16 Institutions 42 Full-Text Articles 68 Authors 6,628 Downloads
Recent Articles in Structural Biology
Utilizing Nmr Spectroscopy And Molecular Docking As Tools For The Structural Determination And Functional Annotation Of Proteins, Jaime Stark University of Nebraska - Lincoln
Utilizing Nmr Spectroscopy And Molecular Docking As Tools For The Structural Determination And Functional Annotation Of Proteins, Jaime Stark
Student Research Projects, Dissertations, and Theses - Chemistry Department
With the completion of the Human Genome Project in 2001 and the subsequent explosion of organisms with sequenced genomes, we are now aware of nearly 28 million proteins. Determining the role of each of these proteins is essential to our understanding of biology and the development of medical advances. Unfortunately, the experimental approaches to determine protein function are too slow to investigate every protein. Bioinformatics approaches, such as sequence and structure homology, have helped to annotate the functions of many similar proteins. However, despite these computational approaches, approximately 40% of proteins still have no known function. Alleviating this deficit will ...
Filamin Is Required For F-Actin Organization And Calcium Signaling In C. Elegans, Ismar Kovacevic Northeastern University
Filamin Is Required For F-Actin Organization And Calcium Signaling In C. Elegans, Ismar Kovacevic
During organism development cells sense, integrate, and respond to a variety of cues or signals. Mechanical properties of cells, and the matrix that surrounds them, contribute critical signals that direct cell migration and differentiation. In this study we sought to establish a simple model system to study mechanotransduction in an intact organism at the cellular level. The C. elegans spermatheca is a simple organ, consisting of a layer of myoepithelial cells enclosed by a basement membrane. Oocytes are ovulated into the spermatheca, where they are fertilized, and then propelled into the uterus by constriction of the spermatheca. Phenotypic analysis of ...
Phylogenetic Engineering Of The Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase Large Subunit In Chlamydomonas Reinhardtii, Boon Hoe Lim University of Nebraska - Lincoln
Phylogenetic Engineering Of The Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase Large Subunit In Chlamydomonas Reinhardtii, Boon Hoe Lim
Theses and Dissertations in Biochemistry
Thirty-four residues in the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) may account for the kinetic differences between Rubisco enzyme from green algae and land plants. By substituting these "phylogenetic residues" as groups and combinations of groups in the large subunit of the green alga Chlamydomonas reinhardtii with those of land-plant Rubisco, the functions and relationships of these "phylogenetic groups" were determined.
A phylogenetic-group substitution at the base of catalytic loop 6 of the large subunit decreases the CO2/O2 specificity of the enzyme, but function is restored by a further phylogenetic-group substitution at the carboxy-terminal tail ...
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Sound Production In Two Loricariid Catfishes, Amanda Webb
Impact Of Collateral Enlargement On Smooth Muscle Phenotype, Alexander Bynum
Pharmacological Chaperoning In Fabry Disease, Jerome Rogich
Mutation And Complementation Of A Cellulose Synthase (Cesa) Gene, Ahmed El-Araby
Examining The Roles Of Pstoc75 Potra Domains In Chloroplast Protein Import, Richard Simmerman
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