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Possible Regulatory Effects Of Coalition Computations On The Mu Rhythm, Kyle Timothy Gagnon 2010 College of William & Mary - Arts & Sciences

Possible Regulatory Effects Of Coalition Computations On The Mu Rhythm, Kyle Timothy Gagnon

Dissertations, Theses, and Masters Projects

No abstract provided.


Perception Of Emotion In Sounded And Imagined Music, B.L. Lucas, E. Schubert, Andrea Halpern 2010 Bucknell University

Perception Of Emotion In Sounded And Imagined Music, B.L. Lucas, E. Schubert, Andrea Halpern

Faculty Journal Articles

WE STUDIED THE EMOTIONAL RESPONSES BY MUSICIANS to familiar classical music excerpts both when the music was sounded, and when it was imagined.We used continuous response methodology to record response profiles for the dimensions of valence and arousal simultaneously and then on the single dimension of emotionality. The response profiles were compared using cross-correlation analysis, and an analysis of responses to musical feature turning points, which isolate instances of change in musical features thought to influence valence and arousal responses. We found strong similarity between the use of an emotionality arousal scale across the stimuli, regardless of condition (imagined ...


Memory For Melodies, Andrea Halpern, J.C. Bartlett 2010 Bucknell University

Memory For Melodies, Andrea Halpern, J.C. Bartlett

Faculty Contributions to Books

No abstract provided.


Mental Reversal Of Imagined Melodies: A Role For The Posterior Parietal Cortex, R.J. Zatorre, Andrea Halpern, M. Bouffard 2010 Bucknell University

Mental Reversal Of Imagined Melodies: A Role For The Posterior Parietal Cortex, R.J. Zatorre, Andrea Halpern, M. Bouffard

Faculty Journal Articles

Two fMRI experiments explored the neural substrates of a musical imagery task that required manipulation of the imagined sounds: temporal reversal of a melody. Musicians were presented with the first few notes of a familiar tune (Experiment 1) or its title (Experiment 2), followed by a string of notes that was either an exact or an inexact reversal. The task was to judge whether the second string was correct or not by mentally reversing all its notes, thus requiring both maintenance and manipulation of the represented string. Both experiments showed considerable activation of the superior parietal lobe (intraparietal sulcus) during ...


Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto P. Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert G. Struble 2010 Eastern Illinois University

Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto P. Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert G. Struble

Faculty Research & Creative Activity

ApoE, a protein component of lipoproteins, is extensively expressed in the primary olfactory pathway. Because apoE has been shown to play a vital role in nerve repair and remodeling, we hypothesized that apoE expression will increase in the injured olfactory epithelium (OE), and that apoE deficiency in apoE knockout (KO) mice will lead to delayed/incomplete reconstitution of the OE following injury. To directly test this hypothesis, we compared OE regeneration in wild-type (WT) and KO mice following injury induced by intranasal irrigation of Triton X-100. OE was collected at 0, 3, 7, 21, 42, and 56 days post lesion ...


Lost In Translation?: An Essay On Law And Neuroscience, Stephen J. Morse 2010 University of Pennsylvania

Lost In Translation?: An Essay On Law And Neuroscience, Stephen J. Morse

Faculty Scholarship at Penn Law

The rapid expansion in neuroscientific research fuelled by the advent of functional magnetic resonance imaging [fMRI] has been accompanied by popular and scholarly commentary suggesting that neuroscience may substantially alter, and perhaps will even revolutionize, both law and morality. This essay, a contribution to, Law and Neuroscience (M. Freeman, Ed. 2011), will attempt to put such claims in perspective and to consider how properly to think about the relation between law and neuroscience. The overarching thesis is that neuroscience may indeed make some contributions to legal doctrine, practice and theory, but such contributions will be few and modest for the ...


Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert Struble 2010 Eastern Illinois University

Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert Struble

Faculty Research & Creative Activity

ApoE, a protein component of lipoproteins, is extensively expressed in the primary olfactory pathway. Because apoE has been shown to play a vital role in nerve repair and remodeling, we hypothesized that apoE expression will increase in the injured olfactory epithelium (OE), and that apoE deficiency in apoE knockout (KO) mice will lead to delayed/incomplete reconstitution of the OE following injury. To directly test this hypothesis, we compared OE regeneration in wild-type (WT) and KO mice following injury induced by intranasal irrigation of Triton X-100. OE was collected at 0, 3, 7, 21, 42, and 56 days post lesion ...


Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors, Todd Brendon Francis 2010 Wayne State University

Metabolic Targeting Of Malignant Glioma: Modulation Of Glycolytic Flux By Erythropoietic Factors, Todd Brendon Francis

Wayne State University Dissertations

Introduction: Malignant glioma display a highly glycolytic phenotype where the tumors flux glucose to lactic acid independent of oxygen concentration ("aerobic glycolysis"). This altered phenotype is facilitated by expression of primarily fetal enzyme isoforms in these malignant tumors. The end-product lactic acid is rapidly expelled from the cytosol by selective monocarboxylate transporters expressed on the plasma membrane. GATA response element islands are present on the promoter of glioma lactate transporter genes, and GATA-1 has been shown to be over-expressed in glioblastoma. Our long-term goal is to inhibit glioma proliferation by indirectly down-regulating GATA-1 to inhibit glycolysis. (Colen et al., 2006 ...


Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet 2010 Wayne State University

Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet

Wayne State University Dissertations

Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the posterior ...


The Biology Of Reality Testing - Implications For Cognitive Education, Neil Greenberg 2010 University of Tennessee - Knoxville

The Biology Of Reality Testing - Implications For Cognitive Education, Neil Greenberg

Faculty Publications and Other Works -- Ecology and Evolutionary Biology

• This report explores the proposition that teaching effectiveness can be enhanced by accommodating the key differences between two complementary and deeply engrained modes of reality testing, each predominantly centered in different hemispheres of the brain. • (1) Correspondence involves “reality-testing” of a percept, the cerebral representation of an experience in the world. • (2) Coherence involves “textualizing”, that is, reality-testing of a percept by how easily it relates to previous and ongoing parallel and collateral experiences. • Confidence in the validity of any percept throughout development is related to the interplay of these key processes. • As organisms develop, the “reference base” of previous ...


Expression Of The Periplaneta Americana's Α-Adrenergic-Like Octopamine Receptor In The Yeast Saccharomyces Cerevisiae: A High-Throughput Screening System In Search Of Biorational Insecticides, Aaron Donald Gross 2010 Iowa State University

Expression Of The Periplaneta Americana's Α-Adrenergic-Like Octopamine Receptor In The Yeast Saccharomyces Cerevisiae: A High-Throughput Screening System In Search Of Biorational Insecticides, Aaron Donald Gross

Graduate Theses and Dissertations

The use of conventional synthetic insecticides is facing increased scrutiny due to environmental and mammalian health concerns along with resistance to target insects. This has led to an investigation of alternative control measures to combat both economically and medically important arthropods. Octopamine, a biogenic amine, has significant physiological functions in invertebrates, including insects, and signals through G-protein-coupled receptors (GPCRs). Co-evolution of plants with insects has led to plants adapting defensive mechanisms to deter herbivore, microbial, or viral attack. This is sometimes accomplished via the production of essential oils that are composed of a variety of compounds, in particular monoterpenoids, sesquiterpenoids ...


"The Chills" As A Psychological Response: Affective Composition, Trait Antecedents, And Factor Structure, Laura Anne Maruskin 2010 College of William & Mary - Arts & Sciences

"The Chills" As A Psychological Response: Affective Composition, Trait Antecedents, And Factor Structure, Laura Anne Maruskin

Dissertations, Theses, and Masters Projects

No abstract provided.


Metastability And Plasticity In A Conceptual Model Of Neurons, Bo Deng 2010 University of Nebraska - Lincoln

Metastability And Plasticity In A Conceptual Model Of Neurons, Bo Deng

Faculty Publications, Department of Mathematics

For a new class of neuron models we demonstrate here that typical membrane action potentials and spike-bursts are only transient states but appear to be asymptotically stable; and yet such metastable states are plastic — being able to dynamically change from one action potential to another with different pulse frequencies and from one spike-burst to another with different spike-per-burst numbers. The pulse and spike-burst frequencies change with individual ions’ pump currents while their corresponding metastable-plastic states maintain the same transmembrane voltage and current profiles in range. It is also demonstrated that the plasticity requires two one-way ion pumps operating in opposite ...


Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy 2010 Gettysburg College

Play And Adversity: How The Playful Mammalian Brain Withstands Threats And Anxieties, Stephen M. Siviy

Psychology Faculty Publications

Most mammals play, but they do so in a dangerous world. The dynamic relationship between the stresses created by their world and the activity of play helps to explain the evolution of play in mammals, as the author demonstrates in evidence garnered from experiments that introduce elements of fear to rats at play. The author describes the resulting fearful behavior and quantifies the fluctuation in play that results, and then he investigates how these are modified by increased maternal care or the use of benzodiazepines. In conclusion, he discusses how such research can help shed light on the neurobiology underlying ...


Sleep Well To Stay Safe: Ready For Primetime?, Mihai C. Teodorescu, Mariana Szklo-Coxe 2010 Old Dominion University

Sleep Well To Stay Safe: Ready For Primetime?, Mihai C. Teodorescu, Mariana Szklo-Coxe

Community & Environmental Health Faculty Publications

Commentary on Kling et al. Sleep problems and workplace injuries in Canada. Sleep 2010;33:611-618.


Dopamine D1 Receptor-Mediated Enhancement Of Nmda Receptor Trafficking Requires Rapid Pkc-Dependent Synaptic Insertion In The Prefrontal Neurons, Yan-Chun Li, Gang Liu, Jian-Li Hu, Wen-Jun Gao, Yueqiao Huang 2010 Philadelphia College of Osteopathic Medicine

Dopamine D1 Receptor-Mediated Enhancement Of Nmda Receptor Trafficking Requires Rapid Pkc-Dependent Synaptic Insertion In The Prefrontal Neurons, Yan-Chun Li, Gang Liu, Jian-Li Hu, Wen-Jun Gao, Yueqiao Huang

PCOM Scholarly Papers

Understanding the interaction between dopamine and glutamate, particularly the interaction of dopamine and NMDA receptors, may enable a more rational approach to the treatment of schizophrenia, drug addiction, and other psychiatric disorders. We show that, in prefrontal cortical neurons, dopamine D1-induced enhancement of NMDA receptor function depends on rapid insertion of new NMDA receptor 2B subunits on the synaptic surface. Protein kinase A (PKA) inhibitor, but not protein kinase C (PKC) inhibitor, completely blocked dopamine D1 agonist SKF-81297-induced increase of the total expression of NMDA receptors. Furthermore, SKF-81297 failed to alter the surface expression and synaptic insertion of NMDA receptors ...


Dopamine D1 Receptor-Mediated Nmda Receptor Insertion Depends On Fyn But Not Src Kinase Pathway In Prefrontal Cortical Neurons, Jian-Li Hu, Gang Liu, Yan-Chun Li, Wen-Jun Gao, Yueqiao Huang 2010 Philadelphia College of Osteopathic Medicine

Dopamine D1 Receptor-Mediated Nmda Receptor Insertion Depends On Fyn But Not Src Kinase Pathway In Prefrontal Cortical Neurons, Jian-Li Hu, Gang Liu, Yan-Chun Li, Wen-Jun Gao, Yueqiao Huang

PCOM Scholarly Papers

Background. Interactions between dopamine and glutamate in the prefrontal cortex are essential for cognitive functions such as working memory. Modulation of N-methyl-D-aspartic acid (NMDA) receptor functions by dopamine D1 receptor is believed to play a critical role in these functions. The aim of the work reported here is to explore the signaling pathway underlying D1 receptor-mediated trafficking of NMDA receptors in cultured rat prefrontal cortical neurons. Results. Activation of D1 receptor by selective agonist SKF-81297 significantly increased the expression of NR2B subunits. This effect was completely blocked by small interfering RNA knockdown of Fyn, but not Src. Under control conditions ...


Circadian Wheel-Running Activity During Withdrawal From Chronic Intermittent Ethanol Exposure In Mice, Joseph Seggio 2009 Bridgewater State College

Circadian Wheel-Running Activity During Withdrawal From Chronic Intermittent Ethanol Exposure In Mice, Joseph Seggio

Joseph A. Seggio

Alcohol withdrawal is associated with affective–behavioral disturbances in both human alcoholics and in animal models. In general, these phenomena are potentiated by increased alcohol exposure duration and by prior withdrawal episodes. Previous studies have also reported locomotor hypoactivity during ethanol withdrawal in rats and mice, but only in novel test environments and not in the home cage. In the present study, we examined the effects of withdrawal from chronic intermittent ethanol (CIE) vapor exposure on the level and circadian periodicity of wheel-running activity in C57BL/6J mice. CIE treatment resulted in reductions in wheel-running activity compared with plain-air controls ...


Review Of Pregnancy Diagnosis Techniques In Cattle And Small Ruminants, Brian Whitlock, Elizabeth Coffman 2009 University of Tennessee - Knoxville

Review Of Pregnancy Diagnosis Techniques In Cattle And Small Ruminants, Brian Whitlock, Elizabeth Coffman

Brian K Whitlock, PhD, DVM, DACT

Pregnancy diagnosis is a common management practice for ruminants and there are a number of methods available, with each having advantage(s) and/or disadvantage(s). A brief review of pregnancy diagnosis techniques in cattle, goats, and sheep is provided.


Update On Heritable Congenital Defects In Cattle, Brian Whitlock 2009 University of Tennessee - Knoxville

Update On Heritable Congenital Defects In Cattle, Brian Whitlock

Brian K Whitlock, PhD, DVM, DACT

Inherited congenital anomalies are probably present in all breeds of cattle and propagated as a result of specific trait selection. In some breeds, the occurrence of inherited anomalies has become frequent, and economically important. Veterinarians, animal scientists, and cattle breeders should be aware of inherited defects, and be prepared to investigate and report animals exhibiting abnormal phenotypes. This review will describe the morphologic characteristics, mode of inheritance, breeding lines affected, and the availability of testing for selected (newly described) heritable bovine fetal abnormalities.


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