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Open Access Theses & Dissertations

Neurotransmitters

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Comparative Experimental And Theoretical Study Of Dopamine And Serotonin Interaction, Jose A. Guerrero Jan 2020

Comparative Experimental And Theoretical Study Of Dopamine And Serotonin Interaction, Jose A. Guerrero

Open Access Theses & Dissertations

To accurately identify and measure the concentrations of dopamine (DA) and serotonin (5-HT) in mixtures of these neurotransmitters without labeling, a comprehensive, comparative computational and Raman experimental analysis is provided. While the distinction between these two analytes may be accomplished for concentrations in the millimolar range of these mixtures, their accurate quantification remains unattainable. As shown for the first time in this study, potential creation of a new composite resulting from their interactions with each other could be a reason for this lack of quantification.

Although this new hydrogen-bonded complex greatly complicates future analyte differentiation and quantification at concentrations typical ...


Spectroscopic Analysis Of Neurotransmitters: A Theoretical And Experimental Raman Study, Matthew Alonzo Jan 2017

Spectroscopic Analysis Of Neurotransmitters: A Theoretical And Experimental Raman Study, Matthew Alonzo

Open Access Theses & Dissertations

Surface-enhanced Raman spectroscopy (SERS) was applied to investigate the feasibility in the detection and monitoring of the dopamine (DA) neurotransmitter adsorbed onto silver nanoparticles (Ag NPs) at 10-11 molar, a concentration far below physiological levels. In addition, density functional theory (DFT) calculations were obtained with the Gaussian-09 analytical suite software to generate the theoretical molecular configuration of DA in its neutral, cationic, anionic, and dopaminequinone states for the conversion of computer-simulated Raman spectra. Comparison of theoretical and experimental results show good agreement and imply the presence of dopamine in all of its molecular forms in the experimental setting. The dominant ...