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Full-Text Articles in Social and Behavioral Sciences
Nmr Spectroscopy Of 14-3-3zeta Reveals A Flexible C-Terminal Extension: Differentiation Of The Chaperone And Phosphoserine-Binding Activities Of 14-3-3zeta, H Fu, Danielle Williams, Heath Ecroyd, John Carver, Lixin Zhang, Huanqin Dai, Joanna Woodcock, K Goodwin
Nmr Spectroscopy Of 14-3-3zeta Reveals A Flexible C-Terminal Extension: Differentiation Of The Chaperone And Phosphoserine-Binding Activities Of 14-3-3zeta, H Fu, Danielle Williams, Heath Ecroyd, John Carver, Lixin Zhang, Huanqin Dai, Joanna Woodcock, K Goodwin
Heath Ecroyd
Intracellular 14-3-3 proteins bind to many proteins, via a specific phosphoserine motif, regulating diverse cellular tasks including cell signalling and disease progression. The 14-3-3 isoform is a molecular chaperone, preventing the stressinduced aggregation of target proteins in a manner comparable with that of the unrelated sHsps (small heat-shock proteins). 1H-NMR spectroscopy revealed the presence of a flexible and unstructured C-terminal extension, 12 amino acids in length, which protrudes from the domain core of 14-3-3 and is similar in structure and length to the C-terminal extension of mammalian sHsps. The extension stabilizes 14-3-3, but has no direct role in chaperone action. …
Chronic Treatment With Simvastatin Upregulates Muscarinic M1/4 Receptor Binding In The Rat Brain, Kelly Newell, P Wong, Xu-Feng Huang, Qing Wang, Wilfred Yeo, P Wang, Weihai Ying, Midori Yenari, Ayse Zengin
Chronic Treatment With Simvastatin Upregulates Muscarinic M1/4 Receptor Binding In The Rat Brain, Kelly Newell, P Wong, Xu-Feng Huang, Qing Wang, Wilfred Yeo, P Wang, Weihai Ying, Midori Yenari, Ayse Zengin
Xu-Feng Huang
Statins are increasingly being used for the treatment of a variety of conditions beyond their original indication for cholesterol lowering. We previously reported that simvastatin affected the dopaminergic system in the rat brain. This study aims to investigate regional changes of muscarinic M1/4 receptors in the rat brain after 4-week administration of simvastatin (1 or 10 mg/kg/day). M1/4 receptor distribution and alterations in the post-mortem rat brain were detected by [3H]pirenzepine binding autoradiography. Simvastatin (1 mg/kg/day) increased [3H]pirenzepine binding, predominantly in the prefrontal cortex (171%, P<0.001), primary motor cortex (153%, P=0.001), cingulate cortex (109%, P<0.001), hippocampus (138%, P …
Short And Long Term Changes In Nmda Receptor Binding In Mouse Brain Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Short And Long Term Changes In Nmda Receptor Binding In Mouse Brain Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
This study examined regional changes of peptide YY (PYY) binding densities in the rat brain after chronic administration of olanzapine (1.2 mg/kg/day and haloperidol (2.0 mg/kg/day)for 36 days. PYY binding densities and distributions were detected by [125I] binding autoradiography after ratswere sacrificed either 2 h or 48 h after the last drug administration to examine both immediate and delayed effects following the drugwithdrawal. Following 2 h of drug administration, it showed that olanzapine administration significantly decreased PYY binding densities, predominantly in the posterodorsal part of medial amygdaloid nucleus (52 percent, pb0.05), dorsal part of medial geniculate nucleus (56 percent, pb0.05), …
Fatty Acids Differentially Affect 5-Ht2 Receptor And Transporter Binding In The Rat Brain, Xu-Feng Huang, Chao Deng, Warren Bell, Teresa Du Bois
Fatty Acids Differentially Affect 5-Ht2 Receptor And Transporter Binding In The Rat Brain, Xu-Feng Huang, Chao Deng, Warren Bell, Teresa Du Bois
Xu-Feng Huang
No abstract provided.
M2/M4 Muscarinic Receptor Binding In The Anterior Cingulate Cortex In Schizophrenia And Mood Disorders, Xu-Feng Huang, Katerina Zavitsanou, Andrew Katsifis, Yinghua Yu
M2/M4 Muscarinic Receptor Binding In The Anterior Cingulate Cortex In Schizophrenia And Mood Disorders, Xu-Feng Huang, Katerina Zavitsanou, Andrew Katsifis, Yinghua Yu
Xu-Feng Huang
No abstract provided.
Opposing Short- And Long-Term Effects On Muscarinic M1/4 Receptor Binding Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Opposing Short- And Long-Term Effects On Muscarinic M1/4 Receptor Binding Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South
Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South
Xu-Feng Huang
The cannabinoid CB1 receptor has been implicated in the regulation of appetite and the consumption of palatable foods. This experiment aimed to explore the involvement of the CB1 receptor in the early and late stages of high fat diet-induced obesity in C57BL/6 mice. The C57Bl/6 mice were placed on a high fat (HF) or low fat/high carbohydrate (LF) diet for 3 or 20 weeks. Quantitative autoradiography revealed that binding of [3H] CP-55,940 (CB1 receptor ligand) was elevated following 3 weeks of HF feeding in areas including the medial/ventral anterior olfactory nucleus (22.1%), agranular insular cortex (24.0%) and the hypothalamus (31.5%) …
Altered Dopamine Receptor And Dopamine Transporter Binding And Tyrosine Hydroxylase Mrna Expression Following Perinatal Nmda Receptor Blockade, Yulin Li, Xu-Feng Huang, Chao Deng, Yean Tan, Cw Hsu, Teresa Du Bois
Altered Dopamine Receptor And Dopamine Transporter Binding And Tyrosine Hydroxylase Mrna Expression Following Perinatal Nmda Receptor Blockade, Yulin Li, Xu-Feng Huang, Chao Deng, Yean Tan, Cw Hsu, Teresa Du Bois
Xu-Feng Huang
No abstract provided.
Ionotropic Glutamate Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia Patients, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Ionotropic Glutamate Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia Patients, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
High Dose Of Simvastatin Induces Hyperlocomotive And Anxiolytic-Like Activities: The Association With The Up-Regulation Of Nmda Receptor Binding In The Rat Brain, Kelly Newell, Xu-Feng Huang, Chao Deng, Qing Wang, Einar Wilder-Smith, Yun Li, Ying Lu, Ayse Zengin, Guo-Yuan Yang, Heng Zhao
High Dose Of Simvastatin Induces Hyperlocomotive And Anxiolytic-Like Activities: The Association With The Up-Regulation Of Nmda Receptor Binding In The Rat Brain, Kelly Newell, Xu-Feng Huang, Chao Deng, Qing Wang, Einar Wilder-Smith, Yun Li, Ying Lu, Ayse Zengin, Guo-Yuan Yang, Heng Zhao
Xu-Feng Huang
Statins are widely being used for the treatment of a variety of conditions beyond their original indication for lowering cholesterol. We have previously reported that simvastatin affected the dopaminergic system in the rat brain. This study aims to investigate locomotor and anxiety effects along with the regional changes of N-methyl-d-aspartate (NMDA) receptors in the rat brain after 4-week administration of simvastatin. Hyperlocomotive and anxiolytic-like activities in the rat were observed after chronic administration of high dose simvastatin (10 mg/kg/day). Distributions and alterations of NMDA receptors in the post-mortem rat brain were detected by [3H] MK-801 binding autoradiography. Simvastatin increased [3H] …
High-Fat Diet Exposure Increases Dopamine D2 Receptor And Decreases Dopamine Transporter Receptor Binding Density In The Nucleus Accumbens And Caudate Putamen Of Mice, Xu-Feng Huang, Timothy South
High-Fat Diet Exposure Increases Dopamine D2 Receptor And Decreases Dopamine Transporter Receptor Binding Density In The Nucleus Accumbens And Caudate Putamen Of Mice, Xu-Feng Huang, Timothy South
Xu-Feng Huang
No abstract provided.
A High N-6 Polyunsaturated Fatty Acid Diet Reduces Muscarinic M2/M4 Receptor Binding In The Rat Brain, Xu-Feng Huang, Chao Deng, Warren Bell, Teresa Du Bois
A High N-6 Polyunsaturated Fatty Acid Diet Reduces Muscarinic M2/M4 Receptor Binding In The Rat Brain, Xu-Feng Huang, Chao Deng, Warren Bell, Teresa Du Bois
Xu-Feng Huang
No abstract provided.
Decreased Plasma Peptide Yy Accompanied By Elevated Peptide Yy And Y2 Receptor Binding Densities In The Medulla Oblongata Of Diet-Induced Obese Mice, Xu-Feng Huang, Chao Deng, Yean Tan, Gita Rahardjo
Decreased Plasma Peptide Yy Accompanied By Elevated Peptide Yy And Y2 Receptor Binding Densities In The Medulla Oblongata Of Diet-Induced Obese Mice, Xu-Feng Huang, Chao Deng, Yean Tan, Gita Rahardjo
Xu-Feng Huang
It is well known that the peripheral peptide YY (PYY)-central neuropeptide Y (NPY) Y2 receptor axis plays an important role in promoting negative energy balance regulation. Both the hypothalamus and medulla oblongata express a high level of Y2 receptors; however, the functional role of this receptor in chronic high-fat diet-induced obesity has not been fully examined. Using quantitative autoradiography, this study measured binding densities of total [125I]PYY and Y2 receptors in the hypothalamus and medulla of chronic high-fat diet-induced obese (DIO), obese-resistant, and low-fat-fed mice. Plasma PYY was also measured using RIA after 22 wk of dietary intervention. The results …
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Alterations Of Muscarinic And Gaba Receptor Binding In The Posterior Cingulate Cortex In Schizophrenia, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Stephen Kum Jew
Xu-Feng Huang
No abstract provided.