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Full-Text Articles in Psychology

Uncovering The Mimicry Of Online Review Breadth And Depth And Its Subsequent Effect On Consumer Responses, Andrea Pelaez Martinez Jun 2024

Uncovering The Mimicry Of Online Review Breadth And Depth And Its Subsequent Effect On Consumer Responses, Andrea Pelaez Martinez

Dissertations, Theses, and Capstone Projects

Word-of-mouth (WOM) in marketing occurs when consumers discuss a company's product or service or any consumption experience with their friends, family, and others with whom they have any relationship. With the advent of social media, this phenomenon has expanded rapidly into virtual environments where consumer conversation is enabled through chats, forums, social media posts, and online reviews. In response to this rapid growth of online WOM, academics and practitioners have focused their interest on this phenomenon and its implications on consumers, firms, and society. So far, the evidence of the critical role that online WOM plays in helping consumers make …


Examining Visual Processing Of Hierarchical Figures Through Behavioral Measures And Pupillometry In Relation To Autistic Traits In Adults, Chloe Brittenham Jun 2024

Examining Visual Processing Of Hierarchical Figures Through Behavioral Measures And Pupillometry In Relation To Autistic Traits In Adults, Chloe Brittenham

Dissertations, Theses, and Capstone Projects

Autism spectrum disorder (ASD) and autistic traits in the general population are associated with differences in sensory processing, particularly within the visual domain. Previous studies examining global (i.e., overall gist) and local (i.e., detail) visual processing in relation to ASD have sometimes yielded contradictory findings yet converge on a common theme: slowed global processing and increased local bias associated with ASD. Despite this consensus, the mechanism underlying these differences remains unclear, whether it be differences in visual attention, higher or lower visual perception, and/or cognitive style. The use of traditional tasks and stimuli may further complicate the understanding of contributing …


Cross-Linguistic Differences In Neural Encoding And Processing Of Stop Consonants: The Impact Of Language Experience On Attention Allocation, Aline Dos Santos Oliveira Jun 2024

Cross-Linguistic Differences In Neural Encoding And Processing Of Stop Consonants: The Impact Of Language Experience On Attention Allocation, Aline Dos Santos Oliveira

Dissertations, Theses, and Capstone Projects

This study aims to examine the intricate relationship between language experience and the neural processing of stop consonant speech sounds. Previous research has shown minimal differences in amplitudes and latencies of cortical Auditory Evoked Potentials (AEPs) to speech sounds across listeners from various language backgrounds. It is only towards the later latencies (around the P2 peak at 200 ms), that there have been suggestions of cross-linguistic differences. In addition, a recent study, observed an AEP difference between monolinguals and bilinguals when processing speech, specifically an "Nd effect”. The Nd effect, which is an increased negativity of the AEP is proposed …


Exploring Cross-Linguistic Speech Perception In Hindi, English, And Romance-Language Through Temporal Dynamics Of Neural Activity, Yuga Kothari Feb 2024

Exploring Cross-Linguistic Speech Perception In Hindi, English, And Romance-Language Through Temporal Dynamics Of Neural Activity, Yuga Kothari

Dissertations, Theses, and Capstone Projects

This study examines the effect of linguistic experience on the neural processing of Voice Onset Time (VOT) in Hindi and Romance language (Spanish and Portuguese) individuals who are bilingual in English and monolingual English speakers using the event-related potential (ERP) Mismatch Negativity (MMN) response. VOT is a linguistic property that measures the time elapsed between the release of a stop consonant and the beginning of voicing, that is, vocal fold vibration of a following vowel. In a double-oddball paradigm, participants’ (n = 41) ERP were recorded while listening to speech sounds differing in VOT. The bilabial short lag stop [p] …


The Neural Correlates Of Bodily Self-Consciousness In Virtual Worlds, Evan A. Owens Sep 2023

The Neural Correlates Of Bodily Self-Consciousness In Virtual Worlds, Evan A. Owens

Dissertations, Theses, and Capstone Projects

Bodily Self-Consciousness (BSC) is the cumulative integration of multiple sensory modalities that contribute to our sense of self. Sensory modalities, which include proprioception, vestibulation, vision, and touch are updated dynamically to map the specific, local representation of ourselves in space. BSC is closely associated with bottom-up and top-down aspects of consciousness. Recently, virtual- and augmented-reality technology have been used to explore perceptions of BSC. These recent achievements are partly attributed to advances in modern technology, and partly due to the rise of virtual and augmented reality markets. Virtual reality head-mounted displays can alter aspects of perception and consciousness unlike ever …


Voiding The Unwanted Self: An Examination Of Racialized Violence In The United States, Benjamin Stark Jun 2023

Voiding The Unwanted Self: An Examination Of Racialized Violence In The United States, Benjamin Stark

Dissertations, Theses, and Capstone Projects

This dissertation is concerned with the role of the psychic defenses projection and projective identification in the processes which lead to racialized violence in the United States. The dissertation posits that projection has been less considered as a primary driver of racialized violence than other psychic processes and should be better integrated into psychological research and literature on racialized violence. The thesis begins with a detailed examination of two instances of racialized violence, the first a macro example of nation vs. nation: the United States’ invasion of Iraq in 2003, before which the United States fantasized Iraq was developing weapons …


Slow Speed Rail: The Social, Psychological And Environmental Benefits Of Long-Distance Train Travel, Vincent Gragnani Jun 2023

Slow Speed Rail: The Social, Psychological And Environmental Benefits Of Long-Distance Train Travel, Vincent Gragnani

Dissertations, Theses, and Capstone Projects

Long-distance train travel in the United States is slow, inefficient and woefully underfunded. Trains are routinely delayed for freight traffic. Many major cities are served in the middle of the night, or not at all. And the cost of a sleeping compartment is far out of reach for most Americans. This is all in stark contrast to the reliable services offered across Europe and parts of Asia. But for the 3.5 million people who ride Amtrak’s long-distance trains every year, the experience can be a fulfilling one. This web-based project, slowspeedrail.com, explores these benefits, namely, an intimacy with the landscape …


The Effects Of Music Therapy On Elderly Adults With Dementia, Jeante J. Jackson Jun 2023

The Effects Of Music Therapy On Elderly Adults With Dementia, Jeante J. Jackson

Dissertations, Theses, and Capstone Projects

As people age, the brain is more susceptible to changes that diminish cognitive function. In recent years neuroscience has found convergent evidence between music therapy and brain architecture, as it has shown the generation of new connections in the brain or a reorganization and possible strengthening of existing connections already in the brain. However, the literature regarding music training’s effects on executive control, selective attention, and speech processing is lacking particularly when it comes to older populations.

This study investigated Verbal Working Memory, Visuospatial Attention and Task Initiation, and Auditory Selective Attention in a 91-year-old adult (B.P.) diagnosed with dementia. …


Ssri-Induced Emotional Blunting: A Study Of Cognitive Changes In Pharmaceutically Treated Depression, Carly Tocco Sep 2022

Ssri-Induced Emotional Blunting: A Study Of Cognitive Changes In Pharmaceutically Treated Depression, Carly Tocco

Dissertations, Theses, and Capstone Projects

Objective: In recent years, approximately 12.7% of the American population are on a prescribed antidepressant medication. Selective Serotonin Reuptake Inhibitors (SSRIs) are a widely used pharmacological treatment for depressive and anxiety disorders, primarily due to their tolerance levels, mild side effects in comparison to other antidepressants, and broad range of clinical indications. However, there are still numerous concerns about SSRIs’ ability to improve depressive symptoms without adding side effects such as sexual dysfunction, gastrointestinal upset, and a restricted range of emotions. Although patients typically claim that they have less emotional pain while on SSRIs than they do during a depressive …


Individual Differences In Coping With Large Multimodal Conflicts In A Spatial Orientation Paradigm, Cassandra J. Engstrom Jun 2022

Individual Differences In Coping With Large Multimodal Conflicts In A Spatial Orientation Paradigm, Cassandra J. Engstrom

Dissertations, Theses, and Capstone Projects

This study examined how humans respond to large 180º disparities between internally generated self-motion cues and external landmarks in a navigation task. Subjects learned the locations of 4 objects in a virtual environment, navigating back to these sites in a testing phase that probed their sense of direction at dead-ends. In select (incongruent) trials, subjects’ virtual rotations were mirrored relative to their physical turns, forcing them to navigate along separate virtual and physical trajectories. On these trials, subjects were either instructed to navigate using their memory of the required turn sequence (proprioceptive instructions) or the external environment (visual …


Withdrawal From Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities To Behavioral Deficits And Neurochemical Perpetuators Of Neurotoxicity And Drug Seeking Behavior, Nicoletta K. Memos Jun 2022

Withdrawal From Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities To Behavioral Deficits And Neurochemical Perpetuators Of Neurotoxicity And Drug Seeking Behavior, Nicoletta K. Memos

Dissertations, Theses, and Capstone Projects

MA is a potent, highly addictive psychomotor stimulant known to produce neurotoxic effects on the brain leading to neurological impairments1-6 characterized by neurodegeneration of dopaminergic fibers, cell bodies and pathways, as well as brain regions such as the hippocampus, frontal cortex, and midbrain1,5.

In MA addiction, women are more vulnerable to the behavioral and cognitive effects of MA compared to men. Adult human literature reveals gender differences in usage patterns and women demonstrate increased vulnerability to the neurotoxic effects and health effects of MA use. Women begin drug use at an earlier age, escalate drug use quicker, …


Investigation Of Behavioral Responses Including Visual Side Biases To Social Stimuli In Bottlenose Dolphins (Tursiops Truncatus), Jennifer R. Savoie Feb 2022

Investigation Of Behavioral Responses Including Visual Side Biases To Social Stimuli In Bottlenose Dolphins (Tursiops Truncatus), Jennifer R. Savoie

Dissertations, Theses, and Capstone Projects

Cetacean field studies have reported consistent population-level side biases for foraging behaviors and this right side feeding bias is arguably the strongest in any species next to handedness in humans. Notably, experimental studies with cetaceans, particularly dolphins, have struggled to find laterality in other behaviors, and some have reported patterns that are inconsistent with those typically found in vertebrates. Side biases related to social processing have been reported in a few observational studies of wild delphinids but have not been successfully evaluated in a controlled experimental context. This dissertation investigated viewing side biases of bottlenose dolphins in two contexts: when …


Semantic Network Activation Contributes To The Relationship Between Mood And Inhibition, James S. Maniscalco Sep 2021

Semantic Network Activation Contributes To The Relationship Between Mood And Inhibition, James S. Maniscalco

Dissertations, Theses, and Capstone Projects

Prior research has identified several relationships between mood and executive functions. Very broadly, these findings generally suggest that positive moods are associated with enhanced cognitive performance, particularly in working memory and learning. However, recent studies note that there are some instances in which negative moods may benefit select executive skills, such as those involved in divided attention and inhibition. In sum, these findings indicate that positive moods favor top-down, heuristic, or relational processing, whereas negative trait moods favor bottom-up, detail-oriented processing. However, a clear mechanism by which these effects occur has yet to be identified.

The most compelling theories that …


A Schema-Theoretic Approach To Hierarchy In Eighteenth-Century Tonality, Simon K. S. Prosser Sep 2021

A Schema-Theoretic Approach To Hierarchy In Eighteenth-Century Tonality, Simon K. S. Prosser

Dissertations, Theses, and Capstone Projects

Prevalent modern-day theories of tonal hierarchy for eighteenth-century music, especially those influenced by the ideas of Heinrich Schenker, have been called into question by schema theorists such as Robert Gjerdingen and Vasili Byros, who argue from both cognitive and historical evidence that eighteenth-century tonal cognition was sequential or “windowed” rather than hierarchical. This dissertation seeks to recuperate the concept of tonal hierarchy in eighteenth-century music, drawing on research that reconstructs the implicit tonal theories of the partimento and thoroughbass traditions, as well as concepts of hierarchy from schema theory itself, to formulate a historically and cognitively grounded theory of tonal …


Characterizing The Brain Dynamics And Eye Movement Behavior Of Memory-Guided Saccades: A Preliminary Investigation Of Distractor Influence On Memory-Guided Saccades, Angelo V. Colmenero Jun 2021

Characterizing The Brain Dynamics And Eye Movement Behavior Of Memory-Guided Saccades: A Preliminary Investigation Of Distractor Influence On Memory-Guided Saccades, Angelo V. Colmenero

Dissertations, Theses, and Capstone Projects

Research has helped to shed light on the functional organization and neural mechanisms of distractors on memory-guided saccades. In our current study we have utilized eye tracking and EEG technology to simultaneously record the changes in saccadic eye movement (SEM) behavior and event-related potentials (ERPs) associated with performance on a memory-guided saccade task with distractor conditions. Thirteen healthy control participants (n = 13; 6 female) were tasked to complete 864 memory-guided saccade trials with both visible (white) and invisible (black) distractors presented on a black background before saccade initiation. Compared with the control (black) distractor condition, distractor presentation produced a …


Environmental Cues And The Sociospatial Imaginary: An Examination Of Spatial Perception And Meaning-Making In A Gentrifying Neighborhood, Todd Levon Brown Jun 2021

Environmental Cues And The Sociospatial Imaginary: An Examination Of Spatial Perception And Meaning-Making In A Gentrifying Neighborhood, Todd Levon Brown

Dissertations, Theses, and Capstone Projects

What could be more ordinary or pedestrian than two people walking down an urban street and talking about what we see and what we make of it? Yet this simple, quotidian act of walking a street—seeing, perceiving and experiencing physical spaces, places and objects—and making meaning of what is encountered, is the basis of my dissertation. It is also my basis for claiming that I have learned a great deal—and much unexpectedly—about how differently different people see and interpret the urban streetscape. What are the various environmental cues that stand out to different individuals? What are the psychosocial imaginaries that …


The Role Of Perceived Warmth And Competence In Civil Trials With Corporate Litigants, Alexander C. Jay Feb 2021

The Role Of Perceived Warmth And Competence In Civil Trials With Corporate Litigants, Alexander C. Jay

Dissertations, Theses, and Capstone Projects

Corporations are involved in approximately 40% of all civil litigation (Langton & Cohen, 2008), yet there is much to be learned concerning how jurors make decisions in trials involving corporate litigants. Mock juror research suggests that for-profit corporations are treated more harshly than other defendants, such as non-profit corporations and individuals (e.g., Hans, 1998). This discrepant treatment of for-profit corporate defendants might be linked to unmitigated stereotypical perceptions of them being low in warmth (i.e., likely to have immoral intentions) but high in competence (i.e., likely to be capable of acting on those intentions; Aaker et al., 2010). Research shows …


An Evaluation Of An Application Designed For The Ipad® To Measure Stimulus Overselectivity For Future Use In Autism Research, Adrienne A. Fitzer Feb 2021

An Evaluation Of An Application Designed For The Ipad® To Measure Stimulus Overselectivity For Future Use In Autism Research, Adrienne A. Fitzer

Dissertations, Theses, and Capstone Projects

Twenty-three college students participated in two studies evaluating an application designed to measure stimulus overselectivity in pictures depicting facial affect. We analyzed whether this application worked as designed by evaluating whether it could provide a robust analysis of the types of errors users make (e.g., by matching by the top features, the bottom features, or not by the top or the bottom features), and the extent to which the application worked to decrease selective responding in the event a user was not matching consistently by all features. We also evaluated if participant scores on the Autism Quotient and RAADS-14 could …


The Temporal Dynamics Of Ensemble Perception, Michael L. Epstein Sep 2020

The Temporal Dynamics Of Ensemble Perception, Michael L. Epstein

Dissertations, Theses, and Capstone Projects

The striking disparity between the subjective richness of experience and the considerable limitations of perceptual processing has emerged as an essential, enduring question in both vision science and philosophy of mind. A potential solution to this issue is ensemble perception: the ability for the visual system to compute the statistical summaries of object groups, effectively compressing an otherwise overwhelming amount of information. Previous work has supported that ensemble statistics can be perceived quickly and accurately for a wide range of object features. This has motivated models of ensemble perception as an early process in vision, providing an initial sense of …


The Cognitive Thalamus: Source Analysis Of Scene Working Memory Delay Activity, Bernard A. Gomes Sep 2020

The Cognitive Thalamus: Source Analysis Of Scene Working Memory Delay Activity, Bernard A. Gomes

Dissertations, Theses, and Capstone Projects

Working Memory represents a limited-capacity store for maintaining information and manipulating the store's contents over a short period for the guidance of goal-directed behavior. Working Memory is an essential component of executive functions that are intricately associated with the prefrontal cortex (PFC). The PFC has been implicated in maintaining task-related information online for brief periods in the absence of relevant information. This active maintenance phase is called the delay period that occurs between encoding and retrieval of the stimulus. Previous studies have attempted to understand the relationship between working memory and the PFC, especially during the delay or maintenance phase …


A Glance At The Mirror: Ensemble Perception Of Symmetry, Gene Jerskey Sep 2020

A Glance At The Mirror: Ensemble Perception Of Symmetry, Gene Jerskey

Dissertations, Theses, and Capstone Projects

A growing body of research has demonstrated the ability of subjects to extract representative statistics from visual ensembles, images of similar but distinct groups of objects, without conscious effort or attention focused on individual members of the ensemble. When presented with ensembles, subjects have been able to accurately report the mean, range, and even distribution of various features in the ensemble. Research into ensemble perception, as it has become known, has divided mainly into studies of either low-level features, such as orientation, motion, and color, which are processed in early visual areas, at least for individual objects, or high-level features, …


Pre-Report Review Of Body-Worn Camera Footage: An Examination Of Stakeholder Beliefs, Laypeople’S Judgments Of Officer Credibility, And The Consequences For Memory, Kristyn A. Jones Jun 2020

Pre-Report Review Of Body-Worn Camera Footage: An Examination Of Stakeholder Beliefs, Laypeople’S Judgments Of Officer Credibility, And The Consequences For Memory, Kristyn A. Jones

Dissertations, Theses, and Capstone Projects

Aim: This dissertation examines people’s beliefs about police officer access to body-worn camera footage, people’s judgments of officer credibility as it relates to video footage, and the consequences that review of footage has on reporting accuracy.

Rationale: With escalating police-civilian tensions in 2014, American police departments adopted body-worn camera programs. A majority of departments have policies allowing officers unrestricted access to camera footage. Because officers fear that inconsistencies between reports and videos could result in suspicion of officer deceit, they argue that officers should have access to footage before writing their reports to ensure reports match the footage. Yet, because …


Mapping The Spatial And Temporal Dynamics Of Visual Percepts Elicited By A Non-Invasive Brain Stimulation Technique, Kelly Webster Feb 2020

Mapping The Spatial And Temporal Dynamics Of Visual Percepts Elicited By A Non-Invasive Brain Stimulation Technique, Kelly Webster

Dissertations, Theses, and Capstone Projects

While many of us rely on vision to interact with and experience the world, for people with damage or disease to the eye or visual cortex, experience through this modality is extremely limited. Brain and retinal stimulation devices show exciting promise for restoring vision, but little is understood about where and when vision percepts can be induced through stimulation. Using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS), we characterized the spatial and temporal dynamics of perception induced through brain stimulation. In the first set of experiments, we explore the importance of higher visual and non-visual areas vs. …


Visual Entrainment Of Perception-Related Neural Oscillations As A Mechanism For Maintaining Rhythmic Temporal Expectations Across A Wide Range Of Frequencies, Michael James Gray Sep 2019

Visual Entrainment Of Perception-Related Neural Oscillations As A Mechanism For Maintaining Rhythmic Temporal Expectations Across A Wide Range Of Frequencies, Michael James Gray

Dissertations, Theses, and Capstone Projects

Visual sensitivity fluctuates rhythmically, in-synch with ongoing, EEG-recorded neural oscillations across a wide range of frequencies (~1-25hz). Some recent work has suggested that these perception-related neural oscillations can be entrained by rhythmic visual stimulation. Evidence is also emerging that the entrainment of ongoing oscillations in visual and auditory cortices is involved in rhythmic temporal expectations. In the introduction chapter, I attempt to bridge these bodies of literature and hypothesize that rhythmic visual stimuli automatically entrain ongoing, perception-related neural oscillations and that this mechanism supports the maintenance of rhythmic temporal expectations. Chapters 2 and 3 address this hypothesis from different angles. …


Neural Correlates Of Automatic Emotional Processing And Emotion Regulation In Empathy And Psychopathy-Related Coldheartedness, Danielle Difilipo Sep 2019

Neural Correlates Of Automatic Emotional Processing And Emotion Regulation In Empathy And Psychopathy-Related Coldheartedness, Danielle Difilipo

Dissertations, Theses, and Capstone Projects

Psychopathy is a personality disorder that is defined, in part, by a lack of empathy. Psychopathy-related empathic deficits have been associated with atypical behavioral and neural responses to emotional facial expressions. Although the mirror neuron system (MNS) has been implicated in empathy, very few studies have examined the role of MNS functioning as it pertains to empathy impairments in psychopathy. Moreover, there is very little empirical research regarding emotion regulation in psychopathy, and specifically whether emotional responses can be intentionally upregulated. The present study sought to clarify whether the MNS is functionally intact in adults with subclinical psychopathic traits, particularly …


The Use Of Infographics To Assess Context Processing, Beliz Hazan Sep 2019

The Use Of Infographics To Assess Context Processing, Beliz Hazan

Dissertations, Theses, and Capstone Projects

Among high-order cognitive functions is the use of context to enhance comprehension of language or visual scenes. Although use of context is known to be impaired in certain clinical populations (e.g., schizophrenia), no existing test adequately assesses this construct. To fill this gap, we developed and attempted to validate a test of context use that employed Infographics (information graphics), which requires the use of context to interpret visual displays. The primary hypothesis was that interpreting Infographics would be sensitive to context processing. We further hypothesized that different levels of cognitive processing (requiring basic perceptual, real-world application, or verbal reasoning), as …


Internal And External Attention In Autism Spectrum Disorder, Tehila Eilam-Stock Sep 2019

Internal And External Attention In Autism Spectrum Disorder, Tehila Eilam-Stock

Dissertations, Theses, and Capstone Projects

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental condition affecting individuals throughout the lifespan. Sensory hypersensitivity and superior perceptual acuity are well documented in individuals with ASD, and may indicate heightened orientation of attention to external stimuli, as attention can augment sensory perception. Recent evidence from mind-wandering research suggests that the ability to disengage attention from the external environment and direct it internally to self-generated mentation is crucial for adaptive cognition and behavior, as it allows for incorporation of past knowledge and experience in the interpretation of novel situations. We hypothesized that ASD is related to an imbalance between externally …


Queerness, Witchcraft, And Embodied Presence: Aesthetic Knowings Of What A Body Can Do, Megan Bigelow May 2019

Queerness, Witchcraft, And Embodied Presence: Aesthetic Knowings Of What A Body Can Do, Megan Bigelow

Dissertations, Theses, and Capstone Projects

Taking as a point of entry the critique of representation and affirming the limitations of the cuts that language makes, this capstone project explores the imbrications and assemblages between Foucault’s concept of subjugated knowledges, witchcraft and other body-based ways of knowing and being, and the consciousness of non-human forms such as plants and through the framework of non-representational theory, process philosophies, aesthetics, queerness, and the concept of difference itself.

Since such theories themselves are living, breathing entities, this capstone project explores the ideological split that has occurred between sacred and secular beliefs, moving through different figures such as nuns and …


Recognition By Flickering Components: The Effect Of Temporal Modulation On Image Recognition, Alla Chavarga Feb 2019

Recognition By Flickering Components: The Effect Of Temporal Modulation On Image Recognition, Alla Chavarga

Dissertations, Theses, and Capstone Projects

A primary goal of vision is to identify objects rapidly and efficiently. Successful object and scene recognition results from the integration of both feed-forward and feedback processes that correspond a two-dimensional retinal image to a representation of its content stored in memory (Bar, 2003). One general organizing principle may be that the visual system analyzes images and scenes according to their spatial components in a coarse- (low spatial frequency) to-fine (high spatial frequency) sequence (Bullier, 2001; Hegde, 2008). An individual’s sensitivity to these spatial components is described by contrast sensitivity function (CSF), which indicates the minimum contrast required for the …


Detecting Cognitive, Functional And Behavioral Response To Donepezil In Alzheimer’S Disease: The Role Of Attention Tasks, Clara Vila-Castelar Sep 2018

Detecting Cognitive, Functional And Behavioral Response To Donepezil In Alzheimer’S Disease: The Role Of Attention Tasks, Clara Vila-Castelar

Dissertations, Theses, and Capstone Projects

Introduction: Cholinesterase Inhibitors (ChEIs) used in Alzheimer’s Disease (AD) have modest effects, heterogeneous treatment response, and it has been difficult to detect treatment response. The standard research and clinical outcome measure, the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) aggregates multiple cognitive domains, and has limited sensitivity. We propose that because acetylcholine is directly linked to the cognitive domain of attention, and ChEIs increase available acetylcholine, measures of attention under high-load conditions could predict long-term cognitive, functional and behavioral response, and thus, unlike global measures, could be sensitive to treatment efficacy.

Method: We conducted a longitudinal, open label donepezil trial …