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Kent State University

Biochemistry, Biophysics, and Structural Biology

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Full-Text Articles in Physics

The Intermediate Filament Protein, Synemin, Is An Akap In The Heart, Mary Russell, Linda M. Lund, Roy Haber, Kathleen Mckeegan, Nicholas Cianciola, Meredith Bond Dec 2006

The Intermediate Filament Protein, Synemin, Is An Akap In The Heart, Mary Russell, Linda M. Lund, Roy Haber, Kathleen Mckeegan, Nicholas Cianciola, Meredith Bond

Biological Sciences Publications

Targeting of protein kinase A (PKA) by A-kinase anchoring proteins (AKAPs) contributes to high specificity of PKA signaling pathways. PKA phosphorylation of myofilament and cytoskeletal proteins may regulate myofibrillogenesis and myocyte remodeling during heart disease; however, known cardiac AKAPs do not localize to these regions. To identify novel AKAPs which target PKA to the cytoskeleton or myofilaments, a human heart cDNA library was screened and the intermediate filament (IF) protein, synemin, was identified as a putative RII (PKA regulatory subunit type II) binding protein. A predicted RII binding region was mutated and resulted in loss of RII binding. Furthermore, synemin ...