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Correlated Alternative Side Chain Conformations In The Rna-Recognition Motif Of Heterogeneous Nuclear Ribonucleoprotein A1, Jacqueline Vitali, Jianzhong Ding, Jianzhong Jiang, Ying Zhang, Adrian R. Krainer, Rui-Ming Xu

Physics Faculty Publications

The RNA-recognition motif (RRM) is a common and evolutionarily conserved RNA-binding module. Crystallographic and solution structural studies have shown that RRMs adopt a compact α/β structure, in which four antiparallel β-strands form the major RNA—binding surface. Conserved aromatic residues in the RRM are located on the surface of the β-sheet and are important for RNA binding. To further our understanding of the structural basis of RRM—nucleic acid interaction, we carried out a high resolution analysis of UP1, the N-terminal, two-RRM domain of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), whose structure was previously solved at 1.75–1.9 Å …