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Western University

2006

Articles 1 - 16 of 16

Full-Text Articles in Psychology

Hormone Effects On Fmri And Cognitive Measures Of Encoding: Importance Of Hormone Preparation, C. E. Gleason, T. W. Schmitz, T. Hess, R. L. Koscik, M. A. Trivedi, M. L. Ries, C. M. Carlsson, M. A. Sager, S. Asthana, S. C. Johnson Dec 2006

Hormone Effects On Fmri And Cognitive Measures Of Encoding: Importance Of Hormone Preparation, C. E. Gleason, T. W. Schmitz, T. Hess, R. L. Koscik, M. A. Trivedi, M. L. Ries, C. M. Carlsson, M. A. Sager, S. Asthana, S. C. Johnson

Brain and Mind Institute Researchers' Publications

We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs. ©2006AAN Enterprises, Inc.

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Activation Of Brain Regions Vulnerable To Alzheimer's Disease: The Effect Of Mild Cognitive Impairment, S. C. Johnson, T. W. Schmitz, C. H. Moritz, M. E. Meyerand, H. A. Rowley, A. L. Alexander, K. W. Hansen, C. E. Gleason, C. M. Carlsson, M. L. Ries, S. Asthana, K. Chen, E. M. Reiman, G. E. Alexander Nov 2006

Activation Of Brain Regions Vulnerable To Alzheimer's Disease: The Effect Of Mild Cognitive Impairment, S. C. Johnson, T. W. Schmitz, C. H. Moritz, M. E. Meyerand, H. A. Rowley, A. L. Alexander, K. W. Hansen, C. E. Gleason, C. M. Carlsson, M. L. Ries, S. Asthana, K. Chen, E. M. Reiman, G. E. Alexander

Brain and Mind Institute Researchers' Publications

This study examined the functionality of the medial temporal lobe (MTL) and posterior cingulate (PC) in mild cognitive impairment amnestic type (MCI), a syndrome that puts patients at greater risk for developing Alzheimer disease (AD). Functional MRI (fMRI) was used to identify regions normally active during encoding of novel items and recognition of previously learned items in a reference group of 77 healthy young and middle-aged adults. The pattern of activation in this group guided further comparisons between 14 MCI subjects and 14 age-matched controls. The MCI patients exhibited less activity in the PC during recognition of previously learned items, …

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Structural Mri Discriminates Individuals With Mild Cognitive Impairment From Age-Matched Controls: A Combined Neuropsychological And Voxel Based Morphometry Study, Mehul A. Trivedi, Allison K. Wichmann, Britta M. Torgerson, Michael A. Ward, Taylor W. Schmitz, Michele L. Ries, Rebecca L. Koscik, Sanjay Asthana, Sterling C. Johnson Oct 2006

Structural Mri Discriminates Individuals With Mild Cognitive Impairment From Age-Matched Controls: A Combined Neuropsychological And Voxel Based Morphometry Study, Mehul A. Trivedi, Allison K. Wichmann, Britta M. Torgerson, Michael A. Ward, Taylor W. Schmitz, Michele L. Ries, Rebecca L. Koscik, Sanjay Asthana, Sterling C. Johnson

Brain and Mind Institute Researchers' Publications

Background: Several previous studies have reported that amnestic mild cognitive impairment (aMCI), a significant risk factor for Alzheimer's disease (AD), is associated with greater atrophy in the medial temporal lobe (MTL) and posterior cingulate gyrus (PCG). Method: In the present study, we examined the cross-sectional accuracy (i.e., the sensitivity and specificity) of voxel-based morphometry (VBM) in discriminating individuals with MCI (n = 15) from healthy age-matched controls (n = 15). In addition, we also sought to determine whether baseline GM volume predicted aMCI patients that converted to AD from those that did not approximately 2 years after the baseline visit. …

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Paradoxical Facilitation Of Object Recognition Memory After Infusion Of Scopolamine Into Perirhinal Cortex: Implications For Cholinergic System Function., Boyer D Winters, Lisa M Saksida, Timothy J Bussey Sep 2006

Paradoxical Facilitation Of Object Recognition Memory After Infusion Of Scopolamine Into Perirhinal Cortex: Implications For Cholinergic System Function., Boyer D Winters, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

The cholinergic system has long been implicated in learning and memory, yet its specific function remains unclear. In the present study, we investigated the role of cortical acetylcholine in a rodent model of declarative memory by infusing the cholinergic muscarinic receptor antagonist scopolamine into the rat perirhinal cortex during different stages (encoding, storage/consolidation, and retrieval) of the spontaneous object recognition task. Presample infusions of scopolamine significantly impaired object recognition compared with performance of the same group of rats on saline trials; this result is consistent with previous reports supporting a role for perirhinal acetylcholine in object information acquisition. Scopolamine infusions …

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Why Did Mothers With Unresolved Trauma Fail To Benefit From An Attachment Based Intervention? Correlates Of Unresolved Status In A High Risk Sample, Heidi Bailey, Greg Moran, Carey Anne Deoliveira, Karin Gleason, David R. Pederson Jul 2006

Why Did Mothers With Unresolved Trauma Fail To Benefit From An Attachment Based Intervention? Correlates Of Unresolved Status In A High Risk Sample, Heidi Bailey, Greg Moran, Carey Anne Deoliveira, Karin Gleason, David R. Pederson

Psychology Presentations

No abstract provided.

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Interaction In The Home Of Mothers And Infants In Disorganized Attachment Relationships, Greg Moran, Lindsey M. Forbes, David R. Pederson Jul 2006

Interaction In The Home Of Mothers And Infants In Disorganized Attachment Relationships, Greg Moran, Lindsey M. Forbes, David R. Pederson

Psychology Presentations

No abstract provided.

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Exploring Expressions Of Disorganization In The Strange Situation In A High-Risk Sample, Lindsey M. Forbes, Amy Cox, Greg Moran, David R. Pederson Jul 2006

Exploring Expressions Of Disorganization In The Strange Situation In A High-Risk Sample, Lindsey M. Forbes, Amy Cox, Greg Moran, David R. Pederson

Psychology Presentations

No abstract provided.

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Representation Of Head-Centric Flow In The Human Motion Complex., Jeroen Goossens, Sean P Dukelow, Ravi S Menon, Tutis Vilis, Albert V Van Den Berg May 2006

Representation Of Head-Centric Flow In The Human Motion Complex., Jeroen Goossens, Sean P Dukelow, Ravi S Menon, Tutis Vilis, Albert V Van Den Berg

Brain and Mind Institute Researchers' Publications

Recent neuroimaging studies have identified putative homologs of macaque middle temporal area (area MT) and medial superior temporal area (area MST) in humans. Little is known about the integration of visual and nonvisual signals in human motion areas compared with monkeys. Through extra-retinal signals, the brain can factor out the components of visual flow on the retina that are induced by eye-in-head and head-in-space rotations and achieve a representation of flow relative to the head (head-centric flow) or body (body-centric flow). Here, we used functional magnetic resonance imaging to test whether extra-retinal eye-movement signals modulate responses to visual flow in …

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The Roots Of Love: Maternal Behaviour Related To Attachment Security, David R. Pederson, Greg Moran May 2006

The Roots Of Love: Maternal Behaviour Related To Attachment Security, David R. Pederson, Greg Moran

Psychology Presentations

No abstract provided.

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Self-Appraisal Decisions Evoke Dissociated Dorsal-Ventral Ampfc Networks, Taylor W. Schmitz, Sterling C. Johnson Apr 2006

Self-Appraisal Decisions Evoke Dissociated Dorsal-Ventral Ampfc Networks, Taylor W. Schmitz, Sterling C. Johnson

Brain and Mind Institute Researchers' Publications

The anterior medial prefrontal cortex (aMPFC) is consistently active during personally salient decisions, yet the differential contributory processes of this region along the dorsal-ventral axis are less understood. Using a self-appraisal decision-making task and functional magnetic resonance imaging, we demonstrated task-dependent connectivity of ventral aMPFC with amygdala, insula, and nucleus accumbens, and dorsal aMPFC connectivity with dorsolateral PFC and bilateral hippocampus. These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network. © 2005 Elsevier Inc. All rights reserved.

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The Nature And Origins Of Infant-Adolescent Mother Attachment Relationships, Greg Moran, David Pederson Mar 2006

The Nature And Origins Of Infant-Adolescent Mother Attachment Relationships, Greg Moran, David Pederson

Psychology Presentations

No abstract provided.

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Maternal States Of Mind, Reflective Function, Maternal Behavior, And The Mother-Infant Attachment Relationship, Greg Moran, Erinn Hawkins, David R. Pederson Mar 2006

Maternal States Of Mind, Reflective Function, Maternal Behavior, And The Mother-Infant Attachment Relationship, Greg Moran, Erinn Hawkins, David R. Pederson

Psychology Presentations

No abstract provided.

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Task-Dependent Posterior Cingulate Activation In Mild Cognitive Impairment, Michele L. Ries, Taylor W. Schmitz, Tisha N. Kawahara, Britta M. Torgerson, Mehul A. Trivedi, Sterling C. Johnson Jan 2006

Task-Dependent Posterior Cingulate Activation In Mild Cognitive Impairment, Michele L. Ries, Taylor W. Schmitz, Tisha N. Kawahara, Britta M. Torgerson, Mehul A. Trivedi, Sterling C. Johnson

Brain and Mind Institute Researchers' Publications

Neuroimaging research has demonstrated that the posterior cingulate cortex (PCC) is functionally compromised in individuals diagnosed with amnestic mild cognitive impairment (MCI), a major risk factor for the development of Alzheimer's disease (AD). In functional MRI studies with healthy participants, this same region is active during self-appraisal (requiring retrieval of semantic knowledge about the self) as well as episodic recognition of previously learned information. Administering both types of tasks to people with MCI may reveal important information on the role of the PCC in recollection. This study investigated fMRI activation in the PCC in individuals with MCI and matched controls …

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Reduced Hippocampal Activation During Episodic Encoding In Middle-Aged Individuals At Genetic Risk Of Alzheimer's Disease: A Cross-Sectional Study, Mehul A. Trivedi, Taylor W. Schmitz, Michele L. Ries, Britta M. Torgerson, Mark A. Sager, Bruce P. Hermann, Sanjay Asthana, Sterling C. Johnson Jan 2006

Reduced Hippocampal Activation During Episodic Encoding In Middle-Aged Individuals At Genetic Risk Of Alzheimer's Disease: A Cross-Sectional Study, Mehul A. Trivedi, Taylor W. Schmitz, Michele L. Ries, Britta M. Torgerson, Mark A. Sager, Bruce P. Hermann, Sanjay Asthana, Sterling C. Johnson

Brain and Mind Institute Researchers' Publications

Background: The presence of the apolipoprotein E (APOE) ε4 allele is a major risk factor for the development of Alzheimer's disease (AD), and has been associated with metabolic brain changes several years before the onset of typical AD symptoms. Functional MRI (fMRI) is a brain imaging technique that has been used to demonstrate hippocampal activation during measurement of episodic encoding, but the effect of the ε4 allelle on hippocampal activation has not been firmly established. Methods: The present study examined the effects of APOE genotype on brain activation patterns in the media[ temporal lobe (MTL) during an episodic encoding task …

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Quantum Theories Of Consciousness, Imants Barušs Jan 2006

Quantum Theories Of Consciousness, Imants Barušs

Psychology

The assumption is often made in conventional cognitive science that consciousness is a computational process resulting from macroscopic neural activity as described by classical physics. That assumption has been questioned both because it has been unsuccessful in explaining consciousness and because it is based on outdated ideas about the nature of matter. More contemporary quantum theories may be more successful for understanding cognition. For example, Mari Jibu, Kunio Yasue, and Yasushi Takahashi have proposed a theory of memory as a spinor field underlying cortical dipoles in which quantum mechanical tunnelling instantiates memory decay and in which the creation of Goldstone …

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Social, Achievement, And Control Dimensions Of Personality-Life Event Vulnerability To Depression, P.A. Frewen, David J. A. Dozois Jan 2006

Social, Achievement, And Control Dimensions Of Personality-Life Event Vulnerability To Depression, P.A. Frewen, David J. A. Dozois

Psychology Publications

This study investigated whether Sociotropy and the subscales of Autonomy (i.e., Perfectionistic/Self-critical, Need for Control, and Defensive Separation) would show differential patterns of vulnerability to dysphoria in both retrospective and prospective designs. Each of these scales showed a predicted pattern of association with life goals and impact ratings for negative events in a retrospective design. In a prospective design, the scales showed differential associations with goal obtainment and cognitive-affective responses to life events but did not predict follow-up dysphoria independently of baseline dysphoria. These results are discussed in terms of the multidimensionality of personality vulnerability and depressogenic negative life events …

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