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Articles 1 - 17 of 17
Full-Text Articles in Social and Behavioral Sciences
Endogenous Redox Activity In Mouse Spermatozoa And Its Role In Regulating The Tyrosine Phosphorylation Events Associated With Sperm Capacitation, Heath W. Ecroyd, Russell C. Jones, Robert J. Aitken
Endogenous Redox Activity In Mouse Spermatozoa And Its Role In Regulating The Tyrosine Phosphorylation Events Associated With Sperm Capacitation, Heath W. Ecroyd, Russell C. Jones, Robert J. Aitken
Heath Ecroyd
We investigated the role of endogenous redox activity in regulating the signal transduction pathway leading to tyrosine phosphorylation in mouse spermatozoa. Endogenous redox activity was monitored using a luminol-peroxidase chemiluminescent probe. Chemiluminescence increased in spermatozoa that were actively undergoing cAMP-mediated tyrosine phosphorylation events associated with capacitation and was inhibited in a dose-dependent manner by addition of catalase or diphenylene iodonium, both of which also inhibited tyrosine phosphorylation within the cell at points downstream of cAMP. Excluding bicarbonate from the incubation medium reduced the redox activity of sperm by 80-90% and dramatically reduced tyrosine phosphorylation. This study provides the first evidence …
The Effect Of Small Molecules In Modulating The Chaperone Activity Of Alpha B-Crystallin Against Ordered And Disordered Protein Aggregation, Heath Ecroyd, John Carver
The Effect Of Small Molecules In Modulating The Chaperone Activity Of Alpha B-Crystallin Against Ordered And Disordered Protein Aggregation, Heath Ecroyd, John Carver
Heath Ecroyd
Protein aggregation can proceed via disordered or ordered mechanisms, with the latter being associated with amyloid fibril formation, which has been linked to a number of debilitating conditions including Alzheimer's, Parkinson's and Creutzfeldt-Jakob diseases. Small heat-shock proteins (sHsps), such as alpha B-crystallin, act as chaperones to prevent protein aggregation and are thought to play a key role in the prevention of protein-misfolding diseases. In this study, we have explored the potential for small molecules such as arginine and guanidine to affect the chaperone activity of alpha B-crystallin against disordered (amorphous) and ordered (amyloid fibril) forms of protein aggregation. The effect …
The Two Faced Nature Of Milk Casein Proteins: Amyloid Fibril Formation And Chaperone-Like Activity, David Thorn, Heath Ecroyd, John Carver
The Two Faced Nature Of Milk Casein Proteins: Amyloid Fibril Formation And Chaperone-Like Activity, David Thorn, Heath Ecroyd, John Carver
Heath Ecroyd
Molecular chaperones are a diverse group of proteins that stabilise partially folded target proteins to prevent their misfolding, aggregation and potential precipitation under conditions of cellular stress, e.g. elevated temperature. Protein aggregation, particularly the formation of highly ordered protein aggregates termed amyloid fibrils, is of considerable research interest because of its intimate association with a wide range of debilitating diseases, including Alzheimer's, Parkinson's and Huntington's diseases and type II diabetes. In this review, we discuss the ability of the milk casein proteins to act in a chaperone-like manner. This property is of biological importance since at least two of the …
Mimicking Phosphorylation Of Alphab-Crystallin Affects Its Chaperone Activity, Heath W. Ecroyd, Sarah Meehan, J Horwitz, Andrew Aquilina, J L Benesch, C V Robinson, Cait Macphee, John Carver
Mimicking Phosphorylation Of Alphab-Crystallin Affects Its Chaperone Activity, Heath W. Ecroyd, Sarah Meehan, J Horwitz, Andrew Aquilina, J L Benesch, C V Robinson, Cait Macphee, John Carver
Heath Ecroyd
No abstract provided.
The Unit Of Analysis In Is Theory: The Case For Activity, Helen Hasan, Sumayya Banna
The Unit Of Analysis In Is Theory: The Case For Activity, Helen Hasan, Sumayya Banna
Helen Hasan
In the field of IS, researchers use and adapt existing theories to make sense of their data. They also build new theory from their research findings. The way theory is used, adapted or created usually assumes a certain unit of analysis, which could be the artefact, the system, the organisation, the user, the developer, the team or something else. In this paper we propose that ‘activity’ should also be considered as a suitable unit of analysis for theory in IS since the purpose of any information systems is to facilitate activities of use. To support this proposition, we describe tenets …
Activity Counts From Accelerometers Do Not Add Value To Energy Expenditure Predictions In Sedentary Overweight Individuals During Weight Loss Interventions, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell
Activity Counts From Accelerometers Do Not Add Value To Energy Expenditure Predictions In Sedentary Overweight Individuals During Weight Loss Interventions, Sze Yen Tan, Marijka Batterham, Linda C. Tapsell
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background: Knowing the total energy expenditure (TEE) of overweight adults is important for prescribing weight loss interventions. However, objective measurements of TEE may not always be readily available and can be expensive. This study aimed to investigate the validity of RT3 accelerometers in predicting the TEE of sedentary overweight adults, and to identify any sensitivity to anthropometric changes. Methods: The analysis used data from a 12-week weight loss study. At baseline and 12-week, TEE was predicted using RT3 accelerometers during whole room calorimeter stays. Bias between 2 methods was compared at and between the baseline and 12-week measurement points. Multiple …
Relationship Between Plantar Pressures, Physical Activity And Sedentariness Among Preschool Children, Karen J. Mickle, Dylan P. Cliff, Bridget J. Munro, Anthony D. Okely, Julie R. Steele
Relationship Between Plantar Pressures, Physical Activity And Sedentariness Among Preschool Children, Karen J. Mickle, Dylan P. Cliff, Bridget J. Munro, Anthony D. Okely, Julie R. Steele
Faculty of Health and Behavioural Sciences - Papers (Archive)
It has been speculated that high plantar pressures might cause foot pain and discomfort which, in turn, may discourage children from being physically active and result in them spending more time in sedentary activities. The purpose of this study was to determine whether plantar pressure distributions generated by preschool children were correlated with objectively measured time spent in physical activity and sedentary behaviour. Dynamic plantar pressures were measured for 33 preschool children (age = 4.3±0.6 years; height = 1.06±0.1 m; mass = 18.4±2.9 kg; 17 boys) as they walked across an emed AT-4 pressure platform. Physical activity was objectively assessed …
Effects Of Dairy Products On Crohn's Disease Symptoms Are Influenced By Fat Content And Disease Location But Not Lactose Content Or Disease Activity Status In A New Zealand Population, Deborah Nolan, Linda C. Tapsell, Rong Hu, Dug Yeo Han, Lynnette Ferguson
Effects Of Dairy Products On Crohn's Disease Symptoms Are Influenced By Fat Content And Disease Location But Not Lactose Content Or Disease Activity Status In A New Zealand Population, Deborah Nolan, Linda C. Tapsell, Rong Hu, Dug Yeo Han, Lynnette Ferguson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background Dairy products have been perceived as having the potential to cause adverse effects in individuals with Crohn’s disease (CD) and are often avoided, potentially increasing the risk of osteoporosis and related morbidity associated with inadequate dietary calcium intake. Objective To evaluate the self-reported effects of dairy products on CD symptoms and to determine whether these effects differed between types of dairy products consumed and disease state or location. Design Secondary analysis of dietary survey and clinical data from participants in the Genes and Diet in Inflammatory Bowel Disease study based in Auckland, New Zealand. Subjects/setting One hundred and sixty-five …
Wild Type And Tangier Disease Abca1 Mutants Modulate Cellular Amyloid-Beta Production Independent Of Cholesterol Efflux Activity, Kim S. Woojin, Andrew F. Hill, Michael L. Fitzgerald, Mason W. Freeman, Genevieve Evin, Brett Garner
Wild Type And Tangier Disease Abca1 Mutants Modulate Cellular Amyloid-Beta Production Independent Of Cholesterol Efflux Activity, Kim S. Woojin, Andrew F. Hill, Michael L. Fitzgerald, Mason W. Freeman, Genevieve Evin, Brett Garner
Faculty of Science - Papers (Archive)
Cerebral amyloid-β (Aβ) deposition is a critical feature of Alzheimer’s disease. Aβ is derived from the amyloid-β protein precursor (AβPP) via two sequential cleavages that are mediated by β-secretase and the γ-secretase complex. Such amyloidogenic AβPP processing occurs in lipid raft microdomains of cell membranes and it is thought that modulating the distribution of lipids in rafts may regulate AβPP processing and Aβ production. Certain ATP-binding cassette (ABC) transporters regulate lipid transport across cell membranes and, as recent studies reveal, within membrane microdomains. ABCA1 also regulates Aβ metabolism in the brain although its direct impact on AβPP remains an open …
The Sydney Playground Project: Popping The Bubblewrap - Unleashing The Power Of Play: A Cluster Randomized Controlled Trial Of A Primary School Playground-Based Intervention Aiming To Increase Children's Physical Activity And Social Skills, Anita C. Bundy, Geraldine A. Naughton, Paul Tranter, Shirley Wyver, Louise A. Baur, Wendy Schiller, Adrian E. Bauman, Lina Engelen, Jo Ragen, Tim Luckett, Anita Niehues, Gabrielle Stewart, Glenda Jessup, Jennie Brentnall
The Sydney Playground Project: Popping The Bubblewrap - Unleashing The Power Of Play: A Cluster Randomized Controlled Trial Of A Primary School Playground-Based Intervention Aiming To Increase Children's Physical Activity And Social Skills, Anita C. Bundy, Geraldine A. Naughton, Paul Tranter, Shirley Wyver, Louise A. Baur, Wendy Schiller, Adrian E. Bauman, Lina Engelen, Jo Ragen, Tim Luckett, Anita Niehues, Gabrielle Stewart, Glenda Jessup, Jennie Brentnall
Faculty of Social Sciences - Papers (Archive)
Background In the Westernised world, numerous children are overweight and have problems with bullying and mental health. One of the underlying causes for all three is postulated to be a decrease in outdoor free play. The aim of the Sydney Playground Project is to demonstrate the effectiveness of two simple interventions aimed to increase children's physical activity and social skills. Methods/Design This study protocol describes the design of a 3-year cluster randomised controlled trial (CRCT), in which schools are the clusters. The study consists of a 13-week intervention and 1 week each of pre-and post-testing. We are recruiting 12 schools …
Association Between Physical Activity And Motor Skills And Coordination In Portuguese Children, Luis Lopes, Vitor Pires Lopes, Rute Santos, Beatriz Pereira
Association Between Physical Activity And Motor Skills And Coordination In Portuguese Children, Luis Lopes, Vitor Pires Lopes, Rute Santos, Beatriz Pereira
Faculty of Social Sciences - Papers (Archive)
Nowadays, there is growing evidence in literature that Health benefits from regular physical activity (PA). The variance in PA among children is caused by a number of factors including their motor abilities and coordination. The aim of the study was to analyse the relation between usual PA and gross motor abilities and motor coordination in children aged 6 to 7 years. The sample comprised 21 children, aged in average 6,38±0,50 years. Physical activity was accessed by accelerometry, gross motor abilities by using the Test of Gross Motor Development (TGMD-2) and motor coordination by using the Körperkoordination Test für Kinder (KTK). …
Metabolic Risk Factors, Physical Activity And Physical Fitness In Azorean Adolescents: A Cross-Sectional Study, Carla Moreira, Rute Santos, Jose Cazuza De Farias Junior, Susana Vale, Paula Clara Santos, Luisa Soares-Miranda, Ana I. Marques, Jorge Mota
Metabolic Risk Factors, Physical Activity And Physical Fitness In Azorean Adolescents: A Cross-Sectional Study, Carla Moreira, Rute Santos, Jose Cazuza De Farias Junior, Susana Vale, Paula Clara Santos, Luisa Soares-Miranda, Ana I. Marques, Jorge Mota
Faculty of Social Sciences - Papers (Archive)
Background
The prevalence of metabolic syndrome has increased over the last few decades in adolescents and has become an important health challenge worldwide. This study analyzed the relationships between metabolic risk factors (MRF) and physical activity (PA) and physical fitness (PF) in a sample of Azorean adolescents.
Methods
A cross-sectional school-based study was conducted on 417 adolescents (243 girls) aged 15-18 from the Azorean Islands, Portugal. Height, weight, waist circumference, fasting glucose, HDL-cholesterol, triglycerides, and blood pressure were measured. A sum of MRF was computed, and adolescents were classified into three groups: no MRF, one MRF and two or more …
Seasonal Differences In Physical Activity And Sedentary Patterns: The Relevance Of The Pa Context, Pedro Silva, Rute Santos, Gregory Welk, Jorge Mota
Seasonal Differences In Physical Activity And Sedentary Patterns: The Relevance Of The Pa Context, Pedro Silva, Rute Santos, Gregory Welk, Jorge Mota
Faculty of Social Sciences - Papers (Archive)
The aim of this pilot study was to characterize seasonal variationin the moderate to vigorous physical activity (MVPA) and sedentarybehavior of Portuguese school youth, and understand theinfluence of activity choices and settings. The participants inthis study were 24 students, aged 10-13 years. Accelerometersmeasured daily PA over 7 consecutive days, in different seasonsMay - June and January - February. In summer, boys accumulatedmore minutes in MVPA (928 minutes/week) than girls(793 minutes/week). In winter the pattern was reversed withgirls accumulating more activity than boys (736 minutes/weekvs. 598 minutes/week). The repeated measures ANOVA revealedsignificant effects for season (F = 5.98, p = 0.023) …
Evaluation Of Physical Activity Programmes For Elderly People - A Descriptive Study Using The Efqm' Criteria, Ana I. Marques, Maria J. Rosa, Pedro Soares, Rute Santos, Jorge Mota, Joana Carvalho
Evaluation Of Physical Activity Programmes For Elderly People - A Descriptive Study Using The Efqm' Criteria, Ana I. Marques, Maria J. Rosa, Pedro Soares, Rute Santos, Jorge Mota, Joana Carvalho
Faculty of Social Sciences - Papers (Archive)
Background: In the past years, there has been a growing concern in designing physical activity (PA) programmes for elderly people, because evidence suggests that such health promotion interventions may reduce the deleterious effects of the ageing process. Quality is an important issue when designing a PA programme for older people. Some studies support the Excellence Model of the European Foundation for Quality Management (EFQM) as an operational framework for evaluating the quality of an organization. Within this context, the aim of this study was to characterize the quality management models of the PA programmes developed by Portuguese Local Administration to …
Evaluation Of Physical Activity Programmes For The Elderly - Exploring The Lessons From Other Sectors And Examining The General Characteristics Of The Programmes, Ana I. Marques, Pedro Soares, Luisa Soares-Miranda, Carla Moreira, Antonio Oliveira-Tavares, Paula Clara-Santos, Susana Vale, Rute Santos, Joana Carvalho
Evaluation Of Physical Activity Programmes For The Elderly - Exploring The Lessons From Other Sectors And Examining The General Characteristics Of The Programmes, Ana I. Marques, Pedro Soares, Luisa Soares-Miranda, Carla Moreira, Antonio Oliveira-Tavares, Paula Clara-Santos, Susana Vale, Rute Santos, Joana Carvalho
Faculty of Social Sciences - Papers (Archive)
Background
In Portugal, there are several physical activity (PA) programmes for elderly people developed by the local government. The importance of these programmes has been increasing since the evidence has shown that this type of health promotion interventions may reduce the deleterious effects of the ageing process. However, no study has already identified the general characteristics of these programmes nor if they use any scheme to assess the quality of the service provided. A widely-used scheme is the EFQM Excellence Model, which will be in the core of our present work. Thus, the main aims of this preliminary study were …
A Proposed Adaptation Of The European Foundation For Quality Management Excellence Model To Physical Activity Programmes For The Elderly - Development Of A Quality Self-Assessment Tool Using A Modified Delphi Process, Ana I. Marques, Leonel Santos, Pedro Soares, Rute Santos, Antonio Oliveira-Tavares, Jorge Mota, Joana Carvalho
A Proposed Adaptation Of The European Foundation For Quality Management Excellence Model To Physical Activity Programmes For The Elderly - Development Of A Quality Self-Assessment Tool Using A Modified Delphi Process, Ana I. Marques, Leonel Santos, Pedro Soares, Rute Santos, Antonio Oliveira-Tavares, Jorge Mota, Joana Carvalho
Faculty of Social Sciences - Papers (Archive)
Background There has been a growing concern in designing physical activity (PA) programmes for elderly people, since evidence suggests that such health promotion interventions may reduce the deleterious effects of the ageing process. Complete programme evaluations are a necessary prerequisite to continuous quality improvements. Being able to refine, adapt and create tools that are suited to the realities and contexts of PA programmes for the elderly in order to support its continuous improvement is, therefore, crucial. Thus, the aim of this study was to develop a self-assessment tool for PA programmes for the elderly. Methods A 3-round Delphi process was …
Declining Physical Activity Levels As An Unintended Consequence Of Abolishing Mandatory Campus Service Fees, Sandra C. Jones, Lance R. Barrie
Declining Physical Activity Levels As An Unintended Consequence Of Abolishing Mandatory Campus Service Fees, Sandra C. Jones, Lance R. Barrie
Faculty of Health and Behavioural Sciences - Papers (Archive)
Objective: This study investigates the effect of the introduction of voluntary student unionism and subsequent increase in campus facility fees on engagement in physical activity on campus. Participants: Participants were 1,904 students from a large regional NSW (Australia) university across 3 time periods (926 in 2005, 504 in 2006, and 474 in 2007). Methods: Students completed a survey across the 3 time periods, responding to questions about physical activity levels, use of on-campus and off-campus facilities, and barriers to facility use. Results: Participation in physical activity at university facilities was low overall, and declined substantially between 2005 and 2007, with …