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Articles 1 - 5 of 5
Full-Text Articles in Social and Behavioral Sciences
Streptokinase Variants From Streptococcus Pyogenes Isolates Display Altered Plasminogen Activation Characteristics - Implications For Pathogenesis, Simon M. Cook, Amanda Skora, Christine M. Gillen, Mark J. Walker, Jason D. Mcarthur
Streptokinase Variants From Streptococcus Pyogenes Isolates Display Altered Plasminogen Activation Characteristics - Implications For Pathogenesis, Simon M. Cook, Amanda Skora, Christine M. Gillen, Mark J. Walker, Jason D. Mcarthur
Faculty of Science, Medicine and Health - Papers: part A
Streptococcus pyogenes (group A streptococcus, GAS) secretes streptokinase, a potent plasminogen activating protein. Among GAS isolates, streptokinase gene sequences (ska) are polymorphic and can be grouped into two distinct sequence clusters (termed cluster type-1 and cluster type-2) with cluster type-2 being further divided into sub-clusters type-2a and type-2b. In this study, far-UV circular dichroism spectroscopy indicated that purified streptokinase variants of each type displayed similar secondary structure. Type-2b streptokinase variants could not generate an active site in Glu-plasminogen through non-proteolytic mechanisms while all other variants had this capability. Furthermore, when compared with other streptokinase variants, type-2b variants displayed a 29- …
Dietary Docosahexaenoic Acid (22:6) Incorporates Into Cardiolipin At The Expense Of Linoleic Acid (18:2): Analysis And Potential Implications, Colin Cortie, Paul L. Else
Dietary Docosahexaenoic Acid (22:6) Incorporates Into Cardiolipin At The Expense Of Linoleic Acid (18:2): Analysis And Potential Implications, Colin Cortie, Paul L. Else
Faculty of Science, Medicine and Health - Papers: part A
Cardiolipin is a signature phospholipid of major functional significance in mitochondria. In heart mitochondria the fatty acid composition of cardiolipin is commonly viewed as highly regulated due to its high levels of linoleic acid (18:2n − 6) and the dominant presence of a 4×18:2 molecular species. However, analysis of data from a comprehensive compilation of studies reporting changes in fatty acid composition of cardiolipin in heart and liver mitochondria in response to dietary fat shows that, in heart the accrual of 18:2 into cardiolipin conforms strongly to its dietary availability at up to 20% of total dietary fatty acid and …
Will Climate Severity Ever Lead To Climate Action? Implications For Adaptation Policy And Practice, Bastian Seidel, Erica Bell
Will Climate Severity Ever Lead To Climate Action? Implications For Adaptation Policy And Practice, Bastian Seidel, Erica Bell
Faculty of Science, Medicine and Health - Papers: part A
No abstract provided.
Rapid Regolith Formation Over Volcanic Bedrock And Implications For Landscape Evolution, Anthony Dosseto, Heather L. Buss, P O Suresh
Rapid Regolith Formation Over Volcanic Bedrock And Implications For Landscape Evolution, Anthony Dosseto, Heather L. Buss, P O Suresh
Faculty of Science, Medicine and Health - Papers: part A
The ability to quantify how fast weathering profiles develop is crucial to assessing soil resource depletion and quantifying how landscapes evolve over millennia. Uranium-series isotopes can be used to determine the age of the weathering front throughout a profile and to infer estimates of regolith production rates, because the abundance of U-series isotopes in a weathering profile is a function of chemical weathering and time. This technique is applied to a weathering profile in Puerto Rico developed over a volcaniclastic bedrock. U-series isotope compositions are modelled, revealing that it takes 40–60 kyr to develop an 18 m-thick profile. This is …
Re-Creating The Rural, Reconstructing Nature: An International Literature Review Of The Environmental Implications Of Amenity Migration, Jesse B. Abrams, Hannah Gosnell, Nicholas J. Gill, Peter J. Klepeis
Re-Creating The Rural, Reconstructing Nature: An International Literature Review Of The Environmental Implications Of Amenity Migration, Jesse B. Abrams, Hannah Gosnell, Nicholas J. Gill, Peter J. Klepeis
Faculty of Science, Medicine and Health - Papers: part A
The term 'amenity migration' describes a broad diversity of patterns of human movement to rural places in search of particular lifestyle attributes. This review of international literature, drawn from the authors' own prior research and searches on relevant databases, synthesises findings on the implications of amenity migration for the creation and distribution of environmental harms and benefits. Further, we critique common framings of amenity migration-related environmental transformations and offer suggestions for future research. Analysis is positioned within a review of five common themes reflected in the cases we consider: land subdivision and residential development; changes in private land use; cross-boundary …