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Articles 1 - 30 of 635

Full-Text Articles in Physics

Analog Implementation Of The Hodgkin-Huxley Model Neuron, Zachary D. Mobille, George H. Rutherford, Jordan Brandt-Trainer, Rosangela Follmann, Epaminondas Rosa Oct 2019

Analog Implementation Of The Hodgkin-Huxley Model Neuron, Zachary D. Mobille, George H. Rutherford, Jordan Brandt-Trainer, Rosangela Follmann, Epaminondas Rosa

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Period Drift In A Neutrally Stable Stochastic Oscillator, Kevin Sanft Oct 2019

Period Drift In A Neutrally Stable Stochastic Oscillator, Kevin Sanft

Annual Symposium on Biomathematics and Ecology: Education and Research

No abstract provided.


Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel Sep 2019

Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel

Todd N. Rosenstiel

Although the dynamics of methane (CH4) emission from croplands and wetlands have been fairly well investigated, the contribution of trees to global CH4 emission and the mechanisms of tree transport are relatively unknown. CH4 emissions from the common wetland tree species Populus trichocarpa (black cottonwood) native to the Pacific Northwest were measured under hydroponic conditions in order to separate plant transport mechanisms from the influence of soil processes. Roots were exposed to CH4 enriched water and canopy emissions of CH4 were measured. The average flux for 34 trials (at temperatures ranging from 17 to 25 °C) was 2.8 ± 2 ...


Table Of Contents Aug 2019

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Impact Of Excitation-Inhibition Balance/Imbalance On Dynamics Of Cortical Neural Networks, Vidit Agrawal Aug 2019

Impact Of Excitation-Inhibition Balance/Imbalance On Dynamics Of Cortical Neural Networks, Vidit Agrawal

Theses and Dissertations

The purpose of this research is to study the implications of Excitation/Inhibition balance and imbalance on the dynamics of ongoing (spontaneous) neural activity in the cerebral cortex region of the brain.

The first research work addresses the question that why among the continuum of Excitation-Inhibition balance configurations, particular configuration should be favored? We calculate the entropy of neural network dynamics by studying an analytically tractable network of binary neurons. Our main result from this work is that the entropy maximizes at regime which is neither excitation-dominant nor inhibition-dominant but at the boundary of both. Along this boundary we see ...


Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel Jul 2019

Mechanisms Of Methane Transport Through Populus Trichocarpa, Ellynne Marie Kutschera, M. A. K. Khalil, Andrew Rice, Todd Rosenstiel

M.A.K. Khalil

Although the dynamics of methane (CH4) emission from croplands and wetlands have been fairly well investigated, the contribution of trees to global CH4 emission and the mechanisms of tree transport are relatively unknown. CH4 emissions from the common wetland tree species Populus trichocarpa (black cottonwood) native to the Pacific Northwest were measured under hydroponic conditions in order to separate plant transport mechanisms from the influence of soil processes. Roots were exposed to CH4 enriched water and canopy emissions of CH4 were measured. The average flux for 34 trials (at temperatures ranging from 17 to 25 °C) was 2.8 ± 2 ...


A New Approach To The Potential Energy Of Solids, Radhika Chauhan, Sanjeev K. Verma, Anushri Gupta, Anita Kumari, B. D. Indu Jul 2019

A New Approach To The Potential Energy Of Solids, Radhika Chauhan, Sanjeev K. Verma, Anushri Gupta, Anita Kumari, B. D. Indu

Karbala International Journal of Modern Science

A general theory is developed to investigate the expression for potential energy without using (i) empirical results and (ii) process of parameterizing. The simple approach of thermodynamics is adopted to obtain the expressions for the interaction energy of solids in terms of interatomic separation and crystal volume. The new findings have been applied to obtain the expressions for bulk modulus and pressure. The variation of the potential energy function, which provides a means to understand the stability of a crystal has been found in excellent agreements to the earlier results. The use of obtained harmonic and anharmonic force constants may ...


Kinetic Study For The Effect Of New Inhibitors On The Activity Of Purified Gpt From Blood Of Cardiovascular Patients, Firas Maher Jul 2019

Kinetic Study For The Effect Of New Inhibitors On The Activity Of Purified Gpt From Blood Of Cardiovascular Patients, Firas Maher

Karbala International Journal of Modern Science

In this study several biochemical parameters for cardiovascular patients have been measured CK-MB ,LDH ,GPT and GOT in addition to lipid profile , MDA ,Vitamin C and Vitamin E . New derivatives of ascorbic acid have been synthesized and tested to inhibit the purified GPT from the blood of cardiovascular patients Glutamate pyruvate transaminase (GPT) was purified from cardiovascular patients using ammonium sulphate salt for precipitation then dialysed using 0.1 M Tris-HCL buffer pH7.8 , then filtrated by gel filtration chromatography using Sephadex G-100 , followed by electrophoresis using poly acrylamide – bis acrylamide and sodium dodecyl sulphate (SDS). Derivatives of 3-(acetyl ...


Neighborhoods And Partial Sums Of A New Class Of Meromorphic Multivalent Functions Defined By Fractional Calculus, Aqeel Ketab Al-Khafaji, Waggas Galib Atshan, Salwa Salman Abed Jul 2019

Neighborhoods And Partial Sums Of A New Class Of Meromorphic Multivalent Functions Defined By Fractional Calculus, Aqeel Ketab Al-Khafaji, Waggas Galib Atshan, Salwa Salman Abed

Karbala International Journal of Modern Science

In this paper, we introduce and study a new class A^* (λ,μ,ν,η,p,ζ,τ) of meromorphic multivalent functions defined by fractional calculus operator of the punctured unit disc U^*. On this class we obtain several results like, coefficient inequality, modified Hadamard product, (N,δ)- neighborhood, partial sums, convex linear combination and integral operator.


Biomedical Applications Of Chasmanthera Dependens Stem Extract Mediated Silver Nanoparticles As Antimicrobial, Antioxidant, Anticoagulant, Thrombolytic, And Larvicidal Agents, Daniel Ayandiran Aina, Oluwafayoke Owolo, Agbaje Lateef, Folasade O. Aina, Abbas Saeed Hakeem, Morenike Adeoye-Isijola, Victor Okon, Tesleem B. Asafa, Joseph Adetunji Elegbede, Olumide D. Olukanni, Isaac Adediji Jul 2019

Biomedical Applications Of Chasmanthera Dependens Stem Extract Mediated Silver Nanoparticles As Antimicrobial, Antioxidant, Anticoagulant, Thrombolytic, And Larvicidal Agents, Daniel Ayandiran Aina, Oluwafayoke Owolo, Agbaje Lateef, Folasade O. Aina, Abbas Saeed Hakeem, Morenike Adeoye-Isijola, Victor Okon, Tesleem B. Asafa, Joseph Adetunji Elegbede, Olumide D. Olukanni, Isaac Adediji

Karbala International Journal of Modern Science

The stem extract of Chasmanthera dependens was used in the biofabrication of silver nanoparticles (AgNPs) in this study. The AgNPs was characterised using UV-visible spectroscopy, Field Emission Scanning Electron Microscope (FESEM), EDX, and the Fourier Transform Infrared Spectroscopy (FTIR). Antibacterial, antioxidant, anticoagulant, thrombolytic and larvicidal activities of the biosynthesised nanoparticles were carried out. There was a peak at 418 nm with a strong silver peak observed around 2.7KeV when the EDX analysis was carried out. The FESEM showed a large number of cubically shaped nanoparticles with sizes ranging from 24.53 to 92.38 nm. CDE-AgNPs was effective against ...


Editorial Board Jul 2019

Editorial Board

Karbala International Journal of Modern Science

No abstract provided.


Hcp: A Matlab Package To Create Beautiful Heatmaps With Richly Annotated Covariates, Manuela Salvucci, Jochen Hm Prehn Jun 2019

Hcp: A Matlab Package To Create Beautiful Heatmaps With Richly Annotated Covariates, Manuela Salvucci, Jochen Hm Prehn

Physiology and Medical Physics Articles

HCP (HeatmapCovariatePlot) provides a simple high level application programming interface (API) to design elaborated visualizations in a modular fashion. The user can select which elements to include, covariate row annotations and/or heatmaps, by invoking the AddCovariateRow or the AddHeatmap methods. Elements can be vertically stacked and also grouped in functionally related sub-blocks encapsulated by the AddSubBlock method to adjust the figure layout. The plotting options in HCP are chosen sensibly to create production-quality out-of-the-box visualizations in most use-case. HCP features several plotting options to adjust the plot aesthetics to cater for the user preferences in terms of colormaps, labelling ...


Systems Biology Identifies Preserved Integrity But Impaired Metabolism Of Mitochondria Due To A Glycolytic Defect In Alzheimer's Disease Neurons., Pierre Theurey, Niamh M. Connolly, Ilaria Fortunati, Emy Basso, Susette Lauwen, Camilla Ferrante, Catarina Moreira Pinho, Alvin Joselin, Anna Gioran, Daniele Bano, David S. Park, Maria Ankarcrona, Paola Pizzo, Jochen Hm Prehn Jun 2019

Systems Biology Identifies Preserved Integrity But Impaired Metabolism Of Mitochondria Due To A Glycolytic Defect In Alzheimer's Disease Neurons., Pierre Theurey, Niamh M. Connolly, Ilaria Fortunati, Emy Basso, Susette Lauwen, Camilla Ferrante, Catarina Moreira Pinho, Alvin Joselin, Anna Gioran, Daniele Bano, David S. Park, Maria Ankarcrona, Paola Pizzo, Jochen Hm Prehn

Physiology and Medical Physics Articles

Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational approaches to investigate mitochondrial health and bioenergetic function in neurons from a double transgenic animal model of AD (PS2APP/B6.152H). Experiments in primary cortical neurons demonstrated that AD neurons had reduced mitochondrial respiratory capacity. Interestingly, the computational model predicted that this mitochondrial bioenergetic phenotype could not be explained by any defect in the mitochondrial respiratory chain (RC), but could be closely resembled by a simulated impairment in the mitochondrial NADH flux. Further computational analysis predicted that such an impairment would ...


The Challenge For Vision Of Fluctuating Real-World Illumination, David H. Foster May 2019

The Challenge For Vision Of Fluctuating Real-World Illumination, David H. Foster

MODVIS Workshop

No abstract provided.


Experimental Evidence Supportive Of The Quantum Dna Model, F. Matthew Mihelic May 2019

Experimental Evidence Supportive Of The Quantum Dna Model, F. Matthew Mihelic

Faculty Publications

The DNA molecule can be modeled as a quantum logic processor in which electron spin qubits are held coherently in each nucleotide in a logically and thermodynamically reversible enantiomeric symmetry, and can be coherently conducted along the pi-stacking interactions of aromatic nucleotide bases, while simultaneously being spin-filtered via the helicity of the DNA molecule. Entangled electron pairs can be separated by that spin-filtering, held coherently at biological temperatures in the topologically insulated nucleotide quantum gates, and incorporated into separate DNA strands during DNA replication. Two separate DNA strands that share quantum entangled electrons can be mitotically divided into individual cells ...


Feedforward And Feedback Signals In The Olfactory System, Srimoy Chakraborty May 2019

Feedforward And Feedback Signals In The Olfactory System, Srimoy Chakraborty

Theses and Dissertations

The conglomeration of myriad activities in neural systems often results in prominent oscillations. The primary goal of the research presented in this thesis was to study effects of sensory stimulus on the olfactory system of rats, focusing on the olfactory bulb (OB) and the anterior piriform cortex (aPC). Extracellular electrophysiological measurements revealed distinct frequency bands of oscillations in OB and aPC. However, how these oscillatory fluctuations help the animal to process sensory input is not clearly understood. Here we show high frequency oscillations in olfactory bulb carry feedforward signals to anterior piriform cortex whereas feedback from the aPC is predominantly ...


Meta-Analysis Of The Molecular Associations Of Mucinous Colorectal Cancer., Ian S. Reynolds, S J Furney, Elaine W. Kay, Deborah A. Mcnamara, Jochen Hm Prehn, John P. Burke May 2019

Meta-Analysis Of The Molecular Associations Of Mucinous Colorectal Cancer., Ian S. Reynolds, S J Furney, Elaine W. Kay, Deborah A. Mcnamara, Jochen Hm Prehn, John P. Burke

Physiology and Medical Physics Articles

BACKGROUND: Mucinous differentiation occurs in 5-15 per cent of colorectal adenocarcinomas. This subtype of colorectal cancer responds poorly to chemoradiotherapy and has a worse prognosis. The genetic aetiology underpinning this cancer subtype lacks consensus. The aim of this study was to use meta-analytical techniques to clarify the molecular associations of mucinous colorectal cancer.

METHODS: This study adhered to MOOSE guidelines. Databases were searched for studies comparing KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), p53 and p27 status between patients with mucinous and non-mucinous colorectal adenocarcinoma. A random-effects model was used for analysis.

RESULTS: Data from 46 studies ...


Brain Network Structure And Interventions In A Computational Model Of Epilepsy, Joe Emerson Apr 2019

Brain Network Structure And Interventions In A Computational Model Of Epilepsy, Joe Emerson

Student Symposium

Some forms of drug-resistant epilepsy can only be treated via surgical intervention. This form of treatment requires the removal of a part of the brain identified as the seizure source. Current methods for surgical treatment are risky and many times unsuccessful. A deeper understanding of how brain connectivity facilitates seizure propagation is necessary for developing improved surgical techniques. Experimental limitations make certain clinical investigations of epilepsy difficult or impossible, but computational modeling offers a way forward when experimentation in living systems is impractical or unsafe. We used a full-hemisphere computational model for epilepsy to investigate the role of network structure ...


The Effects Of Organic And Inorganic Nanoparticles On Bacterial Deactivation, Lauren Cooper Apr 2019

The Effects Of Organic And Inorganic Nanoparticles On Bacterial Deactivation, Lauren Cooper

Honors College Capstone Experience/Thesis Projects

Antibacterial resistance is one of the greatest problems in modern medicine, as healthcare professionals are experiencing more and more difficulty in providing effective care. As such, alternative methods of treatment are needed in order to overcome this issue. One recently proposed method of alternative treatment is photodynamic therapy. Photodynamic therapy is a light-based method of treatment that utilizes (1) a photosensitizing agent, (2) light, (3) produced oxygen species. When the photosensitizing agent is injected into an infected region of interest and then irradiated with a certain wavelength of light, the agent is photoactivated and begins to produce harmful forms of ...


A Machine Learning Platform To Optimize The Translation Of Personalized Network Models To The Clinic., Manuela Salvucci, Arman Rahman, Alexa J. Resler, Girish M. Udupi, Deborah A. Mcnamara, Elaine W. Kay, Pierre Laurent-Puig, Daniel B. Longley, Patrick G. Johnston, Mark Lawler, Richard Wilson, Manuel Salto-Tellez, Sandra Van Schaeybroeck, Mairin Rafferty, William M. Gallagher, Markus Rehm, Jochen Hm Prehn Apr 2019

A Machine Learning Platform To Optimize The Translation Of Personalized Network Models To The Clinic., Manuela Salvucci, Arman Rahman, Alexa J. Resler, Girish M. Udupi, Deborah A. Mcnamara, Elaine W. Kay, Pierre Laurent-Puig, Daniel B. Longley, Patrick G. Johnston, Mark Lawler, Richard Wilson, Manuel Salto-Tellez, Sandra Van Schaeybroeck, Mairin Rafferty, William M. Gallagher, Markus Rehm, Jochen Hm Prehn

Physiology and Medical Physics Articles

PURPOSE: Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the profiling of multiple model inputs, which hampers clinical translation.

PATIENTS AND METHODS: We applied APOPTO-CELL, a prognostic model of apoptosis signaling, to showcase the establishment of computational platforms that require a reduced set of inputs. We designed two distinct and complementary pipelines: a probabilistic approach to exploit a consistent subpanel of inputs across the whole cohort (Ensemble) and a machine learning approach to identify a reduced protein set tailored for individual patients (Tree ...


Editorial Board Mar 2019

Editorial Board

Karbala International Journal of Modern Science

No abstract provided.


Table Of Contents Mar 2019

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


A Theoretical Model Of Underground Dipole Antennas For Communications In Internet Of Underground Things, Abdul Salam, Mehmet C. Vuran, Xin Dong, Christos Argyropoulos, Suat Irmak Feb 2019

A Theoretical Model Of Underground Dipole Antennas For Communications In Internet Of Underground Things, Abdul Salam, Mehmet C. Vuran, Xin Dong, Christos Argyropoulos, Suat Irmak

Faculty Publications

The realization of Internet of Underground Things (IOUT) relies on the establishment of reliable communication links, where the antenna becomes a major design component due to the significant impacts of soil. In this paper, a theoretical model is developed to capture the impacts of change of soil moisture on the return loss, resonant frequency, and bandwidth of a buried dipole antenna. Experiments are conducted in silty clay loam, sandy, and silt loam soil, to characterize the effects of soil, in an indoor testbed and field testbeds. It is shown that at subsurface burial depths (0.1-0.4m), change in soil ...


When Ron Met Tam In Mesothelioma: All Druggable For One, And One Drug For All?, Anne-Marie Baird, David Easty, Monika A. Jarzabek, Liam Shiels, Alex Soltermann, Sonja Klebe, Stéphane Raeppel, Lauren Macdonagh, Chengguang Wu, Kim Griggs, Michaela B. Kirschner, Bryan Stanfill, Daisuke Nonaka, Chandra M. Goparaju, Bruno Murer, Dean A. Fennell, Dearbhaile M. O'Donnell, Martin P. Barr, Luciano Mutti, Glen Reid, Stephen Finn, Sinead Cuffe, Harvey I. Pass, Isabelle Opitz, Annette Byrne, Kenneth J. O'Byrne, Steven G. Gray Feb 2019

When Ron Met Tam In Mesothelioma: All Druggable For One, And One Drug For All?, Anne-Marie Baird, David Easty, Monika A. Jarzabek, Liam Shiels, Alex Soltermann, Sonja Klebe, Stéphane Raeppel, Lauren Macdonagh, Chengguang Wu, Kim Griggs, Michaela B. Kirschner, Bryan Stanfill, Daisuke Nonaka, Chandra M. Goparaju, Bruno Murer, Dean A. Fennell, Dearbhaile M. O'Donnell, Martin P. Barr, Luciano Mutti, Glen Reid, Stephen Finn, Sinead Cuffe, Harvey I. Pass, Isabelle Opitz, Annette Byrne, Kenneth J. O'Byrne, Steven G. Gray

Physiology and Medical Physics Articles

Malignant pleural mesothelioma (MPM) is an aggressive inflammatory cancer with a poor survival rate. Treatment options are limited at best and drug resistance is common. Thus, there is an urgent need to identify novel therapeutic targets in this disease in order to improve patient outcomes and survival times. MST1R (RON) is a trans-membrane receptor tyrosine kinase (RTK), which is part of the c-MET proto-oncogene family. The only ligand recognized to bind MST1R (RON) is Macrophage Stimulating 1 (MST1), also known as Macrophage Stimulating Protein (MSP) or Hepatocyte Growth Factor-Like Protein (HGFL). In this study, we demonstrate that the MST1-MST1R (RON ...


Volume 11, Jacob Carney, Ryan White, Joseph Hyman, Jenny Raven, Megan Garrett, Ibrahim Kante, Summer Meinhard, Lauren Johnson, William "Editha" Dean Howells, Laura Gottschalk, Christopher Siefke, Pink Powell, Natasha Woodmancy, Katharine Colley, Abbey Mays, Charlotte Potts Jan 2019

Volume 11, Jacob Carney, Ryan White, Joseph Hyman, Jenny Raven, Megan Garrett, Ibrahim Kante, Summer Meinhard, Lauren Johnson, William "Editha" Dean Howells, Laura Gottschalk, Christopher Siefke, Pink Powell, Natasha Woodmancy, Katharine Colley, Abbey Mays, Charlotte Potts

Incite: The Journal of Undergraduate Scholarship

Table of Contents:

Introduction, Dr. Roger A. Byrne, Dean

From the Editor, Dr. Larissa "Kat" Tracy

From the Designers, Rachel English, Rachel Hanson

Synthesis of 3,5-substituted Parabens and their Antimicrobial Properties, Jacob Coarney, Ryan White

Chernobyl: Putting "Perestroika" and "Glasnot" to the Test, Joseph Hyman

Art by Jenny Raven

Watering Down Accessibility: The Issue with Public Access to Alaska's Federal Waterways, Meagan Garrett

Why Has the Democratic Republic of the Congo outsourced its Responsibility to Educate its Citizens? Ibrahim Kante

Art by Summer Meinhard

A Computational Study of Single Molecule Diodes, Lauren Johnson

Satire of the State through ...


Cross Faculty Collaboration In The Development Of An Integrated Mathematics And Science Initial Teacher Education Program, Sharon P. Fraser, Kim Beswick, Margaret Penson, Andrew Seen, Robert Whannell Jan 2019

Cross Faculty Collaboration In The Development Of An Integrated Mathematics And Science Initial Teacher Education Program, Sharon P. Fraser, Kim Beswick, Margaret Penson, Andrew Seen, Robert Whannell

Australian Journal of Teacher Education

This paper describes a collaborative project involving mathematicians, scientists and educators at an Australian university where an innovative initial teacher education (ITE) degree in mathematics/science was developed. The theoretical frameworks of identity theory and academic brokerage and their use in understanding the challenges associated with the early stages of collaborative projects is described. Data from reflections and interviews of the participants after involvement in the project from one to three years are presented to illustrate these challenges. The paper concludes with a description of the importance of the academic broker in overcoming identity challenges and facilitating cultural change for ...


Table Of Contents Dec 2018

Table Of Contents

Journal of the South Carolina Academy of Science

No abstract provided.


Application Of Graphical Models In Protein-Protein Interactions And Dynamics, Amir Vajdi Hoojghan Dec 2018

Application Of Graphical Models In Protein-Protein Interactions And Dynamics, Amir Vajdi Hoojghan

Graduate Doctoral Dissertations

Every organism contains a few hundred to thousands of proteins. A protein is made of a sequence of molecular building blocks named amino acids. Amino acids will be referred to as residues. Every protein performs one or more functions in the cell. In order for a protein to do its job, it requires to bind properly to other partner proteins. Many genetic diseases such as cancer are caused by mutations (changes) of specific residues which cause disturbances in the functions of those proteins.

The problem of prediction of protein binding site is a crucial topic in computational biology. A protein ...


Post-Treatment De-Phosphorylation Of P53 Correlates With Dasatinib Responsiveness In Malignant Melanoma., Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm Dec 2018

Post-Treatment De-Phosphorylation Of P53 Correlates With Dasatinib Responsiveness In Malignant Melanoma., Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm

Physiology and Medical Physics Articles

BACKGROUND: Dasatinib (Sprycel) was developed as a tyrosine kinase inhibitor targeting Bcr-Abl and the family of Src kinases. Dasatinib is commonly used for the treatment of acute lymphoblastic and chronic myelogenous leukemia. Previous clinical studies in melanoma returned inconclusive results and suggested that patients respond highly heterogeneously to dasatinib as single agent or in combination with standard-of-care chemotherapeutic dacarbazine. Reliable biomarkers to predict dasatinib responsiveness in melanoma have not yet been developed.

RESULTS: Here, we collected comprehensive in vitro data from experimentally well-controlled conditions to study the effect of dasatinib, alone and in combination with dacarbazine, on cell proliferation and ...


Investigation Of Flow Disturbances And Multi-Directional Wall Shear Stress In The Stenosed Carotid Artery Bifurcation Using Particle Image Velocimetry, Amanda L. Dicarlo Dec 2018

Investigation Of Flow Disturbances And Multi-Directional Wall Shear Stress In The Stenosed Carotid Artery Bifurcation Using Particle Image Velocimetry, Amanda L. Dicarlo

Electronic Thesis and Dissertation Repository

Hemodynamics and shear forces are associated with pathological changes in the vascular wall and its function, resulting in the focal development of atherosclerosis. Flow complexities that develop in the presence of established plaques create environments favourable to thrombosis formation and potentially plaque rupture leading to stroke. The carotid artery bifurcation is a common site of atherosclerosis development. Recently, the multi-directional nature of shear stress acting on the endothelial layer has been highlighted as a risk factor for atherogenesis, emphasizing the need for accurate measurements of shear stress magnitude as well direction. In the absence of comprehensive patient specific datasets numerical ...