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High Glucose Enhances The Proliferation Effects Of Stress Hormones In Mesenchymal Stem Cell Cultures, Jodi F. Evans Ph.D., Nancy Abrego, Louis Ragolia 2018 Molloy College

High Glucose Enhances The Proliferation Effects Of Stress Hormones In Mesenchymal Stem Cell Cultures, Jodi F. Evans Ph.D., Nancy Abrego, Louis Ragolia

Jodi Evans

Mesenchymal stem cells (MSC) are the progenitor cells to connective tissue cells, epithelial cells, and smooth muscle cells. These cells are currently being investigated as a cellular source for tissue regeneration and repair. The systemic and local tissue environment may have significant influence on the success of such efforts. We hypothesized that elevated glucose and exposure to stress hormones would influence the proliferation of MSC. MSC from the bone marrow of Wistar-Kyoto (WKY) rats were grown under both low glucose (5 mM) and high glucose (20 nM) conditions in the presence and absence of the synthetic glucocorticoid, dexamethasone, and adrenocorticotropin ...


Vascular Tissue-Resident Mesenchymal Stem Cells; Friend Or Foe?, Jodi F. Evans Ph.D., Heather Renna, Lauren McHugh, Eddie Bochynski, Victoria Flemm 2018 Molloy College

Vascular Tissue-Resident Mesenchymal Stem Cells; Friend Or Foe?, Jodi F. Evans Ph.D., Heather Renna, Lauren Mchugh, Eddie Bochynski, Victoria Flemm

Jodi Evans

Mesenchymal stem cells (MSC) are ideal candidates for stem cell-based therapies of vascular inflammation. They are progenitor cells that can replace damaged cells and they can modulate immune response cells. MSC from bone marrow and adipose tissue regulate inflammation by promoting the switch of macrophage cell from an inflammatory to an anti-inflammatory phenotype. Much less is known about the tissue resident MSC’s and their interaction with macrophage cells. We hypothesized that aortaderived mesenchymal stem cells (mAo MSC) would also promote the expression of the antiinflammatory phenotype among macrophage cells. The interaction of mAo MSC with the macrophage was examined ...


The Stress Of Public Speaking Increases Cortisol Levels In Undergraduates: Is Increased Preparation Really The Best Remedy?, Jodi F. Evans Ph.D., Erin Clinton, Grace Cookson, Stephanie Brown, Daniel Woods 2018 Molloy College

The Stress Of Public Speaking Increases Cortisol Levels In Undergraduates: Is Increased Preparation Really The Best Remedy?, Jodi F. Evans Ph.D., Erin Clinton, Grace Cookson, Stephanie Brown, Daniel Woods

Jodi Evans

Perceived stress is prevalent among the undergraduate population. When this stress persists, it has the potential to lead to mental health illnesses. Recent research shows 85% of students experience overwhelming anxiety from academic pressures. Physiologically, during stressful events, cortisol levels rise in the body which disrupts homeostasis. The anticipation prior to a class presentation, a form of public speaking, is a common source of perceived stress among undergraduates. The focus of this experiment was to determine if there is a correlation between factors such as increased preparedness, sleep, level of understanding, perceived anxiety and physiological stress parameters. Twenty-eight student volunteers ...


Stress Axis Hormones Induce Triglyceride Filled Nodule Formation In Vascular Smooth Muscle Cells, Jodi F. Evans Ph.D., Michelle Vigliotti, Pamela Tello 2018 Molloy College

Stress Axis Hormones Induce Triglyceride Filled Nodule Formation In Vascular Smooth Muscle Cells, Jodi F. Evans Ph.D., Michelle Vigliotti, Pamela Tello

Jodi Evans

Homeostatic stress, such as that which occurs in diabetes, is associated with increased risk for the development of atherosclerosis. Atherosclerotic plaques of the artery wall are associated with both lipid accumulation and fibrous and/or calcified tissue accumulation. Vascular smooth muscle cells (VSMC) are derived from mesenchymal stem cells (MSC) which are capable of differentiating into adipocytes, chondrocytes and osteoblasts. MSC of the bone marrow are pushed toward the chondrogenic and adipogenic phenotypes in the presence of the stress hormones glucocorticoid and adrenocorticotropin (ACTH). This led us to hypothesize that the proliferative VSMC of the Goto-Kakizaki (GK) diabetic rat, when ...


Effect Of Circular Motion Exercise On Bone Modeling And Bone Mass In Young Rats: An Animal Model Of Isometric Exercise, Jodi F. Evans Ph.D., J. K. Yeh, Q. Niu, J. Iwamoto, J. F. Aloia 2018 Molloy College

Effect Of Circular Motion Exercise On Bone Modeling And Bone Mass In Young Rats: An Animal Model Of Isometric Exercise, Jodi F. Evans Ph.D., J. K. Yeh, Q. Niu, J. Iwamoto, J. F. Aloia

Jodi Evans

The aims of the study are to develop a non-invasive animal model of circular motion exercise and to evaluate the effect of this type of exercise on bone turnover in young rats. The circular motion exercise simulates isometric exercise using an orbital shaker that oscillates at a frequency of 50 Hz and is capable of speeds from 0-400 rpm. A cage is fixed on top of the shaker and the animals are placed inside. When the shaker is turned on, the oscillatory movement should encourage the animals to hold on to the cage and use various muscle forces to stabilize ...


Acth Enhances Lipid Accumulation In Bone-Marrow Derived Mesenchymal Stem Cells Undergoing Adipogenesis, Jodi F. Evans Ph.D., Thomas Rhodes, Michelle Pazienza 2018 Molloy College

Acth Enhances Lipid Accumulation In Bone-Marrow Derived Mesenchymal Stem Cells Undergoing Adipogenesis, Jodi F. Evans Ph.D., Thomas Rhodes, Michelle Pazienza

Jodi Evans

ACTH is a major hormone of the stress axis or hypothalamic-pituitary-adrenal (HPA) axis. It is derived from pro-opiomelanocortin (POMC) the precursor to the melanocortin family of peptides. POMC produces the biologically active melanocortin peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin. The melanocortin system plays an imperative role in energy expenditure, insulin release and insulin sensitivity. Bone marrow derived mesenchymal stem cells circulate in the blood stream and as progenitor cells have the potential to differentiate into many cell types such as osteoblasts, chondrocytes and adipocytes. Here we ...


Adrenocorticotropin Hormone Expression In The Developing Chicken Limb, Jodi F. Evans Ph.D., Michelle Vigliotti 2018 Molloy College

Adrenocorticotropin Hormone Expression In The Developing Chicken Limb, Jodi F. Evans Ph.D., Michelle Vigliotti

Jodi Evans

In previous studies using mammalian models we have found both clinical and laboratory evidence of a role for melanocortins in endochondral ossification. The melanocortin system has remarkable conservation among vertebrates and melanocortin receptors are expressed with significant sequence homology in teleosts to mammals. The overall goal of these studies is to provide a more accessible model of melanocortin involvement in endochondral growth. We hope to determine if melanocortins play a role during endochondral ossification of the developing chicken limb. Like in mammals melanocortins are widely distributed throughout the body of chicken and participate in a wide range of physiological functions ...


Cd105 Deficieny In Mouse Aorta-Derived Mesenchymal Stem Cells Promotes An Enhanced Inflammatory Response To Lipolysaccharide., Jodi F. Evans Ph.D., Joseph Granata, Hugo Sanchez, Philip Loeschinger, Anthony Goez 2018 Molloy College

Cd105 Deficieny In Mouse Aorta-Derived Mesenchymal Stem Cells Promotes An Enhanced Inflammatory Response To Lipolysaccharide., Jodi F. Evans Ph.D., Joseph Granata, Hugo Sanchez, Philip Loeschinger, Anthony Goez

Jodi Evans

Mesenchymal stem cells (MSCs) are being widely studied for their ability to regulate macrophage cell responses. Previous works have demonstrated that mouse aorta-derived MSC (mAo-MSC) support the macrophage inflammatory response. mAo-MSC have been characterized phenotypically for MSC-associated surface antigens and express CD90 and CD105 but do not express CD73. CD105, also known as endoglin, is a coreceptor in the TGFβ superfamily of receptors. Mouse adipose-derived MSC lacking CD105 have an increased capacity to regulate T-cells by reducing their proliferation while elevated CD105 expression is consistently associated with inflammatory disease. Therefore, we hypothesized that suppression of CD105 in mAo-MSC will reduce ...


Does Stress Make You Fat?, Jodi F. Evans Ph.D., Thomas Rhodes, Michelle Pazienza, Catherine Nunez 2018 Molloy College

Does Stress Make You Fat?, Jodi F. Evans Ph.D., Thomas Rhodes, Michelle Pazienza, Catherine Nunez

Jodi Evans

ACTH is a major hormone of the stress axis or hypothalamic-pituitary-adrenal (HPA) axis. It is derived from pro-opiomelanocortin (POMC) the precursor to the melanocortin family of peptides. POMC produces the biologically active melanocortin peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and β-endorphin. The melanocortin system plays an imperative role in energy expenditure, insulin release and insulin sensitivity. Bone marrow derived mesenchymal stem cells circulate in the blood stream and as progenitor cells have the potential to differentiate into many cell types such as osteoblasts, chondrocytes and adipocytes. Here we ...


A Quest For A Custom-Made Mesenchymal Stem Cell In The Treatment Of Inflammatory Diseases, Jodi F. Evans Ph.D., Natalie Fernandez, Caroline Winters, Maria Barandica, Abi Ocava, Michael Delsignore, Kristina Coppola 2018 Molloy College

A Quest For A Custom-Made Mesenchymal Stem Cell In The Treatment Of Inflammatory Diseases, Jodi F. Evans Ph.D., Natalie Fernandez, Caroline Winters, Maria Barandica, Abi Ocava, Michael Delsignore, Kristina Coppola

Jodi Evans

Mesenchymal stem cells (MSC) are multipotent cells that can differentiate into adipocytes, osteoblasts and chondrocytes. These cells are widely studied in tissue regeneration and for their therapeutic effects in inflammatory disease. MSC interact with cells of the innate and adaptive immunity to promote or suppress the inflammatory response. MSC from the bone marrow (D1 MSC) decrease inflammatory responses by lowering macrophage (Mᶲ) secretion of soluble factors such as nitric oxide (NO), interleukin-12 (IL-12) and tumor necrosis factor-α (TNFα). Aorta-derived MSC (mAo MSC) support the macrophage inflammatory response by contributing to NO secretion and enhancing secretion of TNFα by Mᶲ. Previous ...


Integrating Students Into Interdisciplinary Health And Health Disparities Research Teams, Tanya M. Coakley, Allyson Kelley, Robin Bartlett, Terri Shelton, Schenita D. Randolph, Debra C. Wallace 2018 University of North Carolina at Greensboro

Integrating Students Into Interdisciplinary Health And Health Disparities Research Teams, Tanya M. Coakley, Allyson Kelley, Robin Bartlett, Terri Shelton, Schenita D. Randolph, Debra C. Wallace

Journal of Health Disparities Research and Practice

Major initiatives by the U.S. Department of Health and Human Services as well as the World Health Organization have produced a large and compelling body of evidence on how to reduce health disparities, which entails having a clear understanding of how social factors shape health and healthcare outcomes. Specifically, there is a need for healthcare professionals to understand social determinants of health (e.g., low socioeconomic status, lack of health insurance, and poor education) and how these lead to disparities in health for people of minority racial and ethnic groups. Little is known about how students are developed as ...


Evaluating Energy Expenditure Estimated By Wearable Technology During Variable Intensity Activity On Female Collegiate Athletes, Monica Taylor, Elizabeth Nagle, Fredric Goss, Elaine Rubinstein, Andrew Simonson 2018 University of the Sciences Philadelphia

Evaluating Energy Expenditure Estimated By Wearable Technology During Variable Intensity Activity On Female Collegiate Athletes, Monica Taylor, Elizabeth Nagle, Fredric Goss, Elaine Rubinstein, Andrew Simonson

International Journal of Exercise Science

International Journal of Exercise Science 11(7): 598-608, 2018. Monitoring an athlete’s energy intake and energy expenditure (EE) is an important consideration of nutritional planning for sport conditioning and peak performance. In order to provide appropriate recommendations regarding nutritional requirements and caloric needs, an accurate determination of energy requirements is necessary. By knowing an individual’s EE, a coach, athletic performance staff or trainer can effectively determine training loads and volumes necessary for periodization and seasonal planning for a particular sport. The purpose of this study is to examine the accuracy of the BodyMedia Mini armband while measuring EE ...


San José (Pacheco), Diseño198, Glo No. 45, Sonoma County, And Associated Historical Documents., 2018 California State University, Monterey Bay

San José (Pacheco), Diseño198, Glo No. 45, Sonoma County, And Associated Historical Documents.

Sonoma County

Diseños - Hand-drawn Spanish-Mexican map demonstrating the physical boundaries of land granted to Mexican citizens by the Spanish or Mexican.

Work Progress Administration Abstract (WPA Abstract) – A summary document prepared in 1938 under the U. S. Work Progress Administration program detailing the history of a rancho beginning with the Spanish-American land through the U.S. patenting process.


When Extinction Is More Ethical Than Conservation: The Endangered Species Act And The Keystone Dilemma, Miranda F. Thomas 2018 Danville Community College

When Extinction Is More Ethical Than Conservation: The Endangered Species Act And The Keystone Dilemma, Miranda F. Thomas

Exigence

This paper examines how the Endangered Species Act's measures to protect endangered species have resulted in increased rates of extinction. The author summarizes the concept of endangered keystone species and explains the processes and operations of the environmental legislation enacted to protect the species. The paper discusses the harmful consequences that certain laws have had on both species and humans, such as misappropriating resources to species that are not as endangered as others, and abusing regulations in manners that punish people for conservation efforts. By examining opposing arguments that favor increased regulation, this paper explains through data from leading ...


Hunting A Home: The Abandonment And Neglect Of Hunting Dogs, Jamie B. Walker 2018 Germanna Community College

Hunting A Home: The Abandonment And Neglect Of Hunting Dogs, Jamie B. Walker

Exigence

Each year, an immeasurable number of hunting dogs are found in emaciated, malnourished or even abusive conditions due to neglect and abandonment by their owners. These dogs, primarily hounds, have increasingly become a burden on animal shelters and have cast a negative light on hunting with dogs, particularly in Virginia. The difficulty in identifying the owners of these dogs has stymied law enforcement and animal welfare authorities for years. Mandatory microchipping, now compulsory in England, may be the key to protecting talented working dogs from neglect, cruelty and abandonment by uncaring owners. These microchips can allow abandoned animals to lead ...


The Controversy Of Sunscreen Ingredients: Examining The Relationship Between Oxybenzone And Butylparaben On Stylophorum Pistillata, Brian K. Lee, Natalia Corvalan, Jae Z. Saraum 2018 Northern Virginia Community College, Annandale Campus

The Controversy Of Sunscreen Ingredients: Examining The Relationship Between Oxybenzone And Butylparaben On Stylophorum Pistillata, Brian K. Lee, Natalia Corvalan, Jae Z. Saraum

Exigence

Abstract

The basis of this proposal is to understand the relationship between select UV filters and coral bleaching and provide a framework for additional research. Coral reefs are home to a diversity of marine life and are keystones to major coastal economies around the world. Oxybenzone and butylparaben are major ingredients found in sunscreen that induces coral bleaching to major coral reefs. To alleviate the negative effects, this proposal will attempt to better understand how oxybenzone and butylparaben facilitates coral bleaching and develop an effective and environmentally fair sunscreen. The research proposed will be funded by donors to cover research ...


Remote Sensing Of Seasonal Changes And Disturbances In Mangrove Forest: A Case Study From South Florida, Keqi Zhang, Bina Thapa, Michael S. Ross, Daniel Gann 2018 International Hurricane Research Center and Department of Earth and Environment, Florida International University

Remote Sensing Of Seasonal Changes And Disturbances In Mangrove Forest: A Case Study From South Florida, Keqi Zhang, Bina Thapa, Michael S. Ross, Daniel Gann

Daniel Gann

Knowledge of the spatial and temporal changes caused by episodic disturbances and seasonal variability is essential for understanding the dynamics of mangrove forests at the landscape scale, and for building a baseline that allows detection of the effects of future environmental change. In combination with LiDAR data, we calculated four vegetation indices from 150 Landsat TM images from 1985 to 2011 in order to detect seasonal changes and distinguish them from disturbances due to hurricanes and chilling events in a mangrove-dominated coastal landscape. We found that normalized difference moisture index (NDMI) performed best in identifying both seasonal and event-driven episodic ...


Arthropod Fauna Associated With Wild And Cultivated Cranberries In Wisconsin, Shawn A. Steffan, Merritt E. Singleton, Michael L. Draney, Elissa M. Chasen, Kyle E. Johnson, Juan E. Zalapa 2018 USDA, Agricultural Research Service

Arthropod Fauna Associated With Wild And Cultivated Cranberries In Wisconsin, Shawn A. Steffan, Merritt E. Singleton, Michael L. Draney, Elissa M. Chasen, Kyle E. Johnson, Juan E. Zalapa

The Great Lakes Entomologist

The cranberry (Vaccinium macrocarpon Aiton) is an evergreen, trailing shrub native to North American peatlands. It is cultivated commercially in the US and Canada, with major production centers in Wisconsin, Massachusetts, New Jersey, Washington, Québec, and British Columbia. Despite the agricultural importance of cranberry in Wisconsin, relatively little is known of its arthropod associates, particularly the arachnid fauna. Here we report preliminary data on the insect and spider communities associated with wild and cultivated cranberries in Wisconsin. We then compare the insect and spider communities of wild cranberry systems to those of cultivated cranberries, indexed by region. Approximately 7,400 ...


Leptinotarsa Decemlineata (Coleoptera: Chrysomelidae) Observed Feeding On Chamaesaracha Sp. In Eastern Colorado., Michael S. Crossley, Benjamin Pélissié, Zachary Cohen, Sean D. Schoville 2018 University of Wisconsin-Madison

Leptinotarsa Decemlineata (Coleoptera: Chrysomelidae) Observed Feeding On Chamaesaracha Sp. In Eastern Colorado., Michael S. Crossley, Benjamin Pélissié, Zachary Cohen, Sean D. Schoville

The Great Lakes Entomologist

Egg, larval, and adult life stages of Colorado potato beetle, Leptinotarsa decemlineata (Say), were observed feeding on or attached to a previously undocumented host plant belonging to the genus Chamaesaracha in eastern Colorado on July 2017. At one site, L. decemlineata were more abundant on Chamaesaracha sp. than the accepted ancestral host plant, Solanum rostratum (Dunal). While future studies should confirm the ancestral status of the observed L. decemlineata and suitability of Chamaesaracha sp. for completion of development, our observations suggest a need for further characterization of the ancestral host range of L. decemlineata.


The Ability Of Specific-Wavelength Led Lights To Attract Night-Flying Insects, David Houghton, Ryan S. Zemel 2018 Hillsdale College

The Ability Of Specific-Wavelength Led Lights To Attract Night-Flying Insects, David Houghton, Ryan S. Zemel

The Great Lakes Entomologist

This paper describes a portable collecting light, designed by the authors, that weighs 0.3 kg, is powered by 8 AA batteries, and uses 9 light-emitting diodes (LEDs) to attract night-flying insects. Five different wavelengths of these LED lights, all within the long-wave ultraviolet spectrum, were compared to each other and to a commercially-available 15w fluorescent ultraviolet tube light for their abilities to collect insects over a series of 5 nights in July 2016. There was no difference in order richness, total specimen abundance, or the specimen abundance of most common orders between any of the wavelengths tested. Most LED ...


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