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The Fungal Connection: Characterizing The Ectomycorrhizal Community And Belowground Response To Restoration Treatments In Northern Mississippi., Ashley Jane Craig 2010 University of Mississippi

The Fungal Connection: Characterizing The Ectomycorrhizal Community And Belowground Response To Restoration Treatments In Northern Mississippi., Ashley Jane Craig

Electronic Theses and Dissertations

Ectomycorrhizal (ECM) fungi are symbionts on the roots of woody plant species throughout the world. These fungi provide plants with nutrients and are important drivers of ecosystem processes. ECM fungi vary in their effect on host plants and host-specificity, making them important considerations in restoration projects seeking to restore target tree species. Restoration strategies such as burning and thinning may have strong impacts on ECM fungi, and given the that ECM are important in structuring aboveground communities and maintaining certain dominant plant taxa, knowledge of ECM fungal response is needed to ensure restoration efforts succeed. Using molecular methods, this research ...


Involvement Of Vav2 In The Epha4 Signaling Pathway Of Xenopus Laevis As A Possible Rho Regulator, Jessica Kopala 2010 Eastern Michigan University

Involvement Of Vav2 In The Epha4 Signaling Pathway Of Xenopus Laevis As A Possible Rho Regulator, Jessica Kopala

Senior Honors Theses

The purpose of this research is to shed light on the involvement of the Vav2 guanine nucleotide exchange factor in the Xenopus laevis EphA4 signaling pathway. In the first phase of the project, the presence of Vav2 mRNA within seven different Xenopus laevis embryogenic stages was detected via embryogenic stage collection, retrotranscription, PCR, using forward and reverse Vav2 primers, agarose gel electrophoresis, and UV gel visualization. In the second phase of the project, Western Blotting techniques were used to determine the presence of Vav2 protein in Xenopus laevis embryogenic stages.


Characterization Of Lim Kinase And Activity In Early Amphibian Embryos, Stephanie Seegert 2010 Eastern Michigan University

Characterization Of Lim Kinase And Activity In Early Amphibian Embryos, Stephanie Seegert

Senior Honors Theses

EphA4 is a cellular receptor that functions in mediating tissue interactions in embryonic development. The downstream effectors of EphA4 are mainly unknown, although previous research has indicated that the enzyme p160ROCK is one of the downstream mediators in the pathway. LIM kinase is an enzyme that is activated by p160ROCK. We have hypothesized that LIM kinase acts downstream of p160ROCK in the signaling pathway. Our results showed that LIM kinase is present and activated during development when EphA4 is active in the embryo, which is consistent with a role for LIM kinase in EphA4 signaling. Further testing is necessary to ...


Characterization Of A Microrna Harboring Intron For Pre-Mrna Splicing And Microrna Processing, Neha Aggarwal 2010 Cleveland State University

Characterization Of A Microrna Harboring Intron For Pre-Mrna Splicing And Microrna Processing, Neha Aggarwal

ETD Archive

Nuclear pre-mRNA splicing is an important step in eukaryotic RNA processing and can yield a variety of transcripts. Further, it is known that nuclear pre-mRNA introns are of two types, U2-dependent and U12-dependent. Recently discovered, microRNAs (miRNA) are short, endogenous, 20-22 nucleotide long, non-coding RNA molecules that base pair with target mRNAs to modulate translation. Current evidence suggests that processing of intronic miRNA does not affect the splicing. Since, intronic miRNAs are involved in essential cellular processes, we surmised if splice sites of miRNA coding introns are flexible to support productive precursor and mature miRNA processing. We constructed a minigene ...


Abiotic Differences Between Green Turtle (Chelonia Mydas) Nests In Natural Beach And Engineered Dunes: Effects On Hatching Success, Martha Balfour 2010 University of Central Florida

Abiotic Differences Between Green Turtle (Chelonia Mydas) Nests In Natural Beach And Engineered Dunes: Effects On Hatching Success, Martha Balfour

Electronic Theses and Dissertations

Habitat loss is among the biggest threats to conservation worldwide, so habitat restoration plays an increasing role in endangered species management. This is especially true for species with high site fidelity, such as nesting marine turtles. Sand replenishment is commonly used to restore coastal beaches after severe erosion events, and may affect marine turtles and other species that live or reproduce in that habitat. I investigated how abiotic characteristics of sand used in a dune restoration project at Archie Carr National Wildlife Refuge, Florida, affected reproduction of the federally-endangered green turtle (Chelonia mydas). Sand structure and composition can affect egg ...


Clonality And Genetic Diversity In Polygonella Myriophylla, A Lake Wales Ridge Endemic Plant, Genevieve Metzger 2010 University of Central Florida

Clonality And Genetic Diversity In Polygonella Myriophylla, A Lake Wales Ridge Endemic Plant, Genevieve Metzger

Electronic Theses and Dissertations

Although capable of sexual reproduction, many plants also rely heavily on clonal reproduction. The formation of multiple, physiologically-independent units with the same genotype has important implications for spatial genetic structure and genetic diversity in these plants. The endangered scrub-dwelling perennial, Polygonella myriophylla is known to reproduce both sexually and clonally but no study to date has been able to investigate the spatial genetic patterns that occur in this species. I use microsatellite markers to investigate questions about clonal structure and genetic diversity in five populations of P. myriophylla and address some of the implications of my findings for conservation of ...


Characterization And Evolution Of The Serh Immobilization Antigen Genes In Tetrahymena Thermophila, Christopher Thomas McGinness 2010 Cleveland State University

Characterization And Evolution Of The Serh Immobilization Antigen Genes In Tetrahymena Thermophila, Christopher Thomas Mcginness

ETD Archive

Tetrahymena thermophila express a major cell surface protein known as the immobilization (i-) antigen which coats the entire cell surface including the cilia. T. thermophila has several different i-antigens which are expressed in a mutually exclusive manner under varying environmental conditions. When the genes for these i-antigens were sequenced it was found that they encode proteins consisting of imperfect repeats with cysteine periodicity. The best characterized of these i-antigens are those specified by alleles at the SerH i-antigen locus. The H proteins all contain a section of 8-cysteine containing imperfect repeats. The presence of repeats allows for the possibility that ...


The Role Of Ceruloplasmin In Colitis, Bakytzhan Bakhautdin 2010 Cleveland State University

The Role Of Ceruloplasmin In Colitis, Bakytzhan Bakhautdin

ETD Archive

Ceruloplasmin (Cp) is an acute phase, plasma protein with multiple enzymatic activities consistent with both pro- and anti-inflammatory functions. Our laboratory has recently reported the presence of Cp in intestinal epithelial cells. To determine the potential role of Cp in intestinal inflammation, we induced colitis in Cp-deficient mice by continuous administration of dextran sodium sulfate (DSS) ad libitum in the drinking water. The Cp-null mice rapidly lost weight and all were moribund by day 14, while about 90 of the wild-type (WT) mice survived at least 20 days. Higher amounts of TNF-alpha, and neutrophil (KC) and macrophage (MCP-1) chemokines, were ...


The Role Of Sigirr In Innate And Adaptive Immunity, Muhammet Fatih Gulen 2010 Cleveland State University

The Role Of Sigirr In Innate And Adaptive Immunity, Muhammet Fatih Gulen

ETD Archive

Single immunoglobulin IL-1R-related receptor (SIGIRR) is a transmembrane protein, which belongs to interleukin 1 receptor (IL-1R)/Toll like receptor (TLR) superfamily (Toll-IL-1R superfamily). SIGIRR has been identified as a negative modulator for IL-1R/TLR signaling. Recently, detailed structural and functional analysis of SIGIRR has been published, however physiological function of SIGIRR has not been studied. To asses the physiological function of SIGIRR, the expression of SIGIRR mRNA in different mouse tissues was analyzed. Although SIGIRR is expressed in many tissues, its expression in different cell types was more restricted, with extremely high expression in primary kidney, colon epithelial cells and ...


Ligand-Induced Conformations Of Extracellular Loop 2 Of At1r, Hamiyet Unal 2010 Cleveland State University

Ligand-Induced Conformations Of Extracellular Loop 2 Of At1r, Hamiyet Unal

ETD Archive

Angiotensin II type 1 receptor (AT1R) is a G-protein coupled receptor (GPCR) and an important regulator of blood pressure. It is a target for drug development, because abnormalities in its function are linked to hypertension, cardiac hypertrophy and heart failure. AT1R is composed of seven transmembrane helices connected by three extracellular loops and three intracellular loops. The extracellular loop 2 (ECL2) of AT1R directly interacts with the ligands. This loop is targeted by autoantibodies that activate AT1R in several pathologies such as preeclampsia, malignant hypertension and vascular allograft rejection. Therefore, we proposed that the conformation of ECL2 in AT1R is ...


The Influence Of Sexual Selection On Behavioral And Physiological Mechanisms Underlying Reproductive Success In Male Cape Ground Squirrels (Xerus Inauris), Mary Beth Manjerovic 2010 University of Central Florida

The Influence Of Sexual Selection On Behavioral And Physiological Mechanisms Underlying Reproductive Success In Male Cape Ground Squirrels (Xerus Inauris), Mary Beth Manjerovic

Electronic Theses and Dissertations

Sexual selection is considered a powerful evolutionary force responsible for the enormous diversity found in reproductive morphology, physiology, and behavior. I addressed questions related to selection in the Cape ground squirrel (Xerus inauris), a species characterized as highly social and promiscuous. These attributes often are responsible for variance in male reproductive success and as such, sexual selection theory predicts increased opportunity for sexual selection. I confirm that the predominant mechanism underlying genital evolution and competition for paternity in X. inauris is sperm competition. I find evidence that investment in sperm competition is costly and may reflect immunocompetence. I quantify reproductive ...


Genetics And Genomics Of Complex Diseases;Mouse Atherosclerosis Modifier Genes And Human Gene Expression After Bariatric Surgery, Stela Z. Berisha 2010 Cleveland State University

Genetics And Genomics Of Complex Diseases;Mouse Atherosclerosis Modifier Genes And Human Gene Expression After Bariatric Surgery, Stela Z. Berisha

ETD Archive

The overall goal of our research was to study and identify genes involved in the development of complex diseases in mice and humans through integrative genetic/genomic approaches. Two complex diseases were the focus of research, atherosclerosis and type 2 diabetes. Mouse models of atherosclerosis, in which the genetic background and the environment can be controlled for, were used to identify and validate atherosclerosis modifier genes. We studied an atherosclerosis quantitative trait locus (QTL) on the distal end of chromosome 5, called Ath24, and generated interval-specific congenic mice on the atherosclerosis resistant AKR and susceptible DBA/2 apoE-deficient strains. To ...


Transforming Growth Factor - Beta (Tgfß) Stimulated Isoform Specific Activation Of Akt2 Via Ras Mediates Epithelial-Mesenchymal Transition (Emt), Praveen Chander 2010 Cleveland State University

Transforming Growth Factor - Beta (Tgfß) Stimulated Isoform Specific Activation Of Akt2 Via Ras Mediates Epithelial-Mesenchymal Transition (Emt), Praveen Chander

ETD Archive

TGFß induces epithelial-mesenchymal transdifferentiation (EMT) accompanied by cellular differentiation and migration. EMT has emerged as a fundamental process governing embryonic development, adult tissue homeostasis and metastatic progression. Our lab had earlier identified a post-transcriptional pathway by which TGFß modulates expression of EMT-specific proteins. It was shown that heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) binds a structural, 33 nucleotides (nt) TGF beta-activated translation (BAT) element in the 3'-UTR of disabled-2 (Dab2) and interleukin-like EMT inducer (ILEI)transcripts, and repress their translation. This inhibition is removed following hnRNP E1 phosphorylation by activated Akt2. We now show that specific activation of Akt2 ...


"A Redescription Of Potamonautes Loveni, A Medically Important Feshwater Crab From Western Kenya And Eastern Uganda, East Africa" , Neil Cumberlidge, Paul F. Clark 2010 Northern Michigan University

"A Redescription Of Potamonautes Loveni, A Medically Important Feshwater Crab From Western Kenya And Eastern Uganda, East Africa" , Neil Cumberlidge, Paul F. Clark

Journal Articles

No abstract provided.


Two New Species Of Freshwater Crabs From Mt. Elgon, East Africa With A Redescription Of Potamonautes Niloticus And Notes On Their Natural History" , Neil Cumberlidge, Paul F. Clark 2010 Northern Michigan University

Two New Species Of Freshwater Crabs From Mt. Elgon, East Africa With A Redescription Of Potamonautes Niloticus And Notes On Their Natural History" , Neil Cumberlidge, Paul F. Clark

Journal Articles

No abstract provided.


"An Extra Embryonic Phase In The True Freshwater Crab Sinopotamon Yangtsekiense Bott" , H X. Wu, J Z. Xue, Neil Cumberlidge 2010 Northern Michigan University

"An Extra Embryonic Phase In The True Freshwater Crab Sinopotamon Yangtsekiense Bott" , H X. Wu, J Z. Xue, Neil Cumberlidge

Journal Articles

No abstract provided.


Expression Of Hcmv Ie1 In The U87mg Cell Line Augments Resistance To Temozolomide , Richard A. Rovin, Johnathan Lawrence, Justin J. Segula, Robert J. Winn 2010 Northern Michigan University

Expression Of Hcmv Ie1 In The U87mg Cell Line Augments Resistance To Temozolomide , Richard A. Rovin, Johnathan Lawrence, Justin J. Segula, Robert J. Winn

Journal Articles

INTRODUCTION: Human cytomegalovirus (HCMV) DNA and protein are found in gliomas but not in normal brain or other primary brain tumors. The role of HCMV infection in glioma biology is unclear. While it is unlikely that HCMV infection causes glioma, viral proteins might impart a proliferative and antiapoptotic phenotype that confers a survival advantage. Does this oncomodulation translate into a clinically relevant effect in glioma cells? To answer this question, we compared the response of the U87IE1 and U87MG malignant glioma cell lines to temozolomide. U87IE1 cells are U87MG cells that have been genetically engineered to produce HCMV IE1 protein ...


First Report Of The Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab , J Xue, Y Liu, Neil Cumberlidge, H X. Wu 2010 Northern Michigan University

First Report Of The Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab , J Xue, Y Liu, Neil Cumberlidge, H X. Wu

Journal Articles

No abstract provided.


The Impact And Shortfall Of Conservation On The Status Of The World's Vertebrates , M Hoffmann, C Hilton-Taylor, A Angulo, Monica Bohm PhD, SHM Bbutchart, K E. Carpenter, J Chanson, B Collen, N A. Cox, Neil Cumberlidge 2010 Zoological Society of London

The Impact And Shortfall Of Conservation On The Status Of The World's Vertebrates , M Hoffmann, C Hilton-Taylor, A Angulo, Monica Bohm Phd, Shm Bbutchart, K E. Carpenter, J Chanson, B Collen, N A. Cox, Neil Cumberlidge

Journal Articles

No abstract provided.


Courtship And Copulation In Glaucous-Winged Gulls, Larus Glaucescens, Kelly M. McWilliams 2010 Andrews University

Courtship And Copulation In Glaucous-Winged Gulls, Larus Glaucescens, Kelly M. Mcwilliams

Master's Theses

Using video recordings and scan counts, I examined the occurrence, sequences, and durations of behavior and environmental factors associated with courtship and copulation in glaucous-winged gulls, Larus glaucescens. Males and females in a pair had equivalent pre- and post-Mount behavior occurrences and durations. The main courtship sequence was Head Toss -- Courtship Beg/Respond -- Mounted/Mount, and felames appeared to initiate transitions between these pre-Mount behaviors. More Mounts occurred during the egg-laying stage of the breeding season, but copulation duration, wing-flag duration, and cloacal contacts per copulation showed no significant differences across sampling periods. Poisson analysis showed no significant grouping of ...


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