Lamiinae), 2011 University of New Mexico
New Taxa And Combinations In Onciderini Thomson, 1860 (Coleoptera: Cerambycidae: Lamiinae), Eugenio H. Nearns, Ian P. Swift
Monneoncideres, a new genus of Onciderini Thomson, 1860 (Coleoptera: Cerambycidae: Lamiinae) is described and illustrated. Six new species of Onciderini are also described and illustrated: Hesycha tavakiliani from Brazil; Lesbates milleri from Venezuela; Monneoncideres cristata from Ecuador and Peru; Neodillonia waltersi from Ecuador; Tibiosioma martinsi from Ecuador; and Trestonia wappesi from Panama. Keys to the known species of Lesbates Dillon and Dillon, 1945 and Tibiosioma Martins and Galilleo, 1990 are provided. The genus Ophthalmocydrus Aurivillius, 1925 (Onciderini) is transferred to Pteropliini (Lamiinae); and Xylomimus Bates, 1865 (Apomecynini) is transferred to Onciderini. The following new synonymies are proposed: Kuauna Martins and ...