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Full-Text Articles in Physics
Loss Of Vimentin Enhances Cell Motility Through Small Confining Spaces, Alison E. Patteson, Katarzyna Pogoda, Fitzroy J. Byfield, Kalpana Mandal, Zofia Ostrowska-Podhorodecka, Elisabeth E. Charrier, Peter A. Galie, Piotr Deptuła, Robert Bucki, Christopher A. Mcculloch, Paul A. Janmey
Loss Of Vimentin Enhances Cell Motility Through Small Confining Spaces, Alison E. Patteson, Katarzyna Pogoda, Fitzroy J. Byfield, Kalpana Mandal, Zofia Ostrowska-Podhorodecka, Elisabeth E. Charrier, Peter A. Galie, Piotr Deptuła, Robert Bucki, Christopher A. Mcculloch, Paul A. Janmey
Physics - All Scholarship
The migration of cells through constricting spaces or along fibrous tracks in tissues is important for many biological processes and depends on the mechanical properties of a cytoskeleton made up of three different filaments: F-actin, microtubules, and intermediate filaments. The signaling pathways and cytoskeletal structures that control cell motility on 2D are often very different from those that control motility in 3D. Previous studies have shown that intermediate filaments can promote actin-driven protrusions at the cell edge, but have little effect on overall motility of cells on flat surfaces. They are however important for cells to maintain resistance to repeated …
Vimentin Protects Cells Against Nuclear Rupture And Dna Damage During Migration, Alison E. Patteson, Amir Vahabikashi, Katarzyna Pogoda, Stephen A. Adam, Kalpana Mandal, Mark Kittisopikul, Suganya Sivagurunathan, Anne Goldman, Robert D. Goldman, Paul A. Janmey
Vimentin Protects Cells Against Nuclear Rupture And Dna Damage During Migration, Alison E. Patteson, Amir Vahabikashi, Katarzyna Pogoda, Stephen A. Adam, Kalpana Mandal, Mark Kittisopikul, Suganya Sivagurunathan, Anne Goldman, Robert D. Goldman, Paul A. Janmey
Physics - All Scholarship
Mammalian cells frequently migrate through tight spaces during normal embryogenesis, wound healing, diapedesis, or in pathological situations such as metastasis. Nuclear size and shape are important factors in regulating the mechanical properties of cells during their migration through such tight spaces. At the onset of migratory behavior, cells often initiate the expression of vimentin, an intermediate filament protein that polymerizes into networks extending from a juxtanuclear cage to the cell periphery. However, the role of vimentin intermediate filaments (VIFs) in regulating nuclear shape and mechanics remains unknown. Here, we use wild-type and vimentin-null mouse embryonic fibroblasts to show that VIFs …
Emergence Of Tissue-Like Mechanics From Fibrous Networks Confined By Close-Packed Cells, Anne Van Oosten, Xingyu Chen, Likang Chin, Katrina Cruz, Alison E. Patteson, Katarzyna Pogoda, Vivek B. Shenoy, Paul A. Janmey
Emergence Of Tissue-Like Mechanics From Fibrous Networks Confined By Close-Packed Cells, Anne Van Oosten, Xingyu Chen, Likang Chin, Katrina Cruz, Alison E. Patteson, Katarzyna Pogoda, Vivek B. Shenoy, Paul A. Janmey
Physics - All Scholarship
The viscoelasticity of the crosslinked semiflexible polymer networks—such as the internal cytoskeleton and the extracellular matrix—that provide shape and mechanical resistance against deformation is assumed to dominate tissue mechanics. However, the mechanical responses of soft tissues and semiflexible polymer gels differ in many respects. Tissues stiffen in compression but not in extension1,2,3,4,5, whereas semiflexible polymer networks soften in compression and stiffen in extension6,7. In shear deformation, semiflexible polymer gels stiffen with increasing strain, but tissues do not1,2,3,4,5 …
Quenching Active Swarms: Effects Of Light Exposure On Collective Motility In Swarming Serratia Marcescens, Junyi Yang, Paulo E. Arratia, Alison E. Patteson, Arvind Gopinath
Quenching Active Swarms: Effects Of Light Exposure On Collective Motility In Swarming Serratia Marcescens, Junyi Yang, Paulo E. Arratia, Alison E. Patteson, Arvind Gopinath
Physics - All Scholarship
Swarming colonies of the light-responsive bacteria Serratia marcescens grown on agar exhibit robust fluctuating large-scale flows that include arrayed vortices, jets and sinuous streamers. We study the immobilization and quenching of these collective flows when the moving swarm is exposed to intense wide-spectrum light with a substantial ultraviolet component. We map the emergent response of the swarm to light in terms of two parameters-light intensity and duration of exposure-and identify the conditions under which collective motility is impacted. For small exposure times and/or low intensities, we find collective motility to be negligibly affected. Increasing exposure times and/or intensity to higher …
Memory Formation In Matter, Joseph Paulsen, Nathan C. Keim, Zorana Zeravcic, Srikanth Sastry, Sidney R. Nagel
Memory Formation In Matter, Joseph Paulsen, Nathan C. Keim, Zorana Zeravcic, Srikanth Sastry, Sidney R. Nagel
Physics - All Scholarship
Memory formation in matter is a theme of broad intellectual relevance; it sits at the interdisciplinary crossroads of physics, biology, chemistry, and computer science. Memory connotes the ability to encode, access, and erase signatures of past history in the state of a system. Once the system has completely relaxed to thermal equilibrium, it is no longer able to recall aspects of its evolution. The memory of initial conditions or previous training protocols will be lost. Thus many forms of memory are intrinsically tied to far-from-equilibrium behavior and to transient response to a perturbation. This general behavior arises in diverse contexts …