Physics Commons^™

The Potential Of Raman Spectroscopy In The Diagnosis Of Premalignant Oral Lesions, Ola Ibrahim

Doctoral

Thesis submitted in partial fulfilment for the degree of Doctor of Philosophy (PhD) Technological University Dublin, School of Physics December 2017.

Mode-Sum Prescription For Vacuum Polarization In Black Hole Spacetimes In Even Dimensions, Peter Taylor, Cormac Doran

Articles

We present a mode-sum regularization prescription for computing the vacuum polarization of a scalar field in static spherically symmetric black hole spacetimes in even dimensions. This is the first general and systematic approach to regularized vacuum polarization in higher even dimensions, building upon a previous scheme we developed for odd dimensions. Things are more complicated here since the even-dimensional propagator possesses logarithmic singularities which must be regularized. However, in spite of this complication, the regularization parameters can be computed in closed form in arbitrary even dimensions and for arbitrary metric function f(r). As an explicit example of our method, we …

A Mathematical Analysis Of Drug Dissolution In The Usp Flow Through Apparatus, David Mcdonnell, Deirdre M. D'Arcy, Lawrence J. Crane, Brendan Redmond

Articles

This paper applies boundary layer theory to the process of drug dissolution in the USP (United States Pharmacopeia) Flow Through Apparatus. The mass transfer rate from the vertical planar surface of a compact within the device is examined. The theoretical results obtained are then compared with those of experiment. The paper also examines the effect on the dissolution process caused by the interaction between natural and forced convection within the apparatus and the introduction of additional boundaries.

The Evaluation Of The Effect Of Strain Limits On The Physical Properties Of Magnetorheological Elastomers Subjected To Uniaxial And Biaxial Cyclic Testing., Dave Gorman, Niall Murphy, Ray Ekins, Stephen Jerrams

Articles

Magnetorheological Elastomers (MREs) are “smart” materials whose physical properties are altered by the application of magnetic fields. In a previous study by the authors [1], variations in the physical properties of MREs have been evaluated when subjected to a range of magnetic field strengths for both uniaxial and biaxial cyclic tests. By applying the same magnetic field to similar samples, this paper investigates the effect of both the upper strain limit and the strain amplitude on the properties of MREs subjected to cyclic fatigue testing. As the magnetorheological (MR) effect is due to the dipole-dipole interactions of the …

Broadband Acoustic Measurement Of The Agar-Based Tissue Mimicking Material – A Longitudinal Study, Adela Rabell-Montiel, Jacinta Browne, Stephen Pye, Tom Anderson, Carmel Moran

Articles

Commercially available ultrasound quality assurance test phantoms rely upon the long-term acoustic stability of tissue-mimicking-materials (TMMs). The measurement of the acoustic properties can be technically challenging and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique is proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range of 4.5 – 50 MHz at …

Formulation, Characterisation And Stability Assessment Of A Food Derived 1 Tripeptide, Leucine-Lysine-Proline Loaded Chitosan Nanoparticles, M.K. Danish, Giuliana Vozza, Hugh Byrne, Jesus Maria Frias, Sinead Ryan

Articles

The chicken or fish derived tripeptide, Leucine-Lysine-Proline (LKP), inhibits the Angiotensin Converting Enzyme and may be used as an alternative treatment for pre-hypertension. However, it has low permeation across the small intestine. The formulation of LKP into a nanoparticle (NP) has the potential to address this issue. LKP-loaded NPs were produced using an ionotropic gelation technique, using chitosan (CL113). Following optimisation of unloaded NPs, a mixture amount design was constructed using variable concentration of CL113 and tripolyphosphate at a fixed LKP concentration. Resultant particle sizes ranged from 120-271 nm, zeta potential values from 29-37 mV and polydispersity values from 0.3-0.6. …

Ultra-Filtration Of Human Serum For Improved Quantitative Analysis Of Low Molecular Weight Biomarkers Using Atr-Ir Spectroscopy, Franck Bonnier, Luis Felipe Cs. Carvalho, Matthew J. Baker, Hugh Byrne, Igor Chourpa

Articles

Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering a molecular finger print of the sample. It is expected that its sensitivity would enable detection of small chemical variations in biological samples associated with disease. ATR-IR is particularly suitable for liquid sample analysis and, although air drying is commonly performed before data collection, just a drop of human serum is enough for screening and early diagnosis. However, the dynamic range of constituent biochemical concentrations in the serum composition remains a limiting factor to the reliability of the technique. Using glucose as a model spike in human serum, …

Extraoral Maxillofacial Prosthesis Implant Retention Systems: A Critical Review., Hugh Byrne, Marina L. Pimentel

Articles

Objectives: The purpose of this literature review is to provide information on the different available techniques for implant-supported prosthetic retention, which are bar-clip, o-ring or magnets. Through presenting the practitioner preferences reported in literature, although limited from strict comparison due to the heterogeneity of methodologies and studied individuals, this review aims to identify the choices for maxillofacial prosthesis implant retention systems, regarding patient comfort and good aesthetic outcome, as an aid to surgical and prosthetic planning for implant-supported extraoral maxillofacial prosthetics. With proper knowledge of each implant retention system, a practitioner can design a treatment plan which allows for a …

Industrial Grade 2d Molybdenum Disulphide (Mos2): An In-Vitro Exploration Of The Impact On Cellular Uptake, Cytotoxicity, And Inflammation, Caroline Moore, Hugh Byrne, Jonathan N. Coleman, Yuri Volkov, Jennifer Mcintyre

Articles

The recent surge in graphene research, since its liquid phase monolayer isolation and characterization in 2004, has led to advancements which are accelerating the exploration of alternative 2D materials such as molybdenum disulphide (MoS2), whose unique physico-chemical properties can be exploited in applications ranging from cutting edge electronic devices to nanomedicine. However, to assess any potential impact on human health and the environment, the need to understand the bio-interaction of MoS2 at a cellular and sub-cellular level is critical. Notably, it is important to assess such potential impacts of materials which are produced by large scale production techniques, rather than …

Strain-Induced Spectral Tuning Of The Whispering Gallery Modes In A Cylindrical Micro-Resonator Formed By A Polymer Optical Fiber, Vishnu Kavungal, Arun Mallik, Gerald Farrell, Qiang Wu, Yuliya Semenova

Articles

A mechanical strain assisted technique for spectral tuning of whispering gallery modes (WGM) in a cylindrical micro-resonator formed by a polymer optical fiber (POF) is investigated. WGMs in the POF based micro-cylinder are excited by evanescent light coupling using a tapered single mode silica fiber. WGMs observed in the transmission spectrum of the silica fiber taper have a high extinction ratio of up to 19 dB and a Q-factor of up to 2.64 × 10⁴. The application of tensile axial strain (μɛ) in the range from 0 to 1746 μɛ (0.17 %) to the POF micro-resonator results in …

Evaluation Of A Reel-To-Reel Atmospheric Plasma System For The Treatment Of Polymers, Kate O'Flynn, Vladimir Milosavljevic, Peter Dobbyn, Denis Dowling

Articles

Plasma treatments are widely used to enhance the surface energy of polymers prior to bonding or the application of functional coatings. This study investigates the performance of a linear atmospheric pressure plasma source for the reel-to-reel treatment of polymer webs. The continuous argon plasma treatments were carried out on 15 cm diameter polyethylene terephthalate (PET) web substrates using the linear plasma source (Plamax), operating at 13.56 MHz. The study investigated how the processing parameters influenced the effectiveness of the plasma treatment in enhancing both the polymer web's water contact angle (WCA) and surface energy (SE). Based on these measurements the …

Application Of Phase Shifting Electronic Speckle Pattern Interferometry In Studies Of Photoinduced Shrinkage Of Photopolymer Layers, Mohesh Moothanchery, Viswanath Bavigadda, Manojit Pramanik, Vincent Toal, Izabela Naydenova

Articles

Photoinduced shrinkage occurring in photopolymer layers during holographic recording was determined by Phase Shifting Electronic Speckle Pattern Interferometry. Phase maps were calculated from the changes in intensity at each pixel due to the phase differences introduced between object and reference beams. Shrinkage was then obtained from the changes in phase as recording proceeded. The technique allows for whole field measurement of the dimensional changes in photopolymers during holographic recording.

N-Isopropylacrylamide-Based Photopolymer For Holographic Recording Of Thermosensitive Transmission And Reflection Grating, Tatsiana Mikulchyk, Suzanne Martin, Izabela Naydenova

Articles

In recent years, functionalized photopolymer systems capable of holographic recording are in great demand due to their potential use in the development of holographic sensors. This work presents a newly developed Nisopropylacrylamide(NIPA)-based photopolymer for holographic recording in reflection and transmission modes. The optimized composition of the material is found to reach refractive index modulation of up to 5  10-3 and 1.6  10-3 after recording in transmission and reflection mode, respectively. In addition to fulfilling the requirements for holographic recording materials, the NIPA-based photopolymer is sensitive to temperature and has lower toxicity than acrylamide-based photopolymers. Possible application of the …

Humidity And Temperature Induced Changes In The Diffraction Efficiency And The Bragg Angle Of Slanted Photopolymer-Based Holographic Gratings, Tatsiana Mikulchyk, James Walshe, Dervil Cody, Suzanne Martin, Izabela Naydenova

Articles

This work explores the humidity and temperature response of volume phase slanted gratings recorded in photopolymers with varied chemical composition. Acrylamide and diacetone acrylamide were used as monomers and triethanolamine and N-phenylglycine were used as photoinitiators. The study demonstrates that the response of photopolymer-based holographic gratings to relative humidity (RH) and temperature (T) can be tuned by alteration of the photopolymer composition.Humidity and temperature response of the holograms has been characterized by recording Bragg selectivity curves of transmission gratings and by monitoring the position of the maximum intensity in the spectral response of reflection gratings. Investigation of the humidity response …

Monitoring Doxorubicin Cellular Uptake And Trafficking Using In Vitro Raman Microspectroscopy: Short And Long Time Exposure Effects On Lung Cancer Cell Lines, Zeineb Farhane, Franck Bonnier, Hugh Byrne

Articles

Raman microspectroscopy is a non-invasive, in vitro analytical tool which is being increasingly explored for its potential in clinical applications and monitoring the uptake, mechanism of action and cellular interaction at a molecular level of chemotherapeutic drugs, ultimately as a potential label-free preclinical screening and companion diagnostic tool. In this study, doxorubicin (DOX), a “gold standard” chemotherapeutic drug, is employed as a model in the in vitro lung cancer cell line A549 in order to demonstrate the potential of Raman microspectroscopy to screen and identify spectroscopic markers of its trafficking and mechanism of action. Confocal laser scanning microscopy (CLSM) was …

Strengthening The Development Of The Short-Rotation Plantations Bioenergy Sector: Policy Insights From Six European Countries, Carlos Parra-Lopez, Martin Holley, Kevin Lindegaard, Samir Sayadi, Gonzalo Esteban-Lopez, Victor Duran-Zuazo, Christoph Knauer, Hans-Georg Von Engelbrechten, Ralf Winterber, Annika Henriksson, Annette Lamley, Anders Nylander, Susanne Paulrud, Pauline Leonard, Patrick Daly, Lukasz Drzewaszewski, Wojciech Rzewuski

Articles

This paper, based on a participatory methodological framework involving expert stakeholders and researchers from six European countries (Germany, Ireland, Poland, Spain, Sweden and UK), analyses the priority issues for the development of short-rotation plantations (SRP), and proposes a series of policy strategies to strengthen this development. The results indicate that there is a lack of awareness of the multifaceted benefits of SRP at the level of farmers, policy makers and public authorities. More research is required to put a value on the multifunctionality of SRP and justify its public support. Small-scale projects using established technologies are also required with energy …

Compact Holographic Optical Element-Based Electronic Speckle Pattern Interferometer For Rotation And Vibration Measurements, Viswanath Bavigadda, Mohesh Moothanchery, Manojit Pramanik, Emilia Mihaylova, Vincent Toal

Conference Papers

An out-of-plane sensitive electronic speckle pattern interferometer (ESPI) using holographic optical elements (HOEs) for studying rotations and vibrations is presented. Phase stepping is implemented by modulating the wavelength of the laser diode in a path length imbalanced interferometer. The time average ESPI method is used for vibration measurements. Some factors influencing the measurements accuracy are reported. Some advantages and limitations of the system are discussed.

Retention Systems For Extraoral Maxillofacial Prosthetic Implants: A Critical Review, M.V. Cobein, N.P. Coto, O. Crivello Junior, J.B.D. Lemos, L.M. Vieira, M.L. Pimentel, Hugh Byrne, R.B. Dias

Articles

We describe the techniques available for retention of implant-supported prostheses: bar-clips, O-rings, and magnets. We present reported preferences and, although this is limited by the heterogeneity of methods used and patients studied, we hope we have identified the best retention systems for maxillofacial prosthetic implants. If practitioners know the advantages and disadvantages of each system, they can choose the most natural and comfortable prosthesis. We searched the PubMed and Scopus databases, and restricted our search to papers published 2001–13. MeSH terms used were Maxillofacial prosthesis and Craniofacial prosthesis OR Craniofacial prostheses. We found a total of 2630 papers, and after …

Study Of Phenolic Extractability In Grape Seeds By Means Of Atr-Ftir And Raman Spectroscopy, Julio Nogales-Bueno, Berta Baca-Bocanegra, Abigail Rooney, José Miguel Hernández-Hierro, Hugh Byrne, Francisco José Heredia

Articles

Near infrared hyperspectral imaging has been applied to grape seeds in order to select a representative subset of samples according to their spectral features in the 900-1700nm range. Afterwards, selected grape seeds have been classified according to their total phenol and flavanol extractabilities. In this way, samples were sorted in three different groups identified as low, medium and high extractability levels. In order to establish the chemical structures which can be responsible for the different extractabilities, vibrational spectroscopy has been applied to the non-extracted material after seed extractions. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) and Raman spectra of non-extracted …

Development And Testing Of Low Spatial Frequency Holographic Concentrator Elements For Collection Of Solar Energy, Hoda Akbari, Izabela Naydenova, Hind Ahmed, Sarah Mccormack, Suzanne Martin

Articles

The aim of this research is to use holographically recorded diffractive optical elements (DOEs) recorded in photopolymer in order to effectively collect and concentrate solar radiation. The potential for recording high diffraction efficiency DOEs with a large angular and wavelength range of operation in acrylamide based photopolymer and the optimum recording conditions have been presented in our previous work (Akbari et al., 2014b, 2014a). Theoretical modelling and experimental test are presented which demonstrate that low spatial frequency components, around 300 line pairs/mm, have an appropriate spectral bandwidth, high efficiency and very limited polarization dependence. Pairs of concentrating off-axis lenses are …

Broadband Acoustic Measurement Of The Agar-Based Tissue Mimicking Material: A Longitudinal Study, A. Rabell-Montiel, Jacinta Browne, S. D. Pye, T. A. Anderson, C. Moran

Articles

Commercially available ultrasound quality assurance test phantoms rely on the long-term acoustic stability of the tissue-mimicking-material (TMM). Measurement of the acoustic properties of the TMM can be technically challenging, and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique was proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range 4.5–50 MHz at …

Broadband Acoustic Measurement Of The Agar-Based Tissue Mimicking Material: A Longitudinal Study, A. Rabell-Montiel, Jacinta Browne, S. D. Pyke, T. A. Anderson, C. M. Moran

Articles

Commercially available ultrasound quality assurance test phantoms rely on the long-term acoustic stability of the tissue-mimicking-material (TMM). Measurement of the acoustic properties of the TMM can be technically challenging, and it is important to ensure its stability. The standard technique is to film-wrap samples of TMM and to measure the acoustic properties in a water bath. In this study, a modified technique was proposed whereby the samples of TMM are measured in a preserving fluid that is intended to maintain their characteristics. The acoustic properties were evaluated using a broadband pulse-echo substitution technique over the frequency range 4.5-50 MHz at …

The Mainstream Scientific Community Is Open To Incremental But Not Holistic Ideas, Maurice Goodman

Articles

NeuroQuantology

doi: 10.14704/nq.2017.15.2.1041

Magnetic Field Sensing Using Whispering Gallery Modes In A Cylindrical Microresonator Infilitrated With Ferronematic Liquid Crystal, Aseel Mahmood, Vishnu Kavungal, Sudad S. Ahmed, Peter Kopcansky, Vlasta Zavisova, Gerald Farrell, Yuliya Semenova

Articles

An all-fiber magnetic field sensor based on whispering-gallery modes (WGM) in a fiber micro-resonator infiltrated with ferronematic liquid crystal is proposed and experimentally demonstrated. The cylindrical microresonator is formed by a 1 cm-long section of a photonic crystal fiber infiltrated with ferronematic materials. Both ferronematics suspensions are prepared based on the nematic liquid crystal 1-(trans-4-Hexylcyclohexyl)-4-isothiocyanatobenzene (6CHBT) doped with rod-like magnetic particles in the first case and with spherical magnetic particles in the second case. WGMs are excited in the fiber microresonator by evanescent light coupling using a tapered fiber with a micron-size diameter. The Q-factor of the microresonator determined from …

Electromechanical Instability In Silicone-And Acrylate-Based Dielectric Elastomers, Liang Jiang, Yanfen Shou, Shaojuan Chen, Jianwei Ma, Tony Betts, Stephen Jerrams

Articles

Electromechanical instability (EMI) is regarded as a significant factor in preventing dielectric elastomers (DEs) fromachieving large voltage-induced deformations. In this study, the strain-stiffening effect was used to control the occurrence of EMI in DEs. The results show that the stretching ratio required to provide a feasible strain-stiffening effect in silicone rubber (SR) was smaller than that needed for a commercial DE material, VHB 4910. The experimental data were compared with currently used models for the simulation of EMI in DEs. We found that EMI could be eliminated in the deformation of these elastomers when pre-stretching was used. Through the application …

A Review Of The Recommendations Governing Quality Assurance Of Ultrasound Systems Used For Guidance In Prostate Brachytherapy, Andrea Jane Doyle, Deirdre King, Jacinta Browne

Articles

Ultrasound guided brachytherapy for the treatment of prostate cancer has become a routine treatment option, due to many benefits including patient recovery and dose localisation [1]; however it is not clear whether the standards which govern the image quality for these systems are adequate. Upon review of the recommended standards for ultrasound systems used in prostate brachytherapy procedures, the recommended tests do not appear to be specific to the clinical application of ultrasound guided prostate brachytherapy. Rather they are generic and similar to those recommended for other clinical applications such as general abdominal scanning [2]. Furthermore, there is growing evidence …

Plasmonic Luminescent Down Shifting Layers For The Enhancement Of Cdte Mini-Modules Performance, Hind Ahmed, S.J. Mccormack, John Doran

Articles

In this investigation, plasmonic coupling between luminescent species (lumogen yellow, and silver nanoparticles (Ag NPs) has been exploited to produce significant enhancement in absorption and fluorescence emission of lumogen yellow dye luminescent downshifting (LDS) layers. The optimum dye concentration in a poly(methyl,methacrylate) polymer LDS layer of ∼100μm thickness was established. Subsequently, plasmonic coupling with Ag NPs was introduced and optimum concentration has been determined for the composite plasmonic Luminescent Down-Shifting (pLDS) layers. The optimum plasmonic coupling has been observed to produce fluorescence emission enhancement of up to 81% for the dye-pLDS layers. The pLDS layers were deposited on top of …

Advancing Vibrational Spectroscopy For Cellular And Sub Cellular Analysis: Raman Spectroscopy As A Novel In Vitro Nanotoxicological Assessment Protocol, Esen Efeoglu

Doctoral

This work is designed to establish a ‘High content Nanotoxicological Screening method’ using in vitro Raman microspectroscopy. The undeniable increase of nanotechnology based products has brought challenges in terms of determining their toxicological properties. Considering the total time and cost of screening nanomaterials by conventional methods, the need for a rapid, label-free technique which will provide a wide range of information on multiple parameters is unquestionable. This study investigated the applicability of Raman microspectroscopy as a High Content Screening technique to clarify cell-nanoparticle interaction by determining the localisation of the nanoparticles and consequent effects in these localised areas in terms …

Evaluation Of The Effect Of Plasma Treatment Frequency On The Activation Of Polymer Particles, Hisham Abourayana, Vladimir Milosavljevic, Peter Dobbyn, Denis Dowling

Articles

This study investigates the influence of treatment frequency (1–150 kHz) on the atmospheric plasma activation of both silicone and polyethylene terephthalate (PET) particles. These polymer particles with diameters in the range 3–5 mm, were treated using either helium or helium/oxygen gas mixtures, in a barrel atmospheric plasma system. The level of polymer particles activation was monitored using water contact angle measurements. The effect of plasma treatment frequency on barrel heating was monitored using an infrared thermographic camera, the maximum barrel temperature after 15 min treatment was found to be 98 °C at a frequency of 130 kHz. Optical emission spectroscopy …

A Transfer Matrix Approach To Aid In The Design And Optimization Of Hybrid Advanced Passive Structures For Enhancing Photovoltaic Efficiency, James Walshe, Sarah Mccormack, Hind Ahmed, John Doran

Conference Papers

The addition of a luminescent down-shifting (LDS) layer directly onto a photovoltaic (PV) cell introduces additional loss mechanisms within the system. The combination of non-ideal photo-luminescent materials encapsulated within a limited range of viable host materials, with the increased reflection losses arising from the newly created interface represent losses which must be overcome for LDS to offer an enhancement to the underlying cells efficiency. Exploiting the interaction between the highly enhanced electric fields established close to a metal nanoparticles (MNP’s) surface is one route aimed at mitigating the poor optical properties of the luminophore-host combinations available. Alternative approaches, aimed at …