Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Reduced Intestinal Brain-Derived Neurotrophic Factor Increases Vagal Sensory Innervation Of The Intestine And Enhances Satiation, Jessica E. Biddinger, Edward A. Fox
Reduced Intestinal Brain-Derived Neurotrophic Factor Increases Vagal Sensory Innervation Of The Intestine And Enhances Satiation, Jessica E. Biddinger, Edward A. Fox
Department of Psychological Sciences Faculty Publications
Brain-derived neurotrophic factor (BDNF) is produced by developing and mature gastrointestinal (GI) tissues that are heavily innervated by autonomic neurons and may therefore control their development or function. To begin investigating this hypothesis, we compared the morphology, distribution, and density of intraganglionic laminar endings (IGLEs), the predominant vagal GI afferent, in mice with reduced intestinal BDNF (INT-BDNF_/_) and controls. Contrary to expectations of reduced development, IGLE density and longitudinal axon bundle number in the intestine of INT-BDNF_/_ mice were increased, but stomach IGLEs were normal. INT-BDNF_/_ mice also exhibited increased vagal sensory neuron numbers, suggesting that their survival was enhanced. …
Meal Parameters And Vagal Gastrointestinal Afferents In Mice That Experienced Early Postnatal Overnutrition, Jessica Biddinger, Edward A. Fox
Meal Parameters And Vagal Gastrointestinal Afferents In Mice That Experienced Early Postnatal Overnutrition, Jessica Biddinger, Edward A. Fox
Department of Psychological Sciences Faculty Publications
Early postnatal overnutrition disrupts satiety without altering vagal gastrointestinal afferents. PHYSIOL BEHAV 00(0) 000-000, 2010. Early postnatal overnutrition results in a predisposition to develop obesity due in part to hypothalamic and sympathetic dysfunction. Potential involvement of another major regulatory system component - the vagus nerve - has not been examined. Moreover, feeding disturbances have rarely been investigated prior to development of obesity when confounds due to obesity are minimized. To examine these issues, litters were culled on the day of birth to create small litters (SL; overnutrition), or normal-size litters (NL; normal nutrition). Body weight, fat pad weight, meal patterns, …