Other Statistics and Probability Commons^™

Conjugated Linoleic Acid Does Not Improve Insulin Tolerance In Mice, Kimberly M Hargrave, Michael J. Azain, Stephen D. Kachman, Jess Miner

Department of Statistics: Faculty Publications

Objective: To determine if the addition or removal of dietary conjugated linoleic acid (CLA) would alter insulin tolerances in mice from two genetic lines.

Research Methods and Procedures: High metabolic rate (MH) and low metabolic rate (ML) mice were assigned to consume 1) a control diet ad libitum, 2) a control diet at a restricted intake, or 3) a diet containing 1% CLA ad libitum. After 9 weeks, an insulin tolerance test was conducted, and a portion of the mice were killed. All remaining mice consumed the control diet ad libitum. Insulin tolerance tests were conducted 11 and 32 days …

Adipose Depletion And Apoptosis Induced By Trans-10, Cis-12 Conjugated Linoleic Acid In Mice, Kimberly M. Hargrave, Changlong Li, Brett J. Meyer, Stephen D. Kachman, Diane L. Hartzell, Mary Anne Della-Fera, Jess Miner, Clifton A. Baile

Department of Statistics: Faculty Publications

Objective: To compare the effectiveness of a conjugated linoleic acid (CLA) isomer mixture (mCLA) with each main isomer [trans-10,cis-12 CLA (CLA10,12) and cis-9,trans-11 CLA (CLA9,11)] in causing body lipid loss and adipose tissue apoptosis.

Research Methods and Procedures: Mice selected over 16 generations for high (MH) or low (ML) energy expenditure and a control group (MC) were fed diets containing either soy oil or soy oil plus mCLA, CLA10,12, or CLA9,11 for 5 days in one study and 14 days in a second study.

Results: Mice fed mCLA or CLA10,12 had less body lipid (p _ 0.05), smaller retroperitoneal …