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Full-Text Articles in Social and Behavioral Sciences
The Work Of Living With A Rare Cancer: Multiple Myeloma, Moira Stephens, Heather Mckenzie, Christopher Jordens
The Work Of Living With A Rare Cancer: Multiple Myeloma, Moira Stephens, Heather Mckenzie, Christopher Jordens
Faculty of Science, Medicine and Health - Papers: part A
Aim To report findings from a qualitative study of the experiences of long-term survivors of multiple myeloma. Background Multiple Myeloma is a malignant disease of the bone marrow. Until recently, it was rapidly fatal. Although it remains incurable, people diagnosed with it are living longer on average, largely due to new treatments, some of which have onerous side effects. Design Prospective descriptive study. Method A series of 47 in-depth interviews were conducted at 6-12 month intervals over 18 months in 2008-2010 with 10 long-term survivors of myeloma and their primary support person. Interviews were analysed using the constant comparative method …
Anthropogenic Selection Enhances Cancer Evolution In Tasmanian Devil Tumours, Beata Ujvari, Anne-Maree Pearse, Kate Swift, Pamela Hodson, Bobby Hua, Stephen Pyecroft, Robyn Taylor, Rodrigo Hamede, Menna Jones, Katherine Belov, Thomas Madsen
Anthropogenic Selection Enhances Cancer Evolution In Tasmanian Devil Tumours, Beata Ujvari, Anne-Maree Pearse, Kate Swift, Pamela Hodson, Bobby Hua, Stephen Pyecroft, Robyn Taylor, Rodrigo Hamede, Menna Jones, Katherine Belov, Thomas Madsen
Faculty of Science, Medicine and Health - Papers: part A
The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to elucidate the long-term effects of natural and anthropogenic selection on cancer evolution. Since first observed in 1996, this transmissible cancer has caused local population declines by >90%. So far, four chromosomal DFTD variants (strains) have been described and karyotypic analyses of 253 tumours showed higher levels of tetraploidy in the oldest strain. We propose that increased ploidy in the oldest strain may have evolved in response to effects of genomic decay observed in asexually reproducing organisms. In this study, we focus on the evolutionary response of DFTD to …