Psychology Commons^™

Machine Learning Prediction Of Posttraumatic Stress Disorder Trajectories Following Traumatic Injury: Identification And Validation In Two Independent Samples, Carissa W. Tomas, Jacklynn M. Fitzgerald, Carisa Bergner, Cecilia J. Hillard, Christine L. Larson, Terri A. Deroon-Cassini

Psychology Faculty Research and Publications

Due to its heterogeneity, the prediction of posttraumatic stress disorder (PTSD) development after traumatic injury is difficult. Recent machine learning approaches have yielded insight into predicting PTSD symptom trajectories. Using data collected within 1 month of traumatic injury, we applied eXtreme Gradient Boosting (XGB) to classify admitted and discharged patients (hospitalized, n = 192; nonhospitalized, n = 214), recruited from a Level 1 trauma center, according to PTSD symptom trajectories. Trajectories were identified using latent class mixed models on PCL-5 scores collected at baseline, 1–3 months posttrauma, and 6 months posttrauma. In both samples, nonremitting, remitting, and resilient PTSD symptom …

A Comparison Of Methods To Harmonize Cortical Thickness Measurements Across Scanners And Sites, Delin Sun, Gopalkumar Rakesh, Courtney C. Haswell, Mark Logue, C. Lexi Baird, Erin N. O'Learly, Andrew S. Cotton, Hong Xie, Marijo Tamburrino, Tian Chen, Emily L. Dennis, Neda Jahanshad, Lauren Salminen, Sophia I. Thomopoulos, Faisal Rashid, Christopher R.K. Ching, Saskia B.J. Koch, Jessie L. Frijling, Laura Nawijn, Mirjam Van Zuiden, Xi Zhu, Benjamin Suarez-Jimenez, Anika Sierk, Henrik Walter, Antje Manthey, Jennifer S. Stevens, Negar Fani, Sanne J.H. Van Rooij, Murray Stein, Jessica A. Bomyea, Inga K. Koerte, Kyle Choi, Steven J.A. Van Der Werff, Robert R.J.M. Vermeiren, Julia Herzog, Lauren A. M. Lebois, Justin T. Baker, Elizabeth A. Olson, Thomas Straube, Mayuresh S. Korgaonkar, Elpiniki Andrew, Ye Zhu, Gen Li, Jonathan Ipser, Anna R. Hudson, Matthew Peverill, Kelly Sambrook, Evan Gordon, Lee A. Baugh, Gina L. Forster, Raluca M. Simons, Jeffrey S. Simons, Vincent A. Magnotta, Adi Maron-Katz, Stefan Du Plessis, Seth Disner, Nicholas Davenport, Daniel W. Grupe, Jack B. Nitschke, Terri A. Deroon-Cassini, Jacklynn M. Fitzgerald, John H. Krystal, Ifat Levy, Miranda Olff, Dick J. Veltman, Li Wang, Yuval Neria, Michael D. De Bellis, Tanja Jovanovic, Judith K. Daniels, Martha E. Shenton, Nic J.A. Van De Wee, Christian Schmahl, Milissa L. Kaufman, Isabelle M. Rosso, Scott R. Sponheim, David Hofmann, Richard A. Bryant, Kelene A. Fercho, Dan J. Stein, Sven C. Mueller, Bobak Hosseini, K. Luan Phan, Katie A. Mclaughlin, Richard J. Davidson, Christine L. Larson, Geoffrey May, Steven M. Nelson, Chadi G. Abdallah, Hassaan Gomaa, Amit Etkin, Soraya Seedat, Ilan Harpaz-Rotem, Israel Liberzon, Theo G.M. Van Erp, Yann Quidé, Xin Wang, Paul M. Thompson, Rajendra A. Morey

Psychology Faculty Research and Publications

Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants’ demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data: (1) linear mixed-effects model (LME) that models site-specific random intercepts (LMEINT), (2) LME that models both site-specific random intercepts and age-related random slopes (LMEINT+SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 …

Comparing The Effects Of Immediate Vs. Delayed Differential Reinforcement Of Zero Rate Behavior Schedules On Tic Suppression, Kristine T. Vo

Master's Theses (2009 -)

Persistent Tic Disorder and Tourette Disorder are neuropsychiatric conditions characterized by motor and or/ vocal tics. Treatment surrounding tics involve pharmaceutical or behavior therapy. Individuals seeking behavior therapy receive habit reversal training (HRT) or comprehensive behavioral intervention for tics (CBIT). Much research demonstrates the efficacy of HRT and CBIT, however, as these treatments often teach effective tic suppression skills, it may be useful to better understand the behavioral contingencies that most effectively lead to suppression. This research aims to compare different schedules of reinforcement on tic suppression. Two individuals diagnosed with Tourette’s Disorder, ages 9-14, participated in this study. A …

Nondisclosure Of Supervisee Disagreement To Supervisor Feedback: A Qualitative Study, Elizabeth A. Tinsley

Dissertations (1934 -)

Feedback has been described by researchers and supervisors as an important tool of clinical supervision contributing to supervisees’ development (Hein et al., 2011; Jaworski & Kohli, 1991; Nelson et al., 2008; O’Donovan et al., 2011; Sapyta et al., 2005; Worthington, 2006). Because feedback often comes from one perspective, generally the supervisor’s, it seems reasonable to expect supervisors and supervisees may see feedback differently. This difference in perspectives may foster disagreement between the supervisor and supervisee. Not everyone is comfortable discussing disagreement, nor even conflict, which can lead to larger difficulties in supervision. The act of censoring information provided to supervisors …

Evaluating Interest In Clinical Trial Participation For The Treatment Of Pediatric Food Allergy, Perry Allen Catlin

Master's Theses (2009 -)

Food allergy (FA) is a chronic medical condition that affects one out of every 13 children in the United States. Researchers have recently begun utilizing double-blind, placebo-controlled clinical trials to test novel biological treatments designed to retrain the immune system to be less reactive to food allergens. Although these treatments remain in the clinical trial stage, evidence suggests that individuals differentially engage with these options based on a variety of factors. Using a socioecological framework, this study sought to evaluate the effect of child, parent, and family-level factors on parental interest in clinical trial participation for the treatment of pediatric …

Impact Of Childhood Trauma On Skin Conductance Response To Fear, Safety, And Reward, Tristan Alana Gregg

Master's Theses (2009 -)

Trauma is associated with neurological and physiological differences that can persist years after trauma exposure. Physiologically, trauma has been associated with altered responses to cues in the environment, most commonly threatening stimuli. For instance, in participants who experience trauma during adulthood, such individuals exhibit heightened physiological arousal. Conversely, other studies have found that childhood trauma may be associated with blunted physiological arousal. Most of this research has involved threatening cues, but previous research suggests that trauma is also associated with aberrant physiological arousal responses to positive or rewarding cues. Skin conductance responses (SCRs) are a commonly utilized measure of physiological …

Critical Care Nurse Burnout, Moral Distress, And Mental Health During The Covid-19 Pandemic: A United States Survey, Jill L. Guttormson, Kelly Calkins, Natalie S. Mcandrew, Jacklynn M. Fitzgerald, Holly Lynn Losurdo, Danielle Loonsfoot

Psychology Faculty Research and Publications

Background

The COVID-19 pandemic has and will continue to have a tremendous influence on intensive care unit (ICU) nurses’ mental health.

Objectives

The purpose of this study was to describe the impact of COVID-19 on nurse moral distress, burnout, and mental health.

Methods

Between October 2020 and January 2021 this descriptive study recruited a national sample of nurses who worked in the ICU during the COVID-19 pandemic through American Association of Critical Care Nurses newsletters and social media.

Results

A total of 488 survey responses were received from critical care nurses working in the U.S. during the COVID pandemic. Over …

Strengthening The Procedural Fidelity Research-To-Practice Loop In Animal Behavior, Tiffany Kodak, Samantha Bergmann, Mindy Waite

Psychology Faculty Research and Publications

Procedural fidelity is the extent to which components of an intervention are implemented as designed. Procedural fidelity is measured as a dependent variable and manipulated as an independent variable. In research and practice, procedural-fidelity data should be collected, monitored, and reported. Procedural fidelity as an independent variable has been investigated in humans using parametric analyses, and the current article summarizes some of the research conducted on the effects of procedural-fidelity errors in behavior-reduction and skill-acquisition interventions. Connections were drawn to applied animal researchers and the work of animal behavior practitioners to produce implications for practice with human and animal clients …

Neighborhood Socioeconomic Disadvantage And The Neurobiology Of Uncertainty In Traumatically Injured Adults, Carissa W. Tomas, E. Kate Webb, Kenneth P. Bennett, Ashley A. Huggins, Jacklynn M. Fitzgerald, Tara A. Miskovich, Jessica L. Krukowski, Terri A. Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

Individuals residing in more socioeconomically disadvantaged neighborhoods experience greater uncertainty through insecurity of basic needs such as food, employment, and housing, compared with more advantaged neighborhoods. Although the neurobiology of uncertainty has been less frequently examined in relation to neighborhood disadvantage, there is evidence that neighborhood disadvantage is associated with widespread neural alterations.

Methods

Recently traumatically injured participants (n = 90) completed a picture anticipation task in the magnetic resonance imaging scanner, in which they viewed images presented in a temporally predictable or unpredictable manner. We investigated how neighborhood disadvantage (via area deprivation index [ADI]) was related to …

The Utility Of Clinical And Blood-Based Biomarkers To Discriminate Between Typical And Prolonged Pediatric Mtbi Symptom Recovery, Morgan E. Nitta

Dissertations (1934 -)

Prolonged recovery following mild traumatic brain injury (mTBI) is poorly understood, particularly in pediatric samples, despite significant work to understand prolonged postconcussive symptoms (PPS). Emerging evidence in adult mTBI literature suggests blood-based biomarkers have diagnostic and prognostic value, but there is limited research examining this in pediatric mTBI. Further, while adult research documents that combining physiological biomarkers, emotional distress and symptom reports more optimally differentiates between mTBI and healthy controls, it is unknown if this finding will replicate in pediatric samples. This project examined foundational relationships between clinical, cognitive, inflammatory markers, and kynurenine pathway (KP) metabolites following mTBI in adolescents …

Long-Term Outcomes Of Behavior Therapy For Youth With Tourette Disorder, Flint M. Epsil, Douglas W. Woods, Matthew W. Specht, Shannon M. Bennett, John T. Walkup, Emily J. Ricketts, Joseph F. Mcguire, Jordan T. Stiede, Jennifer S. Schild, Susanna W. Chang, Alan L. Peterson, Lawrence Scahill, Sabine Wilhelm, John Piacentini

Psychology Faculty Research and Publications

Objective

To determine the long-term durability of behavior therapy for tics among youth with Tourette disorder and persistent (chronic) motor or vocal tic disorders.

Method

Of the 126 youth who participated in a randomized controlled trial of behavior therapy 11 years prior, 80 were recruited for this longitudinal follow-up. Consenting participants were interviewed in person or remotely (Web-based video) by trained evaluators to determine the course of tics, current tic severity, and tic-related impairment. Recruitment and data collection occurred between 2014 and 2019, with an average follow-up duration of 11.2 years.

Results

Treatment responders to both conditions in the original …

Comparing Matrix-Training Procedures With Children With Autism Spectrum Disorder, Samantha Bergmann, Gabriella Van Den Elzen, Tiffany Kodak, Haven Niland, Desiree Dawson

Psychology Faculty Research and Publications

Recombinative generalization is the production of responses in the presence of novel combinations of known components. For example, after learning “red triangle” and “blue square,” recombinative generalization is observed when a child can tact “red square” and “blue triangle.” Recombinative generalization can emerge from a history of matrix training, which involves carefully selecting and arranging stimuli and responses along at least two axes and training a subset of responses. With three children with autism spectrum disorder, we compared recombinative generalization of object–action or feature–object tacts when the component stimuli were trained before combination stimuli, trained along with combination stimuli, or …

Subjective Well-Being And Bilateral Anterior Insula Functional Connectivity After Exercise Intervention In Older Adults With Mild Cognitive Impairment, Junyeon Won, Kristy A. Nielson, J. Smith Carson

Psychology Faculty Research and Publications

While it is well known that exercise training is associated with improvement in subjective well-being among older adults, it is unclear if individuals with cognitive impairment experience the same effects elicited by exercise on subjective well-being. We further explored whether the bilateral anterior insula network may be an underlying neural mechanism for the exercise training-related improvements in subjective well-being. We investigated the effects of exercise training on subjective well-being in older adults (78.4 ± 7.1 years) with mild cognitive impairment (MCI; n = 14) and a cognitively normal (CN; n = 14) control group. We specifically assessed the relationship between …

Heart Rate Variability (Hrv), Cortisol, And Trait Anxiety In Mid-Life Adults, Meghan Bennett

Master's Theses (2009 -)

Heart rate variability (HRV) and cortisol are well-established biomarkers of the human stress response system. As such, their respective relationships with trait anxiety have been studied. As high HRV indicates healthy emotion regulation while low HRV signifies poor emotion regulation, a negative relationship between HRV and anxiety is found in the literature. Conversely, cortisol both prepares the body for stress and helps it to recover and current studies yield mixed results on its relationship with anxiety. While the link between vagal activity, which mediates HRV, and the HPA-axis, which outputs cortisol, is generally assumed, few studies have examined these biomarkers …

Constellations Of Family Closeness And Adolescent Friendship Quality, Mengya Xia, Gregory M. Fosco, Bethany C. Bray, John H. Grych

Psychology Faculty Research and Publications

Objective

This study aims to investigate the association between family relationship constellations and adolescent friendship quality in a more holistic way and disentangle gender differences on their associations.

Background

Family relationships are important for adolescent friendship, but little is known about how mother–adolescent and father–adolescent relationships work in the context of each other.

Method

Latent profile analysis was conducted in a sample of 326 ethnically diverse high schoolers (ages: 14–19 years; 60.4% female) to identify different combinations of mother– and father–adolescent closeness and their associations with friendships for adolescent boys and girls.

Results

Findings revealed five family relationship patterns: Cohesive …

Cultural Adaptation Profiles Among Mexican-Descent Latinxs: Acculturation, Acculturative Stress, And Depression., Mark W. Driscoll, Lucas Torres

Psychology Faculty Research and Publications

Objectives: Person-centered analysis was used to examine profiles of acculturation and acculturative stress among Mexican-descent adults in relation to depression. It was hypothesized that identified profiles would support multiple acculturation styles, that acculturation profiles would differentially relate to acculturative stress dimensions, and that those profiles with greater Latinx acculturation and lower acculturative stress would report less severe depression. Method: Mexican-descent Latinx adults (n = 230) completed self-report measures of Latinx and Anglo acculturation, acculturative stress, and depression symptom severity. Latent profile analysis was used to derive acculturation–acculturative stress profiles. Results: Three distinct profiles emerged. One profile was notable for …

Replication Of A Skills Assessment For Auditory–Visual Conditional Discrimination Training, Tiffany Kodak, Samantha Bergmann, Maria Clara Cordeiro, Meredity Bamond, Robert W. Isenhower, Kate E. Fiske

Psychology Faculty Research and Publications

Auditory–visual conditional discrimination training (e.g., receptive identification training, listener responses; AVCD) is ubiquitous in early intervention and special education programs. Nevertheless, some learners with Autism Spectrum Disorder (ASD) do not appear to benefit from this training despite use of empirically validated treatments. To prevent exposure to extended training that does not lead to learning, a skills assessment that measures skills related to AVCD training will be useful for educators and practitioners. The current study replicated the skills assessment developed and evaluated by Kodak et al. (2015) with 8 participants with ASD who received behavior analytic intervention that included at least …

Applying The Vulnerability Stress Adaptation Model To Romantic Relationships Of Couples Raising A Child With Asd, Hillary Katherine Schiltz

Dissertations (1934 -)

Cross-sectional evidence indicates that raising a child with autism spectrum disorder (ASD) is associated with strain on caregivers’ romantic couple relationship, yet many couple relationships thrive (Hock et al., 2012; Markoulakis et al., 2012). Research on general population samples highlights changes in couple romantic relationships across short and longer periods of time (e.g., Karney & Bradbury, 1997); little is known, however, about how the relationships of couples raising a child with ASD unfold and which couples are at greater risk for deterioration than others. According to the Vulnerability Stress Adaptation (VSA) Model, couple romantic relationships are directly shaped by how …

Conditional Risk For Ptsd Traumatically Injured Latinx Sample: Cultural X Biological Model, Claire Maria Bird

Dissertations (1934 -)

Posttraumatic stress disorder (PTSD) is a debilitating disorder that develops in some people following a traumatic event. Latinx communities in the U.S. are at greater risk of developing this disorder and experiencing more severe and chronic symptomology. This population has also been found to experience greater levels of dissociative experiences – possibly explaining the increased conditional risk for PTSD in this ethnic group. It remains unclear what may be connecting the experience of peritraumatic dissociation to heightened PTSD risk. The current study sought to address this gap in the literature by examining peritraumatic dissociation and the interplay between sociocultural and …

Investigating Beliefs & Attitudes Regarding Equitable Teaching & Discipline Practices: Race Essentialism In Schools, Jamee S. Carroll

Dissertations (1934 -)

Black, Latinx, and Indigenous adolescents experience more suspensions, expulsions, and school-based arrests than White students. However, minoritized students do not engage in problematic or disruptive behaviors more frequently but rather at equal or lower rates than their White counterparts. One factor that may contribute to this discipline gap is race essentialism, which is the belief that there are deep-rooted, unalterable traits and abilities unique to each racial group. Race essentialism, which has been linked to stereotyping, prejudice, intergroup trust and closeness, and cognitive flexibility, has not been studied in a school discipline context. Demonstrating associations between race essentialism and teachers’ …

Mixed Methods Exploration Of Low Points And Wellness In Black Women, Jessica Krukowski

Master's Theses (2009 -)

IntroductionTime and again the voices, experiences, and interests of Black women are systematically marginalized, overlooked or dismissed (King, 2019). In addition, and possibly because of this, Black women are consistently underrepresented and historically overlooked in research (Allen, 2008; Corker, 2010). It is imperative to allow the voices of Black women to begin to fill this scientific gap. Mixed-methods narrative research provides a strength-based framework to do so. This study explores how Black women talk about the lowest point in their life and how that relates to various outcomes of wellness. Method The low point response narrative from The Life Story …

Psychophysiological Predictors Of Change In Emotion Dysregulation 6 Months After Traumatic Injury, Jacklynn M. Fitzgerald, Sydney Clare Timmer-Murillo, Claire Sheeran, Hailey Begg, Morgan Christoph, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Emotional dysregulation that occurs after trauma conveys risk for multiple disorders, including posttraumatic stress disorder, depression, and anxiety. Psychophysiological data (e.g., skin conductance level [SCL]) may be a useful biomarker for quantifying emotion dysregulation given that autonomic nervous system (ANS)-mediated arousal may underlie this feature. In this longitudinal study, we tested whether SCL collected following a single-incident traumatic injury could predict changes in emotion dysregulation over 6 months. Sixty-six adults were recruited from the emergency department; SCL was quantified during an active trauma narrative, in which participants re-told their traumatic event to a research staff member, as well as a …

Cognitive Control Processes In Behavior Therapy For Youth With Tourette’S Disorder, Joseph F. Mcguire, Alexandra Sturm, Emily J. Ricketts, Gabrielle E. Montalbano, Susanna W. Chang, Sandra K. Loo, Douglas W. Woods, James T. Mccracken, John Piacentini

Psychology Faculty Research and Publications

Background

Cognitive control processes are implicated in the behavioral treatment of Tourette’s disorder (TD). However, the influence of these processes on treatment outcomes has received minimal attention. This study examined whether cognitive control processes and/or tic suppression predicted reductions in tic severity and treatment response to behavior therapy.

Method

Fifty-three youth with TD or a pervasive tic disorder participated in a randomized wait list-controlled trial of behavior therapy. Following a baseline assessment to evaluate psychiatric diagnoses, tic severity, and cognitive control processes (e.g., response selection, inhibition, and suppression), youth were randomly assigned to receive eight sessions of behavior therapy ( …

“It Still Happened”: A Mixed-Methods Analysis Of College Students’ Rationales For Endorsing Acts Of Violence Victimization, Kristen Yule, John H. Grych

Psychology Faculty Research and Publications

Objective: Measures of relationship violence have been criticized for failing to distinguish intentional acts of aggression from behaviors that occur in a playful context. However, efforts to reduce this concern by modifying the questionnaires’ instructions have not reliably reduced reporting rates or improved the criterion validity of the measures. This experimental study investigated how respondents who were randomly assigned to one of three instruction conditions perceived and responded to a measure of relationship violence.

Method: Undergraduate students (N = 150) reported on partner violence victimization using the Conflict in Adolescent Dating Relationships Inventory (CADRI; Wolfe et al., 2001). They received …

Exploring American Parents' Lived Experiences During The Covid-19 Pandemic: Ramifications For Well-Being, Astrida S. Kaugars, Lindsay E. Holly, Mary Tait, Debra L. Oswald

Psychology Faculty Research and Publications

Objective

The objective of this study was to document the direct impact of the COVID-19 pandemic on parents and families in the United States.

Methods

Parents’ experiences during the pandemic were examined using an online survey (N = 564) collected during May and June 2020.

Results

Parents reported experiencing a high frequency of COVID-19-related events (e.g., job loss and health concerns) and impact on their lives. Parents’ experiences with COVID-19, as well as self-reported perceived increase in home labor, experiences with assisting children with remote schooling, and work-life conflict were all significantly associated with higher levels of parental role …

Exploring American Parents’ Lived Experiences During The Covid-19 Pandemic: Ramifications For Well-Being, Astrida S. Kaugars, Lindsay E. Holly, Mary Tait, Debra L. Oswald

Psychology Faculty Research and Publications

Objective

The objective of this study was to document the direct impact of the COVID-19 pandemic on parents and families in the United States.

Methods

Parents’ experiences during the pandemic were examined using an online survey (N = 564) collected during May and June 2020.

Results

Parents reported experiencing a high frequency of COVID-19-related events (e.g., job loss and health concerns) and impact on their lives. Parents’ experiences with COVID-19, as well as self-reported perceived increase in home labor, experiences with assisting children with remote schooling, and work-life conflict were all significantly associated with higher levels of parental role …

Examining Differences In Parenting Stress, Parenting Efficacy, And Household Context Among Mothers Of Youth With Autism And/Or Adhd, Hillary K. Schiltz, Alana J. Mcvey, Kelsey Gonring, Angela D. Haendel, Christina Murphy, Amy V. Van Hecke, Alyson C. Gerdes

Psychology Faculty Research and Publications

Parents of youth with neurodevelopmental disorders experience unique stressors in family functioning when compared to parents of neurotypical youth. A paucity of research, however, has examined differences in parenting experiences across families of youth with varying neurodevelopmental disorder presentations. This paper focuses on two common and frequently co-occurring conditions: autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). In this study, we compared parenting stress, parenting efficacy, and the household context across a sample of 90 mothers of adolescents ages 11–16 years with (1) autism, (2) ADHD, or (3) autism and clinically-elevated ADHD symptoms (Autism + ADHD). Our findings demonstrated differences in …

Owner-Implemented Functional Analyses And Reinforcement-Based Treatments For Mouthing In Dogs, Mindy Waite, Tiffany Kodak

Psychology Faculty Research and Publications

The most effective behavioral interventions are function based, which requires the identification of the behavioral function. A functional analysis is conducted to isolate and identify the environmental variables maintaining target behavior, and this method is effective across species. In domesticated dogs, mouthing is a common behavior and is considered problematic by many people. However, mouthing is not always simple to treat with standard interventions without identifying the function of the dog’s mouthing. Without efficacious interventions, undesirable behavior in companion animals may result in reduced welfare, an increased likelihood of relinquishment, or an increased probability of euthanasia. The purpose of this …

Academic, Interpersonal, Recreational, And Family Impairment In Children With Tourette Syndrome And Attention-Deficit/Hyperactivity Disorder, Emily J. Ricketts, Sara Beth Wolicki, Melissa L. Danielson, Michelle Rozenman, Joseph F. Mcguire, John Piacentini, Jonathan W. Mink, John T. Walkup, Douglas W. Woods, Rebecca H. Bitsko

Psychology Faculty Research and Publications

This study describes impairment in academic, interpersonal, recreational, and family financial or occupational domains across children in three mutually exclusive diagnostic groups: ever diagnosed with Tourette syndrome (TS), attention-deficit/hyperactivity disorder (ADHD), and both disorders. In 2014, parents reported on impairment and diagnostic status of children aged 4–17 years (n = 3014). Weighted analysis and pairwise t-tests showed more children with ADHD (with or without TS) experienced impairment in overall school performance, writing, and mathematics, relative to children with TS but not ADHD. More children with TS and ADHD had problematic handwriting relative to children with ADHD but not TS. More …

Hippocampal Resting-State Functional Connectivity Forecasts Individual Posttraumatic Stress Disorder Symptoms: A Data-Driven Approach, Jacklynn M. Fitzgerald, Elisabeth Kate Webb, Carissa N. Weis, Ashley A. Huggins, Kenneth P. Bennett, Tara A. Miskovich, Jessica L. Krukowski, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background: Posttraumatic Stress Disorder (PTSD) is a debilitating disorder and there is no current accurate prediction of who develops it after trauma. Neurobiologically, individuals with chronic PTSD exhibit aberrant resting-state functional connectivity (rsFC) between the hippocampus and other brain regions (e.g., amygdala, prefrontal cortex, posterior cingulate), and these aberrations correlate with severity of illness. Prior small-scale research (n < 25) has also shown that hippocampal-rsFC measured acutely after trauma is predictive of future severity using an ROI-based approach. While a promising biomarker, to-date no study has employed a data-driven approach to test whole-brain hippocampal-FC patterns in forecasting the development of PTSD symptoms.

Methods: Ninety-eight adults at risk of PTSD were recruited from the emergency department following traumatic injury and completed resting functional magnetic resonance imaging (rsfMRI; 8min) within 1-month; 6-months later they completed the Clinician-Administered PTSD Scale (CAPS-5) for assessment of PTSD symptom …