The Dangers Of Fat Metabolism And Pufa: Why You Don’T Want To Be A Fat Burner, 2017 Rutgers University - New Brunswick/Piscataway
The Dangers Of Fat Metabolism And Pufa: Why You Don’T Want To Be A Fat Burner, Kyle J. Mamounis
Journal of Evolution and Health
No abstract provided.
Public Perceptions Of Genetically Engineered Foods: Playing God Or Trusting Science, 2017 University of New Hampshire
Public Perceptions Of Genetically Engineered Foods: Playing God Or Trusting Science, Michael D. Mehta
RISK: Health, Safety & Environment
The author considers whether levels of religiosity or scientism affect public perceptions of genetically engineered foods.
Press-Pulse: A Novel Therapeutic Strategy For The Metabolic Management Of Cancer, 2017 George Washington University
Press-Pulse: A Novel Therapeutic Strategy For The Metabolic Management Of Cancer, Thomas Seyfried, George Yu, Joseph Maroon, Dominic D'Agostino
Urology Faculty Publications
A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneous occurrence of “Press-Pulse” disturbances was considered the mechanism responsible for reduction of organic populations during prior evolutionary epochs. Press disturbances produce chronic stress, while pulse disturbances produce acute stress on populations. It was only when both disturbances coincide that population reduction occurred.
This general concept can be applied to the management of cancer by creating chronic metabolic stresses on tumor cell energy metabolism (press disturbance ...
Association Between Energy Balance And Metabolic Hormone Suppression During Ultra-Endurance Exercise, 2017 German Sport University, Cologne, Germany
Association Between Energy Balance And Metabolic Hormone Suppression During Ultra-Endurance Exercise, Bjoern Geesmann, Jenna C. Gibbs, Joachim Mester, Karsten Koehler
Nutrition and Health Sciences -- Faculty Publications
Ultra-endurance athletes often accumulate an energy deficit when engaging in ultra-endurance exercise, and upon completion of the exercise, they exhibit endocrine changes that are reminiscent of starvation. However, it remains unclear whether these endocrine changes are a result of the exercise per se or secondary to the energy deficit, and more importantly, whether these changes can be attenuated by increased dietary intake. Our goal was to assess the relationship between changes in key metabolic hormones following ultra-endurance exercise and measures of energy balance. Metabolic hormones as well as energy intake and expenditure were assessed in 14 well-trained male cyclists who ...
3-Hydroxy Fatty Acid Induce Trophoblast And Hepatocyte Lipoapoptosis, 2016 University of Nebraska Lincoln
3-Hydroxy Fatty Acid Induce Trophoblast And Hepatocyte Lipoapoptosis, Taylor Bruett, Taylor Heng, Sathish Kumar Natarajan
UCARE Research Products
Acute Fatty Liver of Pregnancy (AFLP) is a very rare and fatal condition for both the mother and the unborn offspring accompanied by severe maternal liver dysfunction. AFLP usually develops during the third trimester of pregnancy with symptoms of liver disease. AFLP is associated with a mutation in the enzyme, long-chain 3-hydroxy acyl CoA dehydrogenase (LCHAD) which is involved in the mitochondrial beta-oxidation of fatty acids. Defective beta-oxidation of fatty acids results in the individual unable to metabolize fatty acids which then causes fatty infiltration in their organs, such as the liver. This interferes with normal function of the liver ...
Long-Term Treatment With Insulin And Retinoic Acid Increased Glucose Usage In L6 Muscle Cells Via Glycogenesis, 2016 University of Tennessee, Knoxville
Long-Term Treatment With Insulin And Retinoic Acid Increased Glucose Usage In L6 Muscle Cells Via Glycogenesis, Matthew Ray Goff
Skeletal muscle glucose metabolism can affect whole body glucose homeostasis significantly. Vitamin A (VA) plays a role in a number of physiological functions including glucose metabolism. However, its role in skeletal muscle glucose metabolism has not been well established. Insulin controls glucose metabolism in the skeletal muscle via the regulations of glucose uptake, glycogenesis, and glycolysis. We hypothesize that insulin and VA signaling pathways may converge to regulate glucose metabolism in skeletal muscle. Here, the effects of retinoic acid (RA) alone and in combination with insulin on glucose utilization in rat L6 muscle cells were studied. L6 cells were treated ...
Mechanism Of Triglyceride Lowering Action Of Akkermansia Muciniphila And Fenugreek In A Genetic Induced Hyperlipidemia, 2016 University of Nebraska-Lincoln
Mechanism Of Triglyceride Lowering Action Of Akkermansia Muciniphila And Fenugreek In A Genetic Induced Hyperlipidemia, Jing Shen
Nutrition & Health Sciences Dissertations & Theses
Hyperlipidemia is a condition of abnormally elevated levels of lipids and/or lipoproteins in the blood circulation. It is usually accompanied with obesity, type 2 diabetes, insulin resistance, hypertension and non-alcoholic fatty liver diseases (NAFLD) and has become a great threat to human health. New therapeutic strategies are needed for the prevention and treatment of both genetic intervention-induced hyperlipidemia and environmentally induced hyperlipidemia. In this study, we determined the therapeutic effects of a diseaseprotecting gut bacteria, Akkermansia muciniphila, and an annual legume, fenugreek, on hypertriglyceridemia induced by genetic depletion of cAMP responsive binding protein H (CREBH KO) in mice. We ...
Nutrigenomics Study In Atlantic Salmon (Salmo Salar) Fed Novel Diets Supplemented With Marine By-Products, 2016 Fisheries and Oceans Canada
Nutrigenomics Study In Atlantic Salmon (Salmo Salar) Fed Novel Diets Supplemented With Marine By-Products, Nellie Gagné
2nd International Conference of Fish & Shellfish Immunology
No abstract provided.
Delta Tocotrienol Attenuates Nlrp3 Inflammasome Activation Via Inhibition Of Nf-Κb Priming And Reactive Oxygen Species Generation, 2016 University of Nebraska-Lincoln
Delta Tocotrienol Attenuates Nlrp3 Inflammasome Activation Via Inhibition Of Nf-Κb Priming And Reactive Oxygen Species Generation, Teresa Buckner
Public Access Theses and Dissertations from the College of Education and Human Sciences
Chronic, low-grade inflammation during obesity is associated with the development of metabolic dysfunction. The NLRP3 inflammasome is assembled in response to cellular stressors and leads to cytotoxic cytokines IL-1β and IL-18 production, which implicates the NLRP3 inflammasome in inflammatory conditions, including type 2 diabetes. Tocotrienols are antioxidant and anti-inflammatory forms of vitamin E. Delta-tocotrienol (dT3) displays NF-κB inhibitory and anti-oxidant abilities, and is easily isolated from the Annatto plant. My primary aim was to determine whether dT3 inhibits NLRP3 inflammasome activation and to compare the extent to which dT3 inhibits NLRP3 inflammasome with other tocotrienol forms, i.e. alpha-tocotrienol (aT3 ...
Characterization Of Extraction Methods To Recover Phenolic-Rich Extracts From Black Beans (Phaseolus Vulgaris) That Inhibit Alpha-Amylase And Alpha-Glucosidase Using Response Surface Approaches, 2016 University of Nebraska-Lincoln
Characterization Of Extraction Methods To Recover Phenolic-Rich Extracts From Black Beans (Phaseolus Vulgaris) That Inhibit Alpha-Amylase And Alpha-Glucosidase Using Response Surface Approaches, Mazen Alharbi
Nutrition & Health Sciences Dissertations & Theses
Black beans contain high phenolic contents that are considered potent antioxidants. Relatively little is known about their ability to inhibit the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase from releasing glucose from starch and/or disaccharides. The objective of this project was to determine the optimum procedures for extracting total phenols (TP), total flavonoids (TF) and total condensed tannins (TCT) from black beans (Phaseolus vulgaris), and then to determine the ability of the phenolic rich extracts to inhibit α-amylase and α-glucosidase. Due to their high phenolic levels, it was hypothesized that black beans would be an effective inhibitor of α-amylase and α-glucosidase ...
Programming Heart Disease: Does Poor Maternal Nutrition Alter Expression Of Cardiac Markers Of Proliferation, Hypertrophy, And Fibrosis In Offspring?, Cathy Chun
Honors Scholar Theses
Maternal malnutrition can affect fetal organogenesis, metabolic processes, and factors involved in developmental regulation. Of the many physiological effects poor maternal nutrition can induce in offspring, one of the most important organs affected is the heart. Cardiovascular disease has been associated with poor maternal diet. It also been suggested that hypertension can originate during impaired intrauterine growth and development. Hypertension can trigger hypertensive heart disease and is associated with numerous heart complications. We hypothesized that poor maternal nutrition would alter critical growth factors associated with normal heart development, specifically, insulin-like growth factor (IGF)-1, IGF-2, transforming growth factor (TGF)β ...
The Effect Of Protein Quantity And Quality At Breakfast On Energy Metabolism, Appetite And Metabolic Health, 2016 University of Arkansas, Fayetteville
The Effect Of Protein Quantity And Quality At Breakfast On Energy Metabolism, Appetite And Metabolic Health, Brianna Lynne Neumann
Theses and Dissertations
Obesity is a global health concern and, within the United States, the current obesity rate is 36% and projected to double within the next two decades. Obesity is linked to many chronic diseases such as cancer, heart disease and type 2 diabetes. In young females, weight gain (5-11 kg) between the ages of 20-30 years increases the risk of developing type 2 diabetes and cardiovascular disorders later in life. The cause of obesity is multifactorial in nature, however fundamentally weight gain occurs when energy intake is greater than energy expended (i.e. calories in > calories out). Therefore, identifying and validating ...
Examining Maternal Obesity Effects On Oogenesis, Follicular Development, And Embryonic Myogenesis, 2016 University of Nebraska-Lincoln
Examining Maternal Obesity Effects On Oogenesis, Follicular Development, And Embryonic Myogenesis, Chris Lindeman, Jennifer Wood
UCARE Research Products
The CDC estimates that more than one-third of U.S. adults (approximately 78.6 million) are obese. Despite national efforts to combat this with diet and exercise, the number of obese adults and children continues to climb. It is critical to emphasize that obesity can lead to lifelong, chronic complications and health risks including hypertension, heart disease, and diabetes.
Diet and obesity also have important impacts on the reproductive health of female including the ability to become pregnant (fertility) and risk for complications during pregnancy. Furthermore, for women who do become pregnant, obesity can affect the development of the embryo ...
The Impact Of Depleting Dietary Microrna In A High-Fat Diet, 2016 University of Nebraska-Lincoln
The Impact Of Depleting Dietary Microrna In A High-Fat Diet, Briley Moates, Sonia Manca, Janos Zempleni
UCARE Research Products
We tested the hypothesis that a highfat diet would increase the difference in body weight between C57BL/6J mice provided dietary microRNA (Exo +) and mice which were fed the same diet depleted of microRNA (Exo-).
• The data demonstrate that depleting miRNAs from a high-fat diet does not impact the difference in body weight between Exo+ and Exo- subjects. • Depleting dietary miRNAs from normal low-fat diets do result in differences in body weight, fat, fecundity, purine metabolism, and gut microbiome.
Role Of Acetyl-Coa Synthetase 2 And Acetyl-Coa Precursors, Acetate And Ethanol, On Hepatocyte Gene Expression, 2016 University of Nebraska - Lincoln
Role Of Acetyl-Coa Synthetase 2 And Acetyl-Coa Precursors, Acetate And Ethanol, On Hepatocyte Gene Expression, Noel Bruner, Anjeza Erickson,, Mengna Xia, Bo He, Regis Moreau
UCARE Research Products
Abnormally high blood and tissue lipid levels observed in metabolic disorders and cardiovascular diseases are associated with extensive gene expression changes. Gene expression is modulated by epigenetic mechanisms, which include modifications of DNA-bound protein histones without alteration of DNA sequence. Histone hyperacetylation is observed in the setting of metabolic disorders but the causes have not been described in any detail. We know that histone acetylation is positively correlated with the abundance of acetyl-coenzyme A. This study tests the hypothesis that acetyl-coenzyme A metabolizing enzyme acetyl-coenzyme A synthetase 2 (ACSS2, cytoplasmic, aka AceCS1) impacts liver function through histone acetylation, and that ...
Biotechnology And The Law: A Consideration Of Intellectual Property Rights And Related Social Issues, 2016 University of Saskatchewan, Saskatoon, Canada
Biotechnology And The Law: A Consideration Of Intellectual Property Rights And Related Social Issues, Michael D. Mehta
University of New Hampshire Law Review
[Excerpt] "Recent advances in biotechnology are expected by many to improve crop yield, reduce reliance on agricultural inputs like pesticides and herbicides, alleviate world hunger, improve the safety and effectiveness of pharmaceuticals, assist in the discovery of genes that trigger diseases like cancer, and make more efficient our legal institutions through DNA testing. Clearly, innovations in biotechnology are a powerful force for social change, and they pose unique challenges and opportunities for legal scholars and institutions. This section of the Pierce Law Review focuses on the interface between law and technology by examining how innovations in biotechnology accelerate debates about ...
Effect Of Green Tea On Interaction Of Lipid Oxidation Products With Sarcoplasmic And Myofibrillar Protein Homogenates Extracted From Bovine Top Round Muscle, 2016 California State University - Northridge
Effect Of Green Tea On Interaction Of Lipid Oxidation Products With Sarcoplasmic And Myofibrillar Protein Homogenates Extracted From Bovine Top Round Muscle, Nahathai Stapornkul, Tatiana Prytkova, Lilian Were
Food Science Faculty Articles and Research
The interaction between lipid oxidation products and bovine sarcoplasmic (SP) and myofibrillar protein (MP) homogenates in the presence of green tea was investigated. To monitor the effect of green tea on lipid oxidation, aldehydes were measured while effect on protein was monitored via changes in myoglobin, thiols, and tryptophan fluorescence over nine days of refrigerated storage. The presence of SP and MP decreased free aldehydes in the buffers. The SP bound more aldehydes than MP. The tea compounds exhibited more favorable binding energies than aldehydes near histidine 64 close to the heme moiety of myoglobin. Addition of tea lowered tryptophan ...
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, 2016 University of Kentucky
The Role Of Pxr And Ikkβ Signaling In Cardiometabolic Disease, Robert N. Helsley
Theses and Dissertations--Pharmacology and Nutritional Sciences
Cardiovascular disease (CVD) is the leading cause of death worldwide and is partially attributed to perturbations in lipid metabolism. Xenobiotics, such as pharmaceutical drugs and environmental chemicals, have been associated with increased risk of CVD in multiple large-scale human population studies, but the underlying mechanisms remain poorly defined. We and others have identified several xenobiotics as potent agonists for the pregnane X receptor (PXR), a nuclear receptor that can be activated by numerous drugs as well as environmental and dietary chemicals. However, the role of PXR in mediating the pathophysiological effects of xenobiotic exposure in humans and animals remains elusive ...
Sudden Cardiac Death In Infants, Children And Young Adults: Possible Roles Of Dietary Magnesium Intake And Generation Of Platelet-Activating Factor In Coronary Arteries, 2016 Touro College of Osteopathic Medicine (Middletown)
Sudden Cardiac Death In Infants, Children And Young Adults: Possible Roles Of Dietary Magnesium Intake And Generation Of Platelet-Activating Factor In Coronary Arteries, Burton M. Altura, Wenyan Li, Aimin Zhang, Tao Zheng, Nilank C. Shah, Gatha J. Shah, Bella T. Altura
School of Health Sciences Publications and Research
Magnesium (Mg) is a co-factor for more than 500 enzymes, and is the second most abundant intracellular cation after potassium. It is vital in numerous physiological, cellular and biochemical functions and systems necessary for life. Approximately 35 years ago, our laboratory suggested that a progressive, dietary deficiency and/or metabolic induced loss of Mg from the body, beginning early in life, particularly during development of the coronary arteries, could lead to coronary arterial vasospasm, ischemic heart disease, and sudden-cardiac death (SCD). Herein, we review evidence for a brand-new, novel hypothesis which combines knowledge suggesting a combined role for hypomagnesemia and ...
Potential Roles Of Magnesium Deficiency In Inflammation And Atherogenesis: Importance And Cross-Talk Of Platelet-Activating Factor And Ceramide, 2016 Touro College of Osteopathic Medicine (MIddletown)
Potential Roles Of Magnesium Deficiency In Inflammation And Atherogenesis: Importance And Cross-Talk Of Platelet-Activating Factor And Ceramide, Burton M. Altura, Asefa Gebrewold, Nilank C. Shah, Gatha J. Shah, Bella T. Altura
School of Health Sciences Publications and Research
Epidemiologic studies in North America and Europe have shown that people consuming Western-type diets are low in magnesium (Mg) content (i.e., < 30 - 65% of the RDA for Mg); most such diets in the USA show that 60 - 80% of Americans are consuming only 185 - 235 mg/day of Mg. Low Mg content in areas of soft-water, and Mg-poor soil, is associated with high incidences of ischemic heart disease (IHD), coronary artery disease, hypertension, and sudden cardiac death (SCD). It is clear that the leading underlying cause of death worldwide is atherosclerosis. Importantly, both animal and human studies have shown an inverse relationship between dietary intake of Mg and atherosclerosis. The myocardial level of Mg has consistently been observed to be lower in subjects dying from IHD and SCD in soft-water areas than those in hard-water areas. Over the past 20 years, our laboratories, using several types of primary cultured vascular smooth muscle (VSM) cells, and myocardial cells, demonstrated that declining levels of extracellular Mg ([Mg2+]0) activated several enzymatic pathways to produce increases in cellular sphingolipids, particularly ceramides which are known to exert numerous types of cardiovascular manifestations including inflammatory effects; the latter play important roles in atherogenesis and cardiovascular diseases. Approximately 20 years ago, we reported that low [Mg2+]0 caused formation of platelet-activating factor (PAF) as well as other types of PAF-like molecules and suggested that these molecules might be causative agents in low Mg2+- induced IHD and SCD. Herein, we review results and data from our labs which strongly support roles for ceramides, PAF and PAF-like lipids in low [Mg2+]0-induced IHD and SCD.