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Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential For Endoplasmic Reticulum To Outer Mitochondrial Membrane Protein Transport., Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley 2017 George Washington University

Superresolution Imaging Identifies That Conventional Trafficking Pathways Are Not Essential For Endoplasmic Reticulum To Outer Mitochondrial Membrane Protein Transport., Kyle Salka, Shivaprasad Bhuvanendran, Kassandra Wilson, Petros Bozidis, Mansi Mehta, Kristin Rainey, Hiromi Sesaki, George H Patterson, Jyoti K. Jaiswal, Anamaris M. Colberg-Poley

Integrative Systems Biology Faculty Publications

Most nuclear-encoded mitochondrial proteins traffic from the cytosol to mitochondria. Some of these proteins localize at mitochondria-associated membranes (MAM), where mitochondria are closely apposed with the endoplasmic reticulum (ER). We have previously shown that the human cytomegalovirus signal-anchored protein known as viral mitochondria-localized inhibitor of apoptosis (vMIA) traffics from the ER to mitochondria and clusters at the outer mitochondrial membrane (OMM). Here, we have examined the host pathways by which vMIA traffics from the ER to mitochondria and clusters at the OMM. By disruption of phosphofurin acidic cluster sorting protein 2 (PACS-2), mitofusins (Mfn1/2), and dynamin related protein 1 ...


Spinal Cord Injuries And Evaluation Of Treatments, Amanda Nelson 2017 Augustana College, Rock Island Illinois

Spinal Cord Injuries And Evaluation Of Treatments, Amanda Nelson

Biology: Student Scholarship & Creative Works

Spinal cord injuries (SCI) are common injuries that do not currently have a fully successful treatment. These injuries cause many physical, psychological, and social burdens for the injured person and any close friends or family members. Older treatment options include surgery, pharmacotherapy, and physical therapy, while newer treatment options include stem cell therapy, bionics, and electrical stimulation. After a full evaluation of the treatments, it was concluded that the best treatment for today is pharmacotherapy, but with more research, stem cell therapy will become the ideal treatment for SCI in the future.


Carbon Black Exposure Induces Alterations In Mitochondrial Morphology In Human Lung Cells: A Software-Based Quantitative Analysis, Jennifer D. Duff, Brianna K. LaFerney, Celina Y. Jones, Penn M. McClatchey, Jay Brewster 2017 Pepperdine University

Carbon Black Exposure Induces Alterations In Mitochondrial Morphology In Human Lung Cells: A Software-Based Quantitative Analysis, Jennifer D. Duff, Brianna K. Laferney, Celina Y. Jones, Penn M. Mcclatchey, Jay Brewster

Seaver College Research And Scholarly Achievement Symposium

Nanoparticulates of pure carbon, carbon black (CB), are a common atmospheric pollutant in industrialized and heavily populated areas. They are produced primarily via combustion of fossil fuels, and represent a significant health hazard. They are known to worsen asthma and bronchitis when inhaled and to cause inflammation, heart dysfunction, and oxidative stress when incorporated into other organs. The key focal point of this work was to examine markers of stress signaling and cellular dysfunction when human bronchial epithelial cells (16HBE14o-) were exposed to CB particles ranging in size from 70 nm and averaging 130 nm in diameter. BrdU incorporation and ...


15. Enumeration And Gene Identification Of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae From Impacted Urban Streams In Hall County, Georgia, Usa., Monica Leavell 2017 University of North Georgia

15. Enumeration And Gene Identification Of Extended-Spectrum-Beta-Lactamase-Producing Enterobacteriaceae From Impacted Urban Streams In Hall County, Georgia, Usa., Monica Leavell

University of North Georgia Annual Research Conference

Extended-spectrum beta-lactamases (ESBLs) are a group of enzymes shown to rapidly evolve and confer resistance to a number of antibiotics, including beta lactams. Organisms that produce ESBLs pose both threats and challenges in the administration of appropriate agents to treat infections. ESBLs exhibit antibiotic resistance by destructing the antibiotics’ structure and are typically found encoded on bacterial plasmids that can easily be transferred between bacteria from the family Enterobacteriaceae. Water environments such as streams can help the spread of antibiotic-resistant bacteria which can originate from a variety of sources, including wastewater treatment plants, agricultural sources, and residential septic tank systems ...


A Flexible, Incentivized Budgeting System For Academic Departments, N. Douglas Lees 2017 Indiana University - Purdue University Indianapolis

A Flexible, Incentivized Budgeting System For Academic Departments, N. Douglas Lees

Academic Chairpersons Conference Proceedings

This session will involve a discussion of the budgeting models of the attendees and a discussion of their overall needs for budgeting guidance. An overview of Responsibility Centered Management (RCM) will be provided along with the model used to set budgets for departments in a School of Science.


Facilitating Curriculum Change One Step At A Time, Joanna Mott 2017 James Madison University

Facilitating Curriculum Change One Step At A Time, Joanna Mott

Academic Chairpersons Conference Proceedings

Large departments provide additional challenges when leading change. Participants will learn strategies to thoughtfully move a department forward keeping transparency, respect for all and inclusiveness in mind and identifying, empowering and guiding department faculty leaders who are trusted by their peers.


Hitching A Ride: First Record Of A Least Chipmunk (Tamias Minimus) In Eastern Nebraska, Keith Geluso, Michael L. Forsberg 2017 University of Nebraska—Kearney

Hitching A Ride: First Record Of A Least Chipmunk (Tamias Minimus) In Eastern Nebraska, Keith Geluso, Michael L. Forsberg

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

On 10 October 2016, a Least Chipmunk (Tamias minimus) was discovered in a residential area of Lincoln, Lancaster County, Nebraska. The closest populations of Least Chipmunks reside > 640 km to the west in northwestern Nebraska and southeastern Wyoming. The most parsimonious explanation for this unusual observation is that the chipmunk was transported to the city by humans. A likely scenario is that the chipmunk hitched a ride to Lincoln in a motor vehicle on 2 October 2016, when one of us drove 1500 km in a single day from Jackson, Teton County, Wyoming, after residing in that area for 10 ...


Collaborative Research: The Interplay Between Fluctuating Selection On Symbionts And Life Cycle Evolution In Sap-Sucking Insects, Carol von Dohlen 2017 Utah State University

Collaborative Research: The Interplay Between Fluctuating Selection On Symbionts And Life Cycle Evolution In Sap-Sucking Insects, Carol Von Dohlen

Funded Research and Data

No abstract provided.


Living High And Healthy: Why Coloradans And Others Who Live At High Altitude Live Longer, And What Flatlanders Can Learn From Them, Todd Becker 2017 Getting Stronger blog

Living High And Healthy: Why Coloradans And Others Who Live At High Altitude Live Longer, And What Flatlanders Can Learn From Them, Todd Becker

Journal of Evolution and Health

No abstract provided.


Do You Really Want A Hunter-Gatherer Microbiota? Perils And Pitfalls For Your Gut, Michael Ruscio 2017 Dr. Michael Ruscio

Do You Really Want A Hunter-Gatherer Microbiota? Perils And Pitfalls For Your Gut, Michael Ruscio

Journal of Evolution and Health

Clinicians have long understood the immense impact the health of our gut has on things like weight, energy, depression, autoimmunity and more. With the recent advancements in microbiota research we have learned much more about this connection. Like never before we understand how we can alleviate chronic health conditions and enhance well-being through improving the health of the gut.

However, with this increased research has also come over speculation and ill-informed recommendations. This has high impact on today's healthcare professional or consumer who could unintentionally do harm. For example by replicating the microbiota of hunter-gatherers of Africa, we could ...


The Case For The Long Body, Frank Forencich 2017 Exuberant Animal

The Case For The Long Body, Frank Forencich

Journal of Evolution and Health

No abstract provided.


Characterization Of A New Oda3 Allele, Oda3-6, Defective In Assembly Of The Outer Dynein Arm-Docking Complex In Chlamydomonas Reinhardtii, Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, Maureen Wirschell 2017 Salem State University

Characterization Of A New Oda3 Allele, Oda3-6, Defective In Assembly Of The Outer Dynein Arm-Docking Complex In Chlamydomonas Reinhardtii, Jason M. Brown, Matthew Mosley, Daniela Montes-Berrueta, Yuqing Hou, Fan Yang, Chasity Scarbrough, George B. Witman, Maureen Wirschell

Biology Faculty Publications

We have used an insertional mutagenesis approach to generate new C. reinhardtii motility mutants. Of 56 mutants isolated, one is a new allele at the ODA3 locus, called oda3-6. Similar to the previously characterized oda3 alleles, oda3-6 has a slow-jerky swimming phenotype and reduced swimming speed. The oda3-6 mutant fails to assemble the outer dynein arm motor and outer dynein arm—docking complex (ODA-DC) in the ciliary axoneme due to an insertion in the 5’ end of the DCC1 gene, which encodes the DC1 subunit of the ODA-DC. Transformation of oda3-6 with the wild-type DCC1 gene rescues the mutant swimming ...


Epigenetics And Shared Molecular Processes In The Regeneration Of Complex Structures, Labib Rouhana, Junichi Tasaki 2017 Wright State University - Main Campus

Epigenetics And Shared Molecular Processes In The Regeneration Of Complex Structures, Labib Rouhana, Junichi Tasaki

Labib Rouhana

The ability to regenerate complex structures is broadly represented in both plant and animal kingdoms. Although regenerative abilities vary significantly amongst metazoans, cumulative studies have identified cellular events that are broadly observed during regenerative events. For example, structural damage is recognized and wound healing initiated upon injury, which is followed by programmed cell death in the vicinity of damaged tissue and a burst in proliferation of progenitor cells. Sustained proliferation and localization of progenitor cells to site of injury give rise to an assembly of differentiating cells known as the regeneration blastema, which fosters the development of new tissue. Finally ...


Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata 2017 Wright State University - Main Campus

Cellular And Molecular Dissection Of Pluripotent Adult Somatic Stem Cells In Planarians, Norito Shibata, Labib Rouhana, Kiyokazu Agata

Labib Rouhana

Freshwater planarians, Plathelminthes, have been an intriguing model animal of regeneration studies for more than 100 years. Their robust regenerative ability is one of asexual reproductive capacity, in which complete animals develop from tiny body fragments within a week. Pluripotent adult somatic stem cells, called neoblasts, assure this regenerative ability. Neoblasts give rise to not only all types of somatic cells, but also germline cells. During the last decade, several experimental techniques for the analysis of planarian neoblasts at the molecular level, such as in situ hybridization, RNAi and fluorescence activated cell sorting, have been established. Moreover, information about genes ...


Piwi Homologs Mediate Histone H4 Mrna Localization To Planarian Chromatoid Bodies, Labib Rouhana, Jennifer A. Weiss, Ryan S. King, Phillip A. Newmark 2017 Wright State University - Main Campus

Piwi Homologs Mediate Histone H4 Mrna Localization To Planarian Chromatoid Bodies, Labib Rouhana, Jennifer A. Weiss, Ryan S. King, Phillip A. Newmark

Labib Rouhana

The well-known regenerative abilities of planarian flatworms are attributed to a population of adult stem cells called neoblasts that proliferate and differentiate to produce all cell types. A characteristic feature of neoblasts is the presence of large cytoplasmic ribonucleoprotein granules named chromatoid bodies, the function of which has remained largely elusive. This study shows that histone mRNAs are a common component of chromatoid bodies. Our experiments also demonstrate that accumulation of histone mRNAs, which is typically restricted to the S phase of eukaryotic cells, is extended during the cell cycle of neoblasts. The planarian PIWI homologs SMEDWI-1 and SMEDWI-3 are ...


Time Of Day Regulates Subcellular Trafficking, Tripartite Synaptic Localization, And Polyadenylation Of The Astrocytic Fabp7 Mrna, Jason R. Gerstner, William M. Vanderheyden, Timothy LaVaute, Cara J. Westmark, Labib Rouhana, Allan I. Pack, Marvin Wickens, Charles F. Landry 2017 Wright State University - Main Campus

Time Of Day Regulates Subcellular Trafficking, Tripartite Synaptic Localization, And Polyadenylation Of The Astrocytic Fabp7 Mrna, Jason R. Gerstner, William M. Vanderheyden, Timothy Lavaute, Cara J. Westmark, Labib Rouhana, Allan I. Pack, Marvin Wickens, Charles F. Landry

Labib Rouhana

The astrocyte brain fatty acid binding protein (Fabp7) has previously been shown to have a coordinated diurnal regulation of mRNA and protein throughout mouse brain, and an age-dependent decline in protein expression within synaptoneurosomal fractions. Mechanisms that control time-of-day changes in expression and trafficking Fabp7 to the perisynaptic process are not known. In this study, we confirmed an enrichment of Fabp7 mRNA and protein in the astrocytic perisynaptic compartment, and observed a diurnal change in the intracellular distribution of Fabp7 mRNA in molecular layers of hippocampus. Northern blotting revealed a coordinated time-of-day-dependent oscillation for the Fabp7 mRNA poly(A) tail ...


Germline Defects Caused By Smed-Boule Rna-Interference Reveal That Egg Capsule Deposition Occurs Independently Of Fertilization, Ovulation, Mating, Or The Presence Of Gametes In Planarian Flatworms, Jessica Kathryne Steiner, Junichi Tasaki, Labib Rouhana 2017 Wright State University - Main Campus

Germline Defects Caused By Smed-Boule Rna-Interference Reveal That Egg Capsule Deposition Occurs Independently Of Fertilization, Ovulation, Mating, Or The Presence Of Gametes In Planarian Flatworms, Jessica Kathryne Steiner, Junichi Tasaki, Labib Rouhana

Labib Rouhana

Few animals are known to lay eggs in the absence of ovulation or copulation, as it is presumably energetically wasteful and subjected to negative selection. Characterization of Smed-boule, a member of the DAZ family of germline RNA-binding proteins, revealed that egg capsule (or capsule) production and deposition occurs independently of the presence of gametes in the planarian flatworm Schmidtea mediterranea. Reduction of Smed-boule expression by RNA-interference (RNAi) causes ablation of spermatogonial stem cells and the inability of ovarian germline stem cells to undergo oogenesis. Although animals subjected to Smed-boule RNAi lose their gametes and become sterile, they continue to lay ...


Prmt5 And The Role Of Symmetrical Dimethylarginine In Chromatoid Bodies Of Planarian Stem Cells, Labib Rouhana, Ana P. Vieira, Rachel H. Roberts-Galbraith, Phillip A. Newmark 2017 Wright State University - Main Campus

Prmt5 And The Role Of Symmetrical Dimethylarginine In Chromatoid Bodies Of Planarian Stem Cells, Labib Rouhana, Ana P. Vieira, Rachel H. Roberts-Galbraith, Phillip A. Newmark

Labib Rouhana

Planarian flatworms contain a population of adult stem cells (neoblasts) that proliferate and generate cells of all tissues during growth, regeneration and tissue homeostasis. A characteristic feature of neoblasts is the presence of chromatoid bodies, large cytoplasmic ribonucleoprotein (RNP) granules morphologically similar to structures present in the germline of many organisms. This study aims to reveal the function, and identify additional components, of planarian chromatoid bodies. We uncover the presence of symmetrical dimethylarginine (sDMA) on chromatoid body components and identify the ortholog of protein arginine methyltransferase PRMT5 as the enzyme responsible for sDMA modification in these proteins. RNA interference-mediated depletion ...


Vertebrate Gld2 Poly(A) Polymerases In The Germline And The Brain, Labib Rouhana, Liaoteng Wang, Natascha Buter, Jae Eun Kwak, Craig A. Schiltz, Tania Gonzalez, Ann E. Kelley, Charles F. Landry, Marvin Wickens 2017 Wright State University - Main Campus

Vertebrate Gld2 Poly(A) Polymerases In The Germline And The Brain, Labib Rouhana, Liaoteng Wang, Natascha Buter, Jae Eun Kwak, Craig A. Schiltz, Tania Gonzalez, Ann E. Kelley, Charles F. Landry, Marvin Wickens

Labib Rouhana

Cytoplasmic polyadenylation is important in the control of mRNA stability and translation, and for early animal development and synaptic plasticity. Here, we focus on vertebrate poly(A) polymerases that are members of the recently described GLD2 family. We identify and characterize two closely related GLD2 proteins in Xenopus oocytes, and show that they possess PAP activity in vivo and in vitro and that they bind known polyadenylation factors and mRNAs known to receive poly(A) during development. We propose that at least two distinct polyadenylation complexes exist in Xenopus oocytes, one of which contains GLD2; the other, maskin and Pumilio ...


De Novo Alignment Of Girardia Dorotocephala Transcriptome, Labib Rouhana, Eugene M. P. Almazan 2017 Wright State University - Main Campus

De Novo Alignment Of Girardia Dorotocephala Transcriptome, Labib Rouhana, Eugene M. P. Almazan

Labib Rouhana

De novo alignment of a Girardia dorotocephala (2n = 16) transcriptome using the Trinity platform.


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