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Synchrotron Radiation Based Experimental Determination Of The Optimal Energy For Cell Radiotoxicity Enhancement Following Photoelectric Effect On Stable Iodinated Compounds, S Corde, A Joubert, J F. Adam, A M. Charvet, J F. Le Bas, F Esteve, H Elleaume, J Balosso

Stéphanie Corde

This study was designed to experimentally evaluate the optimal X-ray energy for increasing the radiation energy absorbed in tumours loaded with iodinated compounds, using the photoelectric effect. SQ20B human cells were irradiated with synchrotron monochromatic beam tuned at 32.8, 33.5, 50 and 70 keV. Two cell treatments were compared to the control: cells suspended in 10 mg ml1 of iodine radiological contrast agent or cells pre-exposed with 10 mM of iodo-desoxyuridine (IUdR) for 48 h. Our radiobiological end point was clonogenic cell survival. Cells irradiated with both iodine compounds exhibited a radiation sensitisation enhancement. Moreover, it was energy dependent, with …