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Social and Behavioral Sciences Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Social and Behavioral Sciences
Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch
Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch
Faculty of Science - Papers (Archive)
Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to a progressive decline in a person’s memory and ability to communicate and carry out daily activities. The brain pathology in AD is characterized by extensive neuronal loss, particularly of cholinergic neurons, intracellular neurofibrillary tangles composed of the tau protein (NFTs) and extracellular deposition of plaques composed of β-amyloid (Aβ), a cleavage product of the amyloid precursor protein (APP). These two insoluble protein aggregates are accompanied by a chronic inflammatory response and extensive oxidative damage. Whereas dys-regulation of APP expression or processing appears to be important for the familial, …
A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson
A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson
Faculty of Science - Papers (Archive)
Direct heating of a metal-organic framework provides a simple, controllable way of effecting a covalent post-synthetic modification. Herein we report that an allyloxy-tagged zinc metal-organic framework undergoes a thermally-promoted aromatic Claisen rearrangement through which the framework connectivity and porosity are maintained.
Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett
Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett
Faculty of Science - Papers (Archive)
Collaborative and cross-disciplinary research by a group of artists and scientists in an Australian rural setting generates data and ideas that form the basis of a wider understanding of the ramifications of global warming and cooling within the local, regional and national community. The work is viewed as an initial educational platform that will allow the public to see and understand the complexities of climate-based research.