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Articles 1 - 30 of 74
Full-Text Articles in Statistical Methodology
The Myth Of Making Inferences For An Overall Treatment Efficacy With Data From Multiple Comparative Studies Via Meta-Analysis, Takahiro Hasegawa, Brian Claggett, Lu Tian, Scott D. Solomon, Marc A. Pfeffer, Lee-Jen Wei
The Myth Of Making Inferences For An Overall Treatment Efficacy With Data From Multiple Comparative Studies Via Meta-Analysis, Takahiro Hasegawa, Brian Claggett, Lu Tian, Scott D. Solomon, Marc A. Pfeffer, Lee-Jen Wei
Harvard University Biostatistics Working Paper Series
Meta analysis techniques, if applied appropriately, can provide a summary of the totality of evidence regarding an overall difference between a new treatment and a control group using data from multiple comparative clinical studies. The standard meta analysis procedures, however, may not give a meaningful between-group difference summary measure or identify a meaningful patient population of interest, especially when the fixed effect model assumption is not met. Moreover, a single between-group comparison measure without a reference value obtained from patients in the control arm would likely not be informative enough for clinical decision making. In this paper, we propose a …
Simulating Bipartite Networks To Reflect Uncertainty In Local Network Properties, Ravi Goyal, Joseph Blitzstein, Victor De Gruttola
Simulating Bipartite Networks To Reflect Uncertainty In Local Network Properties, Ravi Goyal, Joseph Blitzstein, Victor De Gruttola
Harvard University Biostatistics Working Paper Series
No abstract provided.
A Regularization Corrected Score Method For Nonlinear Regression Models With Covariate Error, David M. Zucker, Malka Gorfine, Yi Li, Donna Spiegelman
A Regularization Corrected Score Method For Nonlinear Regression Models With Covariate Error, David M. Zucker, Malka Gorfine, Yi Li, Donna Spiegelman
Harvard University Biostatistics Working Paper Series
No abstract provided.
Effectively Selecting A Target Population For A Future Comparative Study, Lihui Zhao, Lu Tian, Tianxi Cai, Brian Claggett, L. J. Wei
Effectively Selecting A Target Population For A Future Comparative Study, Lihui Zhao, Lu Tian, Tianxi Cai, Brian Claggett, L. J. Wei
Harvard University Biostatistics Working Paper Series
When comparing a new treatment with a control in a randomized clinical study, the treatment effect is generally assessed by evaluating a summary measure over a specific study population. The success of the trial heavily depends on the choice of such a population. In this paper, we show a systematic, effective way to identify a promising population, for which the new treatment is expected to have a desired benefit, using the data from a current study involving similar comparator treatments. Specifically, with the existing data we first create a parametric scoring system using multiple covariates to estimate subject-specific treatment differences. …
Multiple Testing Of Local Maxima For Detection Of Peaks In Chip-Seq Data, Armin Schwartzman, Andrew Jaffe, Yulia Gavrilov, Clifford A. Meyer
Multiple Testing Of Local Maxima For Detection Of Peaks In Chip-Seq Data, Armin Schwartzman, Andrew Jaffe, Yulia Gavrilov, Clifford A. Meyer
Harvard University Biostatistics Working Paper Series
No abstract provided.
On The Covariate-Adjusted Estimation For An Overall Treatment Difference With Data From A Randomized Comparative Clinical Trial, Lu Tian, Tianxi Cai, Lihui Zhao, L. J. Wei
On The Covariate-Adjusted Estimation For An Overall Treatment Difference With Data From A Randomized Comparative Clinical Trial, Lu Tian, Tianxi Cai, Lihui Zhao, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
Multiple Testing Of Local Maxima For Detection Of Unimodal Peaks In 1d, Armin Schwartzman, Yulia Gavrilov, Robert J. Adler
Multiple Testing Of Local Maxima For Detection Of Unimodal Peaks In 1d, Armin Schwartzman, Yulia Gavrilov, Robert J. Adler
Harvard University Biostatistics Working Paper Series
No abstract provided.
Estimating Subject-Specific Treatment Differences For Risk-Benefit Assessment With Competing Risk Event-Time Data, Brian Claggett, Lihui Zhao, Lu Tian, Davide Castagno, L. J. Wei
Estimating Subject-Specific Treatment Differences For Risk-Benefit Assessment With Competing Risk Event-Time Data, Brian Claggett, Lihui Zhao, Lu Tian, Davide Castagno, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
Improving The Power Of Chronic Disease Surveillance By Incorporating Residential History, Justin Manjourides, Marcello Pagano
Improving The Power Of Chronic Disease Surveillance By Incorporating Residential History, Justin Manjourides, Marcello Pagano
Harvard University Biostatistics Working Paper Series
No abstract provided.
Landmark Prediction Of Survival, Layla Parast, Tianxi Cai
Landmark Prediction Of Survival, Layla Parast, Tianxi Cai
Harvard University Biostatistics Working Paper Series
No abstract provided.
Stratifying Subjects For Treatment Selection With Censored Event Time Data From A Comparative Study, Lihui Zhao, Tianxi Cai, Lu Tian, Hajime Uno, Scott D. Solomon, L. J. Wei
Stratifying Subjects For Treatment Selection With Censored Event Time Data From A Comparative Study, Lihui Zhao, Tianxi Cai, Lu Tian, Hajime Uno, Scott D. Solomon, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
A Perturbation Method For Inference On Regularized Regression Estimates, Jessica Minnier, Lu Tian, Tianxi Cai
A Perturbation Method For Inference On Regularized Regression Estimates, Jessica Minnier, Lu Tian, Tianxi Cai
Harvard University Biostatistics Working Paper Series
No abstract provided.
Principled Sure Independence Screening For Cox Models With Ultra-High-Dimensional Covariates, Sihai Dave Zhao, Yi Li
Principled Sure Independence Screening For Cox Models With Ultra-High-Dimensional Covariates, Sihai Dave Zhao, Yi Li
Harvard University Biostatistics Working Paper Series
No abstract provided.
Estimating Causal Effects In Trials Involving Multi-Treatment Arms Subject To Non-Compliance: A Bayesian Frame-Work, Qi Long, Roderick J. Little, Xihong Lin
Estimating Causal Effects In Trials Involving Multi-Treatment Arms Subject To Non-Compliance: A Bayesian Frame-Work, Qi Long, Roderick J. Little, Xihong Lin
Harvard University Biostatistics Working Paper Series
No abstract provided.
Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin
Nonparametric Regression With Missing Outcomes Using Weighted Kernel Estimating Equations, Lu Wang, Andrea Rotnitzky, Xihong Lin
Harvard University Biostatistics Working Paper Series
No abstract provided.
Graphical Procedures For Evaluating Overall And Subject-Specific Incremental Values From New Predictors With Censored Event Time Data, Hajime Uno, Tianxi Cai, Lu Tian, L. J. Wei
Graphical Procedures For Evaluating Overall And Subject-Specific Incremental Values From New Predictors With Censored Event Time Data, Hajime Uno, Tianxi Cai, Lu Tian, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
A New Class Of Dantzig Selectors For Censored Linear Regression Models, Yi Li, Lee Dicker, Sihai Dave Zhao
A New Class Of Dantzig Selectors For Censored Linear Regression Models, Yi Li, Lee Dicker, Sihai Dave Zhao
Harvard University Biostatistics Working Paper Series
No abstract provided.
Survival Analysis With Error-Prone Time-Varying Covariates: A Risk Set Calibration Approach, Xiaomei Liao, David M. Zucker, Yi Li, Donna Spiegelman
Survival Analysis With Error-Prone Time-Varying Covariates: A Risk Set Calibration Approach, Xiaomei Liao, David M. Zucker, Yi Li, Donna Spiegelman
Harvard University Biostatistics Working Paper Series
No abstract provided.
A New Class Of Minimum Power Divergence Estimators With Applications To Cancer Surveillance, Nirian Martin, Yi Li
A New Class Of Minimum Power Divergence Estimators With Applications To Cancer Surveillance, Nirian Martin, Yi Li
Harvard University Biostatistics Working Paper Series
No abstract provided.
Comparing Risk Scoring Systems Beyond The Roc Paradigm In Survival Analysis, Hajime Uno, Lu Tian, Tianxi Cai, Isaac S. Kohane, L. J. Wei
Comparing Risk Scoring Systems Beyond The Roc Paradigm In Survival Analysis, Hajime Uno, Lu Tian, Tianxi Cai, Isaac S. Kohane, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
The Effect Of Correlation In False Discovery Rate Estimation, Armin Schwartzman, Xihong Lin
The Effect Of Correlation In False Discovery Rate Estimation, Armin Schwartzman, Xihong Lin
Harvard University Biostatistics Working Paper Series
No abstract provided.
Spatial Cluster Detection For Repeatedly Measured Outcomes While Accounting For Residential History, Andrea J. Cook, Diane Gold, Yi Li
Spatial Cluster Detection For Repeatedly Measured Outcomes While Accounting For Residential History, Andrea J. Cook, Diane Gold, Yi Li
Harvard University Biostatistics Working Paper Series
No abstract provided.
Marginalized Frailty Models For Multivariate Survival Data, Megan Othus, Yi Li
Marginalized Frailty Models For Multivariate Survival Data, Megan Othus, Yi Li
Harvard University Biostatistics Working Paper Series
No abstract provided.
Spatial Cluster Detection For Weighted Outcomes Using Cumulative Geographic Residuals, Andrea J. Cook, Yi Li, David Arterburn, Ram C. Tiwari
Spatial Cluster Detection For Weighted Outcomes Using Cumulative Geographic Residuals, Andrea J. Cook, Yi Li, David Arterburn, Ram C. Tiwari
Harvard University Biostatistics Working Paper Series
No abstract provided.
On The C-Statistics For Evaluating Overall Adequacy Of Risk Prediction Procedures With Censored Survival Data, Hajime Uno, Tianxi Cai, Michael J. Pencina, Ralph B. D'Agostino, L. J. Wei
On The C-Statistics For Evaluating Overall Adequacy Of Risk Prediction Procedures With Censored Survival Data, Hajime Uno, Tianxi Cai, Michael J. Pencina, Ralph B. D'Agostino, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
Estimating Subject-Specific Dependent Competing Risk Profile With Censored Event Time Observations, Yi Li, Lu Tian, L. J. Wei
Estimating Subject-Specific Dependent Competing Risk Profile With Censored Event Time Observations, Yi Li, Lu Tian, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
A Class Of Semiparametric Mixture Cure Survival Models With Dependent Censoring, Megan Othus, Yi Li, Ram C. Tiwari
A Class Of Semiparametric Mixture Cure Survival Models With Dependent Censoring, Megan Othus, Yi Li, Ram C. Tiwari
Harvard University Biostatistics Working Paper Series
No abstract provided.
The Importance Of Scale For Spatial-Confounding Bias And Precision Of Spatial Regression Estimators, Christopher J. Paciorek
The Importance Of Scale For Spatial-Confounding Bias And Precision Of Spatial Regression Estimators, Christopher J. Paciorek
Harvard University Biostatistics Working Paper Series
Increasingly, regression models are used when residuals are spatially correlated. Prominent examples include studies in environmental epidemiology to understand the chronic health effects of pollutants. I consider the effects of residual spatial structure on the bias and precision of regression coefficients, developing a simple framework in which to understand the key issues and derive informative analytic results. When the spatial residual is induced by an unmeasured confounder, regression models with spatial random effects and closely-related models such as kriging and penalized splines are biased, even when the residual variance components are known. Analytic and simulation results show how the bias …
Analysis Of Randomized Comparative Clinical Trial Data For Personalized Treatment Selections, Tianxi Cai, Lu Tian, Peggy H. Wong, L. J. Wei
Analysis Of Randomized Comparative Clinical Trial Data For Personalized Treatment Selections, Tianxi Cai, Lu Tian, Peggy H. Wong, L. J. Wei
Harvard University Biostatistics Working Paper Series
No abstract provided.
Group Comparison Of Eigenvalues And Eigenvectors Of Diffusion Tensors, Armin Schwartzman, Robert F. Dougherty, Jonathan E. Taylor
Group Comparison Of Eigenvalues And Eigenvectors Of Diffusion Tensors, Armin Schwartzman, Robert F. Dougherty, Jonathan E. Taylor
Harvard University Biostatistics Working Paper Series
No abstract provided.