The Current Application Of Nanotechnology In Food And Agriculture,
2020
Taiwan Food and Drug Administration
The Current Application Of Nanotechnology In Food And Agriculture, X. He, H. Deng, H.-M. Hwang
Journal of Food and Drug Analysis
The rapid development of nanotechnology has been facilitating the transformations of traditional food and agriculture sectors, particularly the invention of smart and active packaging, nanosensors, nanopesticides and nanofertilizers. Numerous novel nanomaterials have been developed for improving food quality and safety, crop growth, and monitoring environmental conditions. In this review the most recent trends in nanotechnology are discussed and the most challenging tasks and promising opportunities in the food and agriculture sectors from selected recent studies are addressed. The toxicological fundamentals and risk assessment of nanomaterials in these new food and agriculture products are also discussed. We highlighted the potential application …
Application Of Food Description To The Food Classification System: Evidence Of Risk Assessment From Taiwan As Acrylamide Of Grain Products,
2020
Taiwan Food and Drug Administration
Application Of Food Description To The Food Classification System: Evidence Of Risk Assessment From Taiwan As Acrylamide Of Grain Products, S.-Y. Chiu, H.-T. Lin, W.-C. Ho, M.-H. Lin, P.-C. Chen, H.-Y. Huang
Journal of Food and Drug Analysis
Harmonization of national consumption data for international comparison is an important but challenging work, yet to date there is a lack of comparable food classification system that incorporates food description in Taiwan. In 2015, European Food Safety Authority (EFSA) released a new standardized food classification and description system called FoodEx2, which provides a flexible combination of classifications and descriptions. Based on FoodEx2 and a unique data set of daily food consumption offered by Taiwan Food Consumption Database, this study aims to provide a harmonized, food description incorporated, food classification system (HFDFC system) that captures all the useful details of food …
A Novel Micro-Extraction Strategy For Extraction Of Bisphosphonates From Biological Fluids Using Zirconia Nanoparticles Coupled With Spectrofluorimetry And High Performance Liquid Chromatography,
2020
Taiwan Food and Drug Administration
A Novel Micro-Extraction Strategy For Extraction Of Bisphosphonates From Biological Fluids Using Zirconia Nanoparticles Coupled With Spectrofluorimetry And High Performance Liquid Chromatography, N. Rahbar, L. Nazernezhad, M. Asadinezhad, Z. Ramezani, M. Kouchak
Journal of Food and Drug Analysis
Extraction of bisphosphonates from biological fluids is important and time consuming step in sample preparation procedure. This paper describes a simple and green sample preparation technique for dispersive micro solid phase extraction (DMSPE) of alendronate sodium (ALS) from urine and serum samples prior to direct spectrofluorimetry (DSFL) and high performance liquid chromatography with fluorescence detection (HPLC-FLD), respectively. The DMSPE strategy is based on the selective chemisorption of ALS on zirconia nanoparticles (ZNPs) as an adsorbent followed by derivatization of the eluted analyte using o-phthalaldehyde (OPA) in the presence of 2-mercaptoethanol (2ME) at basic medium to form fluorescent species. The chemical …
Antioxidant Activity, Neuroprotective Properties And Bioactive Constituents Analysis Of Varying Polarity Extracts From Eucalyptus Globulus Leaves,
2020
Taiwan Food and Drug Administration
Antioxidant Activity, Neuroprotective Properties And Bioactive Constituents Analysis Of Varying Polarity Extracts From Eucalyptus Globulus Leaves, E. González-Burgos, M. Liaudanskas, J. Viškelis, V. Žvikas, V. Janulis, M.P. Gómez-Serranillos
Journal of Food and Drug Analysis
Eucalyptus globulus is employed as herbal tea and therapeutical purposes. In this work, it is investigated for first time the neuroprotective activities, based on antioxidant properties, of varying polarity extracts (acetone, ethanol and methanol) from E. globulus leaves and elucidate their main bioactive constituents. Methanol and acetone extracts contained the highest phenolic compounds amount and chlorogenic acid was the major compound identified by UPLC-ESI-MS/MS. Moreover, the three tested extracts showed significant antioxidant properties, varying their potency depending on the in vitro technique used. Furthermore, E. globulus extracts were effective in ameliorating H2O2-induced oxidative stress by increasing cell viability, GSH levels …
Development And Validation Of A Fast Gas Chromatography/Mass Spectrometry Method For The Determination Of Cannabinoids In Cannabis Sativa L,
2020
Taiwan Food and Drug Administration
Development And Validation Of A Fast Gas Chromatography/Mass Spectrometry Method For The Determination Of Cannabinoids In Cannabis Sativa L, V. Cardenia, Toschi T. Gallina, S. Scappini, R.C. Rubino, M.T. Rodriguez-Estrada
Journal of Food and Drug Analysis
A routine method for determining cannabinoids in Cannabis sativa L. inflorescence, based on Fast gas chromatography coupled to mass spectrometry (Fast GC/MS), was developed and validated. To avoid the decarboxylation of carboxyl group of cannabinoids, different derivatization approaches, i.e. silylation and esterification (diazomethane-mediated), reagents and solvents (pyridine or ethyl acetate), were tested. The methylation significantly increased the signal-to-noise ratio of all carboxylic cannabinoids, except for cannabigerolic acid (CBGA). Since diazomethane is not commercially available, is considered a hazardous reactive and requires 1-day synthesis by specialized chemical staff, silylation was used along the whole validation of a routine method. The method …
Comparison Of Anti-Inflammatory Effect And Protein Profile Between The Water Extracts From Formosan Sambar Deer And Red Deer,
2020
Taiwan Food and Drug Administration
Comparison Of Anti-Inflammatory Effect And Protein Profile Between The Water Extracts From Formosan Sambar Deer And Red Deer, C.-Y. Kuo, Y.-T. Cheng, S.-T. Ho, C.-C. Yu, M.-J. Chen
Journal of Food and Drug Analysis
Velvet antler (VA), the unossified antler from members of the family Cervidae, has been used in traditional Chinese medicines and health foods for over 2000 years in enhancement of kidney function and treatment or prevention of cardiovascular, immunological and gynaecological disease. The aim of this study was to investigate the anti-inflammatory effect of velvet antler water extracts from Formosan sambar deer (Rusa unicolor swinhoei, SVAE) and red deer (Cervus elaphus, RVAE). Results indicated that both SVAE and RVAE significantly reduced the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) productions in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells at concentrations above …
Benefits Of Combination Low-Dose Pioglitazone Plus Fish Oil On Aged Type 2 Diabetes Mice,
2020
Taiwan Food and Drug Administration
Benefits Of Combination Low-Dose Pioglitazone Plus Fish Oil On Aged Type 2 Diabetes Mice, Y. Iizuka, H. Kim, S. Hirako, K. Chiba, M. Wada, A. Matsumoto
Journal of Food and Drug Analysis
The elderly patients with type 2 diabetes suffer more adverse drug events than young adults due to pharmacokinetic and pharmacodynamic changes associated with aging. Reducing the risks of these medication-related problems are equally important for the clinical care of older type 2 diabetes patients. Pioglitazone is used for treating type 2 diabetes as an oral antidiabetic drug. Despite pioglitazone is used helpful insulin sensitizers, the accumulation of subcutaneous fat is considered a major adverse effect of pioglitazone therapy. We investigated to reduce the adverse effect of pioglitazone by combination with fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid …
Curculigoside And Polyphenol-Rich Ethyl Acetate Fraction Of Molineria Latifolia Rhizome Improved Glucose Uptake Via Potential Mtor/Akt Activated Glut4 Translocation,
2020
Taiwan Food and Drug Administration
Curculigoside And Polyphenol-Rich Ethyl Acetate Fraction Of Molineria Latifolia Rhizome Improved Glucose Uptake Via Potential Mtor/Akt Activated Glut4 Translocation, D.J. Ooi, N.H. Azmi, M.U. Imam, N.B. Alitheen, M. Ismail
Journal of Food and Drug Analysis
Adipose tissue is one of the major organs responsible for rapid restoration of postprandial glucose fluxes. Being the major isoform of glucose transporter in adipose tissue, regulations of insulin-dependent GLUT4 trafficking have always been of research interest. The present study aimed to examine the molecular mechanisms underlying the efficacy of curculigoside and polyphenol-rich ethyl acetate fraction (EAF) of Molineria latifolia rhizome in triggering glucose uptake. We assessed the adipogenic potential and glucose uptake stimulatory activity of curculigoside and EAF by employing a murine 3T3-L1 adipocyte model. The transcriptional and translational expressions of selected intermediates in the insulin signalling pathway were …
Effect Of Phyllanthus Emblica L. Fruit On Methionine And Choline-Deficiency Diet-Induced Nonalcoholic Steatohepatitis,
2020
Taiwan Food and Drug Administration
Effect Of Phyllanthus Emblica L. Fruit On Methionine And Choline-Deficiency Diet-Induced Nonalcoholic Steatohepatitis, Y.-T. Tung, C.-Z. Huang, J.-H. Lin, G.-C. Yen
Journal of Food and Drug Analysis
Phyllanthus emblica L. fruit contains abundant bioactive components and exhibits a variety of biological activities. In this study, the hepatoprotective effect of water extract of P. emblica (WEPE) on nonalcoholic steatohepatitis (NASH) was evaluated. C57BL/6 mice were fed methionine and choline-deficiency diet (MCD diet) for 4 or 8 weeks to induce NASH. Results showed that administration of WEPE could significantly reduce serum AST and ALT as compared to MCD diet-alone group. Administration of WEPE could significantly decrease lipid peroxidation and CYP2E1 mRNA expression, and elevate the antioxidant activities in mice livers. In addition, administration of WEPE after 8 weeks could …
Profiles Of Commensal And Opportunistic Bacteria In Human Milk From Healthy Donors In Taiwan,
2020
Taiwan Food and Drug Administration
Profiles Of Commensal And Opportunistic Bacteria In Human Milk From Healthy Donors In Taiwan, P.-W. Chen, Y.-L. Lin, M.-S. Huang
Journal of Food and Drug Analysis
Recent studies indicate that milk from healthy mothers may harbor potential probiotics. Nonetheless, the distribution of bacterial profiles in human milk samples in Taiwan is not fully understood. Therefore, with the aim to address this question, in this study, milk samples were collected from 33 healthy mothers (D1 to D33) visiting our hospital during a 6-month period. The milk microbiota was analyzed by a molecular approach (Illumina MiSeq sequencing). The results indicate that the milk samples have a unique profile and patterns of bacterial abundance levels. Moreover, in colostrum and transitional-milk samples, we detected 154 and 127 bacterial species, respectively, …
Kinetics Of Lactose Fermentation In Milk With Kombucha Starter,
2020
Taiwan Food and Drug Administration
Kinetics Of Lactose Fermentation In Milk With Kombucha Starter, K.G. Kanurić, S.D. Milanović, B.B. Ikonić, E.S. Lončar, M.D. Iličić, V.R. Vukić, D.V. Vukić
Journal of Food and Drug Analysis
The aim of this research was to investigate the effect of new, non-conventional starter culture on the kinetics of the lactose transformation during milk fermentation by kombucha, at pH 5.8; 5.4; 5.1; 4.8; and 4.6, at two different temperatures 37 °C and 42 °C. Milk fermentation at 42 °C lasted significantly shorter (about 5 h, 30 min) compared to the fermentation at 37 °C. Changes of lactose concentration at the both temperatures are consisting of two retaining stages and very steep decline in–between. The analysis of the rate curves showed that the reaction rate passes through the maximum after 9 …
Nanoparticle-Based Laser Desorption/Ionization Mass Spectrometric Analysis Of Drugs And Metabolites,
2020
Taiwan Food and Drug Administration
Nanoparticle-Based Laser Desorption/Ionization Mass Spectrometric Analysis Of Drugs And Metabolites, H.-W. Chu, B. Unnikrishnan, A. Anand, J.-Y. Mao, C.-C. Huang
Journal of Food and Drug Analysis
Nanoparticle-assisted laser desorption/ionization mass spectrometry (LDI-MS) is a powerful tool for the analysis of a wide range of molecules. Many of the drawbacks in the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) can be avoided with the application of nanomaterials as matrices as well as substrates for the LDI-MS to achieve a low background noise in low m/z region and high reproducibility. Surface-assisted LDI (SALDI)-MS, especially the nanoparticle-based LDI-MS, has emerged as a promising technique for the analysis of trace amounts of substances in various biological samples due to their high surface area for analyte enrichment, efficient desorption/ionization, and homogeneous crystallization …
Prospects Of Using Nanotechnology For Food Preservation, Safety, And Security,
2020
Taiwan Food and Drug Administration
Prospects Of Using Nanotechnology For Food Preservation, Safety, And Security, V.K. Bajpai, M. Kamle, S. Shukla, D.K. Mahato, P. Chandra, S.K. Hwang, P. Kumar, Y.S. Huh, Y.-K. Han
Journal of Food and Drug Analysis
The rapid development of nanotechnology has transformed many domains of food science, especially those that involve the processing, packaging, storage, transportation, functionality, and other safety aspects of food. A wide range of nanostructured materials (NSMs), from inorganic metal, metal oxides, and their nanocomposites to nano-organic materials with bioactive agents, has been applied to the food industry. Despite the huge benefits nanotechnology has to offer, there are emerging concerns regarding the use of nanotechnology, as the accumulation of NSMs in human bodies and in the environment can cause several health and safety hazards. Therefore, safety and health concerns as well as …
Rapid Detection And Quantitation Of Drugs-Of-Abuse By Wooden-Tip Electrospray Ionization Mass Spectrometry,
2020
Taiwan Food and Drug Administration
Rapid Detection And Quantitation Of Drugs-Of-Abuse By Wooden-Tip Electrospray Ionization Mass Spectrometry, T.-T. Ng, P.-K. So, B. Hu, Z.-P. Yao
Journal of Food and Drug Analysis
Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international …
Blotting Paper As A Disposable Tool For Sampling Chemical Residues From Skin Surface,
2020
Taiwan Food and Drug Administration
Blotting Paper As A Disposable Tool For Sampling Chemical Residues From Skin Surface, P.-C. Wu, E.P. Dutkiewicz, P.-H. Liao, H.-Y. Chiu, P.L. Urban
Journal of Food and Drug Analysis
[No abstract available]
Analytical Methods For Cholesterol Quantification,
2020
Taiwan Food and Drug Administration
Analytical Methods For Cholesterol Quantification, L.-H. Li, E.P. Dutkiewicz, Y.-C. Huang, H.-B. Zhou, C.-C. Hsu
Journal of Food and Drug Analysis
Cholesterol is an important lipid molecule in cell membranes and lipoproteins. Cholesterol is also a precursors of steroid hormones, bile acids, and vitamin D. Abnormal levels of cholesterol or its precursors have been observed in various human diseases, such as heart diseases, stroke, type II diabetes, brain diseases and many others. Therefore, accurate quantification of cholesterol is important for individuals who are at increased risk for these diseases. Multiple analytical methods have been developed for analysis of cholesterol, including classical chemical methods, enzymatic assays, gas chromatography (GC), liquid chromatography (LC), and mass spectrometry (MS). Strategy known as ambient ionization mass …
Identification Of Bacteria In Juice/Lettuce Using Magnetic Nanoparticles And Selected Reaction Monitoring Mass Spectrometry,
2020
Taiwan Food and Drug Administration
Identification Of Bacteria In Juice/Lettuce Using Magnetic Nanoparticles And Selected Reaction Monitoring Mass Spectrometry, C.-T. Chen, J.-W. Yu, Y.-P. Ho
Journal of Food and Drug Analysis
Ensuring food safety requires a rapid and reliable method for detecting food-borne pathogens. Mass spectrometry has been demonstrated as a powerful tool to classify pure bacterial species. However, matrix interference from food backgrounds may lead to false results because of the suppression of microbial signals. It is useful to develop a method for bacterial enrichment and marker identification in food samples. Magnetic zirconia nanoparticles were used to concentrate spiked microorganisms from apple juice/lettuce under specific conditions (pH 4.5). Bacterial identification was achieved using nanoLC–MS. Selected reaction monitoring of bacteria-related peptides was applied for the first time to identify bacteria including …
Stability Of Glyoxal- And Methylglyoxal-Modified Hemoglobin On Dried Blood Spot Cards As Analyzed By Nanoflow Liquid Chromatography Tandem Mass Spectrometry,
2020
Taiwan Food and Drug Administration
Stability Of Glyoxal- And Methylglyoxal-Modified Hemoglobin On Dried Blood Spot Cards As Analyzed By Nanoflow Liquid Chromatography Tandem Mass Spectrometry, H.-J.C. Chen, Y.-C. Teng
Journal of Food and Drug Analysis
Blood sampling by the dried blood spot (DBS) technique has become commonly applied in newborn screening. It is often used for analysis of small molecules, such as metabolites. Recently, DBS sampling has been applied for quantification of post-translational protein modifications. Glyoxal and methylglyoxal are two simple oxoaldehydes released from glycated proteins in the Maillard reaction. They are widely distributed in the environment (e.g. cigarette smoke) and found in foods and beverages. Glyoxal and methylglyoxal are shown to react with biomolecules including DNA and proteins. In this laboratory, we previously identified the sites of modification by these two oxoaldehydes in human …
Method Development Of Immunoglobulin G Purification From Micro-Volumes Of Human Serum For Untargeted And Targeted Proteomics-Based Antibody Repertoire Studies,
2020
Taiwan Food and Drug Administration
Method Development Of Immunoglobulin G Purification From Micro-Volumes Of Human Serum For Untargeted And Targeted Proteomics-Based Antibody Repertoire Studies, Y.-T. Chang, M.-C. Chang, Y.-J. Tsai, C. Ferng, H.-C. Shih, Y.-P. Kuo, C.-H. Chen, I.-L. Tsai
Journal of Food and Drug Analysis
Immunoglobulins (Igs) are major serum proteins which play important roles in immunity. Both untargeted and targeted proteomic workflows can be applied to investigate antigen-binding sites and the glycosylation profiles of Igs. For a more-comprehensive picture of IgG from human serum, we developed an IgG purification process and coupled the standardized method to untargeted and targeted proteomic workflows for IgG investigations. Parameters such as the type of purification beads, volume of the bead slurry, incubation conditions, and binding capacities were evaluated in this study. Only 2 μL of human serum was required for each sample. The performance of coupling the purification …
Pon-1 Carbamylation Is Enhanced In Hdl Of Uremia Patients,
2020
Taiwan Food and Drug Administration
Pon-1 Carbamylation Is Enhanced In Hdl Of Uremia Patients, C.-T. Chang, Y.-P. Lim, C.-W. Lee, H.-Y. Liao, F.-Y. Chen, C.-M. Chang, F.-Y. Tang, C.-Y. Yang, C.-J. Chen
Journal of Food and Drug Analysis
High-density lipoprotein (HDL) carbamylation has been known in uremia patients. Paraoxonase-1 (PON-1) is an important HDL protein responsible for HDL anti-oxidant, arylesterase and lactonase activities. PON-1 carbamylation in uremic HDL has never been explored. We isolated HDL from uremia patients and control healthy subjects for study. Sandwich ELISA was used to estimate carbamylated PON-1 protein expression in HDL, and nanoflow liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) was applied to identify the amino acid in PON-1 carbamylated. PON-1 enzyme activities were estimated by substrates conversion method. HDL anti-oxidant activity was gauged by fluorescence changes of indicator dye in the presence of H …
