A Controversial New Hope: Exploring Recent Advancements In Alzheimer’S Disease Treatment, 2022 Kenyon College
A Controversial New Hope: Exploring Recent Advancements In Alzheimer’S Disease Treatment, Lauren Limbach
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Exercise Can Give Us Brain-Boosting Superpowers?, 2022 Kenyon College
Exercise Can Give Us Brain-Boosting Superpowers?, Selam Habtemariam
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Consciousness: Our Most Basic State Is More Complicated Than You Think!, 2022 Kenyon College
Consciousness: Our Most Basic State Is More Complicated Than You Think!, Alyssa Dowling
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Are You Depressed? Or Are You Just On Birth Control..., 2022 Kenyon College
Are You Depressed? Or Are You Just On Birth Control..., Olive Cowan
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
How The Bacteria In Your Gut May Calm The Butterflies In Your Stomach, 2022 Kenyon College
How The Bacteria In Your Gut May Calm The Butterflies In Your Stomach, Hailey Naiper
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Short Term Cravings, Long Term Effects: A Call For More Comprehensive Alcohol Education, 2022 Kenyon College
Short Term Cravings, Long Term Effects: A Call For More Comprehensive Alcohol Education, Madde Hyland
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Your Mind’S Eye: Metaphor Or Reality? An Exploration Of The Varieties Of Visual Imagery, 2022 Kenyon College
Your Mind’S Eye: Metaphor Or Reality? An Exploration Of The Varieties Of Visual Imagery, Alia Korot
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
I Feel Your Pain, Do You Feel Mine?, 2022 Kenyon College
I Feel Your Pain, Do You Feel Mine?, Lucy Friedberg
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
In 500 Feet, Turn Right Onto Memory Lane: How Our Brains Create Maps Of Our Memories, 2022 Kenyon College
In 500 Feet, Turn Right Onto Memory Lane: How Our Brains Create Maps Of Our Memories, Sofia Alonso
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Scientific Kenyon: Neuroscience Edition (Full Issue), 2022 Kenyon College
Scientific Kenyon: Neuroscience Edition (Full Issue)
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Mice Lacking Full Length Adgrb1 (Bai1) Exhibit Social Deficits, Increased Seizure Susceptibility, And Altered Brain Development, 2022 Emory University School of Medicine
Mice Lacking Full Length Adgrb1 (Bai1) Exhibit Social Deficits, Increased Seizure Susceptibility, And Altered Brain Development, Fu Hung Shiu, Jennifer C. Wong, Takahiro Yamamoto, Trisha Lala, Ryan H. Purcell, Sharon Owino, Dan Zhu, Erwin G. Van Meir, Randy A. Hall, Andrew Escayg
Neuroscience: Faculty Publications
The adhesion G protein-coupled receptor BAI1/ADGRB1 plays an important role in suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor. BAI1 is also a critical regulator of dendritic spine and excitatory synapse development and interacts with several autism-relevant proteins. However, little is known about the relationship between altered BAI1 function and clinically relevant phenotypes. Therefore, we studied the effect of reduced expression of full length Bai1 on behavior, seizure susceptibility, and brain morphology in Adgrb1 mutant mice. We compared homozygous (Adgrb1−/−), heterozygous (Adgrb1+/−), and wild-type (WT) littermates using a battery of tests to assess social behavior, anxiety, repetitive …
The Effect Of Cognitive Status And Residency On Oral Health In Patients With Dementia, 2022 The Texas Medical Center Library
The Effect Of Cognitive Status And Residency On Oral Health In Patients With Dementia, Nicole Stephens
Dissertations & Theses (Open Access)
Poor oral health is a predictor of cognitive decline in elderly populations and has been shown to precede dementia. As cognitive decline progresses, patients are likely to move from the community into nursing facilities. We hypothesize that severity of dementia and residency type will impact the oral health of patients with dementia. Fifty-two participants of two dementia levels were recruited from the UTHealth Neurocognitive Disorders Center and two Houston-area nursing homes. A standardized oral health assessment, plaque index, and oral bacteria analysis determined participants’ oral health status. Further, data was collected on participants’ medical history, oral hygiene habits, dietary habits, …
Sex And Age Differences In Approach Behavior Toward A Port That Delivers Nicotine Vapor, 2022 The University of Texas at El Paso
Sex And Age Differences In Approach Behavior Toward A Port That Delivers Nicotine Vapor, Veronika Evangelina Espinoza
Open Access Theses & Dissertations
The goal of our laboratory is to study the mechanisms that promote nicotine use, particularly in vulnerable populations such as adolescents and females. Thus, the purpose of this thesis was to characterize age and sex differences in the motivational/rewarding effects of nicotine (Aim 1) and withdrawal behavior (Aim 2). To more closely model human use patterns, the present study employed nicotine vapor methods involving passive exposure for 14 days in adolescent and adult female and male rats. Age and sex differences in approach behavior (nosepokes) were assessed in a port that delivered nicotine plumes on Day 1 and 14. Controls …
The Cognitive & Educational Implications Of Color Use In Drawing To Learn, 2022 William & Mary
The Cognitive & Educational Implications Of Color Use In Drawing To Learn, Juliana F.M. Cantarutti
Undergraduate Honors Theses
Drawing to Learn (D2L) is a learning aid that encourages STEM students to interact with abstract concepts in STEM by sketching. D2L is not an intuitive skill, and researchers strive to provide students with guidelines on how to master this method. One potential way to enhance the D2L method for students is by incorporation of visual cues, specifically color. While many students choose to incorporate color into their models without explicit instruction to do so, we have found no research on: a) why students use color in sketching, b) its effects on D2L. This study used interviews, surveys, and course …
Scale-Free Behavioral Dynamics Directly Linked With Scale-Free Cortical Dynamics, 2022 University of Arkansas, Fayetteville
Scale-Free Behavioral Dynamics Directly Linked With Scale-Free Cortical Dynamics, Sabrina Jones
Physics Undergraduate Honors Theses
In organisms, an interesting phenomenon occurs in both behavior and neuronal activity: organization with fractal, scale-free fluctuations over multiple spatiotemporal orders of magnitude (1,2). In regard to behavior, this sort of complex structure-- which manifests itself from small scale fidgeting to purposeful, full body movements-- may support goals such as foraging (3-6), visual search (4), and decision making (7,8). Likewise, the presence of this sort of structure in the cerebral cortex in the form of spatiotemporal cascades, coined “neuronal avalanches,” may offer optimal information transfer (9). Thus, when considering the functional relationship between the cerebral cortex and movements of the …
Ongoing Calculus In The Cerebral Cortex, 2022 University of Arkansas, Fayetteville
Ongoing Calculus In The Cerebral Cortex, Luke Long
Physics Undergraduate Honors Theses
Various modes of neuronal computations have long been theorized to be possible based on the structure and geometry of the brain. These computations also seem necessary for many of the integral functions of the brain, like information processing and regulatory processes in the body. However, experimental data directly supporting these claims have been rare.
In this study, data collected in mice from a large number of neurons over a long period of time provided the opportunity to search for some of these computations, specifically change detection and squaring calculations. Using Matlab, the goal of this analysis was to find statistically …
Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis, 2022 The Texas Medical Center Library
Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis, Blake Mcalpin
Dissertations & Theses (Open Access)
One in 8 women in the US will be diagnosed with breast cancer. Currently, doxorubicin is one of the most effective chemotherapies for breast cancer. Unfortunately, up to 60% of survivors report long-term chemotherapy-induced cognitive dysfunction (CICD) characterized by deficits in working memory, processing speed, and executive functioning. Currently, no interventions for CICD have been approved by the US Food and Drug Administration. I show here that a 14-day treatment with a blood-brain barrier permeable histone deacetylase 6 (HDAC6) inhibitor successfully reverses long-term CICD following a therapeutic doxorubicin dosing schedule in female mice, as assessed by the puzzle box test …
Impact Of Brain State On Visual And Prefrontal Population Coding In Behaving Animals, 2022 The Texas Medical Center Library
Impact Of Brain State On Visual And Prefrontal Population Coding In Behaving Animals, Russell Milton
Dissertations & Theses (Open Access)
Patterns of neural activity in the brain constantly shift between different processing states. Earlier studies have established that the ongoing, spontaneous activity has major repercussions regarding how the brain processes incoming sensory stimuli. However, the interaction between behavioral activity and brain states throughout the cortical hierarchy of primates has not been understood. In particular, technical considerations have greatly limited the range of physical activities in which primate neuronal activity can be recorded. We have implemented two separate strategies to overcome these limitations. First, we have advanced wireless electrophysiological methodologies that enable recording high-yield neuronal data from animals as they freely …
Vitamin D And Its In Vitro Therapeutic Action Mediated Through Vdr Rather Than Pdia3, 2022 East Tennessee State University
Vitamin D And Its In Vitro Therapeutic Action Mediated Through Vdr Rather Than Pdia3, Jaeden Pyburn
Undergraduate Honors Theses
Brain calcification is a common occurrence in the aging process, with >20% of individuals over the age of 65 showing hardened plaques in the basal ganglia. Loss of the vitamin D receptor (VDR) in transgenic mice leads to formation of calcified plaques in the basal ganglia and thalamus within the mice. Vitamin D signals through two known vitamin D responsive proteins, protein disulfide isomerase A3 (PDIA3) and VDR. In vitro, vitamin D has been demonstrated to suppress calcification in osteoblast-like cells. Here, we aim to elucidate which of either PDIA3 or VDR transduce vitamin D mediated suppression of calcification in …
Defining The Role Of Locus Coeruleus Noradrenergic Neurons In The Modulation Of Homeostatic Feeding, 2022 University of Connecticut
Defining The Role Of Locus Coeruleus Noradrenergic Neurons In The Modulation Of Homeostatic Feeding, Julia Paul
Honors Scholar Theses
The locus coeruleus (LC) is a hindbrain structure that is the major source of norepinephrine (NE) input to the cortex and other forebrain areas. It is involved in processes of arousal, attention, and stress. It has been shown that the locus coeruleus norepinephrine system is also involved in the modulation of feeding. In this experiment, we used triple transgenic mice expressing the hM3Dq receptor in LC-NE neurons. These mice and littermate controls were overnight fasted then injected with vehicle or deschloroclozapine (DCZ), which is an inert ligand that solely activates the designer hM3Dq receptor. The mice were then immediately placed …