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Full-Text Articles in Psychology
The Abuse Liability Profile Of An Unflavored, Sucralose-Sweetened, Electronic Cigarette In Combustible Cigarette Smokers, Sarah F. Maloney
The Abuse Liability Profile Of An Unflavored, Sucralose-Sweetened, Electronic Cigarette In Combustible Cigarette Smokers, Sarah F. Maloney
Theses and Dissertations
The purpose of this study was to examine the effects of sucralose and nicotine in otherwise unflavored PG/VG ECIG liquid solutions, via a 30-watt ECIG, using multiple measures predictive of abuse liability to provide a basic understanding of the effects of sweeteners and perceived sweetness on ECIG abuse liability in reference to combustible cigarettes. Fourteen dependent smokers completed five independent study sessions that were within-subject, Latin-square ordered, and were identical in regards to all aspects but the product used. In each session, participants were given either their own brand of cigarettes or one of the four ECIG conditions: 0 mg/mL …
Abuse Liability Of An Electronic Cigarette In Traditional Cigarette Smokers, Sarah F. Maloney
Abuse Liability Of An Electronic Cigarette In Traditional Cigarette Smokers, Sarah F. Maloney
Theses and Dissertations
Electronic cigarettes have grown in popularity across the U.S. and concerns have been raised about their abuse liability. The purpose of the current study was to evaluate and compare the abuse liability of an electronic cigarette with and without nicotine to a nicotine inhaler (the Nicotrol inhaler) and participants’ own brand of cigarettes. A total of 24 smokers attended four sessions in which the abuse liability of each product was examined using the Multiple-Choice Procedure (MCP), nicotine delivery, nicotine abstinence symptom suppression, and subjective reinforcing effects. Results revealed that the nicotine containing and non-nicotine containing electronic cigarette had a higher …
Dissociable Antidepressant-Like And Abuse-Related Effects Of The Noncompetitive Nmda Receptor Antagonists Ketamine And Mk-801 In Rats., Todd Hillhouse
Dissociable Antidepressant-Like And Abuse-Related Effects Of The Noncompetitive Nmda Receptor Antagonists Ketamine And Mk-801 In Rats., Todd Hillhouse
Theses and Dissertations
The noncompetitive NMDA receptor antagonist ketamine produces rapid and sustained antidepressant effects in patients suffering from major depressive disorder. However, abuse liability is a concern. To further evaluate the relationship between antidepressant-like and abuse-related effects of NMDA receptor antagonists, this study evaluated the effects of ketamine, MK-801, and phencyclidine in male Sprague-Dawley rats responding under two procedures that have been used to assess antidepressant-like effects [differential-reinforcement-of-low-rate (DRL) 72 s schedule of food reinforcement] and abuse-related drug effects [intracranial self-stimulation (ICSS)]. Under DRL 72 s, ketamine produced an antidepressant-like effect by increasing reinforcers, decreasing responses, and producing a rightward shift in …