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All HMC Faculty Publications and Research

Optics

Optical coherence tomography

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Full-Text Articles in Physics

Role Of Beat Noise In Limiting The Sensitivity Of Optical Coherence Tomography, Richard C. Haskell, David Liao, Adam E. Pivonka, Tera L. Bell, Brendan R. Haberle, Barbara M. Hoeling, Daniel C. Petersen Jun 2006

Role Of Beat Noise In Limiting The Sensitivity Of Optical Coherence Tomography, Richard C. Haskell, David Liao, Adam E. Pivonka, Tera L. Bell, Brendan R. Haberle, Barbara M. Hoeling, Daniel C. Petersen

All HMC Faculty Publications and Research

The sensitivity and dynamic range of optical coherence tomography (OCT) are calculated for instruments utilizing two common interferometer configurations and detection schemes. Previous researchers recognized that the performance of dual-balanced OCT instruments is severely limited by beat noise, which is generated by incoherent light backscattered from the sample. However, beat noise has been ignored in previous calculations of Michelson OCT performance. Our measurements of instrument noise confirm the presence of beat noise even in a simple Michelson interferometer configuration with a single photodetector. Including this noise, we calculate the dynamic range as a function of OCT light source power, and ...


An Optical Coherence Microscope For 3-Dimensional Imaging In Developmental Biology, Barbara M. Hoeling, Andrew D. Fernandez, Richard C. Haskell, Eric Huang, Whittier R. Myers, Daniel C. Petersen, Sharon E. Ungersma, Ruye Wang, Mary E. Williams, Scott E. Fraser Mar 2000

An Optical Coherence Microscope For 3-Dimensional Imaging In Developmental Biology, Barbara M. Hoeling, Andrew D. Fernandez, Richard C. Haskell, Eric Huang, Whittier R. Myers, Daniel C. Petersen, Sharon E. Ungersma, Ruye Wang, Mary E. Williams, Scott E. Fraser

All HMC Faculty Publications and Research

An optical coherence microscope (OCM) has been designed and constructed to acquire 3-dimensional images of highly scattering biological tissue. Volume-rendering software is used to enhance 3-D visualization of the data sets. Lateral resolution of the OCM is 5 mm (FWHM), and the depth resolution is 10 mm (FWHM) in tissue. The design trade-offs for a 3-D OCM are discussed, and the fundamental photon noise limitation is measured and compared with theory. A rotating 3-D image of a frog embryo is presented to illustrate the capabilities of the instrument.