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Open Access Theses & Dissertations

Dopamine

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Comparative Experimental And Theoretical Study Of Dopamine And Serotonin Interaction, Jose A. Guerrero Jan 2020

Comparative Experimental And Theoretical Study Of Dopamine And Serotonin Interaction, Jose A. Guerrero

Open Access Theses & Dissertations

To accurately identify and measure the concentrations of dopamine (DA) and serotonin (5-HT) in mixtures of these neurotransmitters without labeling, a comprehensive, comparative computational and Raman experimental analysis is provided. While the distinction between these two analytes may be accomplished for concentrations in the millimolar range of these mixtures, their accurate quantification remains unattainable. As shown for the first time in this study, potential creation of a new composite resulting from their interactions with each other could be a reason for this lack of quantification.

Although this new hydrogen-bonded complex greatly complicates future analyte differentiation and quantification at concentrations typical ...


Imaging Live Drosophila Brain With Two-Photon Fluorescence Microscopy, Syeed Ehsan Ahmed Jan 2017

Imaging Live Drosophila Brain With Two-Photon Fluorescence Microscopy, Syeed Ehsan Ahmed

Open Access Theses & Dissertations

Two-photon fluorescence microscopy is an imaging technique which delivers distinct benefits for in vivo cellular and molecular imaging. Cyclic adenosine monophosphate (cAMP), a second messenger molecule, is responsible for triggering many physiological changes in neural system. However, the mechanism by which this molecule regulates responses in neuron cells is not yet clearly understood. When cAMP binds to a target protein, it changes the structure of that protein. Therefore, studying this molecular structure change with fluorescence resonance energy transfer (FRET) imaging can shed light on the cAMP functioning mechanism. FRET is a non-radiative dipole-dipole coupling which is sensitive to small distance ...


Spectroscopic Analysis Of Neurotransmitters: A Theoretical And Experimental Raman Study, Matthew Alonzo Jan 2017

Spectroscopic Analysis Of Neurotransmitters: A Theoretical And Experimental Raman Study, Matthew Alonzo

Open Access Theses & Dissertations

Surface-enhanced Raman spectroscopy (SERS) was applied to investigate the feasibility in the detection and monitoring of the dopamine (DA) neurotransmitter adsorbed onto silver nanoparticles (Ag NPs) at 10-11 molar, a concentration far below physiological levels. In addition, density functional theory (DFT) calculations were obtained with the Gaussian-09 analytical suite software to generate the theoretical molecular configuration of DA in its neutral, cationic, anionic, and dopaminequinone states for the conversion of computer-simulated Raman spectra. Comparison of theoretical and experimental results show good agreement and imply the presence of dopamine in all of its molecular forms in the experimental setting. The dominant ...