Open Access. Powered by Scholars. Published by Universities.®
Design of Experiments and Sample Surveys Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Keyword
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Design of Experiments and Sample Surveys
Assessing The Accuracy Of A New Diagnostic Test When A Gold Standard Does Not Exist, Todd A. Alonzo, Margaret S. Pepe
Assessing The Accuracy Of A New Diagnostic Test When A Gold Standard Does Not Exist, Todd A. Alonzo, Margaret S. Pepe
UW Biostatistics Working Paper Series
Often the accuracy of a new diagnostic test must be assessed when a perfect gold standard does not exist. Use of an imperfect test biases the accuracy estimates of the new test. This paper reviews existing approaches to this problem including discrepant resolution and latent class analysis. Deficiencies with these approaches are identified. A new approach is proposed that combines the results of several imperfect reference tests to define a better reference standard. We call this the composite reference standard (CRS). Using the CRS, accuracy can be assessed using multistage sampling designs. Maximum likelihood estimates of accuracy and expressions for …
A Messy, But Instructive, Case Study In Design Of Experiments, Leroy A. Franklin, Belva J. Cooley, Gary Elrod
A Messy, But Instructive, Case Study In Design Of Experiments, Leroy A. Franklin, Belva J. Cooley, Gary Elrod
Mathematical Sciences Technical Reports (MSTR)
A company manufacturing fans wished to conduct an experimental design to determine the best combination of three factors affecting the breaking torque of the fans. Analysis of the data ceased to be straightforward when the authors found that the data failed the test for homogeneity of variances. After unsuccessfully attempting to transform the data and thereby meet the assumptions necessary to carry on the analysis, the authors relied upon a graphical analysis and a careful study of the means for each design point. This paper describes a statistically sound but novel strategy used to complete the analysis.
Risk Regulation And The Faces Of Uncertainty, Vern R. Walker
Risk Regulation And The Faces Of Uncertainty, Vern R. Walker
RISK: Health, Safety & Environment (1990-2002)
Dr. Walker addresses the difficulty of regulators' working with potentially inaccurate information and clarifies related aspects of decision making by presenting a taxonomy for the kinds of uncertainty inherent in necessarily incomplete data.
Unrelieved Pain And Distress In Animals: An Analysis Of Usda Data On Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, Tamara Hamilton
Unrelieved Pain And Distress In Animals: An Analysis Of Usda Data On Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, Tamara Hamilton
Experimentation Collection
Pain and distress are core issues in the field of animal experimentation and in the controversy that surrounds it. We sought to add to the empirical base of the literature on pain and distress by examining government data on experimental procedures that caused unrelieved pain and distress (UPAD) in animals. Of the species regulated by the U.S. Department of Agriculture (USDA), most of the approximately 100,000 animals subjected to UP AD during the year analyzed (1992) were guinea pigs and hamsters. Most of these animals were used in industry laboratories for various testing procedures, primarily vaccine potency testing. We discuss …