Open Access. Powered by Scholars. Published by Universities.®

Molecular and Cellular Neuroscience Commons

Open Access. Powered by Scholars. Published by Universities.®

753 Full-Text Articles 1,566 Authors 101,587 Downloads 90 Institutions

All Articles in Molecular and Cellular Neuroscience

Faceted Search

753 full-text articles. Page 1 of 29.

Development Of An Imaging Analysis Algorithm For Fluorescence-Based High Content Screening In Parkinson’S Disease, Ryan Arlinghaus 2019 Purdue University

Development Of An Imaging Analysis Algorithm For Fluorescence-Based High Content Screening In Parkinson’S Disease, Ryan Arlinghaus

The Journal of Purdue Undergraduate Research

No abstract provided.


Molecular Specialization Of Gabaergic Synapses On The Soma And Axon In Cortical And Hippocampal Circuit Function And Dysfunction, April Contreras, Dustin J. Hines, Rochelle M. Hines 2019 University of Nevada, Las Vegas

Molecular Specialization Of Gabaergic Synapses On The Soma And Axon In Cortical And Hippocampal Circuit Function And Dysfunction, April Contreras, Dustin J. Hines, Rochelle M. Hines

Psychology Faculty Publications

The diversity of inhibitory interneurons allows for the coordination and modulation of excitatory principal cell firing. Interneurons that release GABA (γ-aminobutyric acid) onto the soma and axon exert powerful control by virtue of proximity to the site of action potential generation at the axon initial segment (AIS). Here, we review and examine the cellular and molecular regulation of soma and axon targeting GABAergic synapses in the cortex and hippocampus. We also describe their role in controlling network activity in normal and pathological states. Recent studies have demonstrated a specific role for postsynaptic dystroglycan in the formation and maintenance of cholecystokinin ...


Investigation Of Even-Skipped, A Developmentally-Regulated Gene Controlling Neural Segmentation In Dragonflies, Kathryn Bangser 2019 Union College - Schenectady, NY

Investigation Of Even-Skipped, A Developmentally-Regulated Gene Controlling Neural Segmentation In Dragonflies, Kathryn Bangser

Honors Theses

A comprehensive understanding of the genetic mechanisms underlying pattern formation and neurogenesis is necessary in order to trace the evolutionary history of insect embryogenesis.

One of the most important processes of embryogenesis is the organized pattern formation that allows for proper body segmentation and neural development. Proper segmentation, which relies on a series of specific gene expressions, is necessary for the development of an operational nervous system. Even-skipped (eve), one such regulatory gene, has been studied extensively in certain model organisms, and theories regarding the evolution of its functional role could be further elucidated by visualizing its expression in adult ...


Towards A Better Understanding Of Temporomandibular Disorder, Jessica R. Cox 2019 MIssouri State University

Towards A Better Understanding Of Temporomandibular Disorder, Jessica R. Cox

MSU Graduate Theses

Results from the OPPERA study provided evidence that risk factors such as neck muscle tension, prolonged jaw opening, and female gender increase the likelihood of developing temporomandibular joint disorders (TMJD), which are prevalent, debilitating orofacial pain conditions. Peripheral and central sensitization, which mediate a lowering of the stimulus required for pain signaling, are implicated in the underlying pathology of chronic TMJD. The goal of my study was to investigate cellular changes in the expression of proteins associated with the development of central sensitization. Female Sprague-Dawley rats were injected with complete Freund’s adjuvant in the upper trapezius muscles to promote ...


The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin 2019 The Graduate Center, City University of New York

The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin

All Dissertations, Theses, and Capstone Projects

Anxiety affects nearly twice as many women as it affects men across all cultures and economic groups. Importantly, girls have a higher chance of inheriting anxiety disorders than boys, and many anxiety disorders appear at a very young age. However, little is known about sex differences in brain and behavioral development and how they relate to anxiety in adulthood. Serotonin 1A receptor (5-HT1A-R) mediated signaling has been implicated in depression and anxiety, however most studies that focus on the involvement of the 5-HT1A-R have been conducted in adults. Little is known about how the 5-HT1A ...


The Effect Of Cysteine-Reactive Catechol Antioxidants On Alcohol Dehydrogenase As A Model For Oxidative Stress In Neurodegenerative Disease, Rachel Smith 2019 William & Mary

The Effect Of Cysteine-Reactive Catechol Antioxidants On Alcohol Dehydrogenase As A Model For Oxidative Stress In Neurodegenerative Disease, Rachel Smith

Undergraduate Honors Theses

The cellular mechanisms underlying age-related neurodegeneration, especially in disease states, are poorly understood. Oxidative stress has been heavily implicated as one factor both produced by and contributing to the progression of neurodegenerative diseases such as Alzheimer’s disease. In particular, it can destroy a cell’s ability to produce energy through aerobic and anaerobic respiration, thus leading to the death of individual cells and brain tissues as a whole. This study focuses on the relationship between oxidative stress and energy production in disease states. In particular, we examine the ability of catechol molecules to take on pro-oxidative properties and modify ...


Modeling Changes In Cellular Micro-Environment In Mild To Moderate Head Trauma, XiangFu Zhang, Subhendra N. Sarkar PhD, RT 2019 CUNY New York City College of Technology

Modeling Changes In Cellular Micro-Environment In Mild To Moderate Head Trauma, Xiangfu Zhang, Subhendra N. Sarkar Phd, Rt

Publications and Research

Our work aims to connect and model multiple small, inter-related tissue injuries as a consequence of mild traumatic brain injuries (mTBI). It has been shown that frontal and temporal lobes are vulnerable regions for brain traumatic injury. A brain injury from a blow or high-speed impact can cause undersurface of the frontal and temporal lobes to deform against the anterior and cranial fossae. This deformation can often trigger damage to the cerebral vasculature, which is ill-understood and can result in chronic damage to larger vessels over time. These physiological injuries can be manifested psychologically; such as patients’ sleep-wake disturbances. The ...


A Hidden Markov Factor Analysis Framework For Seizure Detection In Epilepsy Patients, Mahboubeh Madadi 2019 University of Arkansas, Fayetteville

A Hidden Markov Factor Analysis Framework For Seizure Detection In Epilepsy Patients, Mahboubeh Madadi

Theses and Dissertations

Approximately 1% of the world population suffers from epilepsy. Continuous long-term electroencephalographic (EEG) monitoring is the gold-standard for recording epileptic seizures and assisting in the diagnosis and treatment of patients with epilepsy. Detection of seizure from the recorded EEG is a laborious, time consuming and expensive task. In this study, we propose an automated seizure detection framework to assist electroencephalographers and physicians with identification of seizures in recorded EEG signals. In addition, an automated seizure detection algorithm can be used for treatment through automatic intervention during the seizure activity and on time triggering of the injection of a radiotracer to ...


Interhemispheric Communication And Lateralization In The Mouse Hippocampus, Jake Jordan 2019 The Graduate Center, City University of New York

Interhemispheric Communication And Lateralization In The Mouse Hippocampus, Jake Jordan

All Dissertations, Theses, and Capstone Projects

The hippocampus is essential for memory and spatial navigation. Many theories have been proposed to explain how the hippocampus contributes to cognition; however, none has fully explained relevant neurophysiological and behavioral data. Hemispheric lateralization of hippocampal function has been reported in humans and in rodents, and lateralization of hippocampal neural circuitry has been reported in rodents. Most theories of hippocampal function fail to consider the hippocampus as a bilateral structure with hemispheric differences. Further, proposed theories of hippocampal lateralization have their own limitations in explaining empirical data concerning left/right function. Little is known about communication between the hippocampi across ...


Glycine Receptor Expression Across Identified Retinal Ganglion Cell Types., Ian Scot Pyle 2019 University of Louisville

Glycine Receptor Expression Across Identified Retinal Ganglion Cell Types., Ian Scot Pyle

Electronic Theses and Dissertations

Retinal ganglion cells (RGCs) represent the culmination of all retinal signaling and their output forms the substrate for vision throughout the rest of the brain. About 40 different RGC types have been defined by differences in their visually evoked responses, morphology, and genetic makeup. These responses arise from interactions between inhibition and excitation throughout the retinal circuit (Franke et al., 2017; Masland, 2012; Sanes & Masland, 2015; Werblin, 2011). Unlike most other areas of the central nervous system (CNS), the retina utilizes both GABA and glycine inhibitory neurotransmitters to refine glutamatergic excitatory signals (Franke & Baden, 2017; Werblin, 2011; C. Zhang, Nobles, & McCall, 2015). Glycine receptors (GlyRs) are heteromers composed of a single β subunit and one of four α subunits, with a stoichiometry of 3β:2α (Grudzinska et al., 2005; Heinze, Harvey, Haverkamp, & Wassle, 2007; Lynch ...


A Novel Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Synapse Development, Hao Wu 2019 The Graduate Center, City University of New York

A Novel Kinesin Adapter Directly Mediates Dendritic Mrna Localization During Synapse Development, Hao Wu

All Dissertations, Theses, and Capstone Projects

Cytoskeleton based active transport with motor proteins is essential for mRNA localization and local protein translation in animal cells, yet how mRNA granules interact with motor proteins remains poorly understood. Using an unbiased screen for interaction between mRNA binding proteins (RBP) and motor proteins, we identified protein interacting with APP tail 1 (PAT1) as a potential direct adapter between the β-actin mRNA Zipcode-binding protein 1 (ZBP1) and Kinesin-1 motor complex.

Mouse PAT1 is similar to the Kinesin Light Chain (KLC) in amino acid sequence and binds directly to KLC. High-resolution images from structured illumination microscopy (SIM) indicates that synaptic stimulation ...


Notch Inhibitors And The Bet Inhibitor Jq-1 Decrease The Growth Of Primary Tumor Cells Derived From A Novel Mouse Model Of C11orf95-Rela Induced Brain Tumor, Ericka Randazzo, Jesse Dunnack, Justin Fang, Joseph LoTurco PhD 2019 University of Connecticut - Storrs

Notch Inhibitors And The Bet Inhibitor Jq-1 Decrease The Growth Of Primary Tumor Cells Derived From A Novel Mouse Model Of C11orf95-Rela Induced Brain Tumor, Ericka Randazzo, Jesse Dunnack, Justin Fang, Joseph Loturco Phd

University Scholar Projects

Brain tumors are the most common childhood solid malignancy, and because of remarkable advances in treating many cancers outside of the brain, they have become the leading cause of cancer mortality in children. Ependymomas are a class of brain tumors which can be further subdivided into three groups based upon their location and genetic features. Of the three classes, supratentorial ependymomas are the only subgroup known to be marked by an oncogenic driver gene, which consists of a fusion mutation between the C11orf95 and RELA genes. C11orf95-RELA positive tumors are the most aggressive and lethal of ...


Effect Of Ethanol Withdrawal On Dunce Gene Expression And Learning In Drosophila Melanogaster, Dylan Jones, Nolan Hofstee, Alex Skoulis 2019 Carroll College

Effect Of Ethanol Withdrawal On Dunce Gene Expression And Learning In Drosophila Melanogaster, Dylan Jones, Nolan Hofstee, Alex Skoulis

Carroll College Student Undergraduate Research Festival

The purpose of this experiment was to test whether ethanol withdrawal inhibits short-term memory in Drosophila melanogaster. Prior research has shown that Drosophila who have experienced withdrawal from ethanol display an inability to associate a positive odorant with the negative response of a heat shock. For this experiment, it was hypothesized that these effects are due to a malfunction in cAMP Phosphodiesterase formation, which causes a buildup of cAMP and impairs intracellular neuronal cell signaling. This hypothesis was tested by measuring short-term memory formation and expression of the Dunce gene in Drosophila that experienced ethanol withdrawal. The dunce gene was ...


Effects Of E-Cigarette Vapor On Dalpha7 Gene Expression In Adult Drosophila Melanogaster, Roma Seal, Bella Maag 2019 Carroll College

Effects Of E-Cigarette Vapor On Dalpha7 Gene Expression In Adult Drosophila Melanogaster, Roma Seal, Bella Maag

Carroll College Student Undergraduate Research Festival

While it is commonly known that there are many negative effects of nicotine on humans, the effects of nicotine specifically from vapor produced by Electric Cigarettes (E-Cigarettes), have not yet been determined. In this study, students test to see if a gene specifically related to nicotine addiction in both fruit flies (Drosophila melanogaster) and humans is expressed upon exposure to E-Cigarette vapor. Furthermore, students will test to determine if exposure to E-Cigarette vapor has a deleterious effect on the motor function of flies; as similar studies using nicotine alone have concluded. In this study, students will focus on the expression ...


Effect Of Lead Exposure On Drosophila Melanogaster And Expression Of The Neru Gene, Vanessa Rodriguez, Michael Larsen 2019 Carroll College

Effect Of Lead Exposure On Drosophila Melanogaster And Expression Of The Neru Gene, Vanessa Rodriguez, Michael Larsen

Carroll College Student Undergraduate Research Festival

Lead is a common environmental toxin that has been shown to have various negative effects on human health including developmental delays, seizures, and high blood pressure. In this study, we wanted to test the effect of lead exposure on neural development and mobility in the model organism Drosophila melanogaster. More specifically, we looked at the expression of the Neuralized gene, which is involved in the process of neural development, and at larval crawling. We hypothesized that exposing Drosophila larvae to lead salt would decrease both expressions of the Neur gene and larval mobility. To test our hypothesis, the experimental group ...


Effect Of High Fat/High Sugar Diets On Fruitless Gene Expression And Copulatory Behavior In Drosophila Melanogaster, Megan Bousliman, Jacob Meek 2019 Carroll College

Effect Of High Fat/High Sugar Diets On Fruitless Gene Expression And Copulatory Behavior In Drosophila Melanogaster, Megan Bousliman, Jacob Meek

Carroll College Student Undergraduate Research Festival

A diet high in fat has been shown to cause Diabetes, Cardiovascular Disease, and different types of Cancer in humans. In the model organism Drosophila melanogaster, a diet high in fat and sugar has been shown to decrease sexual functioning significantly. The fruitless gene in Drosophila is a neuronal gene that codes for a transcription factor whose functional role is to control the mating ability of male fruit flies. Through our research, we attempted to answer the question: Does a diet high in fat and sugar change sexual functioning in Drosophila - and is this change caused by decreased expression of ...


Effect Of Ethanol On The Hangover Gene And Synaptic Growth In Drosophila Melanogaster, Christopher Genin, Benjamin McFarland 2019 Carroll College

Effect Of Ethanol On The Hangover Gene And Synaptic Growth In Drosophila Melanogaster, Christopher Genin, Benjamin Mcfarland

Carroll College Student Undergraduate Research Festival

In this project, we aimed to answer the question: ‘How will the development of synaptic growth in the neuromuscular junction and expression of the hangover gene in Drosophila melanogaster be affected by ethanol exposure?’ Exposure to ethanol is significant to the hangover gene (hang) because, among numerous other stressors, hang pertains to rapid ethanol tolerance through a cellular stress pathway. The early development of neuromuscular junctions is also regulated by the expression of hang. It was hypothesized that exposure of Drosophila larvae to ethanol would increase expression of the hangover gene and decrease their mobility due to stunted synaptic growth ...


Pesticides And Parkinson's: An Investigation Of The Effect Of Roundup Exposure On Drosophila Melanogaster, Siobhan O'Neill 2019 Carroll College

Pesticides And Parkinson's: An Investigation Of The Effect Of Roundup Exposure On Drosophila Melanogaster, Siobhan O'Neill

Carroll College Student Undergraduate Research Festival

From commercial farms to private households, Roundup is the most commonly used herbicide in the United States. In recent years, exposure to Roundup has been correlated with a variety of health problems including Celiac Disease, birth defects, kidney and liver diseases, Alzheimer's Disease, and Parkinson's Disease. To date, the use of Roundup has been banned or restricted in several foreign countries, including the Netherlands, Portugal, Germany and Italy, because it has been classified as a possible carcinogen by the World Health Organization. The goal of this research was to determine the effects of Roundup exposure on dopaminergic neurons ...


Circadian Rhythmicity And Neurodevelopment Of Disco And Grim Mutations In Drosophila Melanogaster, John Patrick Story 2019 University of Tennessee, Knoxville

Circadian Rhythmicity And Neurodevelopment Of Disco And Grim Mutations In Drosophila Melanogaster, John Patrick Story

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

The death gene grim and its pathway for apoptosis has been studied extensively in Drosophila Melanogaster. The effects of grim mutations on circadian neurodevelopment and locomotor assays have yet to be investigated. Mutations in the gene disconnected (disco) has been shown to disrupt the normal development of the circadian circuitry, specifically the small ventro-lateral neurons (s-LNv’s). Which has shown to severely decrease rhythmicity during free-running periods. Alternatively, we have observed an increase in rhythmicity during free-running periods in grim mutations. Our goal is to investigate the neurodevelopment of the circadian circuitry and their associated locomotor activities in these Drosophila ...


Development Of An Intrahippocampal Kindling Model Of Epilepsy, Carter F. Jones 2019 Trinity College, Hartford Connecticut

Development Of An Intrahippocampal Kindling Model Of Epilepsy, Carter F. Jones

Senior Theses and Projects

Epilepsy is a neurological condition that affects about 1% of the global population. This debilitating condition is associated with overexcitation and ineffective inhibition of neuronal pathways in the brain causing serious and a diverse set of symptoms, most prominently seizures. While some antiepileptic drug (AED) regimes have been proven to be effective in treating this condition, there are many cases where the drugs do not do enough. The ketogenic diet (KD) has been used for decades as an effective anticonvulsant. Its powerful and natural processes result in some patients becoming seizure-free. Sometimes, these patients remain free of seizures even after ...


Digital Commons powered by bepress