10 Institutions 41 Full-Text Articles 58 Authors 3,849 Downloads
Recent Articles in Microbial Physiology
Novobiocin As An Allosteric Modulator Of Ste2p, Jeffrey K. Rymer, Melinda Hauser, Jeffrey M. Becker University of Tennessee, Knoxville
Novobiocin As An Allosteric Modulator Of Ste2p, Jeffrey K. Rymer, Melinda Hauser, Jeffrey M. Becker
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
G protein-coupled receptors (GPCRs) are the target of 30-50% of all prescribed drugs for human medicine and are therefore the subject of intense study by the scientific community. It has been recognized recently that compounds called allosteric modulators can regulate GPCR activity by binding a GPCR at sites not occupied by the normal receptor-activating molecule. Such allosteric compounds are desirable drug candidates as they may produce fewer toxic side-effects than standard drugs that target GPCRs. The purpose of this study was to determine the interaction of different allosteric modulators with Ste2p, a model GPCR expressed in the yeast Saccharomyces cerevisiae ...
Phenotypic And Genotypic Characterization Of Escherichia Coli Isolated From Untreated Surface Waters, Steven L. Daniel, Kai F. Hung, Kristopher J. Janezic, Blake Ferry, Eric W. Hendricks, Brian A. Janiga, Tiffany Johnson, Samantha Murphy, Morgan E. Roberts, Sarah M. Scott, Alexandra N. Theisen Eastern Illinois University
Phenotypic And Genotypic Characterization Of Escherichia Coli Isolated From Untreated Surface Waters, Steven L. Daniel, Kai F. Hung, Kristopher J. Janezic, Blake Ferry, Eric W. Hendricks, Brian A. Janiga, Tiffany Johnson, Samantha Murphy, Morgan E. Roberts, Sarah M. Scott, Alexandra N. Theisen
Steven L. Daniel
A common member of the intestinal microbiota in humans and animals is Escherichia coli. Based on the presence of virulence factors, E. coli can be potentially pathogenic. The focus of this study was to isolate E. coli from untreated surface waters (37 sites) in Illinois and Missouri and determine phenotypic and genotypic diversity among isolates. Water samples positive for fecal coliforms based on the Colisure® test were streaked directly onto Eosin Methylene Blue (EMB) agar (37°C) or transferred to EC broth (44.5°C). EC broth cultures producing gas were then streaked onto EMB agar. Forty-five isolates were identified ...
The Evolution Of Host Specificity In The Vertebrate Gut Symbiont Lactobacillus Reuteri, Steven Frese University of Nebraska - Lincoln
The Evolution Of Host Specificity In The Vertebrate Gut Symbiont Lactobacillus Reuteri, Steven Frese
Dissertations & Theses in Food Science and Technology
The vertebrate gut is home to one of the densest populations of life on Earth. This microbial community has a profound effect on host health, nutrition, development, behavior, and evolution. However, very little is known about how these microbes have evolved with their vertebrate hosts, how and whether they select hosts or how they remain associated with their hosts. Recent work identified Lactobacillus reuteri as an organism that is composed of host-specific sub-populations, each population associated with a different host animal. Representatives from each host-associated population were tested for their ability to colonize gnotobiotic mice, which only rodent strains could ...
Using Small Molecules To Alter Secondary Metabolism In Streptomyces, Salman Ahmed McMaster University
Using Small Molecules To Alter Secondary Metabolism In Streptomyces, Salman Ahmed
Open Access Dissertations and Theses
Secondary metabolites produced by bacterial species serve many clinically useful purposes such as anti-bacterial, anti-cancer, and immunosuppresive agents. Actinobacteria, particularly the genus Streptomyces, have been an abundant source of such metabolites for the past half century. The production of secondary metabolites is controlled through vast regulatory cascades, but the activation and control of these pathways is still poorly understood. This leads to the inability to isolate all of the secondary metabolites that Streptomyces are capable of producing. This study focuses on the comparison of synthetic small molecules, which were found to alter the production of secondary metabolites in S. coelicolor ...
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Physiological Studies On Candida Albicans, Swetha Tati
Old Acetogens, New Light, Steven Daniel
Use Of Proteomics Tools To Investigate Protein Expression In Azospirillum Brasilense, Gurusahai Khalsa-Moyers
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