Open Access. Powered by Scholars. Published by Universities.®

Social and Behavioral Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Faculty of Science, Medicine and Health - Papers: part A

2007

Cx3cr1

Articles 1 - 1 of 1

Full-Text Articles in Social and Behavioral Sciences

Polymorphisms Of Cx3cr1 And Cxcr6 Receptors In Relation To Haart Therapy Of Hiv Type 1 Patients, Andreas M. Passam, George Sourvinos, Elias Krambovitis, Spyridon Miyakis, Nikolaos G. Stavrianeas, Ioannis Zagoreos, Demetrios A. Spandidos Jan 2007

Polymorphisms Of Cx3cr1 And Cxcr6 Receptors In Relation To Haart Therapy Of Hiv Type 1 Patients, Andreas M. Passam, George Sourvinos, Elias Krambovitis, Spyridon Miyakis, Nikolaos G. Stavrianeas, Ioannis Zagoreos, Demetrios A. Spandidos

Faculty of Science, Medicine and Health - Papers: part A

The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX3CR1-V249I, and CX3CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following end-point criteria: (1) time from HAART initiation to undetectable viral load (VL < 50 copies/ml), (2) maximum duration of viral suppression, (3) time from HAART administration until CD4 elevation above 200 cells/ul for patients with baseline CD4 below 200 cells/ul and above 500 cells/ul for patients with baseline CD4 between 200 and 500 cells/ul, respectively, and (4) time from HAART initiation until CD4 reduction below baseline values. Our results revealed an improved immunologic response to HAART in patients with the CX3CR1-249I or CX3CR1-280M allele. On the contrary, patients with initial VL suppression due to HAART showed a faster virologic failure in the presence of the CXCR6-3K allele. The In1.1T/C polymorphism and H7 haplotype did not reveal any specific effect on HAART response.