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Full-Text Articles in Statistics and Probability
Development Of A Metapgs For Accurate Prediction Of Osteoporotic Fracture, Xiangxue Xiao
Development Of A Metapgs For Accurate Prediction Of Osteoporotic Fracture, Xiangxue Xiao
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction: Early identification of individuals at high-risk for osteoporotic fractures who may benefit from preventive intervention is essential. However, the predictive accuracy of the currently used fracture risk assessment tool remains suboptimal. The first aim of this research is to construct genome-wide polygenic scores for the femoral neck (PGS_FNBMDidpred) and total body BMD (PGS_TBBMDidpred) and to estimate their potential in identifying individuals with a high risk of osteoporotic fractures. The second aim is to validate the predictive performance of two previously established PGSs (PGS_FNBMDidpred and PGS_TBBMDidpred) in an external cohort …