Psychology Commons^™

Choline Supplementation Alters Hippocampal Cytokine Levels In Adolescence And Adulthood In An Animal Model Of Fetal Alcohol Spectrum Disorders, Jessica A. Baker, Tamara S. Bodnar, Kristen Breit, Joanne Weinberg, Jennifer D. Thomas

Psychology Faculty Publications

Alcohol (ethanol) exposure during pregnancy can adversely affect development, with long-lasting consequences that include neuroimmune, cognitive, and behavioral dysfunction. Alcohol-induced alterations in cytokine levels in the hippocampus may contribute to abnormal cognitive and behavioral outcomes in individuals with fetal alcohol spectrum disorders (FASD). Nutritional intervention with the essential nutrient choline can improve hippocampal-dependent behavioral impairments and may also influence neuroimmune function. Thus, we examined the effects of choline supplementation on hippocampal cytokine levels in adolescent and adult rats exposed to alcohol early in development. From postnatal day (PD) 4-9 (third trimester-equivalent), Sprague-Dawley rat pups received ethanol (5.25 g/kg/day) or sham …

Psychology Of Addiction: Discussion & Essay Questions, Brent Maximin

Open Educational Resources

No abstract provided.

The Role Of Athletic Identity In General Mental Health And Alcohol-Related Help-Seeking Intentions Of College Students, Michael Grant Young

Psychology Theses & Dissertations

Young adults are vulnerable to a range of mental health concerns and tend to drink in high quantities and tend to not seek help for these concerns. Specifically, college students involved in athletics tend to have low help-seeking rates—though help-seeking research for this population is relatively limited. Athletic identity (i.e., identification with the athlete role) is a relevant construct for examining this population, however little is known about its association with help-seeking beliefs and ideas. This study examines: (1) the association between athletic identity and help-seeking intentions for both mental health and alcohol use concerns, (2) the association between …

Voluntary Alcohol Consumption And Sleep Deprivation In Rats, Aesha Khan

Masters Theses, 2020-current

Alcohol is one of the most common psychoactive drugs and has depressant effects on the central nervous system. The vast majority of research on alcohol and sleep commonly indicates chronic alcohol use has a detrimental impact on sleep architecture and homeostasis. However, less research has been conducted investigating the effects of sleep deprivation on alcohol consumption. Our lab's previous studies have looked at a potential bi-directional relationship between sleep and alcohol with promising results. However, there was concern that the method of sleep deprivation may have resulted in stress. The present study examines the effect of sleep deprivation on voluntary …

Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton

Theses and Dissertations--Psychology

Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse.

Following ethanol consumption ethanol enters the bloodstream from the small intestine where it gets distributed to peripheral tissues. Ethanol in the bloodstream is cleared from the system by the liver. The primary …

Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt

Theses and Dissertations

Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …

The Effects Of Historical Alcohol Use On Neuropsychological Functioning In Older Adults Following A Traumatic Brain Injury, Ryan Sever

Dissertations

The present study aimed to determine the effects of alcohol abuse and dependence in long term functioning of older adults who have experienced a moderate to severe traumatic brain injury. The research question being answered in the current study was if a history of alcohol abuse or dependence would worsen neuropsychological functioning in older adults who experienced at least one moderate to severe traumatic brain injury. Participants of the study were selected from the more extensive database provided by the Brain Aging in Vietnam War Veterans (DOD-ADNI) database. All participants were Vietnam War veterans between the ages of 61 and …

Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna

Theses and Dissertations

Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.

The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …

Anxiety-Like Behaviors And C-Fos Expression In Adult Zebrafish: Effects Of Housing Conditions, Alcohol And Caffeine, Adam Douglas Collier

Dissertations

Alcohol abuse is the third largest risk factor for disease world, responsible for an estimated 3.3 million deaths each year. The concomitant ingestion of alcohol and caffeine is hypothesized to increase risk factors associated with alcohol use alone by reducing subjective effects of intoxication. The zebrafish (Danio rerio) has recently garnered attention from researchers as an effective pre-clinical in-vivo animal model in behavioral pharmacology research, largely due to small size, low-cost and ease of drug delivery. A number of studies have reported the effects of alcohol and caffeine on zebrafish behavior at a variety of doses. However, the …

The Effects Of Chronic Partial Sleep Deprivation And Chronic Voluntary Alcohol Consumption On Δfos B Accumulation, Kristian Ponder

Masters Theses, 2010-2019

The present study explores the relation between sleep restriction and alcohol use and the neural substrates that result from chronic behaviors. Accumulation of the transcription factors ΔFosB is suggested as a possible outcome of chronic behaviors, such as addiction. Sleep is discussed as possible mediating factor in the relationship between ΔFosB and chronic alcohol consumption. There were four experimental groups in this study: Control (C), Sleep Deprivation only (SD), Alcohol Exposure only (AO), and both sleep deprivation and alcohol exposure (B). Levels of ΔFosB accumulation in the Nucleus Accumbens (NAc) revealed a significant main effect of sleep deprivation, but no …

The Contribution Of A Polygenic Risk Score To Individual Differences In Aggressive Behavior: The Moderating And Mediating Roles Of Stressful Events, Christa C. Christ

Department of Psychology: Dissertations, Theses, and Student Research

Although aggression can be beneficial in certain situations (e.g. playing sports, self-defense), excessive and inappropriate aggression can lead to adverse physical and psychological health outcomes in both perpetrators and victims. Genetic susceptibility to negative environments can increase the likelihood of aggressive behavior in the context of situational risk factors. Low efficiency of serotonin neurotransmission and exposure to stress appear to play a prominent role in the etiology of aggressive behavior. A set of three studies assessed the contribution of polygenic risk (TPH2 rs4570625, SLC6A4 5-HTTLPR+rs25531, HTR1B rs13212041, MAOA uVNTR) to aggressive behavior, including alcohol-related aggression, in university students at varying …

Cognitive And Behavioral Mechanisms Underlying Alcohol-Induced Risky Driving, Jennifer R. Laude

Theses and Dissertations--Psychology

Alcohol intoxication represents one situation an individual might increase their amount of risk taking when driving. This dissertation is comprised of three studies that investigate the mechanisms by which alcohol increases driver risk-taking. Study 1 examined the effect of alcohol on driver risk-taking using a proxemics approach. The study also tested whether alcohol-induced increases in risky driving co-occurred with pronounced impairment in the driver’s skill. The study also examined whether the most disinhibited drivers were also the riskiest. Indeed, alcohol increased driver risk-taking and impaired driving skill. The study also revealed risky driving can be dissociable from impairing effects on …

Zebrafish And Conditioned Place Preference: A Translational Model Of Drug Reward, Adam Douglas Collier

Master's Theses

Addiction and substance abuse commonly lead to negative outcomes such damaged health, domestic violence, child abuse, failure in school, and loss of employment. In the United States, hundreds of billions of dollars accrue annually in costs associated with healthcare, crime and lost productivity due to addiction. Efficacious treatments remain few in number, the development of which will be facilitated by comprehension of environmental, genetic, pharmacological and neurobiological mechanisms implicated in the pathogenesis of addiction. The zebrafish (Danio rerio) has recently gained popularity as a model organism of complex brain disorders (e.g., substance use disorder). Behavioral quantification within the conditioned place …

Alcohol, Pregnancy And The Developing Child, Sandra J. Kelly

Sandra J. Kelly

No abstract provided.

Alexithymia And Alcohol: The Roles Of Punishment Sensitivity And Drinking Motives, Michael Lyvers, Penelope Hasking, Bonnie Albrecht, Fred Thorberg

Mike Lyvers

Alexithymia refers to difficulties identifying and describing feelings. It is suspected of being a risk factor for problematic drinking, an idea examined by this study. In 178 women and 84 men alexithymia was associated with male gender, coping motives for drinking and sensitivity to punishment. Individuals with alexithymia reported stronger coping motives and sensitivity to punishment compared to those with borderline or no alexithymia. Path analysis indicated that the relationship between the alexithymia dimension difficulties identifying feelings and coping motives was mediated by sensitivity to punishment, and the relationship between sensitivity to punishment and risky drinking was mediated by coping …

The Effects Of Adolescent Binge Drinking On Corticotropin-Releasing Factor Cells In The Amygdala And Social Predictors Of Alcohol Intake In Male And Female Rats, Chrisanthi Karanikas

Masters Theses 1911 - February 2014

Alcohol is one of the most common drugs of choice among adolescents. Normally, the method of consumption is drinking large quantities of alcohol in short periods of time, otherwise known as “binge drinking.” Corticotropin releasing factor (CRF) stress peptide producing cells in central nucleus of the amygdala (CeA) has been implicated in behavioral responses to stress and addiction. The goals of this thesis were to determine the effects of voluntary binge drinking in adolescence and vapor-induced alcohol dependence in adulthood on CRF cells in the CeA. These studies were done using an operant model of voluntary binge drinking in rodents …

Repeated Binge Pattern Ethanol Administration During Adolescence Or Adulthood: Long-Term Changes In Voluntary Ethanol Intake And Mesolimbic Dopamine Functionality In Male Rats, Antoniette Michelle Maldonado-Devincci

USF Tampa Graduate Theses and Dissertations

Binge alcohol consumption is a rising concern in the United States, especially among adolescents as during this developmental period alcohol use is usually initiated and has been shown to cause detrimental effects on brain structure and function. These findings have been established through the use of binge models in animals, where animals are repeatedly administered high doses of ethanol typically over a period of three or four days. While such work has examined the effects of a four-day and repeated three-day binge, there has been almost no work conducted aimed at investigating the long-term behavioral and neurochemical and/or functional consequences …

Beer Goggles: Blood Alcohol Concentration In Relation To Attractiveness Ratings For Unfamiliar Opposite Sex Faces In Naturalistic Settings, Michael Lyvers, E. Cholakians, M. Puorro, S. Sundram

Mike Lyvers

The popular notion that alcohol intoxication enhances perceptions of the physical attractiveness of the opposite sex has been inconsistently supported. The current study tested intoxicated and non-intoxicated persons of both genders in naturalistic settings after measuring their blood alcohol concentration (BAC) by a breath test. A sample of 80 heterosexual university student social drinkers was recruited at a campus pub and campus parties over a 3-month period to take a survey rating the attractiveness of unfamiliar faces of the opposite gender presented in photographs. Attractiveness ratings were positively correlated with BAC. Analysis of covariance (ANCOVA) was conducted on attractiveness ratings …

Alcohol, Pregnancy And The Developing Child, Sandra J. Kelly

Faculty Publications

No abstract provided.