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Folate And Inflammatory Markers Moderate The Association Between Helicobacter Pylori Exposure And Cognitive Function In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges

Faculty Publications

Background: Helicobacter pylori(H. pylori) infection is associated with cogni-tive deficits in humans, an association potentially mediated or moderated byfolate concentration or inflammation.Materials and

Methods: We used the National Health and Nutrition Exami-nation Survey (NHANES) datasets to examine whether folate concentrationor inflammation mediates or moderates the relationship betweenH. pyloriand cognitive function. Models were performed using linear, Poisson, andzero-inflated Poisson regression, and we performed separate analyses forgroups aged 20–59 and 60–90 years with sample sizes ranging from 700 to1700.Results:We did not find evidence of mediation in either age group. In the20- to 59-year group, interactions betweenH. pyloriand ferritin (pvaluesranging from .004 to …