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Full-Text Articles in Social and Behavioral Sciences
Infrared Spectra Of The Li +_(H 2)N(N=1-3) Cation Complexes, C Emmeluth, B L. J Poad, C D. Thompson, G H. Weddle, E J. Bieske
Infrared Spectra Of The Li +_(H 2)N(N=1-3) Cation Complexes, C Emmeluth, B L. J Poad, C D. Thompson, G H. Weddle, E J. Bieske
Faculty of Science - Papers (Archive)
The Li+–(H2)n n = 1–3 complexes are investigated through infrared spectra recorded in the H–H stretch region (3980–4120 cm−1) and through ab initio calculations at the MP2∕aug-cc-pVQZ level. The rotationally resolved H–H stretch band of Li+–H2 is centered at 4053.4 cm−1 [a −108 cm−1 shift from the Q1(0) transition of H2]. The spectrum exhibits rotational substructure consistent with the complex possessing a T-shaped equilibrium geometry, with the Li+ ion attached to a slightly perturbed H2 molecule. Around 100 rovibrational transitions belonging to …
The Repressor Element 1-Silencing Transcription Factor Regulates Heart-Specific Gene Expression Using Multiple Chromatin-Modifying Complexes, Andrew J. Bingham, Lezanne Ooi, Lukasz Kozera, Edward White, Ian C. Wood
The Repressor Element 1-Silencing Transcription Factor Regulates Heart-Specific Gene Expression Using Multiple Chromatin-Modifying Complexes, Andrew J. Bingham, Lezanne Ooi, Lukasz Kozera, Edward White, Ian C. Wood
Faculty of Science - Papers (Archive)
Cardiac hypertrophy is associated with a dramatic change in the gene expression profile of cardiac myocytes. Many genes important during development of the fetal heart but repressed in the adult tissue are reexpressed, resulting in gross physiological changes that lead to arrhythmias, cardiac failure, and sudden death. One transcription factor thought to be important in repressing the expression of fetal genes in the adult heart is the transcriptional repressor REST (repressor element 1-silencing transcription factor). Although REST has been shown to repress several fetal cardiac genes and inhibition of REST function is sufficient to induce cardiac hypertrophy, the molecular mechanisms …
Widespread Disruption Of Repressor Element-1 Silencing Transcription Factor/Neuron-Restrictive Silencer Factor Occupancy At Its Target Genes In Huntington's Disease, Chiara Zuccato, Nikolai D. Belyaev, Paola Conforti, Lezanne Ooi, Marzia Tartari, Evangelia Papadimou, Marcy Macdonald, Elisa Fossale, Scott Zeitlin, Noel J. Buckley, Elena Cattaneo
Widespread Disruption Of Repressor Element-1 Silencing Transcription Factor/Neuron-Restrictive Silencer Factor Occupancy At Its Target Genes In Huntington's Disease, Chiara Zuccato, Nikolai D. Belyaev, Paola Conforti, Lezanne Ooi, Marzia Tartari, Evangelia Papadimou, Marcy Macdonald, Elisa Fossale, Scott Zeitlin, Noel J. Buckley, Elena Cattaneo
Faculty of Science - Papers (Archive)
Huntingtin is a protein that is mutated in Huntington's disease (HD), a dominant inherited neurodegenerative disorder. We previously proposed that, in addition to the gained toxic activity of the mutant protein, selective molecular dysfunctions in HD may represent the consequences of the loss of wild-type protein activity. We first reported that wild-type huntingtin positively affects the transcription of the brain-derived neurotrophic factor (BDNF) gene, a cortically derived survival factor for the striatal neurons that are mainly affected in the disease. Mutation in huntingtin decreases BDNF gene transcription. One mechanism involves the activation of repressor element 1/neuron-restrictive silencer element (RE1/NRSE) located …
Association Analysis Of Chromosome 1 Migraine Candidate Genes, Francesca Fernandez, Robert P. Curtain, Natalie J. Colson, Micky Ovcaric, John Macmillan, Lyn R. Griffiths
Association Analysis Of Chromosome 1 Migraine Candidate Genes, Francesca Fernandez, Robert P. Curtain, Natalie J. Colson, Micky Ovcaric, John Macmillan, Lyn R. Griffiths
Faculty of Social Sciences - Papers (Archive)
Background Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci. The type 2 FHM (FHM-2) susceptibility locus maps to chromosome 1q23 and mutations in the ATP1A2 gene at this site have recently been implicated. We have previously provided evidence of linkage of typical migraine (predominantly MA) to microsatellite markers on chromosome 1, in the 1q31 and 1q23 regions. In this study, we have undertaken a large genomic investigation involving candidate genes that lie within the chromosome 1q23 and 1q31 regions …
A Nonlinear 1-D Case Backward Heat Problem: Regularization And Error, Dang Duc Trong, Pham Hoang Quan, Tran Vu Khanh, Nguyen Huy Tuan
A Nonlinear 1-D Case Backward Heat Problem: Regularization And Error, Dang Duc Trong, Pham Hoang Quan, Tran Vu Khanh, Nguyen Huy Tuan
Faculty of Engineering and Information Sciences - Papers: Part A
No abstract provided.
Polymorphisms Of Cx3cr1 And Cxcr6 Receptors In Relation To Haart Therapy Of Hiv Type 1 Patients, Andreas M. Passam, George Sourvinos, Elias Krambovitis, Spyridon Miyakis, Nikolaos G. Stavrianeas, Ioannis Zagoreos, Demetrios A. Spandidos
Polymorphisms Of Cx3cr1 And Cxcr6 Receptors In Relation To Haart Therapy Of Hiv Type 1 Patients, Andreas M. Passam, George Sourvinos, Elias Krambovitis, Spyridon Miyakis, Nikolaos G. Stavrianeas, Ioannis Zagoreos, Demetrios A. Spandidos
Faculty of Science, Medicine and Health - Papers: part A
The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX3CR1-V249I, and CX3CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following end-point criteria: (1) time from HAART initiation to undetectable viral load (VL < 50 copies/ml), (2) maximum duration of viral suppression, (3) time from HAART administration until CD4 elevation above 200 cells/ul for patients with baseline CD4 below 200 cells/ul and above 500 cells/ul for patients with baseline CD4 between 200 and 500 cells/ul, respectively, and (4) time from HAART initiation until CD4 reduction below baseline values. Our results revealed an improved immunologic response to HAART in patients with the CX3CR1-249I or CX3CR1-280M allele. On the contrary, patients with initial VL suppression due to HAART showed a faster virologic failure in the presence of the CXCR6-3K allele. The In1.1T/C polymorphism and H7 haplotype did not reveal any specific effect on HAART response.