Multivariate Analysis Commons^™

Toxicity Profiling Of Engineered Nanomaterials Via Multivariate Dose Response Surface Modeling, Trina Patel, Donatello Telesca, Saji George, Andre Nel

COBRA Preprint Series

New generation in-vitro high throughput screening (HTS) assays for the assessment of engineered nanomaterials provide an opportunity to learn how these particles interact at the cellular level, particularly in relation to injury pathways. These types of assays are often characterized by small sample sizes, high measurement error and high dimensionality as multiple cytotoxicity outcomes are measured across an array of doses and durations of exposure. In this article we propose a probability model for toxicity profiling of engineered nanomaterials. A hierarchical framework is used to account for the multivariate nature of the data by modeling dependence between outcomes and thereby …

Geographic Disparities Associated With Stroke And Myocardial Infarction In East Tennessee, Ashley Pedigo Golden

Doctoral Dissertations

Stroke and myocardial infarction (MI) are serious conditions whose burdens vary by socio-demographic and geographic factors. Although several studies have investigated and identified disparities in burdens of these conditions at the county and state levels, little is known regarding their geographic epidemiology at the neighborhood level. Both conditions require emergency treatments and therefore timely geographic accessibility to appropriate care is critical. Investigation of disparities in geographic accessibility to stroke and MI care and the role of Emergency Medical Services (EMS) in reducing treatment delays are vital in improving health outcomes. Therefore, the objectives of this work were to: (i) classify …

Energy Functional For Nuclear Masses, Michael Giovanni Bertolli

Doctoral Dissertations

An energy functional is formulated for mass calculations of nuclei across the nuclear chart with major-shell occupations as the relevant degrees of freedom. The functional is based on Hohenberg-Kohn theory. Motivation for its form comes from both phenomenology and relevant microscopic systems, such as the three-level Lipkin Model. A global fit of the 17-parameter functional to nuclear masses yields a root- mean-square deviation of χ[chi] = 1.31 MeV, on the order of other mass models. The construction of the energy functional includes the development of a systematic method for selecting and testing possible functional terms. Nuclear radii are computed within …

Water Quality Models For Stormwater Runoff In Two Lincoln, Nebraska Urban Watersheds, Jake Fisher

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Water quality monitoring was conducted in two urban watersheds (Colonial Hills and Taylor Park) located in southeast Lincoln, NE over a three year period spanning from October 2008 through September 2011. In-line probes continuously measured for turbidity, conductivity, dissolved oxygen, and water temperature while other water quality constituents were analyzed for discrete water samples collected using grab and automatic sampling techniques. The water quality data was used to calculate event mean concentrations (EMCs) for sixteen storm events sampled over the duration of the project period. Three types of stormwater quality multiple linear regression models were developed for the estimation of …

Likelihood Based Population Independent Component Analysis, Ani Eloyan, Ciprian M. Crainiceanu, Brian S. Caffo

Johns Hopkins University, Dept. of Biostatistics Working Papers

Independent component analysis (ICA) is a widely used technique for blind source separation, used heavily in several scientific research areas including acoustics, electrophysiology and functional neuroimaging. We propose a scalable two-stage iterative true group ICA methodology for analyzing population level fMRI data where the number of subjects is very large. The method is based on likelihood estimators of the underlying source densities and the mixing matrix. As opposed to many commonly used group ICA algorithms the proposed method does not require significant data reduction by a twofold singular value decomposition. In addition, the method can be applied to a large …

Depicting Estimates Using The Intercept In Meta-Regression Models: The Moving Constant Technique, Blair T. Johnson Dr., Tania B. Huedo-Medina Dr.

CHIP Documents

In any scientific discipline, the ability to portray research patterns graphically often aids greatly in interpreting a phenomenon. In part to depict phenomena, the statistics and capabilities of meta-analytic models have grown increasingly sophisticated. Accordingly, this article details how to move the constant in weighted meta-analysis regression models (viz. “meta-regression”) to illuminate the patterns in such models across a range of complexities. Although it is commonly ignored in practice, the constant (or intercept) in such models can be indispensible when it is not relegated to its usual static role. The moving constant technique makes possible estimates and confidence intervals at …

An Occupational-Based Experimental Study Of Collective Vs. Personal Efficacy To Encourage Sun Protective Behaviors In Head Start Preschool Teachers, Elizabeth A. Holzhauser

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Skin cancer is one of the most common types of cancers in the United States. An analysis of literature shows that skin cancer can be partially mitigated through personal behavior changes (Glanz, Buller, & Saraiya; 2007, Canadian Centre of Occupational Health and Safety [CCOHS], 2010). Currently national sun-safety educational campaigns promote sun-protective behaviors to individuals who receive exposure due to their work environment (Task Force on Community Preventive Services, 2004). Preschool teachers employed with San Bernardino County Head Start are inadvertently exposed to sunlight during mandatory recess periods posing risks to their health.

Purpose. This study evaluated two instructional …

Multiple Testing Of Local Maxima For Detection Of Peaks In Chip-Seq Data, Armin Schwartzman, Andrew Jaffe, Yulia Gavrilov, Clifford A. Meyer

Harvard University Biostatistics Working Paper Series

No abstract provided.

Manova: Type I Error Rate Analysis, Christopher Dau Wei Ling

Statistics

No abstract provided.

Perceived Parent-Child Relationship And High-Risk Behaviors Among Christian College Students, Karla G. Lavin Williams

Loma Linda University Electronic Theses, Dissertations & Projects

Background. Adolescents and young adults today are participating in high-risk behaviors such as dangerous sexual behaviors and drug and alcohol abuse at high rates. An increased incidence of negative effects associated with the aforementioned behaviors has led researchers to examine factors that influence and protect adolescents from certain devastating effects (Davis, Hendershot, George, Norris, & Heiman, 2007; Goldstein, Bamett, Pedlow, & Murphy, 2007; Hamilton, et al., 2007; Hingson, Heeren, & Winter, 2006; Hingson, Heeren, Winter, & Wechsler, 2003; Hingson, Heeren, Zakocs, Winter, & Wechsler, 2003; McCarty, et al., 2004; Mokdad, Marks, Stroup, & Gerberding, 2004; Mosher, Chandra, & Jones, 2005; …

Statistical Analysis Of Fatalities Due To Vehicle Accidents In Las Vegas, Nv, Annabelle Marie Mathis

UNLV Theses, Dissertations, Professional Papers, and Capstones

The goal of this thesis is to investigate factors that affect the odds of having a fatality in a vehicle collision. We will be looking at characteristics of the driver that caused the accident (age, gender, behavior, actions, influences, and seat belt worn), the characteristics of the vehicle the driver drove (type of vehicle, and air bag deployment), the characteristics of the environment in which the accident occurred (weather, road condition, lighting, time of day, the day of the week, and month of the year), the characteristics of the crash (direction of accident and how many vehicles were involved), and …

Impact Of An Online Support System On Health Related Quality Of Life Among Men Diagnosed With Prostate Cancer, Daniel K. Osei

Loma Linda University Electronic Theses, Dissertations & Projects

Prostate cancer is a major public health issue worldwide and a significant cause of male cancer death in the USA. Though early screening and treatment has greatly enhanced the outcome, men diagnosed with prostate cancer face problems that compromise quality of life after treatment. Online support for prostate cancer clients is a convenient way to help because it is anonymous, inexpensive, and can be used at clients’ convenience. Yet few studies have explored how these supports impact these clients. This study used a longitudinal randomized experimental design to examine the impact of online services on quality of life of prostate …

Mixture Model Cluster Analysis Under Different Covariance Structures Using Information Complexity, Bahar Erar

Masters Theses

In this thesis, a mixture-model cluster analysis technique under different covariance structures of the component densities is developed and presented, to capture the compactness, orientation, shape, and the volume of component clusters in one expert system to handle Gaussian high dimensional heterogeneous data sets to achieve flexibility in currently practiced cluster analysis techniques. Two approaches to parameter estimation are considered and compared; one using the Expectation-Maximization (EM) algorithm and another following a Bayesian framework using the Gibbs sampler. We develop and score several forms of the ICOMP criterion of Bozdogan (1994, 2004) as our fitness function; to choose the number …

Identifying Unique Neighborhood Characteristics To Guide Health Planning For Stroke And Heart Attack: Fuzzy Cluster And Discriminant Analyses Approaches, Ashley Pedigo, William Seaver, Agricola Odoi

Agricola Odoi

Background: Socioeconomic, demographic, and geographic factors are known determinants of stroke and myocardial infarction (MI) risk. Clustering of these factors in neighborhoods needs to be taken into consideration during planning, prioritization and implementation of health programs intended to reduce disparities. Given the complex and multidimensional nature of these factors, multivariate methods are needed to identify neighborhood clusters of these determinants so as to better understand the unique neighborhood profiles. This information is critical for evidence-based health planning and service provision. Therefore, this study used a robust multivariate approach to classify neighborhoods and identify their socio-demographic characteristics so as to provide …

Diagnostic Checking, Time Series And Regression, Esam Mahdi

Electronic Thesis and Dissertation Repository

In this thesis, a new univariate-multivariate portmanteau test is derived. The proposed test statistic can be used for diagnostic checking ARMA, VAR, FGN, GARCH, and TAR time series models as well as for checking randomness of series and goodness-of- fit VAR models with stable Paretian errors. The asymptotic distribution of the test statistic is derived as well as a chi-square approximation. However, the Monte-Carlo test is recommended unless the series is very long. Extensive simulation experiments demonstrate the usefulness of this test and its improved power performance compared to widely used previous multivariate portmanteau diagnostic check. The contributed R package …

On The Covariate-Adjusted Estimation For An Overall Treatment Difference With Data From A Randomized Comparative Clinical Trial, Lu Tian, Tianxi Cai, Lihui Zhao, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.

A Unified Approach To Non-Negative Matrix Factorization And Probabilistic Latent Semantic Indexing, Karthik Devarajan, Guoli Wang, Nader Ebrahimi

COBRA Preprint Series

Non-negative matrix factorization (NMF) by the multiplicative updates algorithm is a powerful machine learning method for decomposing a high-dimensional nonnegative matrix V into two matrices, W and H, each with nonnegative entries, V ~ WH. NMF has been shown to have a unique parts-based, sparse representation of the data. The nonnegativity constraints in NMF allow only additive combinations of the data which enables it to learn parts that have distinct physical representations in reality. In the last few years, NMF has been successfully applied in a variety of areas such as natural language processing, information retrieval, image processing, speech recognition …

Multiple Testing Of Local Maxima For Detection Of Unimodal Peaks In 1d, Armin Schwartzman, Yulia Gavrilov, Robert J. Adler

Harvard University Biostatistics Working Paper Series

No abstract provided.

Component Extraction Of Complex Biomedical Signal And Performance Analysis Based On Different Algorithm, Hemant Pasusangai Kasturiwale

Johns Hopkins University, Dept. of Biostatistics Working Papers

Biomedical signals can arise from one or many sources including heart ,brains and endocrine systems. Multiple sources poses challenge to researchers which may have contaminated with artifacts and noise. The Biomedical time series signal are like electroencephalogram(EEG),electrocardiogram(ECG),etc The morphology of the cardiac signal is very important in most of diagnostics based on the ECG. The diagnosis of patient is based on visual observation of recorded ECG,EEG,etc, may not be accurate. To achieve better understanding , PCA (Principal Component Analysis) and ICA algorithms helps in analyzing ECG signals . The immense scope in the field of biomedical-signal processing Independent Component Analysis( …

Relationship Of Vitamin D Levels To Blood Pressure In A Biethnic Cohort, Rosario O. Sakamoto

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Serum hydroxyvitamin D [25(OH)D] has been well-accepted as not an ordinary vitamin but a pro-hormone that has many benefits beyond its well-known effects on bone. Cardiovascular risk factors such as hypertension remain a huge health burden and Blacks have been recognized to have higher prevalence of hypertension compared to non-Hispanic Whites. Despite increasing evidence of the benefits of vitamin D on blood pressure control, there is much more to be learned about the relationship of serum 25(OH)D to blood pressure among different ethnicities.

Purpose: The goal of this study was to determine whether vitamin D serum 25(OH)D levels were …

Use Of Remote Sensing, Hydrologic Tree-Ring Reconstructions, And Forecasting For Improved Water Resources Planning And Management, Cody Lee Moser

Doctoral Dissertations

Uncertainties were analyzed in three areas (remote sensing, dendroclimatology, and climate modeling) relevant to current water resources management. First, the research investigated the relationships between remotely sensed and in situ Snow Water Equivalent (SWE) datasets in three western U.S. basins. Agreement between SWE products was found to increase in lower elevation areas and later in the snowpack season. Principal Components Analysis (PCA) revealed two distinct snow regions among the datasets and Singular Value Decomposition (SVD) was used to link both data products with regional streamflow. Remotely sensed SWE was found to be sufficient to use in statistically based forecast models …

Statistical Inference Of A Measure For Two Binomial Variates, Serena Petersen

UNLV Theses, Dissertations, Professional Papers, and Capstones

We study measures of a comparison for two independent binomial variates which frequently occur in real situations. An estimator for measure of reduction (MOR) is considered for two sample proportions based on a modified maximum likelihood estimation. We study the desirable properties of the estimator: the asymptotic behavior of its unbiasedness and the variance of the estimator. Since the measure ρ is approximately normally distributed when sample sizes are sufficiently large, one may establish approximate confidence intervals for the true value of the estimators. For numerical study, the Monte Carlo experiment is carried out for the various scenarios of two …

Arima Models For Bank Failures: Prediction And Comparison, Fangjin Cui

UNLV Theses, Dissertations, Professional Papers, and Capstones

The number of bank failures has increased dramatically over the last twenty-two years. A common notion in economics is that some banks can become "too big to fail." Is this still a true statement? What is the relationship, if any, between bank sizes and bank failures? In this thesis, the proposed modeling techniques are applied to real bank failure data from the FDIC. In particular, quarterly data from 1989:Q1 to 2010:Q4 are used in the data analysis, which includes three major parts: 1) pairwise bank failure rate comparisons using the conditional test (Przyborowski and Wilenski, 1940); 2) development of the …

Relationship Between Perceived And Actual Quality Of Data Checking, Hunter Speich, Sophia Karas, Dan Erosa, Kelly Grob, Kimberly A. Barchard

Festival of Communities: UG Symposium (Posters)

Data quality is critical to reaching correct research conclusions. Researchers attempt to ensure that they have accurate data by checking the data after it has been entered. Previous research has demonstrated that some methods of data checking are better than others, but not all researchers use the best methods. Perhaps researchers continue to use less optimal data checking methods because they mistakenly believe that they are highly accurate. The purpose of this study was to examine the relationship between perceived data quality and actual data quality. A total of 29 participants completed this study. Participants checked that letters and numbers …

Demonstrating Library Value: Examples And Applications For Arts Libraries, Jeanne M. Brown

Library Faculty Publications

Demonstrating library value is of critical importance to all libraries, both to protect services and to serve patrons effectively. This paper presents suggestions for art and architecture libraries as they engage in determining what patrons value and documenting that value for library and campus administrators. Methods for calculating worth and for presenting a case are provided, as are ways of using strategic thinking and the assessment process to ensure the continuance of valuable services should budget reductions be unavoidable.

Carboxymethylation Of Kappa-Carrageenan For Intestinal-Targeted Delivery Of Bioactive Macromolecules, Kok Hoong Leong

Kok Hoong Leong

The work presented herein discusses the carboxymethylation of kappa-carrageenan, a natural linear polysaccharide, to afford a pH-dependent swelling property allowing for intestinal-targeted delivery of bioactive macromolecules. The carboxymethylation conditions with respect to the volume and concentration of sodium hydroxide (VNaOH, CNaOH), weight of monochloroacetic acid (WMCA), and reaction temperature (T) were optimized using a response surface method incorporating a multivariate spline interpolation technique (RSMS). Fluorescein isothiocyanate-labeled dextran (FD-4; 4.4 kDa) was used as a hydrophilic macromolecule model. Beads made from encapsulating FD-4 in the carboxymethylated kappa-carrageenan displayed pH-dependent swelling and encapsulation efficiency of 74%. The release of FD-4 was low …

Cv, Lorán Chollete

Lorán Chollete

No abstract provided.

International Diversification: An Extreme Value Approach, Lorán Chollete, Victor De La Peña, Ching-Chih Lu

Lorán Chollete

No abstract provided.

Estimation And Forecasting Of Dynamic Conditional Covariance: A Semiparametric Multivariate Model, Xiangdong Long, Liangjun Su, Aman Ullah

Research Collection School Of Economics

We propose a semiparametric conditional covariance (SCC) estimator that combines the first-stage parametric conditional covariance (PCC) estimator with the second-stage nonparametric correction estimator in a multiplicative way. We prove the asymptotic normality of our SCC estimator, propose a nonparametric test for the correct specification of PCC models, and study its asymptotic properties. We evaluate the finite sample performance of our test and SCC estimator and compare the latter with that of PCC estimator, purely nonparametric estimator, and Hafner, Dijk, and Franses’s (2006) estimator in terms of mean squared error and Value-at-Risk losses via simulations and real data analyses.

Rejoinder: Estimation Issues For Copulas Applied To Marketing Data, Peter Danaher, Michael Smith

Michael Stanley Smith

Estimating copula models using Bayesian methods presents some subtle challenges, ranging from specification of the prior to computational tractability. There is also some debate about what is the most appropriate copula to employ from those available. We address these issues here and conclude by discussing further applications of copula models in marketing.